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Patent # Description
US-1,003,5810 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative
There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and...
US-1,003,5809 Substituted 2,3,4,5,7,9,13,13a-octahydro-1,5-methanopyrido[1',2':4,5]pyrazino[1,2-a][- 1,3]diazepines and...
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): ##STR00001## ...
US-1,003,5808 Isatin peroxo compounds with antibacterial activities and a method of preparing the same
An isatin peroxo compound has the following formula (I): ##STR00001## R.sub.1 is H, halogen, or C.sub.1-3 alkyl, and R.sub.2, is H, C.sub.1-3 alkyl, or phenyl.
US-1,003,5807 Method of manufacturing stereoisomers of buprenorphine and analogues thereof
The present invention relates to a method of preparing a compound of Formula II-a' or Formula II-b', wherein R.sup.I represents hydrogen or a linear, branched...
US-1,003,5806 Derivatized corroles and metallocorroles and their use as imaging and therapeutic agents
The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the...
US-1,003,5805 Tricyclic triazolic compounds
The present invention relates to new tricyclic triazolic compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the...
US-1,003,5804 Spirodiamine derivatives as aldosterone synthase inhibitors
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7,...
US-1,003,5803 Synthesis of copanlisib and its dihydrochloride salt
The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said...
US-1,003,5802 Solid state forms of ibrutinib
The present invention encompasses solid state forms of Ibrutinib, including forms G, J and K, and pharmaceutical compositions thereof.
US-1,003,5801 Pyrazolo compounds and uses thereof
Provided are compounds useful as inhibitors of one or more histone demethylases, such as KDM5. The invention also provides pharmaceutically acceptable...
US-1,003,5800 Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and...
The present invention provides for compounds of formula (I) wherein R.sup.1, R.sup.2, R.sup.6, Y.sup.1, Y.sup.3, A.sup.1, A.sup.2, A.sup.3 and A.sup.4 have any...
US-1,003,5799 COMT inhibiting methods and compositions
The present inventions include a method of inhibiting COMT enzyme in a subject as well as compounds of formula I, or a pharmaceutically acceptable salt thereof,...
US-1,003,5798 Preparation method for praziquantel and intermediate compounds thereof
Disclosed is a preparation method for praziquantel and intermediates thereof. The method includes: obtaining a target product praziquantel by using...
US-1,003,5797 Fused amino pyridine as HSP90 inhibitors
The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of...
US-1,003,5796 Crystalline forms of a BACE inhibitor, compositions, and their use
The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable...
US-1,003,5795 Phenothiazine derivatives having CaM inhibitory activity
The present invention provides a phenothiazine derivative or a pharmaceutically acceptable salt thereof, a method of preparing a compound selected therefrom and...
US-1,003,5794 Heterocyclic derivatives and their use in the treatment of neurological disorders
The invention relates to novel heterocyclic compounds of the formula ##STR00001## in which all of the variables are as defined in the specification,...
US-1,003,5793 Method for producing 1,2,4-oxadiazole derivative
The invention provides a production method of a 1,2,4-oxadiazole derivative represented by formula (A), which comprises reacting a compound represented by...
US-1,003,5792 Resorcinol derivative as HSP90 inhibitor
The present invention relates to a compound represented by formula (I) of a resorcinol derivative as an HSP90 inhibitor or pharmaceutically accepted salts...
US-1,003,5791 Bicyclic compound and pharmaceutical composition thereof for treating stroke and use thereof
The present disclosure relates to a bicyclic compound, a pharmaceutical composition thereof, and its novel use. More particularly, the present disclosure...
US-1,003,5790 ROR.gamma. modulators
Described are RORy modulators of the formula (I), and N-oxides thereof, and pharmaceutically acceptable salts thereof, and solvates and hydrates thereof,...
US-1,003,5789 Compounds useful for treating disorders related to RET
Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using...
US-1,003,5788 Maleate salts of (E)-N-{4[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quino- ...
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quin- ...
US-1,003,5787 Intermediate and process useful in the preparation of ...
The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanon- e benzoate, and ...
