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Patent # Description
US-9,884,910 Anti-PDGF-C antibodies
The invention relates to antibodies binding to the PDGF-C antigen and capable of inhibiting binding of PDGF-C to the PDGFR.alpha. receptor and of inhibiting...
US-9,884,909 Anti-NGF compositions and use thereof
The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the...
US-9,884,908 Methods for treating headache using antagonist antibodies directed against calcitonin gene-related peptide
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster...
US-9,884,907 Methods for treating headache using antagonist antibodies directed against calcitonin gene-related peptide
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster...
US-9,884,906 Humanized antibodies that recognize alpha-synuclein
The present application discloses humanized 9E4 antibodies. The antibodies bind to human alpha synuclein and can be used for immunotherapy of Lewy body disease.
US-9,884,905 Bispecific HIV-1 neutralizing antibodies
In various embodiments, the present invention relates generally to using bispecific antibodies in the prevention and treatment of HIV.
US-9,884,904 Method for purifying polypeptide solutions
Herein is reported a method for purifying cell cultivation supernatants either directly after fermentation or after one or more preliminary purification steps,...
US-9,884,903 B7-H5, a costimulatory polypeptide
B7-H5 costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell...
US-9,884,902 CTLA-4 variants
Variants of cytotoxic T-lymphocyte antigen 4 (CTLA-4) with high affinity, potency and stability. Formulations of CTLA-4 variants at high concentration for...
US-9,884,901 Long-acting polypeptides and methods of producing and administering same
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest...
US-9,884,900 Methods for treating Janus kinase-associated disorders by administering soluble transforming growth factor beta...
In part, the present disclosure relates methods for treating, preventing, or reducing the severity of a myeloproliferative disorder (e.g., polycythemia vera,...
US-9,884,899 Methods for treating fibrosis using CRP antagonists
The application provides methods for determining a patient's risk for developing fibrosis or a fibrosis-related disorder. Concentrations of C reactive protein...
US-9,884,898 Proteins specific for pyoverdine and pyochelin
The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical...
US-9,884,897 Method for producing protein
It has been believed that promoting the assembly of polysomes composed of many ribosomes attached to mRNA is very effective for highly efficient protein...
US-9,884,896 Polynucleotides and methods for making plants resistant to fungal pathogens
This invention relates to polynucleotide sequences encoding a gene that can confer resistance to the plant pathogen Colletotrichum, which causes anthracnose...
US-9,884,895 Methods and compositions for chimeric coronavirus spike proteins
The present invention provides compositions and methods comprising a chimeric coronavirus spike protein.
US-9,884,894 Fine epitope peptide capable of inducing cross-reactive antibodies among homologous proteins in human papilloma...
This invention relates to the minimal motif of an epitope on the E6 protein from human papilloma virus (HPV), and this minimal motif of the epitope induces a...
US-9,884,893 Epitope focusing by variable effective antigen surface concentration
The present disclosure provides compositions and methods for the generation of an antibody or immunogenic composition, such as a vaccine, through epitope...
US-9,884,891 KISS1R receptor agonist compounds and use thereof for inducing ovulation in mammals
A KISS1R agonist peptide compound capable of inducing ovulation in a female mammal is provided. The compound is a pseudopeptide having the C-terminal sequence:...
US-9,884,890 Process using dual specificity oligonucleotide and dual specificity oligonucleotide
The present invention relates to various processes by a template-dependent extension reaction using a dual specificity oligonucleotide and a dual specificity...
US-9,884,889 Multisignal labeling reagents and processes and uses therefor
Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents...
US-9,884,888 Chemical regeneration method of oxidized coenzyme NAD (P)+
It discloses a chemical regeneration method of oxidized coenzyme NAD(P).sup.+ which is under an oxygen or air atmosphere condition, adding a catalytic amount of...
US-9,884,886 Disulfide masked prodrug compositions and methods
The present invention relates to disulfide masked prodrug compounds of formula I, compositions and methods that are amenable to bioactivation by a reducing...
US-9,884,885 Synthesis of labile base protected-modified deoxy and modified ribo nucleosides, corresponding phosphoramidites...
This invention relates to novel method of synthesis of RNA utilizing N-2-acetyl protected guanine as nucleoside base, nucleosides, succinates, phosphoramidites,...
US-9,884,884 Compound extracted from husk and fruit stem of xanthoceras sobifolia and its extracting method and use thereof
This invention relates to the compound extracted from husk and fruit stem of Xanthoceras Sobifolia and its extracting method and use thereof. Its chemical...
