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Patent # Description
US-9,828,432 Cancer treatment and monitoring methods using OX40 agonists
OX40 is a potent immune stimulating target. Provided herein are methods for the treatment of cancer patients using (3X40 agonists methods to predict clinical...
US-9,828,431 Use of IL-31RA monoclonal antibodies for treating neuronal inflammation
Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing...
US-9,828,430 Anti-IL-6/IL-6R antibodies
This invention provides fully human monoclonal antibodies that recognize the IL-6/IL-6R complex. The invention further provides methods of using such monoclonal...
US-9,828,429 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
Provided are methods for modifying the isoelectric point of an antibody while retaining its antigen-binding activity, comprising modifying the charge of at...
US-9,828,428 Anti-IL-13 receptor alpha 2 antibodies and antibody-drug conjugates
Disclosed herein are anti-IL-13-R.alpha.2 antibodies and antibody drug conjugates and methods for preparing and using the same.
US-9,828,427 Anti-KIR3D antibodies
The present invention provides antigen-binding proteins capable of binding to KIR3D polypeptides. The antibodies have increased activity in the treatment of...
US-9,828,426 Antibodies against kidney associated antigen 1 and antigen binding fragments thereof
Novel antibodies and antigen binding fragments that specifically bind to KAAG1 and which may be used in the treatment, detection and diagnosis of cancer...
US-9,828,425 Anti-ILT5 antibodies and ILT5-binding antibody fragments
Disclosed herein are antibodies and ILT5-binding fragments thereof that specifically bind to ILT5, e.g., human ILT5 (hILT5), and pharmaceutical compositions...
US-9,828,424 Anti-TNF antibodies, compositions, methods and uses
The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light...
US-9,828,423 Anti-BLyS antibody
The present invention belongs to the field of biopharmaceutics. Disclosed is an anti-BLyS antibody. The anti-BLyS antibody specifically targets BLyS, can...
US-9,828,422 Anti-Ang2 antibody
An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with...
US-9,828,421 Protein-based therapy and diagnosis of tau-mediated pathology in Alzheimer's disease
The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions...
US-9,828,420 Method of providing disease-specific binding molecules and targets
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes...
US-9,828,419 Antibody and antibody-containing composition
For many diseases due to microbes or the like, proliferation of microbes themselves is a cause of a symptom. However, there were cases where a substance...
US-9,828,418 Process for enriching IgA
The invention relates to a process for enriching IgA (and IgM) from IgA-comprising material. In particular, it relates to a sequential elution process of an...
US-9,828,417 Long-acting polypeptides and methods of producing and administering same
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest...
US-9,828,416 Modified polynucleotides for the production of secreted proteins
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
US-9,828,415 Compositions and methods of use for treating metabolic disorders
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
US-9,828,414 Pr13.5 promoter for robust T-cell and antibody responses
The invention encompasses recombinant poxviruses, preferably modified Vaccinia Ankara (MVA) viruses, comprising a Pr13.5 promoter operably linked to a...
US-9,828,413 Vancomycin derivative, and preparation method and application thereof
The present invention provides a vancomycin derivative, and a preparation method and an application thereof. The vancomycin derivative of the present invention...
US-9,828,412 Short peptide targeting EPS8 binding with EGFR and use thereof
The present invention discloses a short peptide targeting EPS8 binding with EGFR and use thereof, and sequence of the short peptide is ...
US-9,828,411 Method for isolating caspofungin
The present invention relates to a method for isolating caspofungin and to a novel crystalline form of caspofungin diacetate thus obtained.
US-9,828,410 .beta.-D-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-C-substituted-2-modified-N.s- up.6-substituted purine nucleotides...
A compound of the structure: ##STR00001## or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to...
US-9,828,409 Bridged-cyclo-ProTides as prodrugs of therapeutic nucleosides and nucleotides
Provided herein are bridged cyclic phosphates and phosphoramidates (bc-ProTides) of nucleosides, which is a compound, its stereoisomers, isotope-enriched...
US-9,828,408 HCV polymerase inhibitors
The invention provides compounds of the formula: ##STR00001## wherein B is a nucleobase selected from the groups (a) to (d): ##STR00002## and the other...
US-9,828,407 Water soluble and activable phenolic derivatives with dermocosmetic and therapeutic applications and process...
