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Patent # Description
US-1,003,0042 Synthesis of bicyclic nucleosides
The present disclosure provides methods for synthesizing modified nucleosides, nucleotides, and oligonucleotides comprising at least one 2'-C-Bridged Bicyclic...
US-1,003,0041 C-terminal Hsp90 inhibitors
Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment...
US-1,003,0040 Preparation of (S,S)-secoisolariciresinol diglucoside and (R,R)-secoisolariciresinol diglucoside
The invention relates to processes for preparing (S,S)-secoisolariciresinol diglucoside and (R,R)-secoisolariciresinol diglucoside and compositions comprising...
US-1,003,0039 Anti-cancer agent and cancer cell killing method
[Object] An anticancer agent capable of continuously killing cancer cells in a plurality of phases is provided. [Solution] An anticancer agent contains a...
US-1,003,0038 Monoaminosilane compounds
Disclosed is a compound of formula (I): (R.sup.1R.sup.2N)Si.sub.nH.sub.2n+1 (I), wherein subscript n is an integer from 3 to 9; and each R.sup.1 and R.sup.2...
US-1,003,0037 Diaminosilane compounds
Disclosed is a compound of formula (I): (R.sup.1 R.sup.2N)Si.sub.nH.sub.2n(NR.sup.3R.sup.4) (I) wherein subscript n, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are...
US-1,003,0036 Method and dyes for detecting and destroying cancer cells
This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared...
US-1,003,0035 Muscarinic receptor agonists
This invention relates to compounds that are agonists of the muscarinic M.sub.1 receptor and which are useful in the treatment of muscarinic M.sub.1 receptor...
US-1,003,0034 Heterocycle amines and uses thereof
Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of...
US-1,003,0033 Synthesis of an antiviral compound
The present disclosure provides processes for the preparation of a compound of formula I: ##STR00001## which is useful as an antiviral agent. The disclosure...
US-1,003,0032 Methods useful in the synthesis of halichondrin B analogs
In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically...
US-1,003,0031 Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse, depression, anxiety, or a...
The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the...
US-1,003,0030 Crystals of dispiropyrrolidine derivatives
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of ...
US-1,003,0029 Imidazole derivative used as antiviral agent and use thereof in preparation of medicament
Disclosed are an antiviral compound and a use thereof in the preparation of a medicament for the treatment of virus infections. Specifically, the present...
US-1,003,0028 Method for producing a spirooxindole derivative
The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a...
US-1,003,0027 Soluble guanylate cyclase stimulators
The invention provides compounds of the Formula (I) ##STR00001## or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R.sup.1, R.sup.2, R.sup.4,...
US-1,003,0026 Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists
Disclosed are chemical entities of formula (I) wherein X, Y, Z, R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein, as NR2B subtype selective...
US-1,003,0025 Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
Novel compounds of Formula I ##STR00001## and their use in therapeutic treatments.
US-1,003,0024 Imidazopyridazines useful as inhibitors of the PAR-2 signaling pathway
The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable...
US-1,003,0023 Mercaptoalkylglycolurils and use of same
The invention provides a mercaptoalkylglycoluril represented by the general formula (I): ##STR00001## wherein R.sup.1 and R.sup.2 each independently represent...
US-1,003,0022 Method of stabilizing riboflavin
A method of stabilizing riboflavin by affixing the riboflavin to at least one substrate for the riboflavin by covalent bonding, hydrogen bonding, Van der Waals...
US-1,003,0021 Spirocyclic morphinans and use thereof
In one aspect, the invention provides compounds of Formula I: (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3,...
US-1,003,0020 Spirocycle compounds and methods of making and using same
Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as...
US-1,003,0019 Bicyclic compounds and their use as antibacterial agents and .beta.-lactamase inhibitors
A compound of formula (I): ##STR00001## wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR.sup.1 or NR.sup.2R.sup.3, and...
US-1,003,0018 Hydroxyethyl sulfonate of cyclin-dependent protein kinase inhibitor, crystalline form thereof and preparation...
Provided are a hydroxyethyl sulfonate of a cyclin-dependent protein kinase inhibitor, a crystalline form thereof and a preparation method therefor....
US-1,003,0017 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted ...
US-1,003,0016 Heterocyclic compounds useful as PDK1 inhibitors
The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating...
US-1,003,0015 Amine compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity
Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic,...
US-1,003,0014 Process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimid- ...
The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimid- ...
US-1,003,0013 Heteroaryl compounds as IRAK inhibitors and uses thereof
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
US-1,003,0012 Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists
The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R.sup.2 and...
US-1,003,0011 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and...
US-1,003,0010 Route of synthesis for the preparation of suvorexant
The present invention relates to a process for the preparation of a compound of formula (A), Further, the present invention relates to the respective compound...
US-1,003,0009 Flavonoid derivative compounds and method for preparing same by depolymerization of condensed tannins
A compound of general formula (I) in which R.sub.1, R.sub.2, R.sub.3 and R.sub.5, identical or different, each represent a hydrogen atom or a hydroxyl group,...
US-1,003,0008 Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human...
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to...
US-1,003,0007 Quinazolin-THF-amines as PDE1 inhibitors
The present invention provides Quinazolin-THF-amines as PDE I inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative...
US-1,003,0006 Coumarin based Hsp90 inhibitors with urea and ether substituents
Compounds of the formulas: wherein: R.sub.1-R.sub.4, X.sub.1, Y.sub.1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds...
US-1,003,0005 Inhibitors of RET
Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using...
US-1,003,0004 Compounds and methods of use
This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with...
US-1,003,0003 Synthesis of isoflavanes and intermediates thereof
Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the...
US-1,003,0002 Coumarin derivative for detection of cysteine and process for the synthesis thereof
The present invention relates to a coumarin derivative of Formula (L) for detection of cysteine and process for preparation thereof. The present invention...
US-1,003,0001 Process for the production and isolation of 5-hydroxymethylfurfural
The present invention relates to a process for the synthesis of 5-hydroxymethyl furfural (HMF) comprising the steps of: 1) dehydrating at least one saccharide...
US-1,003,0000 Acesulfame potassium compositions and processes for producing same
A process for producing acesulfame potassium, the process comprising the steps of providing a cyclizing agent composition comprising a cyclizing agent and a...
US-1,002,9999 Acesulfame potassium compositions and processes for producing same
Compositions and processes for producing high purity acesulfame potassium are described. One process comprises the steps of providing a crude acesulfame...
US-1,002,9998 Acesulfame potassium compositions and processes for producing same
Compositions and processes for producing high purity acesulfame potassium are described. One process comprises the steps of forming a cyclic sulfur trioxide...
US-1,002,9997 Compositions and methods for treating cancers
The invention describes compounds that inhibit both HDAC and GSK3.beta. (i.e., HDAC/GSK3.beta. dual inhibitors). The invention further describes compositions...
US-1,002,9996 Class of cyano-substituted asymmetric cyanine dyes, synthesizing method and application thereof
The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing...
US-1,002,9995 [6,6] fused bicyclic HDAC8 inhibitors
The present invention is directed to compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or...
US-1,002,9994 Isoxazole hydroxamic acid compounds as LpxC inhibitors
This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such...
US-1,002,9993 Disubstituted 1, 2, 4-triazine compound
This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase...
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