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Patent # Description
US-1,002,3638 Anti-integrin .beta.1 antibody compositions and methods of use thereof
The current invention provides human variable chain framework regions and humanized antibodies comprising the framework regions, the antibodies being specific...
US-1,002,3637 Combination immunotherapy for the treatment of cancer
Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-1, etc.) are demonstrated herein to be useful for the...
US-1,002,3636 Caninized murine antibodies to human PD-1
The present invention provides caninized murine anti-human PD-1 antibodies that have specific sequences and a high binding affinity for canine PD-1. The...
US-1,002,3635 Antibodies to ICOS
Provided herein are various embodiments relating to antibodies. Some of the embodiments include agonist antibodies that bind ICOS. Such antibodies can be used...
US-1,002,3634 Antibodies against TIM3 and uses thereof
Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also...
US-1,002,3633 Method for generation of immunoglobulin sequences
The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are...
US-1,002,3632 Antigenic GM-CSF peptides and antibodies to GM-CSF
Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against...
US-1,002,3631 Albumin binding antibodies and binding fragments thereof
A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or...
US-1,002,3630 Methods of neutralizing C5 with anti-C5 antibodies
An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the...
US-1,002,3629 Anti-influenza antibody
The present invention relates to an antibody that confers protection against influenza virus infection. More specifically, it relates to an anti-neuraminidase...
US-1,002,3628 Cell line expressing single chain factor VIII polypeptides and uses thereof
The present invention provides cell lines for producing single chain FVIII polypeptides, e.g., chimeric single chain FVIII polypeptides, methods of producing...
US-1,002,3627 Vascular endothelial growth factor fusion protein
The present invention relates to a fusion protein binding to a vascular endothelial growth factor (VEGFR) and/or a placental growth factor (PIGF). The fusion...
US-1,002,3626 Polynucleotides encoding immune modulating polypeptides
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one...
US-1,002,3625 Engineered high-affinity human T cell receptors
T cell receptors (TCRs) that have higher affinity for the Survivin antigen are provided. The high affinity TCRs were engineered through the generation of...
US-1,002,3624 Long-acting recombinant human follicle-stimulating hormone-Fc fusion protein
Recombinant Fc fusion proteins of human follicle-stimulating hormone (hFSH) with in vivo biological activities comparable to those of human follicle-stimulating...
US-1,002,3623 Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide
The present invention provides fusion proteins comprising a mucin-domain polypeptide covalently linked to an active protein that has improved properties (e.g....
US-1,002,3622 Method of immunization for reducing toxic damaged caused by oligomeric form of the amyloid-beta protein with...
The invention provides monomeric and oligomeric amyloid beta peptide isomers that are resistant towards fibrillogenesis and their use as screening reagents or...
US-1,002,3621 Follistatin-related fusion proteins
The disclosure provides, in part, follistatin polypeptides that are suitable for use in local administration and methods for use.
US-1,002,3620 Methods for treatment of nephrotic syndrome and related conditions
The present disclosure provides a polypeptide and method for treating and/or preventing nephrotic syndrome, such as but not limited to those associated with...
US-1,002,3619 Production of spider silk protein in corn
Methods for the production of synthetic spider silk-like proteins in corn endosperm, plant leaf or plant shoot tissue are provided. The present invention...
US-1,002,3618 Protein expression strains
The invention provides an improved host strain for production of desired protein.
US-1,002,3617 Methods and systems of producing pharmaceutical grade lantibiotics
Methods and systems for efficient and cost-effective production of lantibiotics. The methods and systems are capable of producing lantibiotics having high...
US-1,002,3616 Fusion proteins and combination vaccines comprising Haemophilus influenzae Protein E and Pilin A
The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to...
US-1,002,3615 Efficient transport into white blood cells
The present invention relates to the use of specific transporter cargo conjugate molecules for the transport of a substance of interest (cargo molecule) into...
US-1,002,3614 Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of...
US-1,002,3613 Peptidomimetic macrocycles as modulators of MCL-1
The disclosed peptidomimetic macrocycles modulate the activity of MCL-1. Myeloid cell leukemia 1 (MCL-1) is a protein that inhibits cell death. Peptidomimetic...
US-1,002,3612 Method of treating endometriosis
The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in...