US-9,884,883 Production of rhamnolipid compositions
Provided are organic solvent free methods for obtaining compositions comprising one or more rhamnolipids as well as compositions obtainable from said methods.
US-9,884,882 Method for producing thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate
There is provided a production method of a compound represented by the following formula (II) through a step of reacting a compound represented by the following...
US-9,884,881 Chelates of lead (II) and bismuth (III) based on trans-di-N-picolinate tetraazacycloalkanes
The invention relates to a chelate resulting from the complexing of a trans-di-N-picolinate tetraazacycloalkane ligand with a metal cation, said ligand...
US-9,884,880 Bisphosphonates vinylic monomers and polymers and uses thereof
The present invention provides novel bisphosphonates vinylic monomers, polymers and particles that have utility as biologically active molecule (such as drugs)...
US-9,884,879 Method of synthesizing siloxane monomers and use thereof
A method for preparation and polymerization of siloxane monomers of Formula I is presented. The synthesis includes the selective reaction between silanol...
US-9,884,878 FLAP modulators
The present invention relates to compounds of Formula (I), ##STR00001## or a form thereof, wherein ring A, R.sub.1, R.sub.2, R.sub.3, R.sub.3', L, W, and V are...
US-9,884,877 Compound and organic photoelectronic device and image sensor
A compound may be represented by Chemical Formula 1, an organic photoelectronic device may include a first electrode and a second electrode facing each other...
US-9,884,875 Heterocyclic compound and use thereof
Provided is a compound represented by the formula (I): ##STR00001## wherein each symbol is as defined in the specification, or a salt thereof, which has an...
US-9,884,874 Bromodomain-inhibiting compounds and pharmaceutical composition comprising same for preventing or treating a cancer
Provided is a novel compound having bromodomain and extra terminal domain (BET) protein inhibiting activities, and a pharmaceutical composition comprising the...
US-9,884,873 Solid forms of an antiviral compound
Crystalline solid forms of methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-ph- ...
US-9,884,872 Organic compounds
Provided are PDE1 inhibitors of Formula I, processes for their production, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
US-9,884,871 Crystals of dispiropyrrolidine derivatives
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of ...
US-9,884,870 Polymorphic substance of yonkenafil hydrochloride, preparation method therefor, and composition and use thereof
The present application discloses an A-type polymorphic substance of yonkenafil hydrochloride and a preparation method, a composition and use thereof. The...
US-9,884,869 Ibrutinib solid forms and production process therefor
Provided are ibrutinib polymorphs, e.g., crystalline ibrutinib Forms III, IV, V, VI, VII, VIII and Form IX and processes for producing these crystalline forms,...
US-9,884,868 TGF-beta inhibitors
Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the...
US-9,884,867 Bicyclic alkyne derivatives and uses thereof
The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazopyrimidine compounds) that act as...
US-9,884,866 Immunomodulators and immunomodulator conjugates
The invention provides compounds of formula I: ##STR00001## wherein R.sub.1-R.sub.3, R.sup.a, and R.sup.b have any of the values defined herein, and salts...
US-9,884,865 Azaspiro[4.5] decane derivatives and use thereof
The invention provides azaspiro[4.5]decane derivatives of Formula (A): and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, and diastereomers...
US-9,884,864 Antibacterial cyclopenta[C]pyrrole substituted 3,4-Dihydro-1H-[1,8]naphthyridinones
The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of...
US-9,884,863 STAT3 inhibitor
Provided are STAT3 inhibitors and methods of treating inflammation or a hyperproliferative disease such as, e.g., cancer. In some aspects, compounds may be used...
US-9,884,862 Pyridopyrimidinedione derivatives
The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its...
US-9,884,861 Compositions useful for treating disorders related to kit
Compounds and compositions useful for treating disorders related to KIT and PDFGR are described herein.
US-9,884,860 Fused pyrroledicarboxamides and their use as pharmaceuticals
The present invention relates in fused pyrroledicarboxamides of the formula (I), in which R1 to R9, X, m and n are as defined in claims. The compounds of the...
US-9,884,859 Solid form of pyrazolopyridine compound
A novel crystalline form or amorphous of formula (I) and preparation method thereof are disclosed in present invention, wherein the novel crystalline form is...
US-9,884,858 Diaryl-azole compound
Provided is a diaryl-azole compound represented by formula (1) ##STR00001## wherein R.sup.1-3 are C.sub.1-6 chain hydrocarbon, etc.; p=0-3; q=0-4; n=0-2; X is...
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