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| Patent # | Description |
|---|---|
| US-1,003,0038 |
Monoaminosilane compounds Disclosed is a compound of formula (I): (R.sup.1R.sup.2N)Si.sub.nH.sub.2n+1 (I), wherein subscript n is an integer from 3 to 9; and each R.sup.1 and R.sup.2... |
| US-1,003,0037 |
Diaminosilane compounds Disclosed is a compound of formula (I): (R.sup.1 R.sup.2N)Si.sub.nH.sub.2n(NR.sup.3R.sup.4) (I) wherein subscript n, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are... |
| US-1,003,0036 |
Method and dyes for detecting and destroying cancer cells This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared... |
| US-1,003,0035 |
Muscarinic receptor agonists This invention relates to compounds that are agonists of the muscarinic M.sub.1 receptor and which are useful in the treatment of muscarinic M.sub.1 receptor... |
| US-1,003,0034 |
Heterocycle amines and uses thereof Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of... |
| US-1,003,0033 |
Synthesis of an antiviral compound The present disclosure provides processes for the preparation of a compound of formula I: ##STR00001## which is useful as an antiviral agent. The disclosure... |
| US-1,003,0032 |
Methods useful in the synthesis of halichondrin B analogs In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically... |
| US-1,003,0031 |
Orvinol and thevinol derivatives useful in the treatment of drug and
alcohol abuse, depression, anxiety, or a... The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the... |
| US-1,003,0030 |
Crystals of dispiropyrrolidine derivatives Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of ... |
| US-1,003,0029 |
Imidazole derivative used as antiviral agent and use thereof in
preparation of medicament Disclosed are an antiviral compound and a use thereof in the preparation of a medicament for the treatment of virus infections. Specifically, the present... |
| US-1,003,0028 |
Method for producing a spirooxindole derivative The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a... |
| US-1,003,0027 |
Soluble guanylate cyclase stimulators The invention provides compounds of the Formula (I) ##STR00001## or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R.sup.1, R.sup.2, R.sup.4,... |
| US-1,003,0026 |
Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists Disclosed are chemical entities of formula (I) wherein X, Y, Z, R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein, as NR2B subtype selective... |
| US-1,003,0025 |
Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor
antagonists Novel compounds of Formula I ##STR00001## and their use in therapeutic treatments. |
| US-1,003,0024 |
Imidazopyridazines useful as inhibitors of the PAR-2 signaling pathway The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable... |
| US-1,003,0023 |
Mercaptoalkylglycolurils and use of same The invention provides a mercaptoalkylglycoluril represented by the general formula (I): ##STR00001## wherein R.sup.1 and R.sup.2 each independently represent... |
| US-1,003,0022 |
Method of stabilizing riboflavin A method of stabilizing riboflavin by affixing the riboflavin to at least one substrate for the riboflavin by covalent bonding, hydrogen bonding, Van der Waals... |
| US-1,003,0021 |
Spirocyclic morphinans and use thereof In one aspect, the invention provides compounds of Formula I: (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3,... |
| US-1,003,0020 |
Spirocycle compounds and methods of making and using same Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as... |
| US-1,003,0019 |
Bicyclic compounds and their use as antibacterial agents and
.beta.-lactamase inhibitors A compound of formula (I): ##STR00001## wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR.sup.1 or NR.sup.2R.sup.3, and... |
| US-1,003,0018 |
Hydroxyethyl sulfonate of cyclin-dependent protein kinase inhibitor,
crystalline form thereof and preparation... Provided are a hydroxyethyl sulfonate of a cyclin-dependent protein kinase inhibitor, a crystalline form thereof and a preparation method therefor.... |
| US-1,003,0017 |
Histone demethylase inhibitors The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted ... |
| US-1,003,0016 |
Heterocyclic compounds useful as PDK1 inhibitors The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating... |
| US-1,003,0015 |
Amine compounds having anti-inflammatory, antifungal, antiparasitic, and
anticancer activity Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic,... |
| US-1,003,0014 |
Process for preparing methyl
{4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimid-
... The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimid- ... |
| US-1,003,0013 |
Heteroaryl compounds as IRAK inhibitors and uses thereof The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors. |
