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Patent # Description
US-1,001,7783 Baculovirus system for the expression of a gene therapy vector
The invention relates to a recombinant baculoviral genome useful for the production of viral vectors for gene therapy, allowing said production from a single...
US-1,001,7782 Immune cells modified by transient transfection of RNA
RNA prepared by in vitro transcription using a polymerase chain reaction (PCR)-generated template can be introduced into a cell to modulate cell activity. This...
US-1,001,7781 Rhizomania-resistant gene
The present invention provides a new nucleic acid molecule which encodes a polypeptide that is able to convey a resistance to a pathogen, in particular to "Beet...
US-1,001,7780 Clubroot resistant Brassica oleracea plants
The present invention discloses B. oleracea plants resistant to clubroot disease. In particular, the plants of the present invention comprise a monogenic...
US-1,001,7779 Gene implicated in abiotic stress tolerance and growth accelerating and use thereof
The present invention provides a method for improving the tolerance of a plant to an abiotic stress and a method for promoting growing of a plant, comprising a...
US-1,001,7778 Means and methods for the reduction of photorespiration in crops
The present invention relates to the field of plant molecular biology and concerns methods for enhancing the abiotic stress tolerance in plants by modulating...
US-1,001,7777 DGAT genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
Transgenic oilseeds having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of...
US-1,001,7776 Transgenic plants with altered nitrate levels in leaves
The present invention relates to genetic constructs, which can be used in the preparation of transgenic plants. The constructs can have the ability of reducing...
US-1,001,7775 Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis
The present disclosure relates to engineered zinc finger proteins that target genes in plants involved in fatty acid biosynthesis. Methods of using such zinc...
US-1,001,7774 Control of pests in plants
The present invention relates to the field of controlling pests, such as insects, using a virus to express pest genes in hosts. More specifically, the present...
US-1,001,7773 HSF-like transcription factor, TBF1, is a major molecular switch for growth-to-defense transition in plants
The present invention relates to new methods to study and control the expression of plant genes, particularly nucleotide sequences located downstream from...
US-1,001,7772 Biological indicator
This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for...
US-1,001,7771 Construction of a quadruple enterotoxin-deficient mutant of bacillus thuringiensis
Some HBL and NHE enterotoxins are known to cause food-borne diseases in humans. Enterotoxin-deficient mutants of member strains of the Bacillus cereus group...
US-1,001,7770 TNT cloning system
Disclosed herein are vectors and components for a nucleic acid cloning system, and methods of use of the vectors and components in cloning nucleic acid...
US-1,001,7769 MGMT-based method for obtaining high yeilds of recombinant protein expression
The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells,...
US-1,001,7768 Method of treatment of chlamydial infections with selected EGFR inhibitors
The present invention provides compositions and methods of use in the treatment/prevention of chlamydial infection and/or diseases and disorders associated with...
US-1,001,7767 Targets in multiple myeloma and other disorders
An agent that increases YAP1 levels for use in the treatment of hematopoietic disorders.
US-1,001,7766 SiRNA and their use in methods and compositions for inhibiting the expression of the FLAP gene
The invention relates to si RNA molecules and their use in methods and pharmaceutical compositions for inhibiting the expression of the FLAP gene. The invention...
US-1,001,7765 Inhibitors of CACNA1A/ALPHA1A subunit internal ribosomal entry site (IRES) and methods of treating...
The disclosure provides methods of treating polyglutamine diseases, e.g., spinocerebellar ataxia Type 6, in a subject, comprising administering to the subject...
US-1,001,7764 Oligomeric compounds comprising bicyclic nucleotides and uses thereof
The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but...
US-1,001,7763 dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
Morpholino oligomers containing modified intersubunit linkages and/or terminal groups are provided for use within dsRNA molecules. The oligomers are...
US-1,001,7762 Compositions and methods for treating or preventing lupus
The present disclosure provides methods for inhibiting and/or reducing self-reactive IgE and/or basophils, thereby treating or preventing lupus, lupus...
US-1,001,7761 Methods for preparing cDNA from low quantities of cells
Methods for preparing cDNA libraries from single and low quantities of cells are disclosed. The methods are based on the principles of multi-strand displacement...
US-1,001,7760 Methods for generating barcoded combinatorial libraries
Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive...
US-1,001,7759 Library preparation of tagged nucleic acid
A method of preparing a library of tagged nucleic acid fragments including contacting a population of cells directly with a lysis reagent having one or more...
