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Patent # Description
US-1,002,2376 Pyrazolopyridines and pyrazolopyrimidines
A compound having the structure: ##STR00001## or a pharmaceutically acceptable salt or solvate thereof, wherein A and A' are C or N, where C may be...
US-1,002,2375 Methods and compositions for inhibition of polymerase
The present invention is directed to methods and compositions for inhibition of viral nucleic acid polymerases, such as RNA and DNA polymerases, and methods and...
US-1,002,2374 Certain protein kinase inhibitors
Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.
US-1,002,2373 Posaconazole pharmaceutical compositions and preparation methods, uses and pharmaceutical formulations thereof
The present invention relates to a pharmaceutical composition comprising posaconazole and a carrier material, wherein the carrier material comprises a...
US-1,002,2372 Caveolin-1 related methods for treating glioblastoma with temozolomide
This invention provides a method for treating a subject afflicted with glioblastoma multiforme comprising administering a therapeutically effective regimen of...
US-1,002,2371 Procaspase-activating compounds and methods
The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death,...
US-1,002,2370 Morphinan compounds
This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a...
US-1,002,2369 Pharmaceutical formulation containing irritant
Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of...
US-1,002,2368 Methods of manufacturing oral formulations
A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a...
US-1,002,2367 Sustained-release buprenorphine solutions
The disclosure provides extended release pharmaceutical formulations comprising an opioid, particularly buprenorphine, a biocompatible organic solvent, and,...
US-1,002,2366 Extending and maintaining micropore viability of microneedle treated skin with lipid biosynthesis inhibitors...
Microneedles and their use as a physical skin permeation enhancement technique facilitate drug delivery across the skin in therapeutically relevant...
US-1,002,2365 Liposome of irinotecan or irinotecan hydrochloride and preparation method thereof
A liposome of irinotecan or irinotecan hydrochloride and its preparation method are disclosed. The liposome contains irinotecan or irinotecan hydrochloride,...
US-1,002,2364 Methods of treating cancer patients with farnesyltransferase inhibitors
The present invention relates to the field of molecular biology and cancer biology. Specifically, the present invention relates to methods of treating a subject...
US-1,002,2363 Pharmaceutical topical compositions
The invention provides pharmaceutical stable semisolid topical compositions comprising between 0.2 to 5% of a des-fluoroquinolone compound, and a suitable...
US-1,002,2362 Anti-allergy benzocycloheptathiophene derivatives
The present invention provides a method for treating an allergy disease or disorder or symptoms related thereto, in a subject in need thereof, the method...
US-1,002,2361 Animal treatments
Compositions and methods for the treatment and control of various conditions in an animal which comprises administering to said animal an effective amount of a...
US-1,002,2360 Polymeric nanoparticles and methods of making and using same
Described herein are polymeric nanoparticles that comprise 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]-triazolo-[3,4-fJ[1,6]- -naphthyridin-3-one...
US-1,002,2359 1,9-diazaspiro undecane compounds having multimodal activity against pain
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opiod receptor and more...
US-1,002,2358 Methods for improving muscle and heart function
The present invention encompasses combinations comprising a plurality of amino acids, formulations thereof for use in humans and animals, as well as methods for...
US-1,002,2357 Amyloid precursor protein MRNA blockers for treating Down syndrome and Alzheimer's disease
The present disclosure relates to methods for treating a neurodegenerative disorder by administering an effective amount of an agent that inhibits or reduces...
US-1,002,2356 Compounds for treatment of cancer
The present invention relates to pharmaceutical compositions for treating cancer comprising BRAF inhibitors, (e.g. vemurafenib) and/or MEK inhibitor, (e.g....
US-1,002,2355 Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the...
The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the...
US-1,002,2354 Pyrrolidine amide compounds as histone demethylase inhibitors
The present invention relates to compounds useful as inhibitors of one or more histone demethylases, such as KDM5. The invention also provides pharmaceutically...
US-1,002,2353 Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function
The invention relates to Cebranopadol or a physiologically acceptable salt thereof for use in the treatment or the prevention of pain and/or opioid drug...
US-1,002,2352 Modulators of ATP-binding cassette transporters
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters...
US-1,002,2351 SIRT 1 activator including syringaresinol
The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically...
