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Patent # Description
US-9,840,569 Spacer groups for functionalized resins in tires
This invention relates to a functionalized resin composition having the formula P--S--X where S is a spacer selected from at least one of C.sub.2-C.sub.40...
US-9,840,568 Polymer and method for producing same
The time when at least a monomer and a chain transfer agent are supplied in a reactor and the solution temperature in the reactor has reached a predetermined...
US-9,840,567 Olefin polymerization process with continuous transfer
A process for the preparation of a polyolefin is disclosed. The process includes introducing one or more olefin reactants, diluents and polymerization catalyst...
US-9,840,566 Preparations and methods for treating a GD2 positive cancer
The present invention relates to preparations and methods for treating a GD2 positive cancer by administering a preparation comprising a chimeric or humanized...
US-9,840,565 HER1 antigen binding proteins binding to the beta-hairpin of HER1
The invention relates to anti-HER1 antigen binding proteins, e.g. anti-HER1 antibodies, that bind to the beta-hairpin of HER1, methods for selecting these...
US-9,840,564 Cytotoxic benzodiazepine derivatives
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula...
US-9,840,563 Method for treating and/or preventing atrial fibrillation
Disclosed herein is a method for treating and/or preventing atrial fibrillation in a subject, comprising administering to the subject a pharmaceutical...
US-9,840,562 Binding molecules to the human OX40 receptor
The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding...
US-9,840,561 Human anti-human epidermal growth factor receptor antibody and encoding gene and application thereof
The present invention provides human anti-human epidermal growth factor receptor (EGFR) antibodies and their encoding genes and applications thereof. By gene...
US-9,840,560 Monoclonal antibodies to EGFR, and uses therefor
The present invention relates to isolated monoclonal anti-EGFR antibodies, and to the use of such antibodies and antibody fragments to detect EGFR, particularly...
US-9,840,559 Anti-CD83 antibodies and use thereof
The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.
US-9,840,558 Human antibody specific for interleukin-1alpha
Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1.alpha. and (ii) a constant region...
US-9,840,557 Anti-IL-25 antibodies and uses thereof
The present invention provides antibodies that bind to human interleukin-25 (IL-25) and methods of using the same. According to certain embodiments, the...
US-9,840,556 Anti-TNF alpha antibodies which selectively inhibit TNF alpha signalling through the p55R
The present invention provides anti-TNF.alpha. antibodies which selectively inhibit TNF.alpha. signalling through the p55R. In particular the present invention...
US-9,840,555 Method for producing human monoclonal antibodies that binds to at least one part of HMGB1
The present invention relates to methods of making human anti-HMGB1 antibodies, compositions comprising these antibodies and methods of using the antibodies and...
US-9,840,554 Antibodies against platelet-derived growth factor (PDGF)
Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding...
US-9,840,553 Dual PDGF/VEGF antagonists
The invention provides a dual VEGF/PDGF antagonist comprising a VEGF antagonist linked to a PDGF antagonist. The VEGF antagonist is an antibody to a VEGF or...
US-9,840,552 Monoclonal antibody against human midkine
A monoclonal antibody, which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human...
US-9,840,551 Blood markers for diagnosing epithelium derived cancers and monoclonal antibodies thereof
The present invention provides uses of cytokeratins as markers for diagnosing epithelium derived cancers. The present invention provides cancer-related epitopes...
US-9,840,550 Compounds for treating the remyelination blockade in diseases associated with the expression of HERV-W envelope...
The present invention deals with innovative compounds and compositions for preventing and/or treating a newly discovered detrimental mechanism, which blocks the...
US-9,840,549 Fusion polypeptides capable of activating receptors
A fusion polypeptide comprising (A).sub.x-M-(A').sub.y, wherein A and A' are each polypeptides capable of binding a target receptor. The fusion polypeptides of...
US-9,840,548 Peptides and combination of peptides for use in immunotherapy against various tumors
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-9,840,547 Hepatic insulin sensitizing substance and test meal for insulin sensitization
The present invention provides methods of treating prediabetes, hyperglycemia, type 2 diabetes, AMIS syndrome, and obesity in a subject by administering to the...
US-9,840,546 Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof
The growth hormone with high biological activity modified by the double-stranded polyethylene glycol at a single site and the preparation method thereof are...
