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Patent # Description
US-9,902,753 Method of purifying a long-acting human growth hormone
The present invention relates to a long-acting human growth hormone NexP-hGH protein and its production method. More specifically, it relates to a specific...
US-9,902,752 5-fluorouracil derivatives
The present invention is directed to a compound that can be used in the treatment of cancer. The compound is represented by formula (I) ##STR00001## Further, X...
US-9,902,751 Process for the preparation of empagliflozin
An improved process for the preparation of empagliflozin is disclosed. Novel intermediates of formulas (13) and (14) for the preparation of empagliflozin are...
US-9,902,750 Process for producing a fructoside-containing product
A fructoside-containing product is manufactured from a glucose-rich feedstock, in a process where glucose to fructose is isomerized by contacting the...
US-9,902,749 Metallocene complex and olefin polymerization method
Provided are a metallocene complex that facilitates copolymerization of olefin monomers including propylene at a higher uptake rate of comonomers, i.e.,...
US-9,902,748 Photoactive energetic materials
Energetic materials that are photoactive or believed to be photoactive may include a conventional explosive (e.g. PETN, nitroglycerine) derivatized with an...
US-9,902,747 Phosphite compound, method for producing the same and uses thereof
The present invention relates to a novel phosphite compound represented by the formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each...
US-9,902,746 Benzoxaphosphole compounds and a process for preparation thereof
The present inventors prepared novel benzoxaphosphole compounds and shown a process for the synthesizing these novel compounds. The process of preparing the...
US-9,902,745 High-purity large-scale preparation of stannsoporfin
Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
US-9,902,744 Highly dispersible antimicrobial and adhesion agents
Compositions of matter that have antimicrobial properties and adhesion properties and are highly dispersible in aqueous solutions. The presence of a large...
US-9,902,743 Copper complex for capturing carbon dioxide
A composition and method are disclosed for capturing CO.sub.2. A pollutant/greenhouse gas can be converted into a valuable organic compound using a nontoxic...
US-9,902,742 Macrocycles as factor XIa inhibitors
The present invention provides compounds of Formula (Ia): ##STR00001## or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein...
US-9,902,741 Macrocyclic compounds as TRK kinase inhibitors
Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R.sup.2, R.sup.2a, R.sup.3, R.sup.3a, and Z are as...
US-9,902,740 Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses
Macrocyclic benzodiazepine dimers having a structure represented by formula I ##STR00001## where A and B are independently according to formulae Ia or Ib ...
US-9,902,739 Small molecule inhibitors of G protein coupled receptor 6 kinases polypeptides
This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to...
US-9,902,738 Compounds and methods for preventing, treating and/or protecting against sensory hair cell death
Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair...
US-9,902,737 Sweet flavor modifier
The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are...
US-9,902,736 1-oxo/acylation-14-acylated oridonin derivative, preparation method therefor and application thereof
The present invention relates to the fields of natural medicine and medicinal chemistry, and more particularly to a 1-oxo/acylated-14-acylated oridonin...
US-9,902,735 Heteroaryl substituted compounds as ROR.gamma. inhibitors
The present invention relates to novel retinoid-related orphan receptor gamma (ROR.gamma.) modulators of Formula (I) and their use in the treatment of diseases...
US-9,902,734 Nicotinic acetylcholine receptor agonists
The invention provides novel nicotinic acetylcholine receptor agonists, for example, phantasmidine and derivatives thereof, for example a compound of formula I....
US-9,902,733 Furopyridines as inhibitors of protein kinases
The invention relates to furo[3,2-b]pyridines substituted at least in position 5 as inhibitors of protein kinases, regulators or modulators, methods of...
US-9,902,732 Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
Stable crystalline forms of a compound represented by the formula (IA): ##STR00001## an acid addition salt, and/or a solvate thereof are provided by the...
US-9,902,731 Chemical compounds
The present disclosure concerns compounds of Formula (I) ##STR00001## or pharmaceutically-acceptable salts thereof, wherein R.sup.1, R.sup.2 and R.sup.3 have...