US-1,001,7758 Protein-protein interaction guided mating of yeast
The invention relates to methods and compositions useful for detection of protein-protein interactions between cell surface proteins.
US-1,001,7757 Cellular libraries of peptide sequences (CLiPS) and methods of using the same
The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety...
US-1,001,7756 Mutant xylanase, manufacturing method and use therefor, and method for manufacturing saccharified lignocellulose
What is aimed at is provision of an inexpensive and efficient saccharification method for lignocellulose using a thermostable xylanase and provision of a mutant...
US-1,001,7755 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention...
US-1,001,7754 Gene encoding cellulase
Polynucleotide sequences are provided encoding a thermostable cellulase and directing its increased expression are provided, and the use of the thermostable...
US-1,001,7753 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention provides isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also...
US-1,001,7752 Alpha-amylase variants and polynucleotides encoding same
The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
US-1,001,7751 Heat-resistant isoamylase
An isoamylase having improved heat resistance and an industrial method for producing maltose from starch. The isoamylase is an isoamylase consisting of the...
US-1,001,7750 Modified polymerases for improved incorporation of nucleotide analogues
The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3' position of the...
US-1,001,7749 Mutant transaminases as well as methods and uses relating thereto
The present invention relates to a mutant transaminase with increased transaminase activity relative to the wild-type transaminase, a fusion protein comprising...
US-1,001,7748 Construction of new variants of dextransucrase DSR-S by genetic engineering
The present invention relates to a recombinant process for the production of truncated or mutated dextransucrases while conserving the enzymatic activity or...
US-1,001,7747 Citrus tristeza virus based vectors for foreign gene/s expression
Disclosed herein are viral vectors based on modifications of the Citrus Tristeza virus useful for transfecting citrus trees for beneficial purposes. Included in...
US-1,001,7746 Methods for purification of recombinant AAV vectors
Provided herein are methods for the purification of recombinant adeno-associated virus (rAAV) vectors that can be used for gene transfer and specifically for...
US-1,001,7745 Hybridoma cell lines (My-C-cC0C2-259-1 A4) and use thereof for producing a monoclonal antibody against human...
Monoclonal antibodies, which can be produced in vitro, against cardiac epitopes of the human My-C are produced by generating myeloma cell clones that produce...
US-1,001,7744 Methods for reprogramming somatic cells
The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes,...
US-1,001,7743 MDCK-derived cell strain suspension-cultured in protein-free medium and method for proliferating virus using...
The present invention relates to a novel MDCK-derived cell line capable of being suspension-cultured in a protein-free medium and a method for proliferating a...
US-1,001,7742 Process for the preparation of disinfected human cell suspensions
In a process for preparing disinfected preparations from mammalian tissues, mammalian tissue is perfused at one step with an enzyme-free liquid antibiotic...
US-1,001,7741 Compositions and methods for obtaining enriched mesenchymal stem cell cultures
The disclosure provides a method of culturing cells of the mesenchymal cell lineage, said method comprising contacting the cells with a culture media comprising...
US-1,001,7740 Deriving brown adipose tissue cells
The present invention relates to brown adipose tissue (BAT) cells derived from adult stern or progenitor cells, derived from adult white fat tissue (WAT), as...
US-1,001,7739 Methods of expanding and assessing B cells and using expanded B cells to treat disease
Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested...
US-1,001,7738 ABCB5 positive mesenchymal stem cells as immunomodulators
The present invention is directed to purified preparations of dermal mesenchymal stem cells that are characterized by the cell surface expression of the ABCB5...
US-1,001,7737 Methods for reprogramming cells and uses thereof
A method of obtaining a neural multipotent, unipotent or somatic cell, comprising: i) providing a cell of a first type which is not a neural multipotent,...
US-1,001,7736 Method of inhibiting tau phosphorylation
A method of inhibiting phosphorylation of the tau protein and/or a TLR4-mediated immune response is disclosed. The method contemplates administering to cells in...
US-1,001,7735 Cell culture of corneal endothelial cells
The invention relates to a dual-media approach for culturing isolated corneal endothelial cells. Isolated corneal endothelial cells are first contacted with a...
US-1,001,7734 Method for producing dopaminergic neurons
The present invention provides a method of more efficiently producing a high-quality dopaminergic neuron from neural progenitor cells, specifically, a...
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