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Patent # Description
US-1,001,7582 Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological...
Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as...
US-1,001,7581 Methods and compositions for treatment of Pompe disease
In certain embodiments, the present disclosure provides compositions and methods for treating Pompe disease.
US-1,001,7580 Humanized anti-Tn-MUC1 antibodies and their conjugates
Humanized anti-Tn-MUC1 antibodies and conjugates thereof. Conjugates comprising pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a...
US-1,001,7579 Anti-cancer antibodies with reduced complement fixation
The invention provides modified antibodies directed against GD2 that have diminished complement fixation relative to antibody-dependent, cell-mediated...
US-1,001,7578 Methods of treating cancer in a patient by administering anti-folate-receptor-1 (FOLR1) antibodies
The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using...
US-1,001,7577 Antibodies and immunoconjugates
The invention provides immunoconjugates and methods of using the same.
US-1,001,7576 Generation of a cancer-specific immune response toward MUC1 and cancer specific MUC1 antibodies
The present invention provides a method for inducing a cancer specific immune response against MUC1 using an immunogenic glycopeptide. Other aspects of the...
US-1,001,7575 Antibody molecules having specificity for human OX40
The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods...
US-1,001,7574 Methods, kits and devices for promoting cardiac regeneration
A method of potentiating cardiac regeneration with neuregulin treatment in a subject in need thereof. The method comprising administering to the subject a...
US-1,001,7573 Anti-.alpha..beta.TCR antibody
The present invention relates to humanized monoclonal antibodies comprising the CDRs of murine antibody BMA031, which bind to the apTCR.CD3 complex and possess...
US-1,001,7572 Anti-tigit antibodies and methods of use
The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
US-1,001,7570 Repebody for novel interleukin-6 and use thereof
The present invention relates to an repebody capable of binding specifically to interleukin-6 (IL-6) to inhibit the biological activity of IL-6, a...
US-1,001,7569 Interleukin-10 peptides and antibodies thereof for inhibiting adverse effects of protozoan infection
The present disclosure is directed to interleukin-10 (IL-10) peptides and isolated antibodies that specifically bind to the IL-10 peptides. The IL-10 peptides...
US-1,001,7568 Polypeptides that bind to IL-17A, IL-17F and/or IL17-A/F and method of treatment using same
The present disclosure relates to amino acid sequences that are directed against (as defined herein) any of IL-17A, IL-17F and/or IL-17A/F including...
US-1,001,7567 Treatment of cancer with anti-LAP monoclonal antibodies
Described herein are compositions and methods relating to LAP-binding agents, including, for example, anti-LAP antibodies, and to their use in methods of...
US-1,001,7566 Growth differentiation factor (GDF) for treatment of diastolic heart failure
The methods and uses described herein relate to the treatment of age-related conditions, e.g. by administering an agent that inhibits the interaction of GDF11...
US-1,001,7565 Modulators and methods of use
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.
US-1,001,7564 Monoclonal antibodies against claudin-18 for treatment of cancer
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including...
US-1,001,7563 Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as...
US-1,001,7562 RSV G protein specific antibodies
The invention relates to human isolated, synthetic or recombinant antibodies or functional parts thereof, specific for the RSV G protein. Antibodies specific...
US-1,001,7561 Neutralizing molecules to influenza viruses
The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the...
US-1,001,7560 Nanobody against begomoviruses
A nanobody directed against begomoviruses is capable of selectively binding to ToLCSDV viral particles, TYLCV particles, and/or other begomoviruses. The...
US-1,001,7559 Synthetic single domain antibody
The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain...
US-1,001,7558 Consumable cryopreserved cells transiently overexpressing gene(s) encoding drug transporter protein(s)
The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter proteins...
US-1,001,7557 Insulin analogs and use thereof
Insulin analog with an improved in vitro effect compared with native insulin, a nucleic acid encoding the same, an expression vector including the nucleic acid,...
US-1,001,7556 Insulin receptor partial agonists
Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.
US-1,001,7555 Long-acting blood sugar decreasing fusion protein
The present invention provides an anthropogenic glucagon-like peptide-1 (GLP-1) recombinant protein molecule fused with an anthropogenic immunoglobulin subtype...