The invention relates to the preparation of phenolic derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the...
US-9,828,406 Antitumor agent
The invention is intended to provide an excellent antitumor agent. An antitumor agent contains a glycolipid glycoside compound represented by Formula (1) or a...
US-9,828,405 Morpholinyl anthracycline derivatives
The present invention relates to new morpholinyl anthracycline derivatives which have cytotoxic activity and are useful in treating diseases such as cancer,...
US-9,828,404 Crosslinked polymeric substrates methods of preparation and end use applications of the substrates
A composition of matter wherein the composition comprises a siliceous substrate having silanols on the surface and a polymer selected from the group consisting...
US-9,828,403 Metallocene compounds, catalyst compositions comprising the same, and method for preparing olefin polymers...
The present invention relates to a transition metal compound that may exhibit high activity in olefin polymerization, and easily control the properties of...
US-9,828,402 Film-forming composition and method for fabricating film by using the same
A film-forming composition including a 3-intracyclic cyclopentadienyl precursor and dimethyethylamine is useful for Atomic Layer Deposition, and improves...
US-9,828,401 Ruthenium-based complex catalysts
The present invention provides novel Ruthenium-based transition metal complex catalysts comprising specific ligands, their preparation and their use in...
US-9,828,400 Iridium pincer complex for alkane dehydrogenation process
Disclosed herein are processes for dehydrogenation of an alkane to an alkene using an iridium pincer complex and iridium pincer complexes. In the...
US-9,828,399 TC-PTP inhibitors as APC activators for immunotherapy
The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also...
US-9,828,398 Compound for bone scanning and use thereof
The disclosure provides a compound comprising bisphosphonate functional group and chelating agent. The bisphosphonate functional group part has high affinity...
US-9,828,397 Prodrugs of pyridone amides useful as modulators of sodium channels
The invention relates to prodrug compounds of formula I: ##STR00001## wherein R.sup.2, R.sup.3, R.sup.5, R.sup.7 and X are as defined herein. The invention...
US-9,828,396 Alkyne compounds for treatment of complement mediated disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-9,828,395 Nanocrystal and preparation method thereof
A nanocrystal represented by the following Formula 1 and a preparation method thereof: AMX.sub.3L Formula 1 wherein A is cesium (Cs), rubidium (Rb), or an...
US-9,828,394 Method of preparing dialkyl-, diaryl-, and alkylaryl-dihalosilanes with high selectivity in a Grignard coupling...
A method of making a diakyl-, diaryl-, or alkylaryl-dihalosilane in a Grignard coupling reaction with a high degree of selectivity is provided. More...
US-9,828,393 Silylalkyloxyaryl compounds and methods for treating cancer
Silylalkyloxyaryl compounds useful as anti-cancer agents. The compounds and pharmaceutical compositions containing them are particularly useful for the...
US-9,828,392 Low chloride compositions of olefinically functionalised siloxane oligomers based on alkoxysilanes
The invention relates to a composition comprising olefinically functionalized siloxane oligomers derived from olefinically functionalized alkoxysilanes and...
US-9,828,391 Beta-lactamase inhibitors
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
US-9,828,390 Tetrahydropyrrolo[3,4-D][1,3]thiazine-derivative as BACE inhibitor
The present invention provides a compound of Formula I: which is crystalline. The compound of Formula (I) is useful in the treatment of Alzheimer's disease...
US-9,828,389 Tetrazolinone compounds and their use as pesticides
The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1) [wherein Q represents a...
US-9,828,388 Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory...
Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I)...
US-9,828,387 Control of color-body formation in isohexide esterification
A method for preparing esters from isohexide compounds, and a means by which color bodies that may be made in situ during esterification of isohexide compounds...
US-9,828,386 Sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof
The present invention discloses a sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof. The present invention introduces a...
US-9,828,385 Spiro-oxazolones
The present invention provides spiro-oxazolones, which act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture,...
US-9,828,384 Spiro-lactam NMDA receptor modulators and uses thereof
Disclosed are compounds having enhanced potency in the modulation of NMD A receptor activity. Such compounds are contemplated for use in the treatment of...
US-9,828,383 Crystalline forms of a bruton's tyrosine kinase inhibitor
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
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