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Patent # Description
US-9,856,500 Method of consolidated bioprocessing of lignocellulosic biomass for production of L-lactic acid
The present invention pertains to a method for consolidated bio processing of lignocellulosic biomass to L-Lactic acid. Particularly, the present invention...
US-9,856,499 Long chain organic acid bioproduction
Method of cell culture, comprising adding a redox active compound with a redox potential of between -0.116 to -0.253 to a culture capable of forming hydrogen...
US-9,856,498 Processes of producing fermentation products
The invention relates to processes of producing a fermentation product, comprising liquefying a starch containing material with an alpha-amylase; ...
US-9,856,497 Chimeric proteins and methods of regulating gene expression
The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and...
US-9,856,496 Membrane-penetrating peptides to enhance transfection and compositions and methods for using same
The present invention is directed to non-naturally occurring peptides containing a membrane-penetrating amino acid sequence and further at least one...
US-9,856,495 Compositions and methods for controlling Leptinotarsa
Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to...
US-9,856,494 Cloning and exploitation of a functional R-gene from Solanum x edinense
The invention relates to a new resistance gene, Rpi-edn2 and functional homologues or functional fragments thereof isolated from S. x edinense. Moreover, the...
US-9,856,493 Method of increasing resistance against soybean rust in transgenic soybean plants
The present invention relates to a method of increasing resistance against soybean rust in transgenic plants and/or plant cells. In these plants, the content...
US-9,856,492 Bacterial resistant transgenic plants having dysfunctional T3SS proteins
A nucleic acid expression vector comprising a nucleic acid sequence encoding a dominant negative T3SS protein is disclosed. The nucleic acid expression vector...
US-9,856,491 Hybrid caulimovirus promoters and constructs thereof
The present invention relates to novel hybrid promoters comprising a caulimovirus promoter operably linked to one or more of an EF1.alpha., Act8, Act2 or Act11...
US-9,856,490 Drought-tolerant transgenic plant
Described herein is a transgenic plant that comprises a recombinant DNA construct that contains a nucleic acid sequence operably linked to a promoter, the...
US-9,856,489 Method for producing high-quality recombinant allergens in a plant
A method for producing a recombinant protein in a plant, in particular a tobacco plant, preferably Nicotiana benthamiana, includes the following steps: a)...
US-9,856,488 Plant with reduced protein productivity in seeds and method for producing same
According to the present invention, a gene having a novel function that can cause an increase or decrease in seed protein content is searched for. A chimeric...
US-9,856,487 Reducing levels of nicotinic alkaloids in plants
Two genes, A622 and NBB1, can be influenced to achieve a decrease of nicotinic alkaloid levels in plants. In particular, suppression of one or both of A622 and...
US-9,856,486 Trichome specific promoters
Trichome specific plant promoters are provided herein. Also provided are transgenic cells and organisms, especially plant cell and plants, comprising such...
US-9,856,485 Recombinant DNA constructs employing site-specific recombination
Recombinant DNA constructs, for use in plants and plant cells, have site-specific recombination sites that allow assessing phenotypes and modes of action by...
US-9,856,484 Plant transformation with in vivo assembly of a trait
A process of endowing a plant or plant cells with a trait of interest by expressing an RNA sequence of interest, said process comprising: providing plant cells...
US-9,856,483 Expression system for producing protein having a N-terminal pyroglutamate residue
Disclosed herein is an expression system and uses thereof. The expression system comprises two vectors that express two fusion proteins and a glutaminyl cyclase...
US-9,856,482 Specific oligonucleotide aptamer for the identification of T-2 toxin
This invention provides a small molecule oligonucleotide aptamer binding to T-2 toxin specifically, and the sequence of the ssDNA aptamer is SEQ ID NO: 1....
US-9,856,481 MicroRNA treatment of fibrosis
Provided herein are microRNAs that target transforming growth factor beta (TGF-.beta.) receptors and attenuate pathways of fibrosis. In particular, ...
US-9,856,480 Dnazyme for silencing the expression of EGFR
The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M...
US-9,856,479 Polycomb-associated non-coding RNAs
This invention relates to long non-coding RNAs (lncRNAs), libraries of those ncRNAs that bind chromatin modifiers, such as Polycomb Repressive Complex 2,...
