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Patent # Description
US-1,002,3609 Methods for reducing chromatin content in protein preparations by treatment with alkyl cations
A method of reducing aggregate content in a preparation having a target protein includes contacting the preparation with an alkyl cation to form a mixture, and...
US-1,002,3608 Protein purification methods to remove impurities
Disclosed are methods of purifying a protein sample. More specifically, provide are methods of removing or reducing the amount of high molecular weight species...
US-1,002,3607 Purification of biological conjugates by size exclusion chromatography
A method for separating a biological conjugate from an aggregate. The molecular weight of the biological conjugate ranges from about 10 kDa to about 1000 kDa....
US-1,002,3606 19-nor neuroactive steroids and methods of use thereof
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): ##STR00001## and pharmaceutical compositions thereof. Such...
US-1,002,3605 Labeled nucleotide analogs having protein shields
Compositions, methods, and systems are provided for nucleotide analogs comprising protein shields for improving enzyme photostability in single molecule real...
US-1,002,3604 Non-caloric sweeteners and methods for synthesizing
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
US-1,002,3603 Preparation of monosaccharides, disaccharides, trisaccharides, and pentasaccharides of heparinoids
The present invention provides preparations of monosaccharides, disaccharides, trisaccharides, and pentasaccharides of heparinoids. The present invention also...
US-1,002,3602 Hamamelitannin analogues and uses thereof
The present invention relates to hamamelitannin analogues, pharmaceutical compositions comprising the same, and combinations thereof with anti-microbial agents...
US-1,002,3601 Hydrolysis resistant sialic acid derivatives and methods for their use
This invention provides compound having a structure of Formulas: Furthermore, methods and uses of such compounds for covalently bonding to a sugar acceptor, to...
US-1,002,3600 Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs
Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of...
US-1,002,3599 Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated...
The present invention relates to the compounds of formula I, pharmaceutically acceptable salts, and solvates thereof: ##STR00001## wherein the various...
US-1,002,3598 Organometallic compound and organic light-emitting device including the same
An organometallic compound represented by Formula 1: ##STR00001## wherein in Formula 1, CY1, M, L, R.sub.1, R.sub.2, R.sub.3, R.sub.4, a1, a2, n1, and n2 are...
US-1,002,3597 RNA interference agents for p21 gene modulation
This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules...
US-1,002,3596 Method for preparing racemic or optically active D- or L-A-glycerophosphoryl choline solids
The present invention is characterized in that racemic or optically active D- or L-.alpha.-glycerophosphoryl choline solids are prepared from liquid type...
US-1,002,3595 Ligated anionic-element reagent complexes as novel reagents formed with metal, metalloid, and non-metal elements
A reagent includes an element, formally in oxidation state zero, in complex with a hydride molecule and an incorporated ligand. The incorporated ligand...
US-1,002,3594 Zwitterionic zinc(II) carboxylate compounds and their use
A method of preparing a crystalline zwitterionic zinc(II)-carboxylate compound includes the steps of preparing a mixture of zinc(II) ions and a first pyridyl...
US-1,002,3593 ALK kinase inhibitor, and preparation method and uses thereof
An ALK kinase inhibitor compound as represented by Formula I, pharmaceutical composition containing the compound, and preparation method and use thereof in the...
US-1,002,3592 Bromodomain inhibitors
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and...
US-1,002,3591 Heterocyclic derivatives and use thereof
A heterocyclic derivative represented by formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, which has an inhibitory effect on the...
US-1,002,3590 Substituted pyridine compounds having herbicidal activity
The present invention provides a substituted pyridine compound of the formula I ##STR00001## or an agriculturally suitable salt or N-oxide thereof, wherein...
US-1,002,3589 Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
Compounds of the formula I or II: ##STR00001## wherein X, m, Ar, R.sup.1 and R.sup.2 are as defined herein. The subject compounds are useful for treatment of...
US-1,002,3588 Compositions and methods for treating cancer
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
US-1,002,3587 Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
This invention provides compounds having the structure ##STR00001## which may be used for the treatment of tumors.
US-1,002,3586 Enhanced regio-selectivity in glycol acylation
A method for acid-catalyzed acylation of an isohexide is described. The method involves a reaction of an isohexide and an excess of carboxylic acid in the...
