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Patent # Description
US-1,000,0483 Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers,...
US-1,000,0482 Kinase inhibitors
The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase),...
US-1,000,0481 1H-pyrrolo[2,3-B] pyridine derivatives and their use as kinase inhibitors
The inventions relates to compounds of (I) and therapeutic uses thereof: (I) The terms Z, Y, and R.sup.1 are as defined in the claims. ##STR00001##
US-1,000,0480 Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
Compounds having the following formula I: ##STR00001## or a stereoisomer or pharmaceutically-acceptable salt thereof, where R.sup.1, R.sup.2, R.sup.3,...
US-1,000,0479 Compounds and their methods of use
Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that...
US-1,000,0478 Pyrazol-3-ones that activate pro-apoptotic BAX
This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or...
US-1,000,0477 Dopamine D3 receptor antagonist compounds
The disclosure is directed to novel dopamine D3 receptor antagonists, processes for their preparation, intermediates used in these processes, pharmaceutical...
US-1,000,0476 Pyridone derivative, pharmaceutical containing the same and methods of use thereof
General formula (I): The present invention pertains to: a pyridone derivate or a salt thereof represented by general formula (I); or a medicine containing the...
US-1,000,0475 Triazine carboxamides as sodium channel blockers
The present disclosure provides substituted triazine carboxamides of Formula I: ##STR00001## and the pharmaceutically acceptable salts and solvates thereof,...
US-1,000,0474 Histone deacetylase inhibitors and uses thereof
Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the...
US-1,000,0473 Indazole derivatives useful as glucagon receptor antagonists
The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of...
US-1,000,0472 Photochromic compounds
A photochromic compound is provided, which may be a pyran, an oxazine, or a fulgide. The photochromic compound has at least one substituent Q attached thereto,...
US-1,000,0471 Pyrazole P38 map kinase inhibitors
There are provided inter alia compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, R.sup.4, L, X, R.sup.5 and R.sup.6 are as...
US-1,000,0470 Method for preparing nilotinib
A method for preparing nilotinib includes the following steps: performing an aminocarbonylation reaction on a compound A and ...
US-1,000,0469 Heat shock protein 70 (hsp-70) receptor ligands
Inducible HSP70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and...
US-1,000,0468 Pyrazines as modulators of GPR6
The present invention provides compounds of formula I: ##STR00001## which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for...
US-1,000,0467 Cyanine compounds
Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological...
US-1,000,0466 Substituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridines as factor XIa inhibitors
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables...
US-1,000,0465 Antifungal compound process
The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new...
US-1,000,0464 Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-A][1,4]benzodiaze- ...
The invention concerns a new process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiaze- pine-4-yl]-propionic acid methyl...
US-1,000,0463 Halogen-substituted heterocyclic compound
A novel .alpha.-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and...
US-1,000,0461 Polycyclocarbonate compounds and polymers formed therefrom
Polycyclocarbonate compounds and upgraded molecular weight polymers made from such compounds are provided. The polymers have particular utility in coating...
US-1,000,0460 Chelate-controlled diastereoselective hydrogenation with heterogeneous catalyst
A hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support, is used in the presence of lithium salts, with...
US-1,000,0459 Heterocyclic compounds useful in the treatment of disease
Heterocyclic compounds are described that are lysophosphatidic acid receptor ligands that are useful in the treatment of lysophosphatidic acid...
US-1,000,0458 Production method of 1, 2, 4-triazole compound
A method for producing a 1,2,4-triazole compound involves reacting an amide compound represented by formula (2) with a hydrazide compound represented by formula...
US-1,000,0457 Process for preparing imidazolium based ionic liquids with di-polymerized oxirane base
The present invention relates to a process of synthesis of certain ionic liquids di-polymerized based Radziszewsky type reaction, whereby primary amines...
US-1,000,0456 Polycyclic compounds as lysophosphatidic acid receptor antagonists
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include...
US-1,000,0455 Method for treating diseases associated with oxidative stress or endothelial dysfunction using substituted...
A method reduces oxidative stress or endothelial dysfunction in a mammal. The method includes administering to the mammal a compound of formula I: ##STR00001## ...
