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Patent # Description
US-9,814,784 Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same
The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide...
US-9,814,782 Modified antibody in which motif comprising cysteine residue is bound, modified antibody-drug conjugate...
The present invention relates to an antibody in which a motif composed of an amino acid or peptide sequence including one or more cysteine residues is bound to...
US-9,814,781 Environmentally sensitive compositions and methods of use thereof
An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility...
US-9,814,780 Compositions for inducing antigen-specific tolerance
Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or...
US-9,814,779 Crosslinked chitosan-lactide hydrogels
Aspects of the invention include crosslinked copolymer hydrogel compositions. Crosslinked copolymer hydrogel compositions according to certain embodiments...
US-9,814,778 Ionically crosslinked polyelectrolytes as underwater adhesives as controlled release vehicles
Underwater adhesive materials, methods of making the same, and methods of using the same are described.
US-9,814,777 Targeting lipids
The present invention provides targeting lipids of structure L.sup.100-linker-L.sup.101 (CI), where L.sup.100 is a lipid, lipophile, alkyl, alkenyl or alkynyl,...
US-9,814,776 Pharmaceutical preparation comprising aminopyrazole derivative
The pharmaceutical formulations according to the present invention include an alkyl sulfate salt and a compound represented by general formula (I) below (where...
US-9,814,775 Method for making and storing stable cannabinoid compositions and method for treatment using such compositions
A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically-acceptable solvent achieves room temperature stability for over 24 months....
US-9,814,774 Dermatological product
An improved composition for alleviating and treating the condition of scarring is provided. The system is directed to a product or composition which includes a...
US-9,814,773 Sustained release formulations for delivery of proteins to the eye and methods of preparing same
The present invention provides for injectable pharmaceutical sustained release formulations for delivery of active agents, particularly therapeutic proteins, to...
US-9,814,772 Synthetic glucopyranosyl lipid adjuvants
Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: ##STR00001## or a pharmaceutically...
US-9,814,771 Live attenuated classical swine fever vaccine based in genetic manipulation of a putative fusion peptide area...
The role of a specific E2 region containing a putative fusion peptide (FP) sequence was evaluated. FPs critically contribute to the interaction between proteins...
US-9,814,770 H3 influenza A virus
The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof.
US-9,814,769 Vaccines against pathogenic Escherichia coli and methods of using the same
Provided herein are compositions and methods for vaccinating against infection with pathogenic Escherichia coli (E. coli). In some embodiments, the compositions...
US-9,814,768 Immunoreactive glycoprotein GP19 of Ehrlichia canis
The present invention concerns gp19 immunoreactive compositions for E. canis and compositions related thereto, including vaccines, antibodies, polypeptides,...
US-9,814,767 Methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a...
This document provides methods and materials for generating CD8.sup.+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide....
US-9,814,766 Multimodal antimicrobial therapy
The present invention is directed to compositions and methods for preventing and/or treating diseases and disorders of patients caused by non-Staphylococcal...
US-9,814,765 One component fibrin glue comprising zymogens
Provided herein is a single component sealant formulation (e.g. in a liquid form), methods for its preparation, and use. The formulation includes fibrinogen;...
US-9,814,764 Treatment of sanfilippo syndrome type b by intrathecal administration of alpha-n-acetylglucosaminidase
Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT)...
US-9,814,763 Method for delivery of somatostatin into a lumen of the intestinal tract
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many...
US-9,814,762 Targeted therapeutic proteins
Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic...
US-9,814,761 Compositions, methods and assays comprising amylin or amlyin analogs for abeta-peptide mediated disorders
Provided herein are methods of reducing and/or inhibiting A deposition or A plaque formation in the brain, and/or inhibiting or slowing the progression of...
US-9,814,760 Modified polynucleotides for the production of biologics and proteins associated with human disease
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
US-9,814,759 Pharmaceutical composition comprising recombinant hemoglobin protein or subunit-based therapeutic agent for...
The present invention provides a pharmaceutical composition containing recombinant hemoglobin protein or tetramer or dimer or subunit for tissue oxygenation and...
US-9,814,758 Inhibitors of apoptosis and uses thereof
The invention relates to fragments of the Death-Domain Associated protein (DAXX protein) and of the Fas-Associated Death Domain protein (FADD protein) that...
US-9,814,757 Products and methods using soy peptides to lower total and LDL cholesterol levels
Controlled studies demonstrate that products and related methods using soy related peptides lower total and LDL cholesterol levels in individuals. In one...
US-9,814,756 Use of isolated bacterial amyloids for treatment of inflammatory disorders or diseases of the epithelium
A method for treatment of a subject having an inflammatory disease of the epithelium comprising the step of administering an amount of a composition comprising...
US-9,814,755 Methods for the treatment of depression and anxiety
Methods of treating a depressive disorder or an anxiety disorder in a subject in need of such treatment are described. A therapeutically effective amount of a...
US-9,814,754 Combinations with a backbone-cyclized peptide
A novel combination comprising a .beta.-hairpin peptidomimetic of the formula cyclo(-Thr-Trp-Ile-Dab-Orn-.sup.DDab-Dab-Trp-Dab-Dab-Ala-Ser-.sup- .DPro-Pro) (I),...
US-9,814,753 Methods and compositions comprising desmopressin in combination with a beta-3-adrenergic receptor agonist
The invention provides methods and compositions for use of desmopressin in combination with a beta-3-adrenergic receptor agonist. The methods and compositions...
US-9,814,752 Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart...
This invention also provides a method to prevent, control, and treat a lipid metabolism disorder, a billary disorder, cardiovascular disease, obesity or an...
US-9,814,751 Lisinopril formulations
Provided herein are stable lisinopril oral liquid formulations. Also provided herein are methods of using lisinopril oral liquid formulations for the treatment...
US-9,814,750 Use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer
This invention relates to use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer in limb or on body surface, or in...
US-9,814,749 Composition for preventing or treating dementia containing prunus mume extract
The present invention relates to a composition for preventing or treating dementia containing an extract of Prunus mume (Fructus Mume), and the Prunus mume...
US-9,814,748 Synergistic salivation agents
Provides is a salivation cocktail that comprises a food acid and a tingling sensate. The combination of a food acid and a tingling sensate has been found to...
US-9,814,747 Methods for inhibiting HIV-1 activity by inhibitory mechanisms of extracts of Guaiacum officinale L....
A therapeutic phenolic extract derived from plant biomass, and more specifically the indigenous Jamaican plant guaiacum officinale L. (Zygophyllaceae), for use...
US-9,814,746 Method of treatment utilizing an acellular amnion derived therapeutic composition
Acellular amnion derived therapeutic compositions are described having a number of various compositional embodiments. An acellular amnion derived therapeutic...
US-9,814,745 Xenograft soft tissue implants and methods of making
The present application is directed to the field of implants comprising soft tissue for use in implantation in humans. The soft tissue implants of the present...
US-9,814,744 Decellularized adipose cell growth scaffold
Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell...
US-9,814,742 Diet product comprising alginate
The present invention relates to a diet product comprising an alginate in an aqueous dissolved or swelled form at a pH value causing the alginate not to gel...
US-9,814,741 Methods relating to DNA-sensing pathway related conditions
The invention provides, inter alia, methods for modulating DNA sensing pathways and the innate immune responses downstream of such pathways. The invention...
US-9,814,740 Methods and compositions combining immunotherapy with monocyte activation
Methods of enhancing the effectiveness of an antibody-based therapeutic agent are provided herein. The methods include administering an antibody-based...
US-9,814,739 2'-ethynyl nucleoside derivatives for treatment of viral infections
The present invention provides a compound of formula A: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein B, Q, R.sup.1, R.sup.5, R.sup.6,...
US-9,814,737 Composition for skin sanitization and protection and method of its use
An improved composition for skin cleansing and protection is disclosed. The composition contains an effective amount of at least one alpha-hydroxyl acid or a...
US-9,814,736 Use of 2-methylene-19-nor-(20S)-1.alpha.,25-dihydroxyvitamin D.sub.3 and calcimimetics to treat secondary...
Disclosed are methods of administering 2-methylene-19-nor-(20S)-1.alpha.,25-dihydroxyvitamin D.sub.3 to treat and/or prevent secondary hyperparathyroidism...
US-9,814,735 Certain chemical entities, compositions, and methods
Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
US-9,814,734 Bufalin liposome, preparation method therefor and application thereof
The present invention provides a bufalin liposome comprising a liposome bilayer and bufalin. The liposome bilayer comprises phospholipid, sterol and...
US-9,814,733 Compositions comprising EPA and obeticholic acid and methods of use thereof
In various embodiments, the present invention provides compositions comprising eicosapentaenoic acid or a derivative thereof and obeticholic acid or a...
US-9,814,732 Ulipristal acetate for prevention and treatment of breast tumors
The invention relates to the use of ulipristal acetate, or any of its metabolites, in preventing or treating a breast tumor in a patient, preferably a patient...
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