US-9,856,478 Method for selectively inhibiting ACAT1 in the treatment of obesity, metabolic syndrome, and atherosclerosis
The present invention features methods for preventing and treating three related diseases, diet-induced obesity, metabolic syndrome, and atherosclerosis, alone...
US-9,856,477 Delivery of therapeutic agent
A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method comprises...
US-9,856,476 Method of regulating gene expression
The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs...
US-9,856,475 Formulations for treating amyloidosis
This invention provides pharmaceutical compositions containing a UNA oligomer targeted to TTR and a pharmaceutically acceptable carrier. The compositions can be...
US-9,856,474 Deep intronic target for splicing correction on spinal muscular atrophy gene
The present invention is directed to methods and compositions for blocking the effect of the intronic inhibitory splicing region of intron 7 of the SMN2 gene....
US-9,856,473 Compositions and methods for modulation of LMNA expression
Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target...
US-9,856,472 Small conditional RNAs
The present subject matter relates to the use conditional hairpins, such as, but not limited to shRNAs. The conditional formation of these structures can allow...
US-9,856,471 Methods and devices for high fidelity polynucleotide synthesis
Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different...
US-9,856,470 Process for generating a variant library of DNA sequences
A method for generating a variant library of DNA sequences starting from at least one DNA starting sequence and including the steps: a) selecting at least two...
US-9,856,469 AAV capsid proteins for nucleic acid transfer
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a...
US-9,856,468 Processable single chain molecules and polypeptides made using same
The present invention features inter alia nucleic acid molecules which encode polypeptides comprising a single chain Fc region and the polypeptides they encode....
US-9,856,467 Modified factor X polypeptides and uses thereof
Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of...
US-9,856,466 Compositions and methods comprising serine protease variants
The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides...
US-9,856,465 Heterologous expression of termite cellulases in yeast
The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be...
US-9,856,464 High fidelity restriction endonucleases
Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a...
US-9,856,463 DNA polymerases with increased 3'-mismatch discrimination
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
US-9,856,462 Method of treating eye disease using glycosylated VEGF decoy receptor fusion protein
The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and placenta growth...
US-9,856,461 Producing alpha-olefins using polyketide synthases
The present invention provides for a polyketide synthase (PKS) capable of synthesizing an .alpha.-olefin, such as 1-hexene or butadiene. The present invention...
US-9,856,460 Nucleic acids encoding synthetic scaffolds and host cells genetically modified with the nucleic acids
The present invention provides methods of producing a product or product precursor of a biosynthetic pathway in a genetically modified host cell. The present...
US-9,856,459 Adsorptive membranes for trapping viruses
A disposable, virus-trapping membrane, and a corresponding method to remove viruses from solution are described. The membrane includes a disposable,...
US-9,856,458 3D in vitro bi-phasic cartilage-bone construct
A 3D in vitro bi-phasic cartilage-bone organoid includes a layer of an artificial cartilage tissue, and a layer of an artificial bone tissue comprising a...
US-9,856,457 Use of cellular extracts for obtaining pluripotent stem cells
The use of a composition including at least one permeabilized nucleus of a first cell, or at least one permeabilized first cell including the nucleus and an...
US-9,856,456 Delivery agent
A composition comprising a polycationic agent and a polyanionic agent, and kits comprising the composition, is provided. In embodiments, the polyanionic agent...
US-9,856,455 Methods of producing stem cell conditioned media
Methods of producing stem cell conditioned media to treat mammalian injuries or insults. In at least one embodiment of a method of producing a stem cell...
US-9,856,454 Rapid mincing of adipose tissues to isolate live cells in vitro
A method for rapid mincing of adipose tissues to isolate live cells in vitro is disclosed to overcome the drawbacks of a lead procedure of isolating live cells...
US-9,856,453 Compositions and methods for prevention or treatment of neoplastic disease in a mammalian subject
Compositions and methods are provided for preventing or treating neoplastic disease in a mammalian subject. A composition is provided which comprises an...
US-9,856,452 Lgr5+ somatic stem cells
Described is an isolated somatic stem cell that is 2 to less than 6 micrometer in size and Lgr5+. Methods of preparing and using the cell are also described.
US-9,856,451 Lactic acid bacterium having IgA production promoting activity, and use thereof
Disclosed are: a lactic acid bacterium belonging to Lactobacillus kunkeei, the bacterium having a higher IgA production inducing activity than that of...
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