US-1,000,0454 Antidiabetic tricyclic compounds
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
US-1,000,0453 Chelation directed C--H activation reactions catalyzed by solid-supported palladium(II) catalysts
Chelation directed C--H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or...
US-1,000,0452 Quinolone-based compounds, formulations, and uses thereof
Provided herein are quinolone-based compounds that can be used for treatment and/or prevention of malaria and formulations thereof. Also provided herein are...
US-1,000,0451 MAP4K4 (HGK) inhibitors
The invention provides mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) inhibitors, and pharmaceutically acceptable salts, hydrides and...
US-1,000,0450 N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors
The present invention provides a pyrrolidine compound of General Formula (1) ##STR00001## or a salt thereof, wherein R.sup.101 and R.sup.102 are each...
US-1,000,0448 Catalysts, methods, and systems for preparing carbamates
Methods, systems and kits for preparing carbamates as well as catalysts for preparing the carbamates, are disclosed. The methods for preparing carbamate can...
US-1,000,0447 Compounds for targeting drug delivery and enhancing siRNA activity
Here described are compounds consisting of the structure (targeting molecule).sub.m-linker-(targeting molecule).sub.n, wherein the targeting molecule is a...
US-1,000,0446 Amino photo-reactive binder
A compound obtained by reaction of one or more amines of the general formula NHR.sup.6R.sup.7 with a compound of the following general formula (IX): ...
US-1,000,0445 Stable crystal modifications of DOTAP chloride
The present invention relates to crystal modifications of racemic (2R,S)- and enantiomerically pure (2R)-resp. (2S)-DOTAP chloride, to processes for the...
US-1,000,0444 Fluorine-containing ether monocarboxylic acid aminoalkyl ester and a method for producing the same
A fluorine-containing ether monocarboxylic acid aminoalkyl ester represented by the general formula: ...
US-1,000,0443 Compositions and methods for glucose transport inhibition
Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining...
US-1,000,0442 Certain metathesized natural oil triacylglycerol polyols for use in polyurethane applications and their related...
Metathesized triacylglycerol polyols derived from certain natural oils, including canola oil, and their related physical properties are disclosed. Such...
US-1,000,0440 Influencing the viscosity of N-butene-based ester mixtures by controlled use of ethene in the preparation of...
The invention relates to a process for preparing an ester mixture, in which an n-butene-containing feed mixture having a composition which changes over time is...
US-1,000,0439 Process for producing alkyl acrylate
The invention relates to the production of alkyl acrylate according to a continuous transesterification process. In one embodiment the process of the invention...
US-1,000,0438 Small molecule inhibitors of TRPA1
The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be...
US-1,000,0437 Nitrogen containing surfactants with alkoxylation on the hydroxyl group of fatty chains
The present invention is directed to a nitrogen containing surfactant composition comprising at least one nitrogen containing surfactant of structure (h) or...
US-1,000,0436 Method for preparing organic vapor-phase dehydration feedstock
The present invention relates to a method including: directly heating a fermentation broth to remove impurities, thereby preparing an organic vapor-phase...
US-1,000,0435 Energy and environmentally integrated method for production of aromatic dicarboxylic acids by oxidation
A continuous process for oxidizing a di-alkyl substituted aromatic compound with compressed air in a primary bubble column reactor; including removing a portion...
US-1,000,0433 Bisphenols and high-performance resins from terpenes
The invention describes a high yield process that utilizes selective catalysts for the conversion of abundant, naturally occurring terpenes into bisphenols, and...
US-1,000,0432 Processes for the synthesis of chiral 1-alkanols
The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.
US-1,000,0431 Process for the production of 1-chloro-3,3,3-trifluoropropene (HCFO-1233zd)
A process for enhancing the selective and efficient production of (E)-1-chloro-3,3,3-trifluoropropene (HCFO-1233zd(E), or 1233zd(E)). During the manufacture of...
US-1,000,0430 Process for separating propylene mixed with propane by adsorption in a simulated moving bed
A process for separating propylene mixed with propane by adsorption in a simulated moving bed is described. The process operates in the gaseous phase or in the...
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