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Patent # Description
US-1,002,3659 Processes for the production of chemically-modified heparins
The present invention relates to a process for the production of heparin derivatives having an average molecular weight of from about 4.6 to about 6.9 kDa and...
US-1,002,3658 Conjugates of oligomer of hyaluronic acid or of a salt thereof, method of preparation thereof and use thereof
The invention relates to conjugates of hyaluronic acid oligomer according to the general formulae I, II III or IV, or a salt thereof, the method of preparation...
US-1,002,3657 Reversible protein multimers, methods for their production and use
Some aspects of this invention are based on the recognition that reversible protein multimers in which monomeric proteins are conjugated to a carrier molecule...
US-1,002,3656 Methods of treating inflammation using IL-17A and IL-17F cross-reactive monoclonal antibodies
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines...
US-1,002,3655 Antibody specific to Staphylococcus aureus, therapeutic method and detection method using same
We provide new monoclonal antibody inhibitors of coagulases for treatment of S. aureus. The monoclonal antibodies are useful in targeting the SC N-terminus and...
US-1,002,3654 Anti-PCSK9 antibodies
An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9...
US-1,002,3653 Anti-metalloprotease antibody for diagnosis and treatment of cancers
Expression of proteolytically active, high molecular weight ADAM protease is relatively increased in tumor cells that also express the putative tumor stem cell...
US-1,002,3652 Method of targeting glycoproteins to treat cancer
The present disclosure relates to a method of inhibiting tumor growth. More specifically, the present disclosure relates to the use of monoclonal antibodies for...
US-1,002,3651 Humanized anti-TF-antigen antibodies
Provided are humanized monoclonal antibodies (mAbs) or fragments thereof that bind with specificity to the Thomsen-Friedenreich (TF) human tumor antigen. Three...
US-1,002,3650 Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with...
US-1,002,3649 Method of treating cancer with a combination of an anti-CCR4 antibody and a 4-1BB agonist
The present disclosure describes combination therapies comprising an antibody which specifically binds to human CCR4 and a selective 4-1BB agonist, and the use...
US-1,002,3648 Anti-TOSO chimeric antigen receptor and its use
In a first aspect, the present invention relates to genetically modified T-cells having a chimeric antigen receptor (CAR) in a method for adoptive cell therapy...
US-1,002,3647 Polypeptides capable of cellular internalization
Provided herein are polypeptides that are capable of crossing the cellular membrane and entering into the intracellular environment, which polypeptides are...
US-1,002,3646 Neutralizing antibodies and methods of use thereof
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the...
US-1,002,3645 Anti-CD40 antibodies
The present disclosure provides novel anti-CD40 antibodies, compositions including the new antibodies, nucleic acids encoding the antibodies, and methods of...
US-1,002,3644 Antigen-binding proteins that activate the leptin receptor
The present invention provides antibodies and antigen-binding fragments of antibodies that bind to leptin receptor (LEPR), and methods of using the same....
US-1,002,3643 Antibodies against human CSF-1R and uses thereof
The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said...
US-1,002,3642 Anti-PDGFR-beta antibodies and uses thereof
The present invention provides antibodies that bind to platelet derived growth factor receptor beta (PDGFR-beta) and methods of using the same. According to...
US-1,002,3641 Anti-TIE2 antibodies and uses thereof
The present invention provides antibodies that bind to Tie2 and methods of using same. According to certain embodiments of the invention, the antibodies are...
US-1,002,3640 Human anti-VEGFR-2/KDR antibodies
The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic...
US-1,002,3639 Multi-functional antibody polypeptide for cryptic epitope of epidermal growth factor receptor and T cell antigen
Multi-functional antibody polypeptide comprises: (a) a first functional domain, specifically recognizing a cryptic epitope formed by 287th to 302nd amino acid...
US-1,002,3638 Anti-integrin .beta.1 antibody compositions and methods of use thereof
The current invention provides human variable chain framework regions and humanized antibodies comprising the framework regions, the antibodies being specific...
US-1,002,3637 Combination immunotherapy for the treatment of cancer
Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-1, etc.) are demonstrated herein to be useful for the...