US-1,003,5786 Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine.dihydrochloride with commercially available 3-ethoxyacrylonitrile to provide...
US-1,003,5785 Phosphoinositide 3-kinase inhibitors
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R.sub.1, R.sub.2, R.sub.3, R and R.sub.6 are each independently (LQ).sub.mY;...
US-1,003,5784 Agonists that enhanced binding of integrin-expressing cells to integrin receptors
A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein...
US-1,003,5783 Process for the production of 1,4-butanediol and tetrahydrofuran from furan
The present invention provides a process for the production of THF and 1,4-BDO from furan in the presence of a catalytic composition, wherein the catalytic...
US-1,003,5782 Relating to ethylene oxide recovery
A process for recovering an ethylene oxide (EO) enriched product stream from fat absorbent (FA) comprising water, EO, and acetaldehyde. The process comprises...
US-1,003,5781 Process for producing ethylene oxide
To provide a novel technique capable of further reducing the argon purge amount in a process for producing ethylene oxide. A method for producing ethylene...
US-1,003,5780 Quinazoline scaffold based compounds, pharmaceutical compositions and methods of use thereof
The present invention relates to novel heterocyclic compounds based on a quinazoline scaffold, which bind effectively to the mitochondrial translocator protein...
US-1,003,5779 Prolyl hydroxylase inhibitors
The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I) ##STR00001## which are antagonists of HIF...
US-1,003,5778 Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
The present disclosure provides pharmaceutical agents of the formula: ##STR00001## wherein the variables are defined herein. Also provided are pharmaceutical...
US-1,003,5777 Heterocyclic kinase inhibitors
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
US-1,003,5776 Process for the preparation of enzalutamide
Disclosed is a process for the preparation of Enzalutamide comprising the reaction (Scheme 2), wherein R can be alkyl, aryl, aryl-alkyl or heterocyclyl. ...
US-1,003,5775 Compositions for the treatment of fibrosis and fibrosis-related conditions
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of fibrosis and fibrosis-related conditions.
US-1,003,5774 Pyrazolyl carboxylic acid and pyrazolyl urea derivative compounds
Pyrazolyl carboxylic acid and pyrazolyl urea derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds.
US-1,003,5773 Method for producing 3,5-bis(fluoroalkyl)-pyrazol-4-carboxylic acid derivatives and 3,5-bis(fluoroalkyl)-pyrazoles
The present invention relates to novel 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and to a process for preparing...
US-1,003,5772 Processes for the preparation of 4-alkoxy-3-(acyl or alkyl)oxypicolinamides
A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic...
US-1,003,5771 Mercaptonicotinic acid compound and preparation method and use thereof
The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the...
US-1,003,5770 Compounds, compositions and methods
Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of...
US-1,003,5769 Quaternary heteroatom containing compounds
The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a...
US-1,003,5767 Method for producing synthetic pentapeptide
Provided are a method for industrially advantageously producing a highly purified pentapeptide and an intermediate thereof. A compound represented by the...
US-1,003,5766 Compositions for preventing and/or treating lysosomal storage disorders
The present invention provides novel compositions as well as methods for preventing and/or treating lysosomal storage disorders. In particular, the present...
US-1,003,5765 Nitrogen-containing polycyclic compound and organic light emitting device using same
The present specification provides a multicyclic compound including nitrogen and an organic light emitting device using the same.
US-1,003,5763 Selective androgen receptor degrader (SARD) ligands and methods of use thereof
This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD)...
US-1,003,5762 Synthesis of succinimides and quaternary ammonium ions for use in making molecular sieves
The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of...
US-1,003,5761 Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
The present invention provides novel phenylcycloalkylmethylamine derivatives, and methods of preparing phenylcycloalkylmethylamine derivatives. The present...
US-1,003,5760 Inhibitors of human immunodeficiency virus replication
Compounds of Formula I with activity against HIV, including pharmaceutical compositions and methods for using these compounds in treating human immunodeficiency...
US-1,003,5759 Method of chromatographic separation
A means of isolating specific stereoisomers and enantiomers from a complex mixture containing a possibility of 32 different stereoconfigurations, thus...
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