US-1,002,2350 Antibacterial microelement chelates and the use thereof in animal feeds
The present invention relates to a microelement organic O-chelate or N-chelate complex compound, for the inhibition of facultative pathogenic bacteria. The...
US-1,002,2349 Cadotril particles
Cadotril particles suitable for solid or liquid dosage forms are the subject of this application.
US-1,002,2348 Topical solution of isotretinoin
The present invention relates to a topical solution comprising a retinoid or its pharmaceutically acceptable salts thereof and process of preparing it.
US-1,002,2347 Compositions and methods for diagnosis and treatment of metabolic syndrome
Compositions including an odd chain fatty acid, and salts and derivatives thereof, and methods for metabolic syndrome treatment and prophylaxis are provided,...
US-1,002,2346 Methods for treating brain injury
The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods...
US-1,002,2345 Agent for preventing and/or treating veisalgia
The object of the present invention is to provide a hangover prophylactic and/or therapeutic agent. The present invention provides a hangover prophylactic...
US-1,002,2344 Liquid dosage forms of sodium naproxen
Described herein are oral pharmaceutical compositions comprising liquid dosage forms of sodium naproxen in soft gel capsules. In one embodiment, the...
US-1,002,2343 Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular...
US-1,002,2342 Methods and compositions for treating multiple myeloma
Methods and compositions for sensitizing multiple myeloma cells to treatment with IMiDs are provided. Aspects include methods of administering AR-42 and an IMiD...
US-1,002,2341 Methods of preventing neurodegeneration of association cortex in a mammal
The present invention provides methods of preventing and/or reducing risk of neurodegeneration of association cortex, and/or inhibiting or reversing formation...
US-1,002,2340 Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same
Topical sphingosine-1-phosphate receptor agonist active agent formulations are provided. Aspects of the transdermal formulations include an amount of a...
US-1,002,2339 Compositions and methods useful for treatment of respiratory illness
Disclosed are compositions including phenylephrine, its free and addition salt forms, and mixtures thereof, alone, or in combination with other pharmaceutical...
US-1,002,2338 Honey bee mite disruptive compounds and methods of application
This disclosure describes compounds that affect the olfactory responses of the honey bee mite (Varroa destructor) and methods of use thereof. The compounds do...
US-1,002,2337 Formulation of sparingly soluble compounds by hot-melt extrusion
The present invention relates to formulation of sparingly-(water)-soluble compounds and its use as (or in a) food or feed product or dietary supplement.
US-1,002,2336 Ropinirole-containing adhesive patch
A patch containing free ropinirole (ropinirole in free form) in an adhesive base is provided, in which the patch exhibits favorable and continuous transdermal...
US-1,002,2335 Homeopathic therapeutic method and compositions
Methods of producing a Hydrophilic Homeopathic Aqueous Substance Active (HASA)-gel matrix, include the steps of: (a) combining a homeopathic compound and an...
US-1,002,2334 Cationic materials and formulations for drug delivery
Cationic polymers are provided for delivering anionic active agents, preferably in the form or nanoparticles and other nanostructures. The polymer can be a...
US-1,002,2333 Image-guided delivery of a mixture of bacteria and non-bacteria linked nanoparticles
A computer-implemented method for image-guided delivery of a nanoparticle mixture to a target tumor located in a region of interest includes selecting a...
US-1,002,2332 Stimuli-responsive interpolymer complex coated hollow silica vesicles
A porous hollow silica particle with an interpolymer complex immobilized thereon is provided. The interpolymer complex comprises a first polymer immobilized to...
US-1,002,2331 Coating agent for solid preparation, and film and coated solid preparation formed therewith
A coating agent imparts gas barrier properties to a solid preparation while keeping rapid disintegration properties of the solid preparation, and a coating...
US-1,002,2330 Methods of preparing oral controlled release formulations
The invention is directed to oral modified/controlled release drug formulations which provide a rapid initial onset of effect and a prolonged duration of...
US-1,002,2329 Carbohydrate tablet and method of fabrication
An edible energy tablet containing at least 80 weight % carbohydrates for consumption during exercise, is fabricated by a process including providing tablet...
US-1,002,2328 Dialkyl sulfosuccinate compositions, method of making, and method of use
A particulate solid composition comprises a blend of dialkyl sulfosuccinate and a water-soluble polymer. The water-soluble polymer can be a cellulose ether, a...
US-1,002,2327 Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same
The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a...
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