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Patent # Description
US-1,000,5790 Process for the synthesis of substituted morphinans
The present invention relates to compounds of formula I and a process for the synthesis: ##STR00001## The invention further relates to a process for the...
US-1,000,5789 Organic compounds
The invention relates to novel inhibitors of phosphodiesterase 1 (PDE1), according to Formula I, below, ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3 and...
US-1,000,5788 Bicyclic fused pyrimidine compounds as TAM inhibitors
This application relates to compounds of Formula I: ##STR00001## or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are...
US-1,000,5787 Highly photo-stable bis-triazole fluorophores
This disclosure is related to photo-stable chromophores which are useful in various applications. Chromophores disclosed herein include a bis-triazole core, two...
US-1,000,5786 Substituted 6,7-dihydropyrazolo[1,5-a]pyrazines as negative allosteric modulators of MGLUR2 receptors
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives of Formula (I) ##STR00001## as negative allosteric modulators...
US-1,000,5785 Substituted 6,7-dihydropyrazolo[1,5-a] pyrazines as negative allosteric modulators of mGlUR2 receptors
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives of Formula (I) ##STR00001## as negative allosteric modulators...
US-1,000,5784 Pyridines, pyrimidines, and pyrazines, as BTK inhibitors and uses thereof
The present invention relates to pyridine, pyrimidine, and pyrazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
US-1,000,5783 Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
US-1,000,5782 Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators
The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed...
US-1,000,5781 Pyrazolopyrimidone or pyrrolotriazone derivatives, method of preparing same, and pharmaceutical applications...
Pyrazolopyrimidone and pyrrolotriazone derivatives, methods of preparation thereof, and pharmaceutical uses thereof are described. Specifically,...
US-1,000,5780 Production method of imidazole derivatives
The present invention provides an advantageous production method of an imidazole derivative, which is suitable for industrial production. Compound (VI) is...
US-1,000,5779 1',4'-thio nucleosides for the treatment of HCV
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments,...
US-1,000,5778 Method for preparing Palbociclib
This invention reveals the method for preparing Palbociclib (I). The preparation includes: produce the ...
US-1,000,5777 Protein kinase C inhibitors and uses thereof
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders...
US-1,000,5776 Compounds as NIK inhibitors
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of ...
US-1,000,5775 Pesticidally active heterocyclic derivatives with sulphur containing substituents
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and...
US-1,000,5774 Syk inhibitors
The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and...
US-1,000,5773 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of ...
US-1,000,5772 Immune response modifier compositions and methods
The present invention provides an immune response modifier (IRM) composition that includes an IRM moiety and a second active moiety covalently linked to the IRM...
US-1,000,5771 Bicyclic derivatives having .beta.2 adrenergic agonist and M3 muscarinic antagonist activities
The present invention relates to novel compounds having .beta.2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions...
US-1,000,5770 Process for the preparation of N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-1,4-benzothiazepi- ...
The present invention relates to a novel process for the preparation of a compound of the formula (I): ##STR00001## and pharmaceutically acceptable acid...
US-1,000,5769 2,3-dihydrobenzofuran-5YL compounds as DYRK kinase inhibitors
The present invention relates to compounds of below Formula (I), physiologically functional derivatives or salts thereof, where the groups R.sup.1, R.sup.2,...
US-1,000,5768 Carboxamide derivatives and use thereof
The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: ##STR00001## ...
US-1,000,5767 Compositions and methods for inhibition of the JAK pathway
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in...
US-1,000,5766 Method for producing fused heterocyclic compound
A compound represented by formula (4) is produced by a step A of reacting a compound represented by formula (2): ##STR00001## wherein R.sup.1 represents an...
US-1,000,5765 Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer
Provided herein are benzimidazole derivatives, for example, of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use...
US-1,000,5764 Halogenated quinazolin-THF-amines as PDE1 inhibitors
The present invention provides halogenated quinazolin-THF-amines as PDE1 inhibitors and their use as a medicament, in particular for the treatment of...
US-1,000,5763 Photochromic compounds
A photochromic compound is provided, which may be a pyran, an oxazine, or a fulgide. The photochromic compound has at least one substituent Q attached thereto,...
US-1,000,5762 Pyridine derivatives
The problem to be solved by the present invention is to provide a compound suitable for a pharmaceutical composition, specifically an agent for treating...
US-1,000,5761 Compounds and compositions as protein kinase inhibitors
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent...
US-1,000,5760 Forms and compositions of an ERK inhibitor
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of one or both of ERK1 and ERK2.
US-1,000,5759 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
The subject matter herein is directed to carbazole-containing amide, carbamate, and urea derivatives and pharmaceutically acceptable salts or hydrates thereof...
US-1,000,5757 Revaprazan hydrochloride polymorphs and preparation method therefor
Provided are revaprazan hydrochloride polymorphs and a preparation method thereof. The method comprises a step of dissolving revaprazan hydrochloride in ethanol...
US-1,000,5756 Pyrrolidinone derivatives as MetAP-2 inhibitors
Compounds according to Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.
US-1,000,5755 Most effective process for base-free preparation of ketone intermediates usable for manufacture of nebivolol
The invention relates to a process for the preparation of a ketone of a general formula 1 ##STR00001## with X being Cl or Br, in particular with X being Cl,...
US-1,000,5754 Form of spirodiclofen, a process for its preparation and use the same
A new crystalline form of spirodiclofen of formula (I), the crystal preparation process, the analyzes of the crystal through various analytical methods and...
US-1,000,5753 Methods for producing beraprost and its derivatives
The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost. In one aspect, a process is provided to...
US-1,000,5752 Anticancer agent
The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound represented...
US-1,000,5751 Process for producing 4-azidosulfonylphthalic anhydride
The present disclosure provides a process for the production of 4-azidosulfonylphthalic anhydride. In an embodiment, a process is provided and includes...
US-1,000,5750 Developing potent urate transporter inhibitors: compounds designed for their uricosuric action
A compound represented by the general Formula I: ##STR00001## a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a...
US-1,000,5749 Closed-loop production of furfural from biomass
Methods and processes for the production of valuable organic products and alcohols from biomass material using a closed-loop process having numerous advantages...
US-1,000,5748 5-hydroxymethylfurfural production using a multi-fluorinated alcohol compound
The present invention relates to a process for producing a water cleavage product, a water cleavage product thus produced, a process for producing at least one...
US-1,000,5747 Process for the production of .gamma.-valerolactone
The present invention provides a process for the hydrogenation of the levulinic acid to .gamma.-valerolactone in a single step with a single Pt supported on...
US-1,000,5746 Molecular catalysts capable of catalyzing oxidation of hydrocarbons and method for oxidizing hydrocarbons
This invention relates to molecular catalysts and chemical reactions utilizing the same, and particularly to molecular catalysts for efficient catalytic...
US-1,000,5745 Amyloid targeting agents and methods of using the same
Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are...
US-1,000,5744 Compounds for the treatment or prevention of breast cancer
It discloses compounds for the treatment and prevention of breast cancer, which are specifically 2-phenyl benzoselenazole compounds, pharmaceutically acceptable...
US-1,000,5743 Methods for producing viloxazine salts and novel polymorphs thereof
Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction...
US-1,000,5742 Method for producing epoxy compound containing hydrogen peroxide stabilizer
The present invention provides a method for producing an epoxy compound by a reaction of an olefin compound with hydrogen peroxide, wherein the epoxy compound...
US-1,000,5741 Therapeutic compounds
The invention provides compounds and compositions that are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer,...
US-1,000,5740 Neprilysin inhibitors
In one aspect, the invention relates to compounds having the formula I: ##STR00001## where R.sup.1-R.sup.6 are as defined in the specification, or a...
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