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Patent # Description
US-9,808,466 Macrocyclic compounds as protein kinase inhibitors
There is provided compounds of formula I, wherein R1, R.sup.2a, R.sup.2b, R.sup.2c, X, Y, Z, R.sup.3 and ring A/B have meanings given in the description, and...
US-9,808,465 Emulsion formulations of aprepitant
Disclosed herein are novel pharmaceutical formulations of aprepitant suitable for parenteral administration including intravenous administration. Also included...
US-9,808,464 Compounds and compositions for ossification and methods related thereto
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition...
US-9,808,463 Safe-driving support system
Providing a system that prevents decrease of attentiveness of drowsiness of a driver of a moving vehicle. A safe-driving support system is provided. The...
US-9,808,462 Modulators of androgen synthesis
The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for...
US-9,808,461 Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6
The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the...
US-9,808,460 Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
Disclosed herein are auris acceptable gel compositions containing a multiparticulate glutamate receptor antagonist, and methods for the treatment of otic...
US-9,808,459 Inhibitors of influenza viruses replication
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample...
US-9,808,458 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria
The invention provides methods of treating or preventing malaria comprising administering to an animal an effective amount of a compound of formula I:...
US-9,808,457 CGRP receptor antagonists
The disclosures herein relate to novel compounds of formula ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, and their use in...
US-9,808,456 Piperazine thiazole derivatives useful in the treatment of tauopathies such as Alzheimer's disease
The present invention relates to a compound of formula (IA), wherein G.sup.1 is lower alkyl; lower alkyl substituted by one or more halogens; cycloalkyl;...
US-9,808,455 Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
The combination of 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline or a pharmaceutically acceptable salt thereof with a second therapeutic agent, wherein the...
US-9,808,454 Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the...
The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for...
US-9,808,453 Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent
Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of an opioid analgesic, an opioid antagonist and one or...
US-9,808,452 Polysubunit opioid prodrugs resistant to overdose and abuse
The invention provides compositions and methods for the treatment or prevention of pain. The invention provides constructs whereby hydrolysis of the construct...
US-9,808,451 Antiproliferative compounds and methods of use thereof
Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as...
US-9,808,450 Solid forms comprising 3-(4-amino-1-OXO-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione and a coformer,...
Provided herein are solid forms comprising (a) 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (Lenalidomide) and (b) a coformer....
US-9,808,449 S1P modulating agents
Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
US-9,808,448 Pharmaceutical compounds and use of same in cancer and tauopathies
Disclosed are compounds of formula (l)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating...
US-9,808,447 Inhibitors of Rho associated protein kinases (ROCK) and methods of use
Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are...
US-9,808,446 Method for decreasing symptoms of alcohol consumption
The present invention relates to methods and compositions of metadoxine and physiologically compatible active derivatives thereof, and their use for decreasing...
US-9,808,445 Factor IXa inhibitors
In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or...
US-9,808,444 Methods for restoration of histamine balance
Several embodiments provided herein relate to histamine dosing regimens are and uses of such regimens in the restoration of histamine balance in subjects...
US-9,808,443 Cyclooxygenase inhibitors
Cyclooxygenase inhibitors include compounds of the formula: ##STR00001## where R represents phenyl, nitrophenyl, 2-nitrophenyl, 3-nitrophenyl, 4-nitrophenyl,...
US-9,808,442 Enalapril formulations
Provided herein are stable enalapril oral liquid formulations. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of...
US-9,808,441 Dietary supplement containing alkaline electrolyte buffers
An improved dietary and/or therapeutic supplement composition comprising a quantity of a dietary and/or therapeutic supplement agent having a pH that upon...
US-9,808,440 Pharmaceutical combination comprising metformin and dihydroquercetin and its use for the treatment of cancer
Provided is a novel medicament capable of reducing the side effects of metformin or a pharmaceutically acceptable salt thereof and useful as an anti-malignant...
US-9,808,439 Use of tangeretin in cancer treatment
The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic...
