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Patent # Description
US-9,884,857 Salts of dasatinib in amorphous form
The present invention primarily relates to salts of Dasatinib, wherein the salts are in amorphous form. The salts described herein preferably comprise a cation...
US-9,884,856 Crystal form of Dabrafenib mesylate and preparation method thereof
The present invention involves novel crystal forms of Dabrafenib mesylate and preparation method thereof, wherein the novel crystal forms are more stable in...
US-9,884,855 Salt and crystal forms of PLK-4 inhibitor
A fumarate salt and a maleate salt of compound (I) represented by the following structural formula, as well as their corresponding pharmaceutical compositions,...
US-9,884,854 N-[(pyrimidinylamino)propanyl]-and N[(pyrazinylamino)proppanyl]arylcarboxamides
The present invention relates to novel N-[(Pyrimidinylamino)propanyl]- and N-[(Pyrazinylamino)-propanyl]arylcarboxamide derivatives, processes for their...
US-9,884,853 Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at...
US-9,884,851 Heterocycle-bisamide inhibitors of scavenger receptor BI
This application describes compounds and methods that can inhibit Scavenger receptor class B, type I (SR-BI) activity, which compounds and methods can be used,...
US-9,884,850 Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
The present invention relates to pyrimidine hydroxy amide compounds, the use of such compounds in the inhibition of HDAC6, and the use of such compounds in the...
US-9,884,849 Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group
The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined...
US-9,884,848 Phenyl triazole derivative and its use for modulating the GABA.sub.A receptor complex
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The...
US-9,884,847 Indazole retinoic acid receptor-related orphan receptor modulators and uses thereof
Provided herein are compounds of the formulas (I) and (II): ##STR00001## as well as pharmaceutically acceptable salts thereof, wherein the substituents are as...
US-9,884,846 Crystalline salts of (S)-6-((1 acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydr- ...
Disclosed are novel crystalline salts of (S)-6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-- yl)-2-hydroxypropyl)pyrimidine-4-carboxamide...
US-9,884,845 Pyrazolyl-ureas as kinase inhibitors
There are provided compounds of formula (I) as defined in the specification, which are p38 MAP kinase inhibitors for use as medicaments for the treatment inter...
US-9,884,844 Heterocyclic compounds and methods of use thereof
Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The...
US-9,884,843 Cyclic sulfone and sulfoximine analogs and uses thereof
The present disclosure relates to cyclic sulfones and sulfoximines that are HIF-2a inhibitors and methods of making and using them for treating cancers. In...
US-9,884,842 Combretastatin analogs
The present invention relates novel heterocyclic analogs of combretastatin, their synthesis, and their use as anti-cancer compounds. In particular, compounds of...
US-9,884,841 Small molecule inhibitors of Mcl-1 and uses thereof
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure...
US-9,884,840 Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect...
US-9,884,839 Inhibitors of 17Beta-hydroxysteroid dehydrogenases type 1 and type 2
Provided herein are non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 and type 2 (17.beta.-HSD1 and 17.beta.-HSD2) inhibitors, their production and use,...
US-9,884,838 Stabilized levulinic ester ketals
The invention describes methods of preparation and compositions of plasticizers. The plasticizers include at least 2 alkyl ketal ester moieties and have a...
US-9,884,837 Method for obtaining phytosterols and/or tocopherols from residue of a distillation of the esters of vegetable...
The invention relates to a method for obtaining and purifying phytosterols and/or tocopherols from distillation residue from a transesterification of vegetable...
US-9,884,836 2-substituted-5-hydroxy-4H-chromen-4-ones as novel ligands for the serotonin receptor 2B (5-HT2B)
A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT.sub.2B) is identified. Some of the compounds are synthetic...
US-9,884,835 Method for preparing isobenzofuran-1(3H)-one compound
A method for preparing an isobenzofuran-1(3H)-one based compound of the following formula I is provided. R1, R2 and p are defined in the specification. ...
US-9,884,834 Combined levulinic acid and furfural production from biomass
A process is provided for improved levulinic acid production form biomass, wherein furfural is recovered from vapor flow from the levulinic acid production...
US-9,884,833 Crystalline forms of neurotrophin mimetic compounds and their salts
The present invention includes crystalline forms of 2-amino-3-methyl-N-(2-morpholinoethyl)-pentanamide disulfate and crystalline forms of...
