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Patent # Description
US-9,896,707 Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius...
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are...
US-9,896,706 Method for producing .beta.-glucan
It is an object of the present invention to provide a method for producing .beta.-glucan having excellent immunopotentiating effects at a lower cost. Black...
US-9,896,705 L-arabinose isomerase variants with improved conversion activity and method for production of D-tagatose using them
The present invention relates to the development of an L-arabinose isomerase variant from Thermotoga neapolitana DSM 5068, which is a kind of thermophile, on...
US-9,896,704 Method for producing L-isoleucine using a bacterium of the family Enterobacteriaceae having overexpressed the...
The present invention provides a method for producing L-isoleucine by fermentation using a bacterium belonging to the family Enterobacteriaceae which has been...
US-9,896,703 Method for producing transesterified fat and/or oil
An object of the present invention is to provide a method in which a fat and/or oil is produced by a transesterification reaction using a lipase. Specifically,...
US-9,896,702 Methods, reagents and cells for biosynthesizing compounds
This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or...
US-9,896,701 Method for producing 1,3-propanediol using microorganism variant with deletion of 2,3-butanediol synthetic gene
The present invention relates to a method for producing 1,3-propanediol using a mutant microorganism lacking a 2,3-butanediol synthetic gene, and more...
US-9,896,700 Engineered recombinant enzymes for methane oxidation
Provided herein are soluble engineered polypeptides for oxidizing hydrocarbons, and methods of use, manufacture, and design thereof. In particular, soluble,...
US-9,896,699 Somatic cell nuclear transfer methods
The present invention provides methods for making reconstructed diploid human oocytes comprising the diploid genome of a human somatic cell, and also methods...
US-9,896,698 miRNA396 and growth regulating factors for cyst nematode tolerance in plants
The present invention presents methods to alter the genetic composition of crop plants susceptible to nematode infection to improve tolerance to the same....
US-9,896,697 Defensin-encoding nucleic acid molecules derived from Nicotiana alata, uses therefor and transgenic plants...
The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the...
US-9,896,696 Compositions and methods for modifying genomes
Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a...
US-9,896,695 HAHB11 provides improved plant yield and tolerance to abiotic stress
The present invention provides isolated HaHB11 polypeptides and nucleic acids encoding the same. Also provided are methods of introducing a nucleic acid...
US-9,896,694 Acyltransferase polynucleotides, polypeptides and methods of use
The invention provides chimeric DGAT1 proteins comprising: a) at their N-terminal ends, an N-terminal portion of a first DGAT1 protein, and b) at their...
US-9,896,693 Promoter, promoter control elements, and combinations, and uses thereof
The present document is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements,...
US-9,896,692 Sugarcane bacilliform viral enhancer-based activation tagging platform for maize, and resultant tagged...
An activation tagging construct for maize that includes one or more sugarcane bacilliform viral (SCBV) enhancer elements, and resulting tagged populations and...
US-9,896,691 Compositions and methods for lipid production
Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals.
US-9,896,690 Notch 1 specific siRNA molecule
The present invention is related to a nucleic acid molecule comprising a double-stranded structure, wherein the double-stranded structure is formed by a first...
US-9,896,689 Purification of triphosphorylated oligonucleotides using capture tags
The present invention relates to a method of preparing triphosphate-modified oligonucleotides using a capture tag. The method allows the synthesis and...
US-9,896,688 Short interfering nucleic acid (siNA) molecules containing a 2' internucleoside linkage
The present invention relates to RNAi molecules, and compositions thereof, comprising a 2' internucleoside linkage connecting the nucleotide at position 1 and...
US-9,896,687 Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA...
US-9,896,686 High throughput discovery of new genes from complex mixtures of environmental microbes
Compositions and methods for isolating new variants of known gene sequences are provided. The methods find use in identifying variants, particularly homologs,...
US-9,896,685 Use of LAMBDA-GAM protein in ribosomal display technology
Methods and systems for increasing the stability of a nucleic acid template that encodes a protein of interest in a cell free translation system or a ribosomal...
US-9,896,684 Device for nucleic acid extraction using magnetic bead method
The present invention provides a device for nucleic acid extraction using a magnetic bead method. The device includes a disc turntable, an arc arch bridge base,...