| US-1,003,0012 |
Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor
agonists The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R.sup.2 and... |
| US-1,003,0011 |
Substituted fused imidazole derivatives, pharmaceutical compositions, and
methods of use thereof Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and... |
| US-1,003,0010 |
Route of synthesis for the preparation of suvorexant The present invention relates to a process for the preparation of a compound of formula (A), Further, the present invention relates to the respective compound... |
| US-1,003,0009 |
Flavonoid derivative compounds and method for preparing same by
depolymerization of condensed tannins A compound of general formula (I) in which R.sub.1, R.sub.2, R.sub.3 and R.sub.5, identical or different, each represent a hydrogen atom or a hydroxyl group,... |
| US-1,003,0008 |
Bifunctional molecules with antibody-recruiting and entry inhibitory
activity against the human... The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to... |
| US-1,003,0007 |
Quinazolin-THF-amines as PDE1 inhibitors The present invention provides Quinazolin-THF-amines as PDE I inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative... |
| US-1,003,0006 |
Coumarin based Hsp90 inhibitors with urea and ether substituents Compounds of the formulas: wherein: R.sub.1-R.sub.4, X.sub.1, Y.sub.1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds... |
| US-1,003,0005 |
Inhibitors of RET Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using... |
| US-1,003,0004 |
Compounds and methods of use This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with... |
| US-1,003,0003 |
Synthesis of isoflavanes and intermediates thereof Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the... |
| US-1,003,0002 |
Coumarin derivative for detection of cysteine and process for the
synthesis thereof The present invention relates to a coumarin derivative of Formula (L) for detection of cysteine and process for preparation thereof. The present invention... |
| US-1,003,0001 |
Process for the production and isolation of 5-hydroxymethylfurfural The present invention relates to a process for the synthesis of 5-hydroxymethyl furfural (HMF) comprising the steps of: 1) dehydrating at least one saccharide... |
| US-1,003,0000 |
Acesulfame potassium compositions and processes for producing same A process for producing acesulfame potassium, the process comprising the steps of providing a cyclizing agent composition comprising a cyclizing agent and a... |
| US-1,002,9999 |
Acesulfame potassium compositions and processes for producing same Compositions and processes for producing high purity acesulfame potassium are described. One process comprises the steps of providing a crude acesulfame... |
| US-1,002,9998 |
Acesulfame potassium compositions and processes for producing same Compositions and processes for producing high purity acesulfame potassium are described. One process comprises the steps of forming a cyclic sulfur trioxide... |
| US-1,002,9997 |
Compositions and methods for treating cancers The invention describes compounds that inhibit both HDAC and GSK3.beta. (i.e., HDAC/GSK3.beta. dual inhibitors). The invention further describes compositions... |
| US-1,002,9996 |
Class of cyano-substituted asymmetric cyanine dyes, synthesizing method
and application thereof The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing... |
| US-1,002,9995 |
[6,6] fused bicyclic HDAC8 inhibitors The present invention is directed to compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or... |
| US-1,002,9994 |
Isoxazole hydroxamic acid compounds as LpxC inhibitors This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such... |
| US-1,002,9993 |
Disubstituted 1, 2, 4-triazine compound This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase... |
| US-1,002,9992 |
Diaminotriazine compounds and their use as herbicides The present invention relates to diaminotriazine compounds and to their use as herbicides. It also relates to agrochemical compositions for crop protection and... |
| US-1,002,9991 |
Modulators of development of adipocyte and cancer cells One aspect of the disclosure relates to derivatives of aryl and heterocyclic ureido aryl and heterocyclic carboxamido isobutyric acids, dichlorophenyl urea,... |
| US-1,002,9990 |
Agent for inducing endogenous interferon The invention relates to medicine and can be used for treating a range of diseases in the treatment of which interferon is used. The agent for inducing... |
| US-1,002,9989 |
Imidazole derivatives The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1' is CH.sub.3; R.sup.1 is methyl, ethyl, CF.sub.3, cyclopropyl, CH.sub.2OH... |
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