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Patent # Description
US-9,833,457 Tricyclic compounds as modulators of TNF-.alpha. synthesis and as PDE4 inhibitors
The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of...
US-9,833,456 Treatment of erectile dysfunction and other indications
The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of...
US-9,833,455 Preparation and methods of use for ortho-aryl 5-membered heteroaryl-carboxamide containing multi-targeted...
The present disclosure relates to compounds of the Formula (I): ##STR00001## and pharmaceutically acceptable salts, as kinase modulators, compatible with the...
US-9,833,454 Difluoromethoxy compound with low bioactivation potential for the reduction of beta-amyloid production
The compound N2-(3-(difluoromethoxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fl- ...
US-9,833,453 Therapeutic compounds and uses thereof
Described herein are compounds of Formula (I)-(III), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are...
US-9,833,452 Compounds
Compounds of formula (I): ##STR00001## are described herein. Compounds of the disclosure are modulators of Kv3 channels and may be used in the prophylaxis or...
US-9,833,451 Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side...
US-9,833,450 Oxabicycloheptanes and oxabicycloheptenes for the treatment of depressive and stress disorders
A method of treating a depressive or stress disorder in a subject afflicted therewith comprising administering to the subject an effective amount of a compound...
US-9,833,449 2-(azaindol-2-yl) benzimidazoles as PAD4 inhibitors
Compounds of formula (I): ##STR00001## wherein; R.sub.1 is hydrogen or C.sub.1-6alkyl; R.sub.2 is hydrogen, C.sub.1-6alkyl, perhalomethylC.sub.0-5alkyl-O--,...
US-9,833,448 Piperidinone carboxamide azaindane CGRP receptor antagonists
The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or...
US-9,833,447 5-HT4 receptor agonist for gastroparesis
This invention relates to 4-{[4-({([4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]-oxy}methyl)pip- eridin-1-yl]methyl}tetrahydro-2H-pyran-4-carboxylic acid for...
US-9,833,446 Hedgehog pathway inhibition for cartilage tumor and metachondromatosis treatment
A method for preventing, slowing, or blocking the formation of an exostosis or an enchondromas comprising administering to an animal in need thereof a hedgehog...
US-9,833,445 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same
The invention provides 5-deuterium-enriched 2,4-thiazolidinediones (e.g., 5-[4-[2-(5-ethyl-2-pyridyl)-2-oxoethoxy]benzyl]-5-deutero-thiazolidine-2,- 4-dione),...
US-9,833,444 Use of chemical compounds that can inhibit the toxic activity of sphingomyelinase D from venoms of Loxosceles...
The present invention relates preferably to the use of 4-bromo-N-[(E)-(2-methyl-1H-indol-3-yl)methyleneamino]benzenesulphonamide and...
US-9,833,443 Pharmaceutical compositions
The present invention relates to the field of methods for providing pharmaceutical compositions comprising poorly water-soluble drugs. In particular the present...
US-9,833,442 Pharmaceutical compositions
The present invention relates to the field of methods for providing pharmaceutical compositions comprising poorly water-soluble drugs. In particular the present...
US-9,833,441 Compositions and methods for the treatment of presbyopia
The invention provides compositions and methods for the treatment of presbyopia. The compositions preferably comprise aceclidine and a cycloplegic agent. The...
US-9,833,440 Substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for...
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I D-M-D ...
US-9,833,439 ERK inhibitors for use in treating spinal muscular atrophy
The present invention relates to a method for treating spinal muscular atrophy and other related neuromuscular disorders in a subject in need thereof, said...
US-9,833,438 Treatment of atopic dermatitis with indigo naturalis or indigo producing plant extract
A pharmaceutical or cosmetic composition comprising an Indigo Naturalis or Indigo-producing plant extract for treating atopic dermatitis and any form of eczema,...
US-9,833,437 Small molecule inhibitor of MYD88 for therapeutic treatment against alphavirus and staphylococcal enterotoxin...
A synthetic molecule 4210 and a therapeutic use of a synthetic small molecule 4210 for treating viral infections, especially encephalitic alphavirus infections....
US-9,833,436 Method of preparing drug agglomerate
A method of preparing drug agglomerates includes adding a drug powder to a first solvent to form a first solution, adding a second solvent to the first solution...
US-9,833,435 Compositions and methods to treat Niemann-Pick disease
The present disclosure is directed to compositions comprising bryostatin-1, and methods comprising administering a composition comprising bryostatin-1, to treat...
US-9,833,434 Methods of treating skin conditions using cyclolignan compounds
The present invention includes compositions and methods for the treatment of skin conditions by administration of a cyclolignan such as picropodophyllin and/or...
US-9,833,433 Compositions, methods of use, and methods of treatment
Embodiments of the present disclosure provide for compositions including an antimicrobial agent, pharmaceutical compositions including the composition or...
US-9,833,432 Aminocarbonylcarbamate compounds
The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake...
