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Patent # Description
US-9,885,062 Ethanol yield with reduction of biomass accumulation in the recombinant strain of Saccharomyces cerevisiae...
Described herein is a method to increase ethanol yield during alcoholic fermentation by expression a truncated versions of the Saccharomyces cerevisiae PHO8...
US-9,885,061 Microbial derived isoprene and methods for making the same
Provided herein is a gaseous isoprene composition comprising isoprene, carbon dioxide and water, wherein the isoprene is in an amount between about 0.1% and...
US-9,885,060 Alkene production
The present invention provides a microbial cell capable of producing at least one terminal alkene from at least one short chain fatty acid, wherein the cell is...
US-9,885,059 Ultrahigh throughput microinjection device
Many applications in cell biology, genetic engineering, cell-based therapeutics, and drug discovery require precise and safe methods for introducing...
US-9,885,058 Production of fertile XY female mice from XY mouse ES cells
Methods and compositions are described for making phenotypically female fertile animals from XY donor cells and suitable host embryos. Culture media and methods...
US-9,885,057 RAAV-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin...
US-9,885,056 Plants having enhanced yield-related traits and methods of making them
Methods and compositions for enhancing yield-related traits in plants by introducing and expressing in a plant a nucleic acid operably linked to a root-specific...
US-9,885,055 Chloroplasts engineered to express pharmaceutical proteins
Vaccines for conferring immunity in mammals to infective pathogens are provided, as well as vectors and methods for plastid transformation of plants to produce...
US-9,885,054 Maize ubiquitin promoters
The Zea mays c.v. B73 Ubiquitin-1 (Z. mays c.v. B73 Ubi-1) promoter drives high levels of constitutive transgene expression in plants. Repeated use of the same...
US-9,885,053 Method of meristem excision and transformation
The present invention relates to excision of explant material comprising meristematic tissue from cotton seeds. Methods for tissue preparation, storage,...
US-9,885,052 Method for the oral/mucosal vaccination by means of recombinant yeasts
Recombinant yeast cells are produced which are used for vaccination, among other uses for the oral vaccination by feeding.
US-9,885,051 Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety
The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated...
US-9,885,050 Molecular affinity clamp technology and uses thereof
The invention provides a molecular affinity clamp. The architecture of the affinity clamp is modular with two biorecognition modules, each capable of binding a...
US-9,885,049 Modulation of pre-MRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
The present invention encompasses a class of compounds known as splice modulating oligonucleotides (SMOs) that modulate pre-mRNA splicing, thereby affecting...
US-9,885,048 Method for reducing circulating leukocytes in a human subject
The present disclosure relates to a method for treatment or prevention of diseases have an increased level of insulin-like growth factor I (IGF-I). The method...
US-9,885,047 Modulation of TMPRSS6 expression
Disclosed herein are antisense compounds and methods for modulating TMPRSS6 and modulating an iron accumulation disease, disorder and/or condition in an...
US-9,885,046 Methods of inducing insulin production
The present invention provides a method of inducing insulin production in a cell by up-regulating a target gene involved in insulin production in said cell...
US-9,885,045 Methods and compositions for modulating apolipoprotein (a) expression
Disclosed herein are antisense compounds and methods for decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a)...
US-9,885,044 Polynucleotides and methods for inhibiting cancer cells
The present invention provides methods of inhibiting or reducing the growth of cancer cells in a subject, by administering a therapeutic effective amount of...
US-9,885,043 Methods for inducing cardiomyocyte proliferation
Methods for inducing cardiomyocyte proliferation, e.g., in vivo, by administering a composition comprising miRNA17-92 cluster oligonucleotides, e.g., miR-19a...
US-9,885,042 miR-92 inhibitors and uses thereof
The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92...
US-9,885,041 Modulation of BCL11A for treatment of hemoglobinopathies
The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A...
US-9,885,040 SMN2 element 1 antisense compositions and methods and uses thereof
The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions...
US-9,885,039 Methods for treating apolipoprotein E4-associated disorders
The present disclosure provides a method of increasing the functionality of a GABAergic interneuron in the hilus of the hippocampus of an individual having at...