US-1,002,3585 Photochromic compounds and intermediate compounds for production thereof
The invention covers new bicyclic bridged [1,3]oksazepine derivatives of the general formula (I) and (II): ##STR00001## which exhibit enhanced photochromic...
US-1,002,3584 Tetrandrine family pharmaceutical formulations and method
Drug formulations, methods and their use in treatment of diseases using formulations of pure di-acid salts of tetrandrine family members, especially...
US-1,002,3583 Bicyclic pyridine compound
The problem to be solved by the present invention is to provide a compound suitable for a pharmaceutical composition, specifically a pharmaceutically...
US-1,002,3582 6-aryl amino pyridone formamide compound crystal and preparation method therefor
The present invention provides a crystal of 6-arylamino pyridone carboxamide compound and a preparation method thereof. The crystal is obtained by dissolving ...
US-1,002,3581 Modified cytotoxins and their therapeutic use
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are...
US-1,002,3579 Pyrrolopyrimidine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof
The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the...
US-1,002,3578 Crystals of dispiropyrrolidine derivatives
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of ...
US-1,002,3577 Crystalline form of JAK kinase inhibitor bisulfate and a preparation method thereof
A crystal form of JAK kinase inhibitor bisulfate and a preparation method thereof are provided. In particular, a type II crystal of ...
US-1,002,3576 Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors
Disclosed are compounds of Formula (I); or a salt thereof; wherein Qi is (i) Cl, Br, I, --CN, --CH.sub.3, or --CF.sub.3; or (ii) pyrazole, triazole, or...
US-1,002,3575 Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
The invention relates to Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide of general formula (I) which are inhibitors of...
US-1,002,3574 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
The present invention relates to substituted xanthines of general formula ##STR00001## wherein R.sup.1 to R.sup.3 are as defined herein, the tautomers, the...
US-1,002,3573 Beta-lactamase inhibitor and process for preparing the same
A process for preparing a diazabicyclooctane compound represented by the following formula (I): ##STR00001## wherein A represents RcO--; B represents NH or...
US-1,002,3572 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
US-1,002,3571 TYK2 inhibitors and uses thereof
The present invention provides compounds of formula I, ##STR00001## compositions thereof, and methods of using the same for the inhibition of TYK2, and the...
US-1,002,3570 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Provided herein are compounds of the General Formula I: ##STR00001## and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A,...
US-1,002,3569 Methods of preparing inhibitors of influenza viruses replication
A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: ##STR00001## comprises: (a) reacting Compound (X): ##STR00002## or a...
US-1,002,3568 Naphthyridine derivatives useful as .alpha..sub.v.beta..sub.6 integrin antagonists
A compound of formula (I) or a salt thereof ##STR00001## wherein R.sub.1 represents a hydrogen atom, a methyl group or a ethyl group R.sub.2 represents a...
US-1,002,3567 Imidazole and thiazole compositions for modifying biological signaling
Compounds having General Formula (I) or General Formula (II): in which R.sup.1 is chosen from C.sub.1 to C.sub.10 aliphatic or heteroaliphatic groups,...
US-1,002,3566 Dasatinib salts
The invention relates to normal or acidic salts of dasatinib and the hydrate and solvate forms thereof. More specifically the invention concerns: dasatinib...
US-1,002,3565 N,N' substituted piperidinamine compounds, and preparation method and usage thereof
The present invention relates to a compound of formula (I), a stereomeride, pharmaceutically acceptable salt, a solvate or an N-oxide thereof, a medicine...
US-1,002,3564 G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and...
US-1,002,3563 Cyclic compounds substituted by a condensed ring system
Compounds of formula I ##STR00001## defined herein are provided. Uses of these compounds for controlling invertebrate pests, protecting plant propagation...
US-1,002,3562 Heteroaryl substituted pyridyl compounds useful as kinase modulators
Compounds having the following formula: ##STR00001## or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R.sup.2 is a monocyclic...
US-1,002,3561 Fumagillol heterocyclic compounds and methods of making and using same
Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods...
US-1,002,3560 Crystalline salt form of (S)-(2-(6 chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-meth- ...
The invention relates to a crystalline form of (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-- ...
US-1,002,3559 Substituted azetidine derivatives
The present invention relates to compounds of formula of formula I wherein R, R.sup.1. R.sup.2, R.sup.2', R.sup.3, R.sup.4, R.sup.5, L.sup.1, L.sup.2 and N are...
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