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Patent # Description
US-9,879,265 Oligonucleotide conjugates
The present invention relates to oligomeric compounds and conjugates thereof that target Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) PCSK9 mRNA in a...
US-9,879,264 Treatment of membrane bound transcription factor peptidase, site 1 (MBTPS1) related diseases by inhibition of...
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Membrane Bound Transcription Factor Peptidase,...
US-9,879,263 Use of microRNA precursors as drugs for inducing CD34-positive adult stem cell expansion
This invention generally relates to a composition and its production method useful for developing drugs/vaccines and/or therapies against a variety of...
US-9,879,262 RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic...
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to...
US-9,879,261 Serpina1 siRNAs: compositions of matter and methods of treatment
The technology described herein relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the Serpina1 gene, and methods of using such dsRNA...
US-9,879,260 Micro-RNA regulation of bone loss
The use of miR-34a and agonists thereof in the treatment of bone loss diseases is described. Such conditions include osteoporosis, rheumatoid arthritis and...
US-9,879,258 Treatment of insulin resistance through inhibitors of transcription factor TSC22D4
The present invention relates to modulators, in particular inhibitors, of TSC22D4 activity or expression and their uses for the prevention, treatment, and/or...
US-9,879,257 Modulators of alpha-synuclein toxicity
Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity....
US-9,879,256 Treatment of hepatocyte growth factor (HGF) related diseases by inhibition of natural antisense transcript to HGF
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Hepatocyte Growth Factor (HGF), in particular, by...
US-9,879,255 Modulation of RNA activity and vascular permeability
The present invention provides oligonucleotides that inhibit the binding of miR-27a to VE-cadherin mRNA, particularly in the form of blockmirs. The invention...
US-9,879,254 Targeting RNAs to microvesicles
Disclosed herein is an isolated nucleic acid molecule comprising a first nucleic acid sequence 5'-ACCCTGCCGCCTGGACTCCGCCTGT-3' (SEQ ID NO: 22), or a functional...
US-9,879,253 Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides...
US-9,879,252 Protein discovery using intracellular ribosome display
The present invention relates to a method of identifying a protein that binds to a target molecule and has intracellular functionality. This method includes...
US-9,879,251 Microbial electrosynthetic cells
Methods are provided for microbial electrosynthesis of H.sub.2 and organic compounds such as methane and acetate. Method of producing mature electrosynthetic...
US-9,879,250 Protein-stabilizing agent and protein-stabilizing method
There is provided a protein stabilizer containing a compound represented by Formula (1) as an active ingredient. The protein stabilizer is capable of...
US-9,879,249 Aldehyde-tagged protein-based drug carriers and methods of use
The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The...
US-9,879,248 Engineered microbes and methods for microbial oil overproduction from cellulosic materials
The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
US-9,879,247 Thermophilic and thermoacidophilic metabolism genes and enzymes from Alicyclobacillus acidocaldarius and...
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are...
US-9,879,246 Reversibly inactivated acidified plasmin composition
The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect...
US-9,879,245 Polypeptides having beta-mannanase activity and methods of use
The present compositions and methods relate to a beta-mannanase from Bacillus hemicellulosilyticus, polynucleotides encoding the beta-mannanase, and methods of...
US-9,879,244 Xylanase variants and polynucleotides encoding same
The present invention relates to xylanase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
US-9,879,243 Culture medium for cell growth and transfection
The present invention is directed generally to cell culture media useful for introducing macromolecules and compounds (e.g., nucleic acid molecules) into cells...
US-9,879,242 Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also...
US-9,879,241 Glucoamylase variants and polynucleotides encoding same and uses thereof
The present invention relates to variants of a parent glucoamylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid...
US-9,879,240 High activity mutants of cocaine esterase for cocaine hydrolysis
The Bacterial cocaine esterase (CocE) mutants disclosed herein each have enhanced catalytic efficiency for (-)-cocaine, as compared to CocE mutants in the prior...
US-9,879,239 Enzyme variants with improved ester synthase properties
The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant...
US-9,879,238 Phytase
Polypeptides having phytase activity and polynucleotide sequences encoding the phytases are provided. The gene expresses the phytase at a level of at least 7...