US-9,808,438 Method for treating mucositis
The invention provides a pharmaceutical composition for preventing or treating mucositis, for example oral mucositis (e.g., oral ulceration) and...
US-9,808,437 Monounsaturated fatty acid compositions and use for treating atherosclerosis
Compositions comprising high concentration of monounsaturated fatty acids having low melting points and high iodine values and use of such compositions as...
US-9,808,436 Treatment of intrahepatic cholestatic diseases
Treatment of intrahepatic cholestatic diseases by therapy with MBX-8025 or an MBX-8025 salt.
US-9,808,435 Antiviral compositions and methods for inactivating non-enveloped viruses using alkyl 2-hydroxycarboxylic acids
The present invention is directed to antiviral compositions that provide efficacy against non-envelope viruses such as noroviruses. The antiviral compositions...
US-9,808,434 Compound for treating cancer and diabetes
One aspect of the disclosure relates to the use of derivatives of dichlorophenyl urea for treating cancers.
US-9,808,433 Combination of a centrally-acting analgesic and a selective cyclooxygenase-2 inhibitor anti-inflammatory agent...
The present invention relates to veterinary pharmaceutical compositions for the treatment of pain and inflammation, containing a combination of Tramadol and...
US-9,808,432 Methods for overcoming resistance to tramadol
There is disclosed a method for treating disorders modulated by at least opiate receptor activity or monoamine activity, including acute and chronic pain,...
US-9,808,431 Immediate release oral guaifenesin solution
Disclosed is an immediate release solution for oral administration of guaifenesin and at least one additional drug. In addition to water the solution comprises...
US-9,808,430 Compositions and methods relating to resveratrol
The present invention relates to compositions and methods comprising resveratrol and uses thereof. Some embodiments include compositions and methods with...
US-9,808,429 Topical drug patch including microspheres
A topical drug delivery patch (1) comprising a drug delivery layer (3) including microspheres (2) encapsulating a drug, said microspheres being carried in a...
US-9,808,428 Compositions and methods for the delivery of therapeutics
The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.
US-9,808,427 Swallowable N-acetylcysteine tablets
This invention relates to swallowable tablets containing at least 80% by weight of N-acetylcysteine (NAC) and at least one pharmaceutically acceptable...
US-9,808,426 Ternary mixture formulations
The invention relates to a novel free-flowing powder pharmaceutical formulation for the delivery of a poorly-water-soluble drug substance that increases the...
US-9,808,425 Targeted liposomes in cancer therapy
The invention provides pharmaceutical compositions containing a vehicle for the targeted delivery of therapeutic and diagnostic agents for the treatment of...
US-9,808,424 Method for formulating large diameter synthetic membrane vesicles
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the...
US-9,808,423 Preparation of suspension aerosol formulations
The present invention provides processes for preparing suspension aerosol formulations, wherein the particles for inhalation are formed in situ during the...
US-9,808,422 Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration...
Dry powder formulations for inhalation comprising a combination of an anticholinergic, a long-acting beta.sub.2-adrenoceptor agonist, and a corticosteroid are...
US-9,808,421 Bioerodible silicon-based devices for delivery of therapeutic agents
This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies,...
US-9,808,420 Drug delivery devices for delivery of ocular therapeutic agents
Drug delivery devices comprising a non-bioabsorbable polymer structure configured to support a composition comprising an active agent. The devices include a...
US-9,808,419 Medicinal treatment of dermal infectious disorders with norketotifen
The methods disclosed herein relate to the treatment of dermal infectious disorders, in human patients, by administering a therapeutically effective amount of...
US-9,808,418 Pharmaceutical dosage form
A pH responsive and mucoadhesive pharmaceutical dosage form for the release of a pharmaceutically active agent is described. The dosage form includes a...
US-9,808,417 Compositions comprising Docynia delavajy extract and/or Elaeagnus lancelotus extract
Disclosed is a method of treating skin in need thereof, the method comprising topically applying to the skin a composition comprising an effective amount of an...
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