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Patent # Description
US-1,002,3863 Therapeutics with conformationally restricted monomers
This invention provides single-stranded and multi-stranded compounds that are useful in various therapeutic modalities to regulate the expression of nucleic...
US-1,002,3862 Organic compositions to treat beta-catenin-related diseases
The present disclosure relates to RNAi agents useful in methods of treating Beta-Catenin-related diseases such as adenomatous polyposis of the colon, colorectal...
US-1,002,3861 Oligomer-conjugate complexes and their use
Oligonucleotides, chemically-modified oligonucleotides, and oligonucleotide-conjugate complexes for use in research, diagnostics, and/or therapeutics are...
US-1,002,3860 Method of purifying nucleic acids and kit for purifying nucleic acids
[Object] To provide a method of purifying nucleic acids where the operation is simple and the nucleic acids can be extracted in a short time with high...
US-1,002,3859 Fabrication of hierarchical silica nanomembranes and uses thereof for solid phase extraction of nucleic acids
The present invention provides a novel method to fabricate silica nanostructures on thin polymer films based on silica deposition and self-wrinkling induced by...
US-1,002,3858 System and method for selective ablation of cancer cells with cold atmospheric plasma
A method for elevating a TRAIL-R1 expression in cancer cells to induce apoptosis. The method comprises the steps of receiving electrical energy having a...
US-1,002,3857 Apparatus and method for dehydrating biological materials with freezing and microwaving
An apparatus and method for dehydrating biological materials, such as vaccines and microorganism cultures, in which the materials are dehydrated in an evacuated...
US-1,002,3856 Enzyme composition for DNA end repair, adenylation, phosphorylation
Enzyme compositions and their method of use that provide ready-to-use master mixtures. The compositions comprise a modified thermophilic DNA polymerase lacking...
US-1,002,3855 Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker
A fusion protein including N-terminal domain of a fusion partner at N-terminal and C-terminal domain of RET protein at C-terminal, a fusion gene encoding the...
US-1,002,3854 Microorganisms genetically engineered to have modified N-glycosylation activity
Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are...
US-1,002,3853 Engineered nucleic-acid targeting nucleic acids
The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the...
US-1,002,3852 Lipase variants and polynucleotides encoding same
The present invention relates to a lipase variant of a parent lipase, which variant has lipase activity, at least 75% but less than 100% sequence identity to...
US-1,002,3851 Compositions and methods comprising a lipolytic enzyme variant
The present invention provides lipolytic enzyme variants. Specifically, the present invention provides lipolytic enzyme variants having one or more...
US-1,002,3850 DNA polymerases with increased 3'-mismatch discrimination
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
US-1,002,3849 DNA polymerases with improved activity
Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful...
US-1,002,3848 Immunogenic composition comprising Panton-Valentine Leukocidin (PVL) derived polypeptides
The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the disclosure...
US-1,002,3847 Immunogenic peptides for use in the prevention and/or treatment of infectious diseases, autoimmune diseases,...
The invention describes new peptides containing epitopes recognized by CD4+ natural killer T (NKT) cells for increasing activity for use in infectious diseases,...
US-1,002,3846 Production method for non-enveloped virus particles
Provided are a production method for non-enveloped virus particles which is characterized in that a sample including non-envelopes virus particles is treated...
US-1,002,3845 Methods of making modified viral genomes
This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the...
US-1,002,3844 Purification method of virus-like particles
The present invention aims at establishing a novel means for purifying norovirus VLPs. There is provided a purification method of norovirus virus-like...
US-1,002,3843 Host cells with artificial endosymbionts
The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts...
US-1,002,3842 Endothelial and endothelial like cells produced from fibroblasts and uses related thereto
This disclosure relates to endothelial or endothelial like cells cultured from fibroblasts exposed to transcription factor ETV2. In certain embodiments, the...
US-1,002,3841 Methods and compositions for treating breast cancer with dendritic cell vaccines
Disclosed are compositions and methods for treatment of breast cancer. Disclosed methods and compositions include dendritic cells loaded with cyclin B1 and WT-1...
US-1,002,3840 Generation of autologous T-cells in mice
The invention provides an animal model and methods of generating large numbers of diverse, functional, naive T cells in mice using bone marrow cells from adult...
US-1,002,3839 Anti-tumour vaccine derived from normal cells
A composition for inducing an immune response in a mammal, comprises lymphoid cells in which expression of tumor antigens has been chemically induced. The tumor...
US-1,002,3838 Method of inducing differentiation from pluripotent stem cells to germ cells
This invention provides a method of producing a primordial germ cell-like cell (PGCLC) from an epiblast isolated from an embryo or an epiblast-like cell (EpiLC)...
