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Patent # Description
US-9,890,139 CYP17 inhibitors/antiandrogens
Compounds of formula (I) ##STR00001## wherein R.sub.1 to R.sub.8, A, B, Z.sub.1, and Z.sub.2 are as defined in the claims and pharmaceutically acceptable...
US-9,890,138 Diaminopyrimidine derivatives and processes for the preparation thereof
The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical...
US-9,890,137 2-halo-5-alkynyl-pyridyl nicotinic ligands
Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any...
US-9,890,136 Selective HDAC6 inhibitors
The present invention provides a compound having the structure: ##STR00001## wherein R.sub.1 is halogen, --NR.sub.5R.sub.6, --NR.sub.5--C(.dbd.O)--R.sub.6,...
US-9,890,135 Processes and intermediates for the preparations of isomer free prostaglandins
Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: ##STR00001## wherein ##STR00002## R.sub.2,...
US-9,890,134 Processes for preparing antiviral compounds
The present disclosure provides processes for the preparation of a compound of formula: ##STR00001## which is useful as an antiviral agent. The disclosure...
US-9,890,133 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for...
Disclosed are novel indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical...
US-9,890,132 Process for the preparation of anti-inflammatory aroylbenzofuran compounds
Disclosed herein an efficient process for synthesis of benzofuran analogs having anti-inflammatory activity which comprises, Ru-catalyzed branched and linear...
US-9,890,131 Direct synthesis of bio-based alkyl and furanic diol ethers, acetates, ether-acetates, and carbonates
A method of preparing a glycol mono-ether or mono-acetate, or carbonate involving either one of two pathways from alkylene glycols, HMF or its reduction...
US-9,890,130 Phenolic epoxy compounds
Disclosed herein are compositions and methods of making phenolic compounds, and resins comprising these phenolic compounds. The compounds include...
US-9,890,129 Aminoalkylbenzothiazepine derivatives and uses thereof
The present invention relates to a novel aminoalkylbenzothiazepine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition...
US-9,890,128 Process for making substituted quinazoline compounds
The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis...
US-9,890,127 Compounds and compositions for the treatment of cancer
Disclosed are compounds, such as pyridazinones, that can be, inter alia, used for treating cancer.
US-9,890,126 Synthesis of novel inhibitors of isoprenoid biosynthesis (ISPF)
Antibacterial and antimalarial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to...
US-9,890,125 Syntheses of N-heterocyclic carbenes and intermediates therefor
A method of preparing a 2,6 disubstituted anilines includes, reacting a 2-amino isophthalic acid diester with sufficient Grignard reagent R.sub.2CH.sub.2MgX to...
US-9,890,124 Benzazepine sulfonamide compounds
This invention relates to novel benzazepine sulfonamide compounds of the formula ##STR00001## wherein R.sup.4 or R.sup.5 is --SO.sub.2--NR.sup.7R.sup.8 and...
US-9,890,123 6-aminoisoquinoline compounds
6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically...
US-9,890,122 Process for the preparation of a PDE4 inhibitor
The present invention relates to a process for the preparation of compounds endowed with phosphodiesterase (PDE4) inhibitory activity having formula (I). The...
US-9,890,121 Process for preparing atazanavir sulphate
The present invention relates to a process for the preparation of Compound (A): ##STR00001## wherein the process comprises contacting atazanavir base...
US-9,890,120 Preparation of N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethan-1-amine by alkylation of 2,2-difluoroethylamine
A process for preparing N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethan-1-amine of formula (III) wherein 2,2-difluoroethylamine of formula (I) is reacted...
US-9,890,119 Indole and azaindole derivative having AMPK-activating activity
A compound is represented by formula: ##STR00001## or its pharmaceutically acceptable salt, wherein Y is substituted or unsubstituted alkyl, alkenyl, alkynyl,...
US-9,890,118 Prostamides for the treatment of glaucoma and related diseases
Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds,...
US-9,890,117 Benzamide compounds and related methods of use
Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's...
US-9,890,116 Process for the preparation of a sulfated derivative of 3,5-diiodo-O-[3-iodophenyl]-L-tyrosine
The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine...
US-9,890,115 Urea finishing method
Disclosed is a method for urea finishing. A urea solution is subjected to crystallization and, other than in conventional processes, the urea crystals are...
US-9,890,114 Urea synthesis method
There is provided a urea synthesis method having excellent reliability and productivity with the amount of oxygen used as a corrosion-resistant agent minimized...
US-9,890,113 Method for continuous production of adiponitrile
A process for the continuous preparation of adiponitrile by hydrocyanation of 3-pentenenitrile is described, wherein a) 3-pentenenitrile is hydrocyanated to...
US-9,890,112 Compounds for use as therapeutic agents affecting p53 expression and/or activity
The present invention relates to compound (I) ##STR00001## wherein R1 and R2 independently represent a hydrogen atom, a (C.sub.1-C.sub.4)alkoxy group, a...
