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Patent # Description
US-1,000,0589 High performance Ziegler-Natta catalyst systems, process for producing such supported catalysts and use thereof
A method for making a solid catalyst component for use in a Ziegler-Natta catalyst includes combining in a hydrocarbon solvent a porous particulate support with...
US-1,000,0588 Coating for the inner surface of plastic bottles for protection against degradation from volatile organic compounds
The present invention relates to coatings for a polymer, the coating comprising a diacrylate of an aliphatic diol, a polyacrylate of an aliphatic polyol, a...
US-1,000,0587 Cross-linked polyethylene fiber, its use and process for its manufacture
The present invention relates to a polymer fiber, in particular a polyethylene polymer fiber obtainable by melt-spinning of a polyethylene polymer, the use of...
US-1,000,0586 Method for producing polyvinyl alcohol
A method for producing polyvinyl alcohols by means of catalytic reactions of alcoholic polyvinyl ester solutions in extruders, wherein the polyvinyl esters are...
US-1,000,0585 Process for producing aromatic vinyl/conjugated diene copolymer and product of hydrogenation thereof
As a method for producing a copolymer with a high oil absorption rate by separating a solvent from a copolymer solution containing a copolymer in a simple...
US-1,000,0584 Hydrogenation of nitrile rubber
This invention relates to a novel process for selectively hydrogenating nitrile rubbers in the presence of specific Ruthenium based complex catalysts without...
US-1,000,0583 Nano-sized hydrogenated diene-based latex particles
The present invention relates to diene-based hydrogenated polymer latex particles having a particle size measured as d.sub.90 value of less than 60 nm and a...
US-1,000,0582 Ethylsulfonated hyaluronic acid biopolymers and methods of use thereof
The present disclosure provides methods for sulfonation of hyaluronic acid. The present disclosure provides sulfonated hyaluronic acid, and compositions,...
US-1,000,0581 Therapeutic and imaging compositions and uses thereof
Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating...
US-1,000,0580 Preparation of poly alpha-1,3-glucan esters and films therefrom
Poly alpha-1,3-glucan ester compounds are disclosed herein with a degree of substitution of about 0.05 to about 3.0. Also disclosed are methods of producing...
US-1,000,0579 Integrated process to recover a spectrum of bioproducts from fresh seaweeds
An integrated process for the recovery of a spectrum of commercially valuable products such as agar, cellulose, lipids, pigments and a liquid rich in minerals...
US-1,000,0578 Method for production of cellulose nanocrystals from Miscathus giganteus and composites therefrom
Methods for isolating cellulose nanocrystals (CNCs) from the plant Miscanthus Giganteus (MxG). Impressive yields are obtained through a combination of...
US-1,000,0577 Treatment of otitis media
A method of treating otitis media in a subject is described that includes administering to the subject a therapeutically effective amount of an Actin-Related...
US-1,000,0576 Bispecific antigen-binding constructs targeting HER2
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding...
US-1,000,0575 Targeting O-acetylated GD2 ganglioside as a new therapeutic and diagnostic strategy for cancer stem cells cancer
An antibody recognizing the O-acetylated-GD2 ganglioside for the treatment of Cancer Stem Cells (CSC) cancer, a pharmaceutical composition including the...
US-1,000,0574 Compositions comprising polypeptides
The present invention relates to compositions comprising polypeptides, especially polypeptides capable of specifically binding predetermined antigens. The...
US-1,000,0573 Monoclonal antibody and a method thereof
The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6...
US-1,000,0572 Method for inhibiting the immune suppressive function of human T regulatory cells by administering an anti-GARP...
The present invention relates to an antibody binding to the transmembrane protein `glycoprotein A repetitions predominant` (GARP) in the presence of TGF-.beta....
US-1,000,0571 Anti-FGFR3 antibodies and methods using same
The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
US-1,000,0570 Antibody variants having modifications in the constant region
The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3...
US-1,000,0569 Anti-cMet/anti-EGFR/anti-HER3 multispecific antibodies and use thereof
An anti-EGFR/anti-HER3 antibody or antigen binding fragment thereof, and a method of preventing and/or treating a cancer using the same.
US-1,000,0568 Compositions and methods for detecting EGFR in cancer
The invention discloses binding agents to the E746-A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and...
US-1,000,0567 Humanized antibodies to cluster of differentiation 3 (CD3)
Humanized monoclonal antibodies (mAbs) or fragments thereof, to human Cluster of Differentiation 3 (CD3), which confer improved immune stimulation and...
US-1,000,0566 Anti-CD33 antibodies and methods for treatment of acute myeloid leukemia using the same
The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these...