US-1,002,3837 Materials and methods for identifying and using yeast strains that metabolize pentose sugars in the presence of...
Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants of Saccharomyces cerevisiae that can grow on...
US-1,002,3836 Medium for yeasts
In order to provide a culture medium eliminating variation by lot of component concentrations, the present invention provides a culture medium, and preferably a...
US-1,002,3835 Method of adjusting the conditions of biological processes and a reactor for carrying out the method
The method of pH controlling during electrolytic fermentation processes of the organic substrates includes placing the biological and chemical reagents in a...
US-1,002,3834 Culture apparatus
A culture apparatus that cultivates a culture, which includes an outer case, an inner case configured with metal plates inside the outer case, a heater outside...
US-1,002,3833 Temperature sensor means and a bioreactor system comprising a temperature sensor means
A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the...
US-1,002,3832 Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators...
The invention relates to a system of fluidic valves and pumps and associated fluidic channels integratable into a bio-object microfluidics module. The module...
US-1,002,3831 Gas delivery devices and associated systems and methods
Systems, devices, and methods for the delivery of gas bubbles to liquids are generally described. The devices can include a primary conduit comprising a...
US-1,002,3830 Systems and methods for the continuous optimization of a microorganism culture profile
Systems and methods are disclosed for continuously optimizing the profile of an aqueous culture comprising microorganisms. The systems and methods comprise a...
US-1,002,3829 Blue whiskey and method for making blue-colored whiskey
The present invention is directed to a method of preparing a blue-colored whiskey by mixing methylene blue, pure alcohol and distilled water. This process...
US-1,002,3828 Methods for decarbonating fermented liquids
A method of decarbonating fermented liquids in-line may include directing a carbonated malt-based liquid through a nozzle, and directing the carbonated...
US-1,002,3827 Cleaning composition for semiconductor substrate and cleaning method
A cleaning composition for a semiconductor substrate contains a solvent, and a polymer that includes a fluorine atom, a silicon atom or a combination thereof....
US-1,002,3826 Soluble unit dose comprising a composition
A water-soluble pouch including a water-soluble film and at least one compartment enclosed by the film, where the compartment includes a composition, and where...
US-1,002,3825 Sulfoxide-based surfactants
The present invention provides sulfoxide compounds comprising hydrophobic ester or amide moieties such that the compounds have surfactant properties. Also...
US-1,002,3824 Lubricant composition
A lubricant composition and a method of lubricating off-road vehicles and/or machinery. The lubricant composition includes (i) a base oil, (ii) at least one...
US-1,002,3823 Refrigerator oil and working fluid composition for refrigerator
The present invention provides a refrigerating machine oil comprising, as a base oil, at least one oxygen-containing oil having a carbon/oxygen molar ratio of...
US-1,002,3822 Production of base oils from petrolatum
Methods are provided for producing lubricant base oils from petrolatum. After solvent dewaxing of a brightstock raffinate to form a brightstock base oil,...
US-1,002,3821 Method and apparatus for improving heat transfer and reaction efficiency of gas hydrate reactor using scraper
The present invention relates to an apparatus comprising a reactor body to which gas and water are supplied to create a gas hydrate; an upper cover which is...
US-1,002,3820 Device and method for producing substitute natural gas and network comprising same
A device includes a gasifier to produce a gaseous compound from a biomass. The gasifier includes inlets for the biomass and for an oxidizing agent and an outlet...
US-1,002,3819 Quaternary ammonium amide and/or ester salts
The invention relates to quaternary ammonium amide and/or ester salts and their use as additives, including their use in fuels, such as diesel fuel. The...
US-1,002,3818 Process for powering a compression ignition engine and fuel therefor
A diesel engine fuel composition comprising methanol at a level of at least 20% by weight of the fuel; water at a level at least 20% by weight of the fuel; a...
US-1,002,3817 Integrated drying and gasification process for simultaneously producing synthetic gas and high rank coal
The present invention relates to a gasification process for efficiently co-producing synthesis gas and high-grade coal from water-containing coal, and to an...
US-1,002,3815 Process for producing high octane gasoline component from renewable raw material
This invention relates generally to a process for producing gasoline component. More particularly, the invention relates to a process for producing high octane...
US-1,002,3814 Noble metal hydrogenation catalysts with low cracking activity
Methods are provided for modifying hydrogenation catalysts having silica supports (or other non-alumina supports) with additional alumina, and using such...
US-1,002,3813 Process for selective deep hydrodesulfurization of a hydrocarbon feedstock using an unsupported nanocatalyst...
A process for producing an unsupported molybdenum sulfide nanocatalyst comprising atomizing a molybdenum oxide solution to form a molybdenum oxide aerosol,...
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