US-9,896,683 Isolating circulating microRNA (miRNA)
Methods for isolating circulating small RNAs, e.g., microRNA (miRNA), from plasma samples, e.g., that comprise using an alkaline phenol:chloroform extraction,...
US-9,896,682 Stabilized RNA solutions
Methods and compositions are described herein for protecting RNA from autocatalytic and divalent cation induced degradation in an aqueous solution.
US-9,896,681 Genetic regulation of bone and cells by electromagnetic stimulation fields and uses thereof
The present invention provides methods to modify the genetic regulation of mammalian tissue, bone, cells or any combination thereof by preferential activation,...
US-9,896,680 Compositions and methods comprising aspartyl-tRNA synthetases having non-canonical biological activities
Isolated aspartyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods...
US-9,896,679 Fused NHase with improved specific activity and stability
The present invention provides a fused NHase with improved specific activity and stability, which relates to the field of genetic engineering. This invention...
US-9,896,678 Mutant with enhanced secretion of L-asparaginase and its application
The present invention provides a mutant with enhanced secretion of L-asparaginase and its application, which relates to the field of enzyme engineering. This...
US-9,896,677 Purification of blood coagulation factors
The present invention relates to the purification of vitamin K-dependent blood coagulation factors, such as Factor IX (FIX). In particular, the invention...
US-9,896,676 Compositions and methods for modulating hemostasis
Factor Xa variants and methods of use thereof are disclosed.
US-9,896,675 Hyperthermostable endoglucanase
A hyperthermostable endoglucanase, having an endoglucanase catalytic domain including: (A) a polypeptide including the amino acid sequence represented by SEQ ID...
US-9,896,674 Variant Hyprocrea jecorina CBH1 cellulases
Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability...
US-9,896,673 Compositions of high stability alpha amylase variants
The present invention relates to variants of an alpha-amylase having improved stability to chelating agents relative to its parent enzyme, compositions...
US-9,896,672 Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof
A composition comprising recombinant iduronate-2-sulfatase (IDS) and a method for producing a purified recombinant IDS are provided. The glycosylation pattern...
US-9,896,671 DNA polymerases
The technology provided herein relates to novel variants of DNA-Polymerases exhibiting high termo-stability as well as a strong strand displacement activity; to...
US-9,896,670 DNA polymerases with increased 3'-mismatch discrimination
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
US-9,896,669 DNA polymerases with increased 3'-mismatch discrimination
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
US-9,896,668 Substrate-mimetic AKT inhibitor
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the...
US-9,896,667 Laccase variants with improved properties
This application relates to laccase variants and uses thereof as eco-friendly biocatalysts in various industrial processes. More in particular, the disclosure...
US-9,896,666 Stabilization of dehydrogenases with stable coenzymes
The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further...
US-9,896,665 Proviral plasmids and production of recombinant adeno-associated virus
Proviral plasmids contain a modular gene expression cassette with one or a combination of (i) a wildtype 5' AAV2 ITR sequence flanked by unique restriction...
US-9,896,664 Oncolytic rhabdovirus
Embodiments of the invention include compositions and methods related to Maraba virus and their use as anti-cancer therapeutics. Such rhabdoviruses possess...
US-9,896,663 Leukaemia stem cell line, its method of production and uses thereof
Bromodomain and extra terminal protein (BET) resistant leukemic cell lines and methods for producing such cell lines are described as are methods for using such...
US-9,896,662 Process for enhancing stem cell bioactivity using tauroursodeoxycholic acid
The present invention relates to a process for enhancing stem cell bioactivity using tauroursodeoxycholic acid (TUDCA) or a pharmaceutical acceptable salt thereof.
US-9,896,661 Method of producing cellulose nanostructures
A method of producing cellulose nanostructures includes obtaining Bassia eriophora plant biomass and treating the Bassia eriophora plant biomass to produce the...
US-9,896,660 Production of red blood cells and platelets from stem cells
This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a MEP precursor cell into a MEP in...
US-9,896,659 Methods, kits, and compositions for stem cell self-renewal
Methods and kits for expanding a stem cell population, particularly a hematopoietic stem cell population, in the presence of a DNA methyltransferase modulator...
US-9,896,658 Generation of inner ear auditory hair cell
Methods for generating cells of the inner ear, e.g., hair cells and supporting cells, from stem cells, e.g., mesenchymal stem cells, are provided, as well as...
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