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Patent # Description
US-9,815,899 Antibody targeting osteoclast-related protein siglec-15
To provide a method of detecting abnormal bone metabolism by using a gene strongly expressed in an osteoclast; a method of screening a compound having a...
US-9,815,898 Antibody molecules to PD-1 and uses thereof
Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or...
US-9,815,897 Antibodies directed against programmed death-1 (PD-1)
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a programmed...
US-9,815,896 Monoclonal antibody STRO-4
The present invention relates to a monoclonal antibody designated STRO-4 which specifically binds human and ovine HSP-90beta and its use for enriching...
US-9,815,895 Methods of reducing basophil levels
The present invention relates to a method of reducing the numbers of eosinophils in a human subject comprising administration to a subject an IL-5R binding...
US-9,815,894 Use of reslizumab to treat moderate to severe eosinophilic asthma
Disclosed herein are methods of treating moderate to severe eosinophilic asthma in a patient comprising administering a therapeutically effective dose of...
US-9,815,893 Anti-VEGF antibodies and their uses
The present disclosure relates to antibodies directed to vascular endothelial growth factor ("VEGF") and uses of such antibodies, for example to treat diseases...
US-9,815,892 Multimeric constructs
Multimeric fusion proteins of an Ig-like domain of Flt-1 are rendered functional by inclusion of a linker moiety. Vectors encoding the fusion proteins and host...
US-9,815,891 Monospecific polypeptide reagents
The present invention relates to a novel antigen-binding protein construct or "modubody", which contains at least three functional single domain modules of an...
US-9,815,890 Antibodies to the C3d fragment of complement component 3
The present invention relates to methods and materials for modulating the complement alternative pathway (CAP), the complement classical pathway (CCP), the...
US-9,815,889 Antibodies for prevention and treatment of diseases caused by clostridium difficile
The present invention relates to an antibody having specificity for an immunogenic determinant consisting of the pentasaccharide repeating unit of the...
US-9,815,888 Therapeutic use of specific ligand in MSRV associated diseases
A ligand includes each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ...
US-9,815,887 Monoclonal antibodies that neutralize a norovirus
Monoclonal neutralizing antibodies are disclosed that specifically bind to a Norovirus. In some embodiments, the Norovirus is a genogroup II Norovirus or a...
US-9,815,886 Compositions and methods for the treatment of immunodeficiency
The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the...
US-9,815,885 Inducible mutagenesis of target genes
The present invention relates generally to mutagenesis of target genes that takes advantage of the natural mutagenic capabilities of B cells, and enhances those...
US-9,815,884 ApoE peptide dimers and uses thereof
The present invention provides novel pharmaceutical compositions comprising ApoE-derived peptide dimers. In particular, the ApoE peptide dimers of the invention...
US-9,815,883 Inhibiting peptides derived from TREM-like transcript 1 (TLT-1) and uses thereof
The present invention relates to polypeptides fragments derived from the protein TLT-1 and their uses for the treatment of inflammatory conditions and more...
US-9,815,882 Tumor targeted Tnf-related apoptosis inducing ligand fusion polypeptide, methods and uses therefor
Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds...
US-9,815,881 Method of inducing labor or treating pre-eclampsia by administering relaxin analogs
Human relaxin analogs, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided.
US-9,815,880 IL-22 Fc fusion proteins
The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of...
US-9,815,879 Method for the purification of G-CSF
The present invention relates to a method for obtaining recombinant granulocyte-colony stimulating factor (G-CSF), comprising at least one cation exchange...
US-9,815,878 Use of PEDF-derived polypeptides for preventing and/or ameliorating skin aging
A method for preventing and/or ameliorating skin aging in a subject includes administering to the subject in need of such treatments a synthetic peptide, which...
US-9,815,877 Controlled gene expression methods
Methods and compositions for controlling gene expression are disclosed.
US-9,815,876 Chimeric inhibitor molecules of complement activation
The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of...
US-9,815,875 Postsynaptically targeted chemodenervation agents and their methods of use
Improved chemodenervation agents are provided comprising polypeptide .alpha.-neurotoxins having high binding specificity and selectivity for the human muscular...