US-1,000,0565 Use of IL-1 .beta. binding antibodies for treating peripheral arterial disease
The present invention relates to a method for treating or alleviating the symptoms of peripheral arterial disease (PAD) in a subject, comprising administering...
US-1,000,0564 Methods of treating an inflammatory condition or sensitivity to an allergen with anti-IL-33 antibodies
The present invention provides antibodies that bind to interleukin-33 (IL-33) and methods of using the same. The invention includes antibodies that inhibit or...
US-1,000,0563 Monoclonal antibodies that bind both IL-17A and IL-17F
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines...
US-1,000,0562 Antibody formulations
Formulations comprising an anti-IL-13 antibody are provided, including pharmaceutical formulations and methods of using such formulations.
US-1,000,0561 Thymic stromal lymphopoietin (TSLP)-binding molecules and methods of using the molecules
The invention provides molecules, e.g., antibodies or antibody fragments, that specifically bind thymic stromal lymphopoietin (TSLP), compositions comprising...
US-1,000,0559 Anti-PHF-tau antibodies and their uses
The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
US-1,000,0558 Use of annexin A3 as a diagnostic and prognostic biomarker and therapeutic target for treating hepatocellular...
Annexin A3 (ANAX3) is utilized as a biomarker for the diagnosis and prognosis of hepatocellular carcinoma (HCC) and the utilization of a monoclonal antibody...
US-1,000,0557 Methods for raising antibodies
The present invention generally relates to methods of generating antibodies against a species of pathogen that involve identifying the pathogen that is most...
US-1,000,0556 Single-domain V.sub.HH antibodies directed to norovirus GI.1 and GII.4 and their use
Isolated V.sub.HH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I...
US-1,000,0555 Monomethylvaline compounds having phenylalanine side-chain modification at the C-terminus
Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which...
US-1,000,0554 Modified laminin containing collagen binding molecule and use thereof
A modified laminin characterized in that a laminin or a heterotrimeric laminin fragment has a collagen binding molecule conjugated to at least one site selected...
US-1,000,0553 CD40L-specific TN3-derived scaffolds and methods of use thereof
The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with...
US-1,000,0552 TRAIL cell-penetrating peptide-like mutant MuR5 and preparation method thereof
A TRAIL cell-penetrating peptide (CPPs)-like mutant MuR5 and a preparation method and the application thereof. The amino acid sequence of said mutant is SEQ ID...
US-1,000,0551 Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
A plant produced chimeric polypeptide is provided. The plant produced chimeric polypeptide comprising: (i) a first domain which comprises a TNF Alpha binding...
US-1,000,0549 Compositions and methods for treatment of hematological malignancies
Use of a chimeric protein selected from the group consisting of CTLA4-FasL and CD40-FasL proteins for treatment of lymphoma and/or a multiple myeloma and/or a...
US-1,000,0548 GAL-1 variants having immuno-modulating properties and methods of using the same
Galectin-1 polypeptide variants that include a mutation of the histidine residue corresponding to position 52 of the full-length amino acid sequence of native...
US-1,000,0547 Peptides and combination of peptides for use in immunotherapy against various tumors
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,000,0546 Compositions and method for use of recombinant T cell receptors for direct recognition of tumor antigen
Provided are compositions and methods for prophylaxis and/or therapy of a variety of cancers which express a NY-ESO-1 antigen. Included are recombinant T cell...
US-1,000,0545 CD147 as receptor for pilus-mediated adhesion of Meningococci to vascular endothelia
The present invention concerns the use of an inhibitor of an interaction between type IV pilus-associated protein and CD147 for preventing or treating...
US-1,000,0544 Process for production of insulin and insulin analogues
A process for production of insulin or insulin analogs by expression of Insulin or Insulin analogs through an expression vector in a host cell is provided. The...
US-1,000,0543 Glucose-regulating polypeptides and methods of making and using same
The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids...
US-1,000,0542 Double-acylated GLP-1 derivatives
The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue and a second K residue, at positions corresponding to...
US-1,000,0541 Trail cell-penetrating peptide-like mutant MUR6 and preparation method thereof
A TRAIL cell-penetrating peptide (CPPs)-like mutant MuR6 and a preparation method and the application thereof. The amino acid sequence of the mutant is SEQ ID...
US-1,000,0540 Fibroblast growth factor mutants having improved functional half-life and methods of their use
Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily...
US-1,000,0539 Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,000,0538 Molecule for treating an inflammatory disorder
The invention provides a L19 source as a medicament, preferably for preventing or treating an inflammatory disorder in an individual.
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