US-9,879,237 DNA polymerases with increased 3'-mismatch discrimination
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
US-9,879,236 GGPS gene for promoting higher growth or biomass of plant and use thereof
A method for increasing growth or biomass of a plant in a shorter period of time, compared to a control plant, includes transforming a plant cell using a...
US-9,879,235 Wheat plants having increased resistance to imidazolinone herbicides
The present invention is directed to wheat plants having increased resistance to an imidazolinone herbicide. More particularly, the present invention includes...
US-9,879,234 Enzymes, enzyme components and uses thereof
The invention provides nucleic acid molecules which encodes a novel fatty acid desaturase, KCS, KCR and/or LACS from Thraustochytrium aureum and Sphaeroforma...
US-9,879,233 Restoring phosphorylation of a novel PINK1 substrate to treat parkinson's disease
The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase...
US-9,879,232 Attenuated vaccinia virus KVAC103 strain
The attenuated vaccinia virus strain KVAC103 was obtained by subculturing a vaccinia virus strain 103 times in VERO cells. The attenuated vaccinia virus strain...
US-9,879,231 Recombinant modified vaccinia ankara (MVA) vaccinia virus containing restructured insertion sites
The present invention relates to recombinant modified vaccinia Ankara (MVA) virus containing restructured sites useful for the integration of heterologous...
US-9,879,230 Chimeric non-integrating lentiviral genomes as vaccines against HIV-1
Novel nucleic acids include non-integrative chimeric retroviral genomes including the 5' and 3' long terminal repeat sequences (LTRs) of the caprine lentivirus:...
US-9,879,229 Method of viral production in cells
A method of using a cell to produce virus is provided involving growing cells under hyperosmotic conditions during a growth phase of the cells, infecting or...
US-9,879,228 Methods and products for transfection
The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these...
US-9,879,227 Diffusible factors and cancer cells
The present invention relates to modified cancer cells that are defective in the production of diffusible factors (e.g., growth factors), and to the use of such...
US-9,879,226 Mesenchymal stem cell basic culturing medium
Disclosed is a basic culture medium for mesenchymal stem cells, and a cell therapeutic agent cultured and differentiated using same. The basic culture medium...
US-9,879,225 Isolated cells and populations comprising same for the treatment of CNS diseases
An isolated human cell and populations thereof is provided comprising at least one astrocytic phenotype and at least one mesenchymal stem cell phenotype,...
US-9,879,224 Label-free identification of stem cell-differentiated cells
Methods are disclosed for isolation of a stem-cell derived differentiated cell, which method entails illuminating an incident light onto a plurality of...
US-9,879,223 Methods and systems for the reduction of leukocytes in a biological fluid
Methods and systems for removing leukocytes from a biological fluid are disclosed. The methods and systems include a chamber containing particles to which the...
US-9,879,222 Gender-specific separation of sperm cells and embryos
Disclosed are sperm cells or embryos comprising a labeled oligonucleotide bound to a gender-specific repeat sequence. Methods for separating sperm cells or...
US-9,879,221 Method of in-vitro fertilization with spermatozoa separated into X-chromosome and Y-chromosome bearing populations
An IVF system for successfully utilizing spermatozoa separated into X-chromosome bearing and into Y-chromosome bearing population for insemination. The IVF...
US-9,879,220 Duplex reactor system for removal of tebuconazole and method thereof
Implementations herein relate to systems and methods for removal of tebuconazole from water using a duplex reactor. Water samples containing tebuconazole enter...
US-9,879,219 Method of producing a chitinous polymer derived from fungal mycelium
The process of growing a homogeneous polymer matrix comprising the steps of growing a viable mycelium in a liquid suspension; extracting mycelium from the...
US-9,879,218 Methods for the production of diatom biomass
The invention relates to methods of producing a diatom biomass. More particularly, the invention relates to methods to produce a diatom biomass using a...
US-9,879,217 Cryopreservation bags and method of use thereof for closed system, high capacity cell-banking
The disclosure provides a cell freezing and storage bag assembly and a method for using the assembly in banking eukaryotic cells for later seed train expansion....
US-9,879,216 Infrared signal monitoring for cell cultures
The present invention is directed to an apparatus for monitoring a cell culture comprising a) one or more infrared sensors positioned adjacent to a cell...
US-9,879,215 Subject moving device
A subject moving device includes: a base; a head section provided with vertically movable rods and moving along a prescribed movement path above the base; a...
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