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Patent # Description
US-1,002,3891 Process of chiral resolution of cyclic and acyclic acetates to enantiomerically pure (R)-alcohols
The patent discloses herein a process for the chiral resolution of racemic cyclic and acyclic acetates to obtain (R)-alcohol. Further, it discloses the...
US-1,002,3890 Genetically modified cell and process for use of said cell
The present invention relates to the field of biotransformation of furanic compounds. More particular the present invention relates to novel genetically...
US-1,002,3889 Microbial approach for the production of 5-hydroxytryptophan
5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes...
US-1,002,3888 Microorganism for producing L-glutamine and method for producing L-glutamine using same
Provided are a Corynebacterium glutamicum mutant that is resistant to high concentrations of L-glutamine, and a method of producing L-glutamine by using the...
US-1,002,3887 Method of manufacturing an amino-acid composition using animal by-products
The present disclosure provides a method for preparing an amino acid composition using an animal byproduct, particularly a method for obtaining an amino acid...
US-1,002,3886 (R)-selective amination
The present invention relates to a method for the enzymatic synthesis of enantiomerically enriched (R)-amines of general formula [1][c] ##STR00001## from the...
US-1,002,3885 Process for the preparation of pregabalin
The present invention provides an improved process for the preparation of a compound of formula (I), which comprises the steps of: formula (I), (a) reacting...
US-1,002,3884 Microorganism producing docosahexaenoic acid and utilization thereof
According to the present invention, a microorganism belonging to the genus Aurantiochytrium having an 18S rRNA gene consisting of the base sequence represented...
US-1,002,3883 Method for treating sugar solution, hydrogenated sugar solution, method for producing organic compound, and...
Provided are a method for treating a saccharide solution, which comprises subjecting a saccharide solution containing at least one selected from the group...
US-1,002,3882 Hetero-oligomers of (S)-carbonyl reductases and their applications in catalyzing reduction of polyphenyl ketones
Provided are novel hetero-oligomers of (S)-carbonyl reductases and their application in catalyzing the reduction of polyphenyl ketones. Also provided are...
US-1,002,3881 Detoxifying pre-treated lignocellulose-containing materials
The invention relates to a process of detoxifying pre-treated lignocellulose-containing material comprising subjecting the pre-treated lignocellulose-containing...
US-1,002,3880 Methods and compositions for the activation of gamma-delta T-cells
The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can...
US-1,002,3879 Minimal volume reprogramming of mononuclear cells
The invention provides compositions and methods for reprogramming minimal volumes of mononuclear cells. In particular aspects, the invention provides methods...
US-1,002,3878 Method for the alteration of plants using CLE polypeptides/peptides
The present invention relates to altering the biomass and/or structure of a plant, in order to maximize its potential as a source of feedstock or increase its...
US-1,002,3877 PHI-4 polypeptides and methods for their use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
US-1,002,3876 Engineered pesticidal proteins
Engineered pesticidal polypeptides that are highly active against a wide range of pests and methods of making such polypeptides are disclosed. The nucleotide...
US-1,002,3875 Fungal resistant plants expressing HCP5
The present invention relates to a method of increasing resistance against fungal pathogens of the order Pucciniales, preferably the family Phacopsoraceae, in...
US-1,002,3874 Herbicide tolerance genes and methods of use thereof
Polypeptides and recombinant DNA molecules useful for conferring tolerance to AOPP herbicides, phenoxy acid herbicides, and pyridinyloxy acid herbicides are...
US-1,002,3873 Methods and compositions for transgenic plants with enhanced cold tolerance, ability to flower without...
The present invention provides transgenic plants having increased tolerance to cold and altered flowering characteristics. Also provided are methods and...
US-1,002,3872 Methods for producing heterologous polypeptides in mutants of trichoderma
The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more genes selected from...
US-1,002,3871 Double-stranded polyC:poly(G/I) RNA for immunostimulation and cancer treatment
The present invention relates to polyC:poly(G/I) dsRNAs for triggering innate immunity, in particular through toll-like receptor 3 (TLR-3) and, optionally,...
US-1,002,3870 DNA aptamers binding the histidine tag and their application
A DNA aptamer was obtained which has an affinity for His-tag, and contains a nucleotide sequence selected from SEQ ID No. 1 and SEQ ID No. 2, which has clear...
US-1,002,3869 Bio-sensor for the detection of small molecules
This present invention provides methods for the detection of small molecules in samples comprising the steps a) coupling a nanoparticle (NP) or microparticle...
