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Patent # Description
US-1,003,5850 Methods for treating neovascular age-related macular degeneration
A method is provided for reducing the treatment burden for patients who have an intraocular neovascular disorder, the method comprising administering a...
US-1,003,5849 Methods and compositions for targeting polyubiquitin
Anti-K63-linked polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.
US-1,003,5848 Antibody targeting cell surface deposited complement protein C3d and use thereof
An anti-C3d antibody or antibody fragment; method for use thereof to kill cancer cells; and related methods and compositions.
US-1,003,5847 Amyloid protofibril antibodies and methods of use thereof
The invention relates to methods for obtaining antibodies that recognize amyloid protofibrils and antibodies that recognize one or more amyloid protofibrils....
US-1,003,5846 Humanized pertussis antibodies and uses thereof
The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present...
US-1,003,5845 Neutralizing antibodies to HIV-1 and their use
Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are...
US-1,003,5844 Broadly neutralizing HIV-1 VRC07 antibodies that bind to the CD4-binding site of the envelope protein
Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding...
US-1,003,5843 RSV-specific binding molecule
The invention provides antibodies and functional equivalents thereof which are capable of specifically binding RSV. Nucleic acid sequences encoding said...
US-1,003,5842 Human antibodies binding to RSV G proteins
The disclosure provides isolated antibodies and antigen-binding fragments that bind to the G protein of RSV and which are capable of neutralizing RSV.
US-1,003,5841 Monoclonal antibody against novel epitopes of foot-and-mouth disease virus protein 3ABC and uses thereof
This disclosure pertains to isolated antibodies or antigen binding fragments thereof that specifically bind to the 3ABC non-structural protein of Foot-and-Mouth...
US-1,003,5840 Targeted coagulation factors and method of using the same
Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is...
US-1,003,5839 Blood glucose lowering compound
The present invention relates to the field of medicine and the treatment of diabetes or hyperglycemia within that field. More particularly, the invention...
US-1,003,5838 Immunotherapy against melanoma and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,003,5837 Water soluble membrane proteins and methods for the preparation and use thereof
The present invention is directed to a method of preparing a water-soluble variant of a G-protein coupled receptor (GPCR), the method comprising replacing...
US-1,003,5836 Modified IL-2 variants that selectively activate regulatory T cells
The invention described herein is a novel IL-2 protein with selective agonist activity for Regulatory T cells and with an additional amino acid substitution...
US-1,003,5835 Targeted modified TNF family members
The present invention relates to a modified cytokine of the TNF superfamily, with reduced activity to its receptor, wherein said modified cytokine is...
US-1,003,5834 Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage
The present invention provides compositions comprising mesenchymal stem cells (MSCs), and methods for their novel use in the repair of cardiac damage and...
US-1,003,5833 Vascular endothelial growth factor antagonists and methods of making
The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding...
US-1,003,5832 HLA-A24 agonist epitopes of MUC1-C oncoprotein and compositions and methods of use
The invention provides a human cytotoxic T lymphocyte (CTL) agonist epitope from the C-terminal subunit of mucin 1 (MUC1-C), which can be used as a peptide,...
US-1,003,5831 Oxidized A.beta. peptide
The invention provides an A.beta. peptide aggregation inhibitor, an A.beta. peptide toxicity reducing agent, and a preventive and/or therapeutic agent for...
US-1,003,5830 Method for treatment of GM1 gangliosidosis
The present invention relates to a method for preparing a GM1 gangliosidosis human cell model based on induced pluripotent stem cells (iPSCs) and iPSCs...
US-1,003,5829 Methods to produce rod-derived cone viability factor (RDCVF)
The invention is related to methods of producing rod-derived cone viability factor (RdCVF). This invention also relates to the treatment of an ocular disease in...
US-1,003,5828 Methods of using polypeptides having cellulolytic enhancing activity
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
US-1,003,5827 Proteins with diagnostic and therapeutic uses
The present invention provides a recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by...
US-1,003,5826 Proteins and nucleic acids from meningitis/sepsis-associated Escherichia coli
Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of...
US-1,003,5825 AAV's and uses thereof
The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention...
US-1,003,5824 Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of...
US-1,003,5823 Compositions for expanding regulatory T cells (TREG), and treating autoimmune and inflammatory diseases and...
Provided are compositions, including isolated, synthetic or recombinant peptides for: expanding regulatory T cells (Treg) populations; for treating or...
US-1,003,5822 Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods
Long-acting compstatin analogs comprising a clearance-reducing moiety attached to two compstatin analog moieties, each compstatin analog moiety comprising a...
US-1,003,5821 Calcium binding compounds based on gamma-carboxy glutamate
Compounds capable of binding calcium ions comprising a certain number of gamma-carboxy glutamate units have been found useful in treating and/or preventing...
US-1,003,5820 Compounds which inhibit neuronal exocytosis
Compounds of general formula (I): R.sub.1--W.sub.n--X.sub.m-AA.sub.1-AA.sub.2-AA.sub.3-AA.sub.4-AA.sub.5-AA- .sub.6-AA.sub.7-Y.sub.p--Z.sub.q--R.sub.2, their...
US-1,003,5819 PPAR agonists and methods of use thereof
Provided herein are deuterated compounds and compositions useful in increasing PPAR.delta. activity. The compounds have a formula ##STR00001## where L.sup.5...
US-1,003,5818 Polyethylene glycol based prodrug of adrenomedullin and use thereof
The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment...
US-1,003,5817 Method of purifying cell-binding agent-cytotoxic agent conjugates with a PVDF membrane
The invention provides processes for preparing purified cell-binding agent cytotoxic agent conjugates comprising subjecting a mixture comprising a cell-binding...
US-1,003,5816 Compound for treating respiratory syncytial virus infection and preparation method and use thereof
The present invention declares a kind of compound to treat respiratory syncytial virus infection and its preparation method and application. The compound stated...
US-1,003,5815 Synthesis of protected 3'-amino nucleoside monomers
Orthogonally protected 3'-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the...
US-1,003,5814 Guanine analogs as telomerase substrates and telomere length affectors
This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are...
US-1,003,5813 Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahy- ...
In part, the present disclosure is directed to prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahy- ...
US-1,003,5812 Perfluoropolyether-modified polysilazane, making method, surface treating agent, and treated article
A perfluoropolyether-modified polysilazane of silazane units of formula (1), where Q is a divalent organic group, p and q are an integer of at least 1, r and s...
US-1,003,5811 Derivatives of 1-amino-2-cyclobutylethylboronic acid
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds...
US-1,003,5810 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative
There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and...
US-1,003,5809 Substituted 2,3,4,5,7,9,13,13a-octahydro-1,5-methanopyrido[1',2':4,5]pyrazino[1,2-a][- 1,3]diazepines and...
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): ##STR00001## ...
US-1,003,5808 Isatin peroxo compounds with antibacterial activities and a method of preparing the same
An isatin peroxo compound has the following formula (I): ##STR00001## R.sub.1 is H, halogen, or C.sub.1-3 alkyl, and R.sub.2, is H, C.sub.1-3 alkyl, or phenyl.
US-1,003,5807 Method of manufacturing stereoisomers of buprenorphine and analogues thereof
The present invention relates to a method of preparing a compound of Formula II-a' or Formula II-b', wherein R.sup.I represents hydrogen or a linear, branched...
US-1,003,5806 Derivatized corroles and metallocorroles and their use as imaging and therapeutic agents
The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the...
US-1,003,5805 Tricyclic triazolic compounds
The present invention relates to new tricyclic triazolic compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the...
US-1,003,5804 Spirodiamