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Patent # Description
US-1,001,0629 Compositions and methods for in vivo imaging
The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging...
US-1,001,0628 Method for inducing antitumor immunity using Sindbis viral vectors and tumor associated antigens
The subject application is directed to a method for treating a mammal harboring a tumor comprising identifying a tumor associated antigen (TAA) expressed by the...
US-1,001,0627 Modified polycationic polymers
A polymeric material comprising a polyethylenimine-based material including the following moiety: ##STR00001## attached thereto, wherein R1 is a group...
US-1,001,0626 Molecular constructs with targeting and effector moieties
The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using...
US-1,001,0625 Antimicrobial compositions comprising single domain antibodies and pseudomonas exotoxin
The present invention provides heavy chain immunoglobulins of the VHH type or fragment thereof having affinity for a target antigen of interest, including...
US-1,001,0624 Pyrrolobenzodiazepine-antibody conjugates
Conjugates of specific PBD dimers with an antibody that binds to PSMA, the antibody comprising a VH domain having the sequence according to any one of SEQ ID...
US-1,001,0623 Lysosome-cleavable linker
The present invention relates to a linker for forming conjugates of a protein or peptide with a therapeutically active agent and which comprise a thiomaleamic...
US-1,001,0622 Factor VIII chimeric and hybrid polypeptides, and methods of use thereof
The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering...
US-1,001,0621 Conjugates of biologically active molecules to functionalized polymers
This document relates to conjugates of a biologically active molecule or a derivative thereof and functionalized (e.g., mono- or bi-functional) polymers (e.g.,...
US-1,001,0620 Tamper-resistant pharmaceutical dosage forms and process for making same
A process for the preparation of an erodible tamper-resistant dosage form that comprises a therapeutic agent-substrate complex embedded in a thermo-formable...
US-1,001,0619 Bipartite inhibitors of bacterial RNA polymerase
The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I): X-.alpha.-Y (I) wherein X is an moiety that...
US-1,001,0618 Methods for treating cancer using combination therapies
Described are methods, uses, and kits for utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system x.sub.c.sup.- inhibitor for...
US-1,001,0617 Peptide pharmaceuticals
Described herein are methods of syntheses and therapeutic uses of covalently modified peptides and/or proteins. The covalently modified peptides and/or proteins...
US-1,001,0616 Immunogenic compositions and reagents for preparing
The invention described herein pertains to compounds and conjugates, to compositions, complexes and formulations comprising the compounds and/or conjugates, and...
US-1,001,0615 Amino acid conjugates of quetiapine, process for making and using the same
The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids. The present...
US-1,001,0614 Derivatives of GLP-1 like peptides, and uses thereof
The invention relates to derivatives of GLP-1 like peptides which are C-terminally extended analogs of native GLP-1. The derivatives comprise two side chains,...
US-1,001,0613 Anionic-core composition for delivery of therapeutic agents, and methods of making and using the same
The present invention is directed to compositions comprising a polymer backbone with protective chain and anionic groups, and a cationic therapeutic agent. The...
US-1,001,0612 Sustained delivery formulations of risperidone compounds
The present invention relates to a risperidone sustained release delivery system for treatment of medical conditions relating delusional psychosis, ...
US-1,001,0611 Antibody formulations
The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a...
US-1,001,0610 Compositions and methods for the treatment of intraocular neovascularization and/or leakage
The invention provides compositions and methods for the treatment of intraocular neovascularization and/or leakage including wet age-related macular...
US-1,001,0609 Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the...
A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the...
US-1,001,0608 Combination therapies for cancer
A novel combination comprising a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2- ...
US-1,001,0607 Method for preparing viral particles with cyclic dinucleotide and use of said particles for inducing immune...
The present invention relates to methods for preparing virus-like particles comprising immunogenic cyclic dinucleotides.
US-1,001,0606 Mosaic conserved region HIV immunogenic polypeptides
Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In...
US-1,001,0605 FMDV recombinant vaccines and uses thereof
The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The...
US-1,001,0604 Treatment of PRDC in pigs
The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment,...
US-1,001,0603 Treatment of pigs with PCV2 antigen
The present invention relates to a method for the treatment or prophylaxis of a PCV2 infection or for reduction of clinical symptoms caused by or associated...
US-1,001,0602 Vaccine compositions against porcine reproductive and respiratory syndrome and porcine circovirus associated...