US-9,884,832 Inhibitors targeting drug-resistant influenza A
Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza...
US-9,884,831 Azocane and azonane derivatives and methods of treating hepatitis B infections
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
US-9,884,830 Synthesis of tetracyclines and analogues thereof
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the...
US-9,884,829 Process for the preparation of tetraconazole
The present invention relates to a new process for the preparation of Tetraconazole or one of its optically active isomers by means of the fluorination of ...
US-9,884,828 Substituted cinnolines as inhibitors of LRRK2 kinase activity
The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined...
US-9,884,827 Selective placement of carbon nanotubes via coulombic attraction of oppositely charged carbon nanotubes and...
A method of forming a structure having selectively placed carbon nanotubes, a method of making charged carbon nanotubes, a bi-functional precursor, and a...
US-9,884,826 Sulfonamide compounds and uses as TNAP inhibitors
Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the...
US-9,884,825 Curcumin analogs and methods of making and using thereof
Compounds having Formula I or II, and methods of making and using thereof, are described herein: ##STR00001##
US-9,884,824 Methods of producing sulfilimine compounds
Methods of producing a sulfilimine compound, such as N-cyano-S-methyl-S-[1-(6-trifluoromethyl-3-pyridinyl)ethyl]sulfilimine or other substituted sulfilimine...
US-9,884,823 Oxime ether acetate compound, preparation method therefor and weeding application thereof
The present invention discloses an oxime ether acetate compound containing a phenylpyridine moiety of formula (I), whose preparation method is as follows: (1)...
US-9,884,822 Process for the preparation of 1-hydroxy-6-substituted pyridones
Disclosed herein is a cost effective and environmentally friendly process to prepare 1-hydroxy-6-substituted pyridones from 2,6-dichloropyridine. The process...
US-9,884,821 N1-cyclic amine-N5-substituted biguanide derivatives, methods of preparing the same and pharmaceutical...
The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a...
US-9,884,820 Pro-neurogenic compounds
This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and...
US-9,884,819 Tetrahydrocarbazole inhibitors of SIRT1 receptors
Described are deuterium-substituted tetrahydrocarbazole compounds of Formulae I, II, or III which are inhibitors of sirtuin 1 (SIRT1). Also described are...
US-9,884,818 Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
Inhibitors of HBV replication of Formula (ID) ##STR00001## including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X,...
US-9,884,817 Auristatin derivatives and conjugates thereof
Disclosed herein are novel compounds of formula (I) as described herein: ##STR00001## and the use of such peptides in making immunoconjugates (i.e Antibody...
US-9,884,816 Sulforaphane-derived compounds, production method thereof and the medical, food and cosmetic use of same
The present invention relates to a new series of compounds having general formula (I) and the optical isomer or enantiomer forms thereof, which belong to the...
US-9,884,815 PGAM1 inhibitors and methods related thereto
In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising...
US-9,884,814 Acylguanidines for treating osteoarthritis
The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula I for use in the...
US-9,884,813 Pharmaceutically acceptable salts of B-guanidinopropionic acid with improved properties and uses thereof
The present invention relates to new pharmaceutical salts of .beta.-GPA which exhibit improved physical properties. In particular, the invention relates to...
US-9,884,812 Use of DDX3X inhibitors for the treatment of pneumovirus infections
The invention relates to a DDX3X inhibitor for use in the treatment of pneumovirus infection in a mammal, wherein the DDX3X inhibitor may be a compound of...
US-9,884,811 Fluid bed granulation of urea and related apparatus
A process for preparation of a granular urea product by granulating a urea solution in a fluidized bed, where the granulation process takes place along a...
US-9,884,810 Separation method and method for producing isocyanate
Disclosed is a method for separating, with a multi-stage distillation column, a mixture containing an active hydrogen-containing compound (A) and a compound (B)...
US-9,884,809 Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: ##STR00001## wherein the variables are defined herein. Also...
US-9,884,808 Preparation of an intermediate compound of ioforminol
The present invention relates to a process for the preparation of iodinated X-ray contrast agents and in particular to key intermediates thereof. More...
US-9,884,807 Neprilysin inhibitors
In one aspect, the invention relates to compounds having the formula XII: ##STR00001## where R.sup.a, R.sup.b, R.sup.2, R.sup.7, and X are as defined in the...
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