US-9,890,111 Crystal structure of bifunctional transglycosylase PBP1b from E. coli and inhibitors thereof
The crystal structure at 2.16 .ANG. resolution of the full-length bacterial bifunctional transglycosylase penicillin-binding protein 1b (PBP1b) from Escherichia...
US-9,890,110 Method for producing amide derivative
An amide derivative represented by Formula (3), which exhibits excellent efficacy in pest control effect, is produced by allowing a compound represented by the...
US-9,890,109 Preparation of chemicals, monomers and polymers from plant oils
Methods for forming a compound from a plant oil compound having a carboxylic acid group attached to an organic group are provided. The method can include...
US-9,890,108 Catalytic hydrogenation for the preparation of amines from amide acetals, ketene N, O-acetals or ester imides
The present invention relates to a process for the preparation of amines, comprising the following steps: Reaction of a (i) amide acetal of the general formula...
US-9,890,107 Cross-linked polyglycerol esters
The invention provides polyglycerol partial esters based on mono- and dicarboxylic acids and their use as solubilizers, particularly in cosmetics, for example...
US-9,890,106 Anti-cancer lead molecule
Derivatives of plumbagin can be selectively cytotoxic to breast cancer cells. Derivative `A` (Acetyl Plumbagin) has emerged as a lead molecule for testing...
US-9,890,105 Method for producing methylmethacrylate
The present invention relates to a process for producing methyl methacrylate, comprising the following steps: A) producing methacrolein and B) reacting the...
US-9,890,104 Amine salts of a prostacyclin analog
The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts. ##STR00001##
US-9,890,103 Process for the production of (meth)acrylic acid and derivatives and polymers produced therefrom
A method of extracting (meth)acrylic acid from an aqueous reaction medium into an organic phase in contact therewith is described. The aqueous reaction medium...
US-9,890,102 Method of making acrylic acid from hydroxypropionic acid
Methods for making acrylic acid, acrylic acid derivatives, or mixtures thereof by contacting a stream containing hydroxypropionic acid, hydroxypropionic acid...
US-9,890,101 Methods of producing para-xylene and terephthalic acid
The present disclosure provides methods to produce para-xylene, toluene, and other compounds from renewable sources (e.g., cellulose, hemicellulose) and...
US-9,890,100 Continuous process for the production of low molecular weight polyethers with a DMC catalyst
Low molecular weight polyoxyalkylene polyether polyols having a hydroxyl content of from about 3.4 to about 12.1% by weight, and OH numbers of from about 112 to...
US-9,890,099 Neutralization of acidic catalysts in the production of phenol
An improved method for the production of phenol. The method comprises (a) synthesizing phenol through a process that utilizes an acidic catalyst; (b)...
US-9,890,098 Process for the production of synthesis gas
Process for the production of a synthesis gas for use in the production of chemical compounds from a hydrocarbon feed stock containing higher hydrocarbons...
US-9,890,097 Method of obtaining a combination of Z and E stereoisomers of 1-chloro-3,3,3-trifluoropropene
Disclosed are the combinations containing Z and E stereoisomers of hydrofluoroolefins where the more toxic isomer is less than about 30% weight of the...
US-9,890,096 Methods of making 2,3,3,3-tetrafluoro-2-propene
Disclosed is a process for the manufacture of 1234yf from 1,1,2,3-tetrachloropropene, abbreviated herein as "TCP," in three integrated steps: (a) the R-1...
US-9,890,095 Treating C8-C10 aromatic feed streams to prepare and recover trimethylated benzenes
Methods are provided for the treatment of a feed stream containing C9 aromatic components to produce mesitylene-containing products. The methods include...
US-9,890,094 High meso-surface area and high acid site density pentasil zeolite for use in xylene conversion
A process for the production of para-xylene is presented. The process includes the isomerization of C8 aromatics to para-xylene utilizing a new catalyst. The...
US-9,890,093 Olefin oligomerizations using chemically-treated solid oxides
Oligomerization processes include the steps of introducing a monomer containing a C.sub.3 to C.sub.30 olefin and a chemically-treated solid oxide into a...
US-9,890,092 Explosives mimic for testing, training, and monitoring
Additive Manufacturing (AM) is used to make mimics for explosives. The process uses mixtures of explosives and matrices commonly used in AM. The explosives are...
US-9,890,091 Persistent vortex generating high regression rate solid fuel grain for a hybrid rocket engine and method for...
An additively manufactured solid fuel grain for a hybrid rocket engine having a cylindrical shape, defining a center combustion port and comprising a stack of...
US-9,890,090 Melt-castable nitramine binders for high energy compositions
Provided is a melt-castable binder useful for stabilizing high energy explosive materials. A melt-castable nitramine binder has high energy in its own right yet...
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