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Patent # Description
US-9,834,621 Method for purifying contaminated polypropylene
A method for purifying reclaimed polypropylene, such as a polypropylene reclaimed from post-consumer use or post-industrial use, is disclosed. The method...
US-9,834,620 Modified conjugated diene-based polymer, preparation method therefor, and rubber composition containing same
Disclosed are a modified conjugated diene-based polymer represented by specific Chemical Formula, a method of preparing the same, and a rubber composition...
US-9,834,619 Modified conjugated diene-based polymer, modified rubber composition containing same, and method for preparing...
Disclosed are a method of preparing a modified conjugated diene-based polymer, a modified conjugated diene-based polymer prepared thereby, a rubber composition...
US-9,834,618 Process for the production of water and solvent-free polymers
The present invention relates to water and solvent-free polymers, in particular water and solvent-free synthetic rubber products like non-halogenated and...
US-9,834,617 Method for immobilizing biologic molecules on solid surfaces
The invention provides a method for immobilization of biological molecules such as nucleic acids, peptides and proteins onto the surface of a glass or plastic...
US-9,834,616 Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding...
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition...
US-9,834,615 Methods for the generation of multispecific and multivalent antibodies
The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods...
US-9,834,614 Method of increasing plasmin activity through antiplasmin conversion
Methods for increasing plasmin activity in a patient in need thereof are provided, comprising administering to the patient a therapeutic amount of an agent...
US-9,834,613 Preparation useful for, and method for treatment of neonatal alloimmune thrombocytopenia (NAIT)
A preparation useful for, and a method for the prophylactic treatment of women post-childbirth in order to avoid immunization and antibody production, which...
US-9,834,612 Antibodies to the B12-transcobalamin receptor
The present invention provides anti-TCblR antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of...
US-9,834,611 Single variable domain antibodies against OX40L, constructs and therapeutic use
The present invention relates to immunoglobulin single variable domain sequences that are directed against (as defined herein) OX40L, as well as to compounds or...
US-9,834,610 Fusion proteins for modulating regulatory and effector T cells
The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene (GITR) and OX40 signaling pathway. In certain...
US-9,834,609 Methods of detecting a tumor expressing fibroblast growth factor receptor 2
The present invention is directed toward a monoclonal antibody to fibroblast growth factor receptor 2, a pharmaceutical composition comprising same, and methods...
US-9,834,608 Binding-triggered transcriptional switches and methods of use thereof
The present disclosure provides binding-triggered transcriptional switch polypeptides, nucleic acids comprising nucleotide sequences encoding the ...
US-9,834,607 Bi-specific antibodies against Tim-3 and PD-1 for immunotherapy in chronic immune conditions
Described herein are novel compositions comprising bispecific and multispecific polypeptide agents, and methods using these agents for targeting cells, such as...
US-9,834,606 Anti-PD1 antibodies and their use as therapeutics and diagnostics
Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in...
US-9,834,605 Antibodies to human programmed death receptor PD-1
Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing...
US-9,834,604 Inhibitors of T-cell activation
The present invention provides a bispecific biologic comprising a ligand specific for CTLA-4 and a ligand specific for a pMHC complex.
US-9,834,603 Antibodies to IL-6 and use thereof
The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of...
US-9,834,602 Use of IL-31 monoclonal antibodies for treating neuronal inflammation
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in...
US-9,834,601 Antagonists of IL-17 isoforms and their uses
The invention relates to antagonists of IL-17 isoforms and their uses in diagnosis and therapy, especially for the treatment or prevention of cancers or...
US-9,834,600 Methods of treatment of eosinophilic bronchitis with an anti-IL-5 antibody
The present invention relates generally to the methods for the treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more...
US-9,834,599 Pain treatment
The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that...
US-9,834,598 Antibodies to amyloid beta
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid...
US-9,834,597 Modified FC polypeptides, FC conjugates, and methods of use thereof
The present disclosure provides modified Fc domains having one or more attachment moieties for attaching a heterologous functional moiety; and methods of...