US-1,001,7554 Neuropeptide Y-derived peptides
The present invention discloses peptide fragments derived from neuropeptide Y (NPY), which are capable of selective binding to the neural cell adhesion molecule...
US-1,001,7553 Splice variants of GDNF and uses thereof
The present invention relates to Glial Cell Line-Derived Neurotrophic Factor (GDNF) protein and gene and is, in particular, directed to a novel splice variant...
US-1,001,7552 Methods of using a composition comprising leukolectin for cosmetic skin treatment
The present invention relates to cosmetic compositions comprising polypeptides obtained or obtainable from Salmonidae hatching fluid, methods of producing said...
US-1,001,7551 Peptides having reduced toxicity that stimulate cholesterol efflux
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length...
US-1,001,7550 Mycobacterium tuberculosis porins and toxins and related methods
Provided herein are isolated polypeptides comprising the amino-terminal domain of Mycobacterium tuberculosis porin A (MtpA), wherein the polypeptide is a porin...
US-1,001,7549 Hemipteran and coleopteran active toxin proteins from Bacillus thuringiensis
A novel Bacillus thuringiensis crystal protein exhibiting insect inhibitory activity is disclosed. Growth of Lygus insects is significantly inhibited by...
US-1,001,7548 Modified biotin-binding protein, fusion proteins thereof and applications
The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins...
US-1,001,7547 Adhesin as immunogen against enterotoxigenic Escherichia coli
The inventive subject matter relates to the methods for the induction of immunity and prevention of diarrhea resulting from Escherichia coli. The inventive...
US-1,001,7546 Monomeric avidin-like proteins with stable biotin binding ability
Disclosed are monomeric avidin-like proteins with a strong and stable biotin-binding ability, protein conjugates containing two or more of the monomeric...
US-1,001,7545 Compositions and vaccines comprising vesicles and methods of using the same
The disclosure relates to compositions, pharmaceutical compositions, vaccines, and methods of making and using the same. The compositions of the disclosure are...
US-1,001,7544 Computationally optimized broadly reactive antigens for H1N1 influenza
Generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates are described. The...
US-1,001,7543 Prefusion RSV F proteins and their use
Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are...
US-1,001,7542 Antimicrobial peptides and methods of use thereof
Aspects of the present invention relate to peptides having antimicrobial activity. In certain aspects, the invention relates to peptides having potent...
US-1,001,7541 Cyclosporin a form 2 and method of making same
Disclosed herein are methods of making cyclosporin A Form 2.
US-1,001,7540 Cyclic peptide binder against oncogenic K-Ras
Cyclic peptides represented by (Formula 1) ##STR00001## selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each...
US-1,001,7539 Melanocortin-1 receptor-specific cyclic hexapeptides
Melanocortin receptor-specific cyclic hexapeptides of the formula ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and...
US-1,001,7538 Bioactive peptides having insecticide activity
Disclosed are novel bioactive peptides derived as antagonists to a fire ant receptor for a pheromone biosynthesis-activating neuropeptide/pyrokinin...
US-1,001,7537 Peptide selectively binding to graphitic materials and volatile organic compounds
Provided is a peptide including X.sub.2SX.sub.1AAX.sub.2X.sub.3P (SEQ ID NO. 1), X.sub.2X.sub.2PX.sub.3X.sub.2AX.sub.3P (SEQ ID NO. 2), ...
US-1,001,7536 Synthetic peptide amides and dimers thereof
The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low...
US-1,001,7535 Amphiphilic compounds with neuroprotective properties
Amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use in methods of treatment of...
US-1,001,7534 Method for producing Tebbe complex
The present invention relates to a method for producing a Tebbe complex having high purity and high activity and having excellent storage stability in a high...
US-1,001,7533 Cytotoxic titanium and vanadium complexes
The present application provides a family of highly resistant and water-stable Titanium and Vanadium complexes, which may be administered directly without a...
US-1,001,7532 Platinum (IV) complex with increased anti-tumor efficacy
The invention relates to a new platinum (IV) complex with substantially increased antitumor efficacy. The invention further discloses a process for preparing of...
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