US-1,002,3611 Process for the preparation of bortezomib mannitol ester
A novel and improved process for preparation of bortezomib mannitol ester is derived, which process avoids excessive use of solvents, involves convenient,...
US-1,002,3610 Ligands for prevention of neurotoxicity of the alzheimer's disease related amyloid-beta peptide
The present invention relates to the field of molecular biochemistry and medicine, and in particular to ligands comprising modified amino acid residues,...
US-1,002,3609 Methods for reducing chromatin content in protein preparations by treatment with alkyl cations
A method of reducing aggregate content in a preparation having a target protein includes contacting the preparation with an alkyl cation to form a mixture, and...
US-1,002,3608 Protein purification methods to remove impurities
Disclosed are methods of purifying a protein sample. More specifically, provide are methods of removing or reducing the amount of high molecular weight species...
US-1,002,3607 Purification of biological conjugates by size exclusion chromatography
A method for separating a biological conjugate from an aggregate. The molecular weight of the biological conjugate ranges from about 10 kDa to about 1000 kDa....
US-1,002,3606 19-nor neuroactive steroids and methods of use thereof
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): ##STR00001## and pharmaceutical compositions thereof. Such...
US-1,002,3605 Labeled nucleotide analogs having protein shields
Compositions, methods, and systems are provided for nucleotide analogs comprising protein shields for improving enzyme photostability in single molecule real...
US-1,002,3604 Non-caloric sweeteners and methods for synthesizing
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
US-1,002,3603 Preparation of monosaccharides, disaccharides, trisaccharides, and pentasaccharides of heparinoids
The present invention provides preparations of monosaccharides, disaccharides, trisaccharides, and pentasaccharides of heparinoids. The present invention also...
US-1,002,3602 Hamamelitannin analogues and uses thereof
The present invention relates to hamamelitannin analogues, pharmaceutical compositions comprising the same, and combinations thereof with anti-microbial agents...
US-1,002,3601 Hydrolysis resistant sialic acid derivatives and methods for their use
This invention provides compound having a structure of Formulas: Furthermore, methods and uses of such compounds for covalently bonding to a sugar acceptor, to...
US-1,002,3600 Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs
Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of...
US-1,002,3599 Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated...
The present invention relates to the compounds of formula I, pharmaceutically acceptable salts, and solvates thereof: ##STR00001## wherein the various...
US-1,002,3598 Organometallic compound and organic light-emitting device including the same
An organometallic compound represented by Formula 1: ##STR00001## wherein in Formula 1, CY1, M, L, R.sub.1, R.sub.2, R.sub.3, R.sub.4, a1, a2, n1, and n2 are...
US-1,002,3597 RNA interference agents for p21 gene modulation
This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules...
US-1,002,3596 Method for preparing racemic or optically active D- or L-A-glycerophosphoryl choline solids
The present invention is characterized in that racemic or optically active D- or L-.alpha.-glycerophosphoryl choline solids are prepared from liquid type...
US-1,002,3595 Ligated anionic-element reagent complexes as novel reagents formed with metal, metalloid, and non-metal elements
A reagent includes an element, formally in oxidation state zero, in complex with a hydride molecule and an incorporated ligand. The incorporated ligand...
US-1,002,3594 Zwitterionic zinc(II) carboxylate compounds and their use
A method of preparing a crystalline zwitterionic zinc(II)-carboxylate compound includes the steps of preparing a mixture of zinc(II) ions and a first pyridyl...
US-1,002,3593 ALK kinase inhibitor, and preparation method and uses thereof
An ALK kinase inhibitor compound as represented by Formula I, pharmaceutical composition containing the compound, and preparation method and use thereof in the...
US-1,002,3592 Bromodomain inhibitors
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and...
US-1,002,3591 Heterocyclic derivatives and use thereof
A heterocyclic derivative represented by formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, which has an inhibitory effect on the...
US-1,002,3590 Substituted pyridine compounds having herbicidal activity
The present invention provides a substituted pyridine compound of the formula I ##STR00001## or an agriculturally suitable salt or N-oxide thereof, wherein...
US-1,002,3589 Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
Compounds of the formula I or II: ##STR00001## wherein X, m, Ar, R.sup.1 and R.sup.2 are as defined herein. The subject compounds are useful for treatment of...
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