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Patent # Description
US-9,850,288 Method of purifying authentic trimeric HIV-1 envelope glycoproteins comprising a long linker and tag
An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers...
US-9,850,287 Means and methods for breaking noncovalent binding interactions between molecules
Described are multimeric proteinaceous molecules comprising at least two members that bind each other via a region of noncovalent interaction, wherein a first...
US-9,850,286 Cytokine
A novel cytokine, U83A, is described, as are variant forms of the cytokine, having a wide range of agonistic and antagonistic activity against chemokine...
US-9,850,285 Process for preparing eptifibatide
The present invention provides processes for preparation of eptifibatide that involve coupling of amino acids in a (2+5), (4+3) and (3+4) sequence method. The...
US-9,850,284 Beta-hairpin peptidomimetics
Beta-hairpin peptidomimetics of the general formula (I), cyclo(P.sup.1-p.sup.2-p.sup.3-p.sup.4-p.sup.5-p.sup.6-p.sup.7p.sup.8p.sup- ...
US-9,850,283 Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the...
US-9,850,282 Stable pentadecapeptide salts, a process for preparation thereof, a use thereof in the manufacture of...
Stable pentadecapeptide salts of formula (I): TABLE-US-00001 (I) SEQ ID NO 1 Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala 1 5 ...
US-9,850,281 Cladosporium peptides
Polypeptides which may be used for preventing or treating allergy to moulds of the Cladosporium and/or Alternaria genus, have up to 30 amino acids in length and...
US-9,850,280 Melanocortin receptor ligands
The present invention is directed to compounds according to formula, (R.sup.2R.sup.3)-A.sup.1-c(A.sup.2-A.sup.3-A.sup.4-A.sup.5-A.sup.6-A.sup.- ...
US-9,850,279 Peptides and analogs for use in the treatment of oral mucositis
Preclinical data obtained in models of chemotherapy-induced mucositis, radiation-induced mucositis, neutropenic infection and colitis indicate oral mucositis is...
US-9,850,278 Synthetic anti-inflammatory peptides and use thereof
The present invention is directed to synthetic anti-inflammatory peptides and use thereof in the treatment and prevention of inflammatory and fibrotic...
US-9,850,277 Therapeutically active compositions and their methods of use
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a...
US-9,850,276 Bidentate-binding modulators of LRRK2 and JNK kinases
Both JNK and LRRK2 are associated with Parkinson's disease (PD), myocardial infarction (MI), and other medical disorders. Here we report a reasonably selective...
US-9,850,275 Photolabile linker for the solid-phase synthesis of hydrazides and pyranopyrazoles
The photolabile hydrazine linker of the present invention is based on the o-nitro-veratryl group, which is capable of releasing hydrazide derivatives upon UV...
US-9,850,274 Peptide combination
The invention relates to a peptide combination characterized by peptides each having the same sequence length (SEQL), that can be produced from a mixture (A)...
US-9,850,273 Combination of estrogens plus antiprogestins with significant partial agonistic effect as an effective...
Described herein are compositions and methods for hormone replacement therapy that address the shortcomings of the existing methods. Described herein are...
US-9,850,272 Therapeutically active estratrienthiazole derivatives as inhibitors of 17.beta-hydroxy-steroid dehydrogenase,...
The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R2, R3, R4, R7 and R8 are as defined in the claims. The...
US-9,850,271 Crystalline solvate forms of a pharmaceutical
The invention provides and describes solid state 17.alpha.-ethynyl-androst-5-ene-3.beta.,7.beta.,17.beta.-triol including amorphous and crystalline forms and...
US-9,850,270 Non-caloric sweeteners and methods for synthesizing
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
US-9,850,269 Methods for purification of messenger RNA
The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of (a) precipitating mRNA from an impure...
US-9,850,268 Metathesis catalysts and methods thereof
The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides...
US-9,850,267 Crystalline fosaprepitant dicyclohexylamine salt and its preparation
The present invention provides dicyclohexylamine salt of fosaprepitant (fosaprepitant DCHA), a process for preparing fosaprepitant DCHA, and a use of...
US-9,850,266 Phosphorylcholine group-containing compound and phosphorylcholine complex
[Object] To provide a phosphorylcholine group-containing compound capable of producing a phosphorylcholine complex, and the phosphorylcholine complex, the...