US-9,902,730 Compounds and compositions as toll-like receptor 7 agonists
The invention provides a compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to...
US-9,902,728 Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors
The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory...
US-9,902,727 Aminoalcohol substituted 2,3-dihydroimidazo[1,2-C]quinazoline derivatives useful for treating...
This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those...
US-9,902,726 Pyridone-sulfone morphinan analogs as opioid receptor ligands
The application is directed to Pyridone-sulfone morphinan analogs compounds of Formula I: or pharmaceutically acceptable salts and solvates thereof, wherein ==,...
US-9,902,725 Heterocyclic derivatives as RORgamma modulators
The present invention provides novel compounds of formula (I) that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the...
US-9,902,724 Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
Conjugates of an immune response modifier, a linker, and an antigen are disclosed. The linker is represented by formula: ##STR00001## wherein A is CH or N, p...
US-9,902,723 Pyrazole derivative manufacturing method
The present invention provides a method for manufacturing a compound represented by formula (I). With this method, provided is a method for manufacturing a ...
US-9,902,722 Biaryl kinase inhibitors
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
US-9,902,720 Pyrazolopyridine derivatives as modulators of TNF activity
A series of substituted pyrazolo[1,5-a]pyridine derivatives, being potent modulators of human TNF.alpha. activity, are accordingly of benefit in the treatment...
US-9,902,719 Inhibitors of lysine specific demethylase-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
US-9,902,717 Process of preparing potassium salt of Azilsartan medoxomil
The present invention relates to a process for the preparation of Azilsartan Medoxomil Potassium. The invention further relates to novel highly crystalline...
US-9,902,716 Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group
The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group of general formula (I) as described and defined...
US-9,902,715 Compounds
The present invention relates to novel retinoid-related orphan receptor gamma (ROR.gamma.) modulators and their use in the treatment of diseases mediated by...
US-9,902,714 Quinoxaline derivatives useful as FGFR kinase modulators
The invention relates to new quinoxaline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the...
US-9,902,713 Neuroprotective compounds and use thereof
Provided herein are compositions and methods for reducing one or both of axonal degeneration and neuronal cell death associated with a disease or traumatic...
US-9,902,712 Nitrogenous heterocyclic derivatives and their application in drugs
The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses...
US-9,902,711 Piperidine compounds having multimodal activity against pain
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opiod receptor and more...
US-9,902,710 Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
The invention relates to compounds of the formula ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R', R.sup.1 through R.sup.7 and Ar are...
US-9,902,709 Polysubstituted pyridine compound, preparation method, use and pharmaceutical composition
The present invention provides a polysubstituted pyridine compound of Formula I, a preparation method, a use and a pharmaceutical composition thereof. The...
US-9,902,708 Cyclic compound and optical material composition including same
One embodiment of the present invention can provide an optical material composition that includes a cyclic compound that is represented by formula (1) and an...
US-9,902,707 Detergent compositions
A compound of formula (I) wherein R.sup.1 is a C.sub.5 to C.sub.39 alkyl or alkenyl group and R.sup.2 is (c) wherein A is an anion. ##STR00001##
US-9,902,706 Process for making benzoxazines
A synthesis process for making a benzoxazine compound containing at least one benzoxazine unit from aromatic amine containing at least one primary amino group,...
US-9,902,705 Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse...
US-9,902,704 Substituted N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamide compounds and their use as herbicides
The present invention relates to a triazole compound of formula I, an N-oxide or an agriculturally suitable salt thereof, wherein the variables are defined as...
US-9,902,703 Somatostatin modulators and uses thereof
Described herein are compounds of Formula (I), or a pharmaceutically acceptable salt, solvate, diastereomeric mixture, or individual enantiomers thereof, that...
US-9,902,702 Spirocycloheptanes as inhibitors of rock
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all...
US-9,902,701 Pyridazones and triazinones for treatment and prophylaxis of hepatitis B virus infection
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, X and a are as described in the description...
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