US-9,815,874 Compositions comprising fibrous polypeptides and polysaccharides
Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide...
US-9,815,873 Method for recovering plant-derived proteins
Methods of recovering plant-derived proteins or suprastructure proteins, are provided. The method may comprise obtaining a plant, or plant matter comprising...
US-9,815,872 Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof
The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the disclosure...
US-9,815,871 Genetic reprogramming of bacterial biofilms
Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions...
US-9,815,870 Monomeric and bright infrared fluorescent proteins
The invention described herein features variants related to infrared fluorescent proteins, in particular to mutants of a phytochrome from the bacterium...
US-9,815,869 SP-B and SP-C peptides, synthetic lung surfactants, and use thereof
The present invention relates to synthetic lung surfactant compositions that include a novel surface active peptide and a phospholipid, including ...
US-9,815,868 Peptides binding to parallel-stranded G-quadruplexes
A peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a derivative thereof is provided. Also provided are conjugates of such a...
US-9,815,867 Peptide for inhibiting vascular endothelial growth factor receptor
An object of the present invention is to provide a VEGFR2 inhibitor peptide having high specificity and available at a low cost. The present invention provides...
US-9,815,866 Peptides that bind to epithelial cell adhesion molecule
[Problem to be Solved] An object of the present invention is to provide a novel peptide that has the high ability to bind to EpCAM, which can be easily prepared...
US-9,815,865 Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
The present invention further provides method of preparing nanocrystals or microcrystals of a hydrophobic therapeutic agent such as fluticasone or...
US-9,815,864 Substituted nucleosides, nucleotides and analogs thereof
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs...
US-9,815,863 Hydrogen bond forming fluoro ketolides for treating diseases
The invention described herein pertains to a novel macrolide antibacterial agent of formula (I): A-L-Q, as defined herein, and pharmaceutically acceptable...
US-9,815,862 Polymorphs of LNnT
A crystalline LNnT polymorph IV, characterized in that it displays X-ray powder diffraction reflections, based on a measurement using CuK.alpha. radiation, at...
US-9,815,861 Selective glycosidase inhibitors and uses thereof
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions...
US-9,815,860 Process for preparing cationic rhodium complexes
A process for the synthesis of a cationic rhodium complex comprises the steps of: (a) forming a mixture of a rhodium-diolefin-1,3-diketonate compound and a...
US-9,815,859 Tricyclic sulfones as ROR.gamma. modulators
There are described ROR.gamma. modulators of the formula (I), ##STR00001## and formula (II) ##STR00002## or stereoisomers, tautomers, pharmaceutically...
US-9,815,858 Hydridosilapyrroles, hydridosilaazapyrroles, thiasilacyclopentanes, method for preparation thereof, and...
Hydridosilapyrroles and hydridosilaazapyrrole are a new class of heterocyclic compounds having a silicon bound to carbon and nitrogen atoms within the ring...
US-9,815,857 Boron-containing small molecules as antiprotozoal agents
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as...
US-9,815,856 Functionalized primary alkyltrifluoroborate salts and method for making the same
The invention provides methods for preparing boronic acids, for example, primary alkyl or alkenyl boronic acids, and alkali metal alkyl trifluoro borate salts,...
US-9,815,855 Method for producing 4-borono-L-phenylalanine having 18F atom introduced thereinto, and precursor of...
.sup.18F-labeled 4-boronophenylalanine (BPA) can be produced by preparing and further processing a precursor of .sup.18F-labeled BPA represented by the...
US-9,815,854 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridine and therapeutic uses thereof
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
US-9,815,853 Bridged bicyclic kallikrein inhibitors
Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
US-9,815,852 Macrocyclic compounds and methods of treatment
The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell...
US-9,815,851 Pyrrolo carboxamides as modulators of orphan nuclear receptor RAR-related orphan receptor-gamma (ROR.gamma.,...
The invention provides modulators for the orphan nuclear receptor ROR.sub..gamma. and methods for treating ROR.sub..gamma. mediated diseases by administrating...
US-9,815,850 Compounds, compositions and methods
The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.
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