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Patent # Description
US-9,815,849 Compositions and methods for treating leukemia
The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.
US-9,815,848 Method for preparing spherical Clopidogrel Hydrogen Sulfate polymorph I
This invention provides a new preparation method of Clopidogrel Hydrogen Sulfate spherical crystal form I, using single 2-butanol as solvent, controlling the...
US-9,815,847 Pyrimidine compounds as kinase inhibitors
This disclosure relates to compounds, methods for their preparation, pharmaceutical compositions including these compounds and methods for the treatment of...
US-9,815,846 TrkA kinase inhibitors, compositions and methods thereof
The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein...
US-9,815,845 Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present...
US-9,815,844 Pharmaceutically acceptable salts and polymorphic forms of hydrocodone benzoic acid enol ester and processes...
Compositions comprising hydrocodone benzoic acid enol ester to form novel prodrugs including hydrocodone benzoic acid enol ester salts, and various polymorphs....
US-9,815,843 Compound, photosensitive resin composition comprising the same, and color filter
A compound represented by Chemical Formula 1 wherein each substituent is the same as defined in the specification, a photosensitive resin composition including...
US-9,815,842 Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors
The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and...
US-9,815,841 Compounds
The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to...
US-9,815,840 Protein kinase inhibitor containing pyrrolopyridazine derivative
The present invention relates to a pyrrolopyridazine derivative represented by Formula 1 of the detailed description, or a pharmaceutically acceptable salt...
US-9,815,839 N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
The present invention provides N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines derivatives that modulate the activity of phosphoinositide 3-kinases (PI3Ks)...
US-9,815,838 Methods and compositions for treating pain
The present application relates to compounds and methods for treating pain, incontinence and other conditions.
US-9,815,837 Polymorphs
The invention relates to polymorphous crystal modifications of a DPP-IV inhibitor, the preparation thereof and the use thereof for preparing a medicament.
US-9,815,836 Macrocyclic compounds as IRAK1/4 inhibitors and uses thereof
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
US-9,815,835 Substituted polycyclic carbamolypyridone derivative
This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted...
US-9,815,834 Quinolone derivatives as fibroblast growth factor receptor inhibitors
Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are...
US-9,815,833 Pyridine derivative and medical use thereof
The present invention relates to the field of pharmaceutical chemistry, specifically to a class of compounds containing lactam and derivative thereof, and...
US-9,815,832 Azabenzimidazole compounds
The present invention is directed to compounds of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the substituents are as...
US-9,815,831 3,5-disubstituted-3H-imidazo[4,5-B]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo[4,5-B] pyridine compounds...
The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and...
US-9,815,830 Isoergoline compounds and uses thereof
Provided herein are isoergoline compounds and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention,...
US-9,815,829 Process for the preparation of optically active isoxazoline compounds
The present invention relates to a process for the preparation of a compound of formula (I) wherein A.sub.1 and A.sub.2 are C--H, or one of A.sub.1 and A.sub.2...
US-9,815,828 Histone demethylase inhibitors
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine...
US-9,815,827 Agent for treatment of schizophrenia
The present invention provides a novel method for treatment of schizophrenia which can improve wide-ranging symptoms of schizophrenia, especially positive...
US-9,815,826 Crystal of azole benzene derivative
There are provided crystals of 2-[4-(2,2-dimethylpropoxy)-3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-4-methyl-1- ,3-thiazole-5-carboxylic acid which is useful as a...
US-9,815,825 Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and...
Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a...
US-9,815,824 Kappa opioid agonists and uses thereof
Provided are compounds of Formula I; and pharmaceutically acceptable salts and solvates thereof. ##STR00001## The present disclosure relates to novel...
US-9,815,823 Carbazole ketoxime ester high-photosensitivity photoinitiator
A carbazolyl ketoxime ester type photoinitiator having a structure represented by the formula (I) is disclosed. This photoinitiator has excellent application...
US-9,815,822 Heteroaromatic compounds as BTK inhibitors
The present invention encompasses compounds of the formula (I) ##STR00001## wherein the groups R.sub.1, Cy and Y are defined herein, which are suitable for the...
US-9,815,821 Condensed-cyclic compound and organic light emitting diode including the same
Embodiments of the present invention are directed to a condensed-cyclic compound and an OLED including the same.
US-9,815,820 Rho kinase inhibitors
The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2.
US-9,815,819 Complement pathway modulators and uses thereof
The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present...
US-9,815,818 Cot modulators and methods of use thereof
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
US-9,815,817 Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation...
US-9,815,816 Chemical process for the synthesis of ...
The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The...
US-9,815,815 Non-selective kinase inhibitors
Disclosed herein are compounds, compositions, and methods for preventing and treating proliferative diseases associated with aberrant receptor tyrosine kinase...
US-9,815,814 Glutarimide derivatives, use thereof, pharmaceutical composition based thereon and methods for producing...
The present invention relates to novel biologically active glutarimide derivatives of general formula I or pharmaceutically acceptable salts thereof, their use...
US-9,815,813 1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions therefor for inhibiting the...
The present invention relates to compounds of formula I: ##STR00001## in which Y.sub.1, Y.sub.2, Y.sub.3, R.sub.1, R.sub.2a, R.sub.2b, R.sub.3a, R.sub.3b,...
US-9,815,812 Thiopyranose compound and method for producing same
There is provided a production method of a thiopyranose compound represented by the following Formula (2) by reacting a compound represented by the following...
US-9,815,811 Inhibitors of the kynurenine pathway
The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase,...
US-9,815,810 Method of cannabinoid preservation through crystallization and other crystal structures
A method of cannabinoid preservation includes separating a cannabinoid ethanol (EtOH) mixture from a cannabis extract through a filtration process; forming a...
US-9,815,809 Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of phenols or thiophenols
The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane...
US-9,815,808 Recovery of monomer from polyurethane materials by depolymerization
Methods for recovering monomers from polymers, such as polyurethanes (including thermoset polyurethanes) include heating the polymer to depolymerize the polymer...
US-9,815,807 Method for producing 2-furaldehyde
An object of the present invention is to provide a method for suppressing the corrosion of a reactor and reducing waste in the production of 2-furaldehyde from...
US-9,815,806 Process for cabazitaxel
The present invention provides an improved process for the preparation of 4.alpha.-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1.beta.,13.alpha.-d- ...
US-9,815,805 Certain (25)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts...
US-9,815,804 Isoxazole hydroxamic acid compounds as LpxC inhibitors
This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such...
US-9,815,803 Process for the preparation of substituted cycloserines
The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) ##STR00001## wherein R.sup.1 is...
US-9,815,802 Herbicidally active N-(1-methyltetrazol-5-yl)benzoic acid amides
N-(1-Methyltetrazol-5-yl)benzamides of the general formula (I) are described as herbicides. ##STR00001## In this formula (I), X, Z and R are radicals such as...
US-9,815,801 Method of refining valsartan comprising more than or equal to 10% D-isomers
The present invention relates to a method of refining valsartan comprising more than or equal to 10% D-isomers, the method comprising: adding a solvent to...
US-9,815,800 Integrated production of urea and melamine
Disclosed is a process for the integrated production of urea and melamine. A urea production zone produces a urea synthesis stream comprising urea, water and...
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