A fusion protein comprising an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain, a translocation peptide, a fusion antigen, an...
US-1,001,0601 PRRS virus variant, European PRRS virus cDNA clone, and uses thereof
The present invention belongs to the field of animal health and provides means to study Porcine Reproductive and Respiratory Syndrome (PRRS), a viral disease...
US-1,001,0600 Compositions and methods for administration of vaccines against dengue virus
Embodiments of the present invention report compositions and methods for vaccinating a subject against dengue viruses. In some embodiments, vaccine compositions...
US-1,001,0599 Norovirus vaccine formulations
The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and...
US-1,001,0598 Compositions and methods for detecting, treating, and protecting against Fusobacterium infection
The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and...
US-1,001,0597 Recombinant Mycobacterium bovis BCG expressing antigens of the Mycobacterium marinum ESX-1 secretion system
Recombinant strains of Mycobacterium bovis bacille Calmette-Guerin (M. bovis BCG) comprising a heterologous nucleic acid sequence of Mycobacterium marinum (M....
US-1,001,0596 Bacterial live vector vaccines expressing chromosomally-integrated foreign antigens
Bacterial live vector vaccines represent a vaccine development strategy that offers exceptional flexibility. In the present invention, genes encoding protective...
US-1,001,0595 Live recombinant booster vaccine against tuberculosis
Embodiments of the invention comprise an improved vaccine for generating an immune response and preventing or treating mycobacterial diseases such as...
US-1,001,0594 Methods and compositions for transgene expression in a herpesvirus vector system
Compositions are provided comprising a replication-competent herpesvirus vector system and/or a herpesvirus vector particle comprising a heterologous...
US-1,001,0593 Recombinant Listeria vaccine strains and methods of using the same in cancer immunotherapy
The present invention provides methods of treating, protecting against, and inducing an immune response against a human papillomavirus-associated oropharyngeal...
US-1,001,0592 Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal...
The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a tumor...
US-1,001,0591 Method of treating fibrosarcoma using a nucleic acid sequence encoding APOBEC3A
The present invention relates to the use of a nucleic acid that comprises a sequence encoding an APOBEC3A protein, in preventing or treating a tumor in a patient.
US-1,001,0590 Pharmaceutical compositions and methods
Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor; melanin, a melanin promoter, or a combination thereof; a p450 3A4 promoter; and...
US-1,001,0589 Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a...
US-1,001,0588 Methods of using pegylated interleukin-10 for treating hyperlipidemia
Methods of treating subjects having diseases, disorders, or conditions, including disorders associated with cholesterol homeostasis, responsive to IL-10,...
US-1,001,0587 IL-2R.beta.-selective agonists in combination with an anti-CTLA-4 antibody or an anti-PD-1 antibody
The invention relates to (among other things) method of administering to a patient suffering from a cancer, the method comprising the steps of: (a) an...
US-1,001,0586 Method of treating intraocular tissue pathologies with nerve growth factor
Nerve Growth Factor (NGF), in the form of a preparation to be administered over ocular surface, is suggested as being suitable for therapy and/or prophylaxis of...
US-1,001,0585 Methods of treating vestibular schwannoma and reducing hearing or neurite loss caused by vestibular schwannoma
Methods to reduce the proliferation of vestibular schwannoma (VS) cells and/or provide neuroprotection to reduce the risk of sensorineural hearing loss (SNHL),...
US-1,001,0584 Treatment of depressive disorders
The invention provides for the use of carbonic anhydrase activators; protein kinase C activators and FGF-18 to treat depressive disorders. The invention also...
US-1,001,0583 Methods for treating inflammatory disorders and traumatic brain injury using stabilized non-hematopoietic EPO...
The described invention provides methods for treating an inflammatory brain disease, disorder or condition and for treating a traumatic brain injury having an...
US-1,001,0582 Soluble mediator
The present disclosure relates to a soluble CD52 glycoprotein and its use in treating diseases regulated by effector T-cells, for example autoimmune diseases...
US-1,001,0581 Syndecan peptides and polypeptides and uses thereof
The invention provides for peptides from syndecan 1 and methods of use therefor. These peptides can inhibit .alpha.4.beta.6 interaction with HER2, thereby...
US-1,001,0580 Insulin independence among patients with diabetes utilizing an optimized hamster Reg3 gamma peptide
Embodiments of the present invention provide for novel therapies, pharmaceutical compositions and methods for insulin independence utilizing a new optimized...
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