US-1,002,3636 Caninized murine antibodies to human PD-1
The present invention provides caninized murine anti-human PD-1 antibodies that have specific sequences and a high binding affinity for canine PD-1. The...
US-1,002,3635 Antibodies to ICOS
Provided herein are various embodiments relating to antibodies. Some of the embodiments include agonist antibodies that bind ICOS. Such antibodies can be used...
US-1,002,3634 Antibodies against TIM3 and uses thereof
Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also...
US-1,002,3633 Method for generation of immunoglobulin sequences
The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are...
US-1,002,3632 Antigenic GM-CSF peptides and antibodies to GM-CSF
Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against...
US-1,002,3631 Albumin binding antibodies and binding fragments thereof
A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or...
US-1,002,3630 Methods of neutralizing C5 with anti-C5 antibodies
An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the...
US-1,002,3629 Anti-influenza antibody
The present invention relates to an antibody that confers protection against influenza virus infection. More specifically, it relates to an anti-neuraminidase...
US-1,002,3628 Cell line expressing single chain factor VIII polypeptides and uses thereof
The present invention provides cell lines for producing single chain FVIII polypeptides, e.g., chimeric single chain FVIII polypeptides, methods of producing...
US-1,002,3627 Vascular endothelial growth factor fusion protein
The present invention relates to a fusion protein binding to a vascular endothelial growth factor (VEGFR) and/or a placental growth factor (PIGF). The fusion...
US-1,002,3626 Polynucleotides encoding immune modulating polypeptides
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one...
US-1,002,3625 Engineered high-affinity human T cell receptors
T cell receptors (TCRs) that have higher affinity for the Survivin antigen are provided. The high affinity TCRs were engineered through the generation of...
US-1,002,3624 Long-acting recombinant human follicle-stimulating hormone-Fc fusion protein
Recombinant Fc fusion proteins of human follicle-stimulating hormone (hFSH) with in vivo biological activities comparable to those of human follicle-stimulating...
US-1,002,3623 Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide
The present invention provides fusion proteins comprising a mucin-domain polypeptide covalently linked to an active protein that has improved properties (e.g....
US-1,002,3622 Method of immunization for reducing toxic damaged caused by oligomeric form of the amyloid-beta protein with...
The invention provides monomeric and oligomeric amyloid beta peptide isomers that are resistant towards fibrillogenesis and their use as screening reagents or...
US-1,002,3621 Follistatin-related fusion proteins
The disclosure provides, in part, follistatin polypeptides that are suitable for use in local administration and methods for use.
US-1,002,3620 Methods for treatment of nephrotic syndrome and related conditions
The present disclosure provides a polypeptide and method for treating and/or preventing nephrotic syndrome, such as but not limited to those associated with...
US-1,002,3619 Production of spider silk protein in corn
Methods for the production of synthetic spider silk-like proteins in corn endosperm, plant leaf or plant shoot tissue are provided. The present invention...
US-1,002,3618 Protein expression strains
The invention provides an improved host strain for production of desired protein.
US-1,002,3617 Methods and systems of producing pharmaceutical grade lantibiotics
Methods and systems for efficient and cost-effective production of lantibiotics. The methods and systems are capable of producing lantibiotics having high...
US-1,002,3616 Fusion proteins and combination vaccines comprising Haemophilus influenzae Protein E and Pilin A
The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to...
US-1,002,3615 Efficient transport into white blood cells
The present invention relates to the use of specific transporter cargo conjugate molecules for the transport of a substance of interest (cargo molecule) into...
US-1,002,3614 Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of...
US-1,002,3613 Peptidomimetic macrocycles as modulators of MCL-1
The disclosed peptidomimetic macrocycles modulate the activity of MCL-1. Myeloid cell leukemia 1 (MCL-1) is a protein that inhibits cell death. Peptidomimetic...
US-1,002,3612 Method of treating endometriosis
The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in...
US-1,002,3611 Process for the preparation of bortezomib mannitol ester
A novel and improved process for preparation of bortezomib mannitol ester is derived, which process avoids excessive use of solvents, involves convenient,...
US-1,002,3610 Ligands for prevention of neurotoxicity of the alzheimer's disease related amyloid-beta peptide
The present invention relates to the field of molecular biochemistry and medicine, and in particular to ligands comprising modified amino acid residues,...
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