US-9,885,038 Gene silencing methods
Provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are...
US-9,885,037 Chiral control
The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the...
US-9,885,036 Double-stranded polynucleotide
It is intended to provide a double-stranded polynucleotide that is resistant to RNase and has RNA interference effect, etc. The present invention provides a...
US-9,885,035 Method for the synthesis of a bifunctional complex
Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex...
US-9,885,034 Methods and compositions for nucleic acid analysis
Provided herein are methods, compositions, and kits for assays, many of which involve amplification reactions such as digital PCR or droplet digital PCR. The...
US-9,885,033 Increasing specificity for RNA-guided genome editing
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
US-9,885,032 Multisort cell separation method
The invention is directed to a method for enriching target cells from a sample of cells characterized by: a) contacting the sample with a cell aggregation...
US-9,885,031 Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells
An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote...
US-9,885,030 Polynucleotide for recombinant expression of sucrose isomerase
The present invention is directed towards genetic modification of native gene encoding for sucrose isomerase and isomaltulose synthase to substantially increase...
US-9,885,029 Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to...
US-9,885,028 Carbohydrate binding modules with reduced binding to lignin
Provided is a modified Family 1 carbohydrate binding module (CBM) comprising amino acid substitutions at one or more of positions 10, 11, 12, 14, 17, 21, 24,...
US-9,885,027 Process for the production of an enzymatic cocktail using solid residues from a process for the biochemical...
The present invention concerns a process for the production of an enzymatic cocktail by submerged culture with a cellulolytic microorganism, comprising two...
US-9,885,026 Modified cascade ribonucleoproteins and uses thereof
A clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for adaptive antiviral defence (Cascade); the Cascade protein complex...
US-9,885,025 Phi29 DNA polymerase mutants having increased thermostability and processivity
Mutants of bacteriophage phi29 DNA polymerase with increased protein stability and increased half-life, compared to wild type DNA polymerase. The disclosed...
US-9,885,024 PEG-urate oxidase conjugates and use thereof
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG),...
US-9,885,023 Cytochrome P450 and cytochrome P450 reductase polypeptides, encoding nucleic acid molecules and uses thereof
Provided are cytochrome P450 polypeptides, including cytochrome P450 santalene oxidase polypeptides, cytochrome P450 bergamotene oxidase polypeptides and...
US-9,885,022 Mutated rep encoding sequences for use in AAV production
Nucleic acids encoding Parvoviral Rep proteins with a mutated nuclear localization signal (NLS) are provided. Also provided is a nucleic acid comprising a...
US-9,885,021 Generation of broadly-specific, virus-immune cells targeting multiple HIV antigens for preventive and...
Compositions for T cell-based immunotherapy of HIV, HIV-associated malignancies, HIV-associated viral infections, or other HIV-related complications. Modified T...
US-9,885,020 ORF7 deficient varicella virus, vaccine comprising the virus and use thereof
Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.
US-9,885,019 Passaging and harvesting formulation and method for human pluripotent stem cells
Formulations and methods are disclosed for the harvesting and subsequent passaging of human pluripotent stem cells without the use of enzymes and/or scraping to...
US-9,885,018 High efficiency reprogramming of fibroblasts into cardiomyocytes
Pro-fibrotic signaling potently antagonizes cardiac reprogramming. Inhibition of pro-fibrotic signaling using small molecules that target the transforming...
US-9,885,017 Compositions and methods to immunize against hepatitis C virus
Compositions comprising viral antigens and antigenic peptides corresponding to or derived from Hepatitis C virus (HCV) proteins or fragments thereof, fused to...
US-9,885,016 Compositions and methods for modulating an immune response
The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune...
US-9,885,015 Chemical reprogramming of human glial cells into neurons with small molecule cocktail
Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to...
US-9,885,014 Re-conditioned serum-free culture medium composition obtained by culturing mammalian cells in Fibromodulin
The present invention provides pluripotent stem cell like (PSCL) cells or clones, a culture medium therefore, and a supernatant thereof, and methods of making...
US-9,885,013 Device for separating cells in fluid
The present disclosure provides a device for separating cells in fluid, comprising a first driving pump, a separation column, a detection column, a second...
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