US-9,833,431 Pharmaceutical combinations for the treatment of cancer
The present invention relates to pharmaceutical combinations comprising aminoacetonitrile derivatives and anticancer compounds. Further, the present invention...
US-9,833,430 Neurodegenerative disorders and methods of treatment and diagnosis thereof
This invention relates to compositions and methods for the therapy and diagnosis of neurodegenerative or neuromuscular disorders. More particularly, this...
US-9,833,429 Therapeutic compositions
Ingenol angelate is a potent anticancer agent, and can be stabilized by dissolving it in an aprotic solvent in the presence of an acidic buffer.
US-9,833,428 Therapeutic compositions
Ingenol angelate is a potent anticancer agent, and can be stabilized by dissolving it in an aprotic solvent in the presence of an acidic buffer.
US-9,833,427 Creatine ester anti-inflammatory compounds and formulations
The present invention provides a creatine ester anti-inflammatory compound which may be received by animals and then metabolized into a biologically active form...
US-9,833,426 Agent for preventing deterioration in vascular endothelial function or improving vascular endothelial function
An agent for enhancing NO production, comprising citrulline or a salt thereof and serine or a salt thereof as an active ingredient. An agent for preventing or...
US-9,833,425 Gentisic acid is used to improve systemic hemodynamics, hepatic mitochondrial function and lactate acidemia in...
Gentisic acid sodium salt is shown to be useful as a treatment to improve systemic hemodynamics, hepatic mitochondrial function and lactic acidemia in patients...
US-9,833,424 Application of fluoxetine to treatment of depigmentation diseases
The present disclosure provides methods and pharmaceutical compositions for treating depigmentation diseases such as vitiligo or leukoctricia. The...
US-9,833,423 1,3-Di-oxo-indene derivative, pharmaceutically acceptable salt or optical isomer thereof, preparation method...
Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical...
US-9,833,422 Anti-cancer activity of (E)-1-(3',4'-dimethoxyphenyl)butadiene
The present invention provides a method of using (E)-1-(3', 4'-dimethoxyphenyl) butadiene to induce anti-tumorigenic effects in pancreatic carcinoma, ovarian...
US-9,833,421 Method for synthesizing (E)-anethol and related compounds by cross coupling reaction of potassium...
Methods of producing substituted and non-substituted beta-methyl styrene by a cross-coupling reaction are provided. The disclosure also provides for methods of...
US-9,833,420 Methods of preventing, treating, and diagnosing disorders of protein aggregation
Disclosed are methods of preventing, treating, or diagnosing in a subject a disorder in protein folding or aggregation, or amyloid formation, deposition,...
US-9,833,419 Transdermal estrogen device and delivery
Described are transdermal drug delivery systems for the transdermal administration of estrogen, comprising a polymer matrix and estrogen. Methods of making and...
US-9,833,418 Transdermal therapeutic system having controlled active substance flow comprising a basic reacting oxide
The present invention relates to transdermal therapeutic systems that include an occlusive back layer impervious to an active substance, a single or multilayer...
US-9,833,417 Felbinac-containing external patch
Provided is a felbinac-containing external patch which can exhibit high drug release properties, low skin irritation, and high drug stability, wherein felbinac...
US-9,833,416 Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same
Compositions for inhibiting oligonucleotide activity in vitro or in vivo to a cell that are formulated with at least one oligonucleotide encapsulated in a lipid...
US-9,833,415 3D tumor targeting with diamagnetic repulsion
With externally applied magnetic fields, we will push and concentrate in vivo diamagnetic Bismuth particles or unipolar magnetic particles as a confined locus,...
US-9,833,414 Uniformly abrasive confectionery product and process therefor
The present invention relates to the field of confectionery products. More particularly, the invention relates to an abrasive confectionery product and a...
US-9,833,413 Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin
Disclosed is a pharmaceutical combination formulation comprising a first discrete part containing amlodipine and rosuvastatin and a second discrete part...
US-9,833,412 Triple combination release multi-layered tablet
This invention pertains to a multi-layered tablet for a triple combination release of active agents to an environment of use. More particularly, the invention...
US-9,833,411 Solid oral dosage forms
The present invention provides pharmaceutical compositions suitable for oral delivery of active agent, such as peptides and small molecules, and methods for...
US-9,833,410 Lyophilized formulation comprising GM-CSF neutralizing compound
The present invention relates to aqueous formulations comprising at least 20 mg/ml of a compound neutralizing GM-CSF, a lyoprotectant and an amino acid and/or a...
US-9,833,408 Orally administrable formulation
An orally administrable chewing gum formulation is provided comprising a pharmaceutically acceptable gum base and particles of a pharmaceutical agent ranging in...
US-9,833,407 Nasal vaccine for Streptococcus pneumoniae
The present invention provides a nasal vaccine for Streptococcus pneumoniae, and a production method therefor. This nasal vaccine formulation for primates...
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