US-1,002,3868 MiRNA for treating diseases and conditions associated with neo-angiogenesis
The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with...
US-1,002,3867 Oligonucleotides for modulating gene expression and uses thereof
The present invention regards oligonucleotides for modulating the expression of a gene, in particular for modulating a gene responsible for a pathology of...
US-1,002,3866 Compositions and methods for inhibition of nucleic acids function
The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions...
US-1,002,3865 RNA-interference by single-stranded RNA molecules
The present invention relates to sequence and structural features of single-stranded (ss)RNA molecules required to mediate target-specific nucleic acid...
US-1,002,3864 Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta
The invention provides HSP90.beta. inhibitors comprising an antisense oligonucleotide targeting HSP90.beta., pharmaceutical compositions comprising said...
US-1,002,3863 Therapeutics with conformationally restricted monomers
This invention provides single-stranded and multi-stranded compounds that are useful in various therapeutic modalities to regulate the expression of nucleic...
US-1,002,3862 Organic compositions to treat beta-catenin-related diseases
The present disclosure relates to RNAi agents useful in methods of treating Beta-Catenin-related diseases such as adenomatous polyposis of the colon, colorectal...
US-1,002,3861 Oligomer-conjugate complexes and their use
Oligonucleotides, chemically-modified oligonucleotides, and oligonucleotide-conjugate complexes for use in research, diagnostics, and/or therapeutics are...
US-1,002,3860 Method of purifying nucleic acids and kit for purifying nucleic acids
[Object] To provide a method of purifying nucleic acids where the operation is simple and the nucleic acids can be extracted in a short time with high...
US-1,002,3859 Fabrication of hierarchical silica nanomembranes and uses thereof for solid phase extraction of nucleic acids
The present invention provides a novel method to fabricate silica nanostructures on thin polymer films based on silica deposition and self-wrinkling induced by...
US-1,002,3858 System and method for selective ablation of cancer cells with cold atmospheric plasma
A method for elevating a TRAIL-R1 expression in cancer cells to induce apoptosis. The method comprises the steps of receiving electrical energy having a...
US-1,002,3857 Apparatus and method for dehydrating biological materials with freezing and microwaving
An apparatus and method for dehydrating biological materials, such as vaccines and microorganism cultures, in which the materials are dehydrated in an evacuated...
US-1,002,3856 Enzyme composition for DNA end repair, adenylation, phosphorylation
Enzyme compositions and their method of use that provide ready-to-use master mixtures. The compositions comprise a modified thermophilic DNA polymerase lacking...
US-1,002,3855 Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker
A fusion protein including N-terminal domain of a fusion partner at N-terminal and C-terminal domain of RET protein at C-terminal, a fusion gene encoding the...
US-1,002,3854 Microorganisms genetically engineered to have modified N-glycosylation activity
Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are...
US-1,002,3853 Engineered nucleic-acid targeting nucleic acids
The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the...
US-1,002,3852 Lipase variants and polynucleotides encoding same
The present invention relates to a lipase variant of a parent lipase, which variant has lipase activity, at least 75% but less than 100% sequence identity to...
US-1,002,3851 Compositions and methods comprising a lipolytic enzyme variant
The present invention provides lipolytic enzyme variants. Specifically, the present invention provides lipolytic enzyme variants having one or more...
US-1,002,3850 DNA polymerases with increased 3'-mismatch discrimination
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
US-1,002,3849 DNA polymerases with improved activity
Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful...
US-1,002,3848 Immunogenic composition comprising Panton-Valentine Leukocidin (PVL) derived polypeptides
The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the disclosure...
US-1,002,3847 Immunogenic peptides for use in the prevention and/or treatment of infectious diseases, autoimmune diseases,...
The invention describes new peptides containing epitopes recognized by CD4+ natural killer T (NKT) cells for increasing activity for use in infectious diseases,...
US-1,002,3846 Production method for non-enveloped virus particles
Provided are a production method for non-enveloped virus particles which is characterized in that a sample including non-envelopes virus particles is treated...
US-1,002,3845 Methods of making modified viral genomes
This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the...
US-1,002,3844 Purification method of virus-like particles
The present invention aims at establishing a novel means for purifying norovirus VLPs. There is provided a purification method of norovirus virus-like...
US-1,002,3843 Host cells with artificial endosymbionts
The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts...
US-1,002,3842 Endothelial and endothelial like cells produced from fibroblasts and uses related thereto
This disclosure relates to endothelial or endothelial like cells cultured from fibroblasts exposed to transcription factor ETV2. In certain embodiments, the...
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