US-9,834,596 Antibodies to tau
This invention relates to antibodies to tau and methods of use thereof.
US-9,834,595 Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the...
The present invention relates in part to amino acid sequences that are directed against and/or that can specifically bind to an envelope protein of a virus, as...
US-9,834,594 Human monoclonal antibodies derived from human B cells and having neutralizing activity against influenza A viruses
The present invention relates to human monoclonal antibodies derived from human B cells present in the blood of patients who had recovered from infection with...
US-9,834,593 IgG stimulated remyelination of peripheral nerves
The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods...
US-9,834,592 Modified colostrum protein and application thereof
Disclosed is a modified colostrum protein having an amino acid sequence shown in SEQ ID NO.: 1, which is generated by replacing Ile at position 33, Glu at...
US-9,834,591 Method of producing recombinant high molecular weight vWF in cell culture
Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a...
US-9,834,590 Chimeric receptors with 4-1BB stimulatory signaling domain
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the...
US-9,834,589 CD86 variants with improved affinity for CTLA-4
The invention provides a polypeptide that specifically binds to CTLA-4, particularly human CTLA-4.
US-9,834,588 Targeted therapeutic lysosomal enzyme fusion proteins and uses thereof
The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases....
US-9,834,587 Targeted therapeutic lysosomal enzyme fusion proteins and uses thereof
The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases....
US-9,834,586 Compositions and methods of use for treating metabolic disorders
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
US-9,834,585 Method of inhibiting C5 cleavage
The invention relates to complement inhibitors that inhibit both the classical and alternative complement pathways. In particular, the invention relates to...
US-9,834,584 Nucleic acids encoding chromophores/fluorophores and methods for using the same
Nucleic acid compositions encoding chromo/fluoroproteins and mutants thereof, as well as the encoded proteins, are provided. The subject proteins of interest...
US-9,834,583 Authentic trimeric HIV-1 GP140 envelope glycoproteins comprising a long linker and tag
An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers...
US-9,834,582 Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The...
US-9,834,581 Cell penetrating peptides for intracellular delivery of molecules
A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of XWXRLXXXXXX (SEQ ID No: 5), wherein X in position 1 is beta-A...
US-9,834,580 Pharmaceutical compositions comprising selective peptide-based agonists of melanocortin 1 receptor
Short tri- and tetrapeptides according to the following Formula I Ar(CH2).sub.mX.sup.1--X.sup.2--CO--X.sup.3--X.sup.4--X.sup.5-(Trp).sub.n-- NX.sup.6R are...
US-9,834,579 Crystalline forms of s-acetyl glutathione, their preparations and uses in pharmaceutical and nutraceutical...
Disclosed are two novel crystalline forms of S-acetyl glutathione (SAG) called Form A and Form B, obtained by crystallization of SAG from mixtures of...
US-9,834,578 Enhanced sensitivity for analysis of ketosteroid compounds using mass spectrometry
The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of...
US-9,834,577 Process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate
The present invention provides a process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate of Formula I in high yield and purity.
US-9,834,576 Synthetic route to 2'-deoxy-2',2'-difluorotetrahydrouridines
The present invention relates to methods and intermediates for synthesizing 2'-deoxy-2',2'-difluorotetrahydrouridine compounds.
US-9,834,575 Cancer therapy
The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of...
US-9,834,574 Crystalline 3-O-fucosyllactose
Crystalline 3-O-fucosyllactose, useful in a pharmaceutical composition and a nutritional formulation, is disclosed.
US-9,834,573 Crystalline form of benzylbenzene SGLT2 inhibitor
Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides...
US-9,834,572 Process for preparing hydridocarbonyltris(triphenylphosphine)rhodium(I)
The present invention relates to a process for preparing hydridocarbonyltris(triphenylphosphine)rhodium(I), RhH(CO)(PPh.sub.3).sub.3, also referred to...
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