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Patent # Description
US-1,001,7531 Lipid-based platinum-N-heterocyclic carbene compounds and nanoparticles
The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to carbene...
US-1,001,7530 Fluorination method for phosphonitrilic chloride trimer and its derivatives
The present invention relates to a fluorination method for phosphonitrilic chloride trimer and its derivatives including using phosphonitrilicchloride or...
US-1,001,7529 Metformin derivatives
The present invention relates to novel biguanide derivatives including their pharmaceutically acceptable salts. The invention also relates processes for the...
US-1,001,7528 Controlled synthesis of polymeric perylene diimide and applications thereof
Perylene diimide phosphoramidite derivatives and methods for polymerization of perylene diimide phosphoramidite derivatives and applications thereof are...
US-1,001,7527 KLK4 inhibitors
The present invention relates to novel compounds and probes which have a common chemical structure necessary to obtain potent inhibitory activity against KLK4...
US-1,001,7526 Method for producing siloxanes from alkali salts of silanols
Cyclic siloxanes are prepared economically by reaction of an alkali metal siliconate having a mol ratio of alkali metal cation to silicon of less than one or...
US-1,001,7525 Multi-sensor array compound and methods of use thereof
The present invention is directed to a multi-sensor array compound including at least three chromophores, at least one receptor and an anchor. Contacting the...
US-1,001,7524 Compound and pharmaceutical composition for neuropsychological disorder or malignant tumor
The present invention provides a compound and a pharmaceutical composition for neuropsychological disorders or malignant tumors, the use of the compound and the...
US-1,001,7523 NAMPT inhibitors and methods
The invention features compounds of Formula (I), Formula (I)-A and Formula (I)-B as disclosed herein, as well as methods of synthesis, therapy, diagnostics, and...
US-1,001,7522 Alpha helix mimetics and methods relating thereto
Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the...
US-1,001,7521 Chromone oxime derivative and its use as allosteric modulator of metabotropic glutamate receptors
The present invention provides a novel chromone oxime derivative of formula (I), which is a modulator of nervous system receptors sensitive to glutamate and,...
US-1,001,7520 Myc modulators and uses thereof
The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). The compounds described herein may be Myc modulators (e.g., Myc...
US-1,001,7519 Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof
The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to the opioid oxycodone, in a manner that substantially...
US-1,001,7517 Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-.alpha.]pyrrolo[2,3-e]-pyrazin-8-yl)-N-- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
US-1,001,7516 BMP inhibitors and methods of use thereof
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation,...
US-1,001,7515 Stable amorphous ticagrelor and a process for its preparation
The present invention relates to a stable amorphous ticagrelor and a process for its preparation.
US-1,001,7514 6,7-dihydropyrazolo[1,5-.alpha.]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of...
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic...
US-1,001,7513 Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido ...
The present invention is directed to a compound of formula (I): ##STR00001## or a crystalline form thereof, or a solvate thereof; to a solid pharmaceutical...
US-1,001,7512 Compounds and compositions useful for treating disorders related to NTRK
This disclosure relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants, such as compounds of Formula (I): ##STR00001##
US-1,001,7511 Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof
The present invention relates to Pyrazolopyrimidinone compounds as PDE5 inhibitors with better IC.sub.50 value, good in vivo efficacy and PK profile and a...
US-1,001,7510 Thiol-X click foldamers for polymer affinity and catalysis libraries
Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol...
US-1,001,7509 Macrocylic pyrimidine derivatives
The present invention relates to substituted macrocylic pyrimidine derivatives of Formula (I) ##STR00001## wherein the variables have the meaning defined in...
US-1,001,7508 Nitrogenated heterocyclic compound
The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of...
US-1,001,7507 Diaza-benzofluoranthrene compounds
Disclosed are a series of diaza-benzofluoranthrene compounds. The present invention particularly relates to a compound represented by formula (I), ...
US-1,001,7506 ATX modulating agents
Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds...
US-1,001,7505 Crystalline forms of a BACE inhibitor, compositions, and their use
The present invention provides four crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful...
US-1,001,7504 Piperidine isoxazole and isothiazole orexin receptor antagonists
The present invention is directed to piperidine isoxazole and isothiazole orexin compounds which are antagonists of orexin receptors. Such compounds are of the...
US-1,001,7503 Compounds, compositions, and methods for increasing CFTR activity
The disclosure encompasses compounds having e.g., Formula (Ia) or (Ib), compositions thereof, and methods of modulating CFTR activity. The disclosure also...
US-1,001,7502 Benzoxazinone amides as mineralocorticoid receptor modulators
Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, (Formula (I)) that act as ...
US-1,001,7501 Benzimidazole derivatives as bromodomain inhibitors
This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing...
US-1,001,7500 1,3-benzodioxole derivative
The present invention provides a compound having a particular chemical structure or a pharmacologically acceptable salt thereof which has an excellent...
US-1,001,7499 Benzimidazole derivatives
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit...
US-1,001,7498 Compounds useful for treating AIDS
A compound having the following formula or a pharmaceutically acceptable salt thereof: ##STR00001## where: R independently represents a hydrogen atom, a...
US-1,001,7497 Pyrrolidine GPR40 modulators for the treatment of diseases such as diabetes
The present invention provides compounds of Formula (I) or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, or a solvate thereof, wherein all of...
US-1,001,7496 Uracil derivatives as AXL and c-MET kinase inhibitors
The present invention provides compounds of Formula I ##STR00001## or pharmaceutically acceptable salt forms thereof, wherein R.sub.a, R.sub.b, R.sub.c,...
US-1,001,7495 Therapeutically active compounds and their methods of use
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
US-1,001,7494 Antifungal compound process
The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new...
US-1,001,7493 2-(2,4,5-substituted-anilino)pyrimidine compounds
The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in...
US-1,001,7492 Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof
Provided are an isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof. The isoindoline derivative and the...
US-1,001,7491 Compounds and uses thereof for the modulation of hemoglobin
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
US-1,001,7490 Endoparasite control agent and method for using the same
An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite...
US-1,001,7489 Method for preparing benzopyran compound and application thereof in treating pulmonary fibrosis
The present invention opens to the public a method to prepare a benzopyran compound and its use for treating pulmonary fibrosis. A benzopyran compound has a...
US-1,001,7488 3-substituted carbonyl-naphtho[2,3-B]furane derivative or pharmaceutically acceptable salt thereof
The present invention provides a compound of the following Formula (1) or a pharmaceutically acceptable salt thereof: ##STR00001## wherein X is an oxygen atom...
US-1,001,7487 Fused heterocyclic compound
The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for...
US-1,001,7486 Conversion of fructose-containing feedstocks to HMF-containing product
The present invention relates generally to processes for converting fructose-containing feedstocks to a product comprising 5-(hydroxymethyl)furfural (HMF) and...
US-1,001,7485 Manufacturing method for compound having N,N-bis(2-hydroxy-3-chloropropyl)amino group
A method efficiently and safely manufactures, on an industrial scale, a compound having an N,N-bis(2-hydroxy-3-chloropropyl)amino group. (1) an amine compound...
US-1,001,7484 Catalysts containing specific titanium polymorphic forms
A catalyst composition which comprises titanium, wherein part of the titanium is present as a titanium dioxide phase and at least some of the titanium dioxide...
US-1,001,7483 Epoxidation using peroxygenase
The invention relates to enzymatic methods for epoxidation of a non-cyclic aliphatic alkene, or a terpene.
US-1,001,7482 Mitotic kinesin inhibitors and methods of use thereof
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. ##STR00001##
US-1,001,7481 Conformationally constrained, fully synthetic macrocyclic compounds
The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A,...
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