US-9,840,545 Fusion protein comprising interleukin-2 and interleukin-33
The present application discloses a novel fusion peptide of IL-2 and IL-33 and its use. It comprises a biologically active domain of Interleukin-2 (IL-2) or a...
US-9,840,544 Method for development of a peptide building block useful for de novo protein design
The present invention relates to a top-down symmetric deconstruction approach which provides a novel alternative means to successfully identify a useful...
US-9,840,543 Anti-BAFF antibodies
The present invention relates to anti-BAFF antibody molecules, including novel humanized anti-BAFF antibodies, therapeutic and diagnostic methods and...
US-9,840,542 Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted...
Methods for expressing a polypeptide of interest in an astroglial cell. The methods permit the localization and transport of nucleic acids in microglial...
US-9,840,541 Opsin polypeptides and methods of use thereof
The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are...
US-9,840,540 Artificial bioparticle and method of manufacturing the same
According to an artificial bioparticle characterized in that a leucine zipper is integrated in each N terminal of an MVP constituting a waist of a vault and a...
US-9,840,539 High affinity digoxigenin binding proteins
Isolated polypeptides with steroid binding activity and methods for their use as therapeutics and detection agents are disclosed herein.
US-9,840,538 Nucleic acids and proteins from Streptococcus groups A and B
The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid...
US-9,840,537 Selective delivery molecules and methods of use
Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells...
US-9,840,536 Methods and compositions for the treatment of gastrointestinal disorders
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional...
US-9,840,535 Method of recovering peptide and method of detecting peptide
Disclosed is a method of recovering a peptide, including: mixing a liquid sample containing a complex of peptide and protein in blood with a reagent containing...
US-9,840,534 Process for the manufacture of cyclic undecapeptides
The present invention relates to processes and intermediates useful for the manufacture of cyclic undecapeptides, such as Alisporivir.
US-9,840,533 Compositions and methods for altering second messenger signaling
The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof;...
US-9,840,532 5'-substituted nucleoside compounds
The present invention relates to novel 5'-substituted nucleoside compounds, pharmaceutical compositions comprising the compounds, and methods of using the...
US-9,840,531 Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or...
US-9,840,530 Mannose-receptor selective lysinylated cationic amphiphiles and a process for preparation thereof
The present invention relates to the mannose-receptor selective lysinylated cationic amphiphile and a process for preparation thereof. The compounds of the...
US-9,840,529 Hydrogen oxidation catalyst
The present invention is to provide a hydrogen oxidation catalyst that does not contain platinum. Disclosed is a hydrogen oxidation catalyst that is a dinuclear...
US-9,840,528 Thione-platinum(II) complexes and pharmaceutical compositions thereof
Platinum(II) complexes having thione-based heterocyclic ligands as anticancer agents. The central platinum atom is coordinated by four of the ligands, each...
US-9,840,527 Metal complex including tridentate aminodicarbene ligand and hydrogenation reduction method using same
The use of a metal complex containing a ruthenium ion or an osmium ion, and a tridentate aminodicarbene ligand, the tridentate aminodicarbene ligand having one...
US-9,840,526 Iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent
Bromodomain-containing protein 4 (BRI)) has recently emerged as an attractive epigenetic target for anticancer therapy. Iridium(III) complexes are useful as...
US-9,840,525 Crystal form of tenofovir prodrug, preparation method thereof, and method of use thereof
A crystal form of 9-[(R)-2-[[(S)-[[[1-(isopropoxycarbonyl)-1-methyl]ethyl]amino]phenoxyphos- phinyl]methoxyl]propyl]adenine fumarate of formula (I) is provided....
US-9,840,524 Process for reducing the chlorine content of organomonophosphites using two solutions
Process with universal usefulness for reducing the chlorine content of organomonophosphites, using two solutions.
US-9,840,523 Process of synthesizing diisopropylamino-disilanes
Chemical processes comprise selectively synthesizing diisopropylamino-disilanes and reduction of chloride in aminosilanes, and the compositions comprise the...
US-9,840,522 Multi-modal bioprobe for bladder cancer imaging and photodynamic therapy
The present invention relates to a new generation of PDT agents based on porphyrin-lanthanide complexes with specific functional groups which can specifically...
US-9,840,521 Organic anion lithium ionic cocrystal compounds and compositions
A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a...
US-9,840,520 Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase...
The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including...
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