US-9,850,265 Amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives and their medical use
The present invention relates to amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of...
US-9,850,264 Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases
The present invention relates to a method for treating ocular inflammatory diseases in a subject in need of such treatment, which comprises administering a...
US-9,850,263 Process for preparing phosphorus containing cyanohydrins
The present invention relates primarily to a process for preparing certain phosphorus-containing cyanohydrins of the formula (I), and also to certain...
US-9,850,262 Proteasome activity enhancing compounds
The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a...
US-9,850,261 Silicon-based cross coupling agents and methods of their use
Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.
US-9,850,260 Hydroxymethyl-carboxamido-substituted silane and its use for curable, silane-terminated polymers
Specific hydroxysilanes of formula (I), a method for the production thereof, the use thereof as a constituent of moisture-curing compositions, and...
US-9,850,259 Apparatus for purifying organic compound and method of purifying organic compound
An apparatus for purifying an organic compound and a method of purifying an organic compound, the apparatus including an inner tube that receives a purification...
US-9,850,258 Substituted tetrahydrocarbazole and carbazole carboxamide compounds
Disclosed are compounds of Formula (I) ##STR00001## wherein: the two dotted lines represent either two single or two double bonds; Q is: ##STR00002## R.sub.1...
US-9,850,257 Tricyclic heterocycles as BET protein inhibitors
The present invention relates to tricyclic heterocycles of Formula (I), which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful...
US-9,850,256 Antibacterial basic biaromatic derivatives with aminoalkoxy substitution
The invention relates to antibacterial compounds of formula I ##STR00001## wherein R.sup.1a, R.sup.2a, R.sup.2b, R.sup.3a, R.sup.3b, R.sup.4, R.sup.5, U.sup.1,...
US-9,850,255 Heterocyclic derivatives as modulators of kinase activity
The invention provides novel imidazol-piperidinyl derivatives of the formula (I) ##STR00001## in which R.sup.1, R.sup.2, W, X.sup.1, X.sup.2, X.sup.3, X.sup.4...
US-9,850,254 Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful...
Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7,...
US-9,850,253 Condensed cyclic compound and organic light emitting device including the same
A condensed cyclic compound represented by Formula 1: ##STR00001## wherein in Formula 1, A.sub.1, A.sub.11, X.sub.21, XY.sub.1, XY.sub.11, R.sub.4, R.sub.14,...
US-9,850,252 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone, prodrugs,...
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxycodone...
US-9,850,251 Imidazole derivative used as antiviral agent and use therof in preparation of medicament
Disclosed are an antiviral compound and a use thereof in the preparation of a medicament for the treatment of virus infections. Specifically, the present...
US-9,850,250 Joint production method and device for aziridine, piperazine and triethylenediamine
Disclosed are a joint production method and device for aziridine, piperazine and triethylenediamine. The method comprises: reaction 1, preparing piperazine and...
US-9,850,249 PDE9 inhibitors with imidazo triazinone backbone
This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically...
US-9,850,248 IDO inhibitors
Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating...
US-9,850,247 Pyrimidopyrimidinones useful as Wee-1 kinase inhibitors
The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical...
US-9,850,246 Process for making CGRP receptor antagonists
The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for...
US-9,850,245 Inhibitors of the renal outer medullary potassium channel
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The...
US-9,850,244 Method for preparing Palbociclib
The invention discloses a method for preparing Palbociclib (I). The preparation method comprises the steps of: causing a ring-closing reaction of...
US-9,850,243 Compounds and methods for inhibiting fascin
Provided are compounds, compositions and methods for inhibiting fascin activity or treating a condition or disorder mediated by fascin activity in a subject in...
US-9,850,242 Tetrahydropyrazolopyrimidine compounds
Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and...
US-9,850,241 Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators
The present invention relates to azaindolle acetic acid derivatives of formula (I), ##STR00001## wherein R.sup.1 and R.sup.2 are as described in the...
US-9,850,239 Pyrazolo[3,4-c]pyridine compounds and methods of use
Pyrazolo[3,4-c]pyridine compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein...
US-9,850,229 Compounds and compositions as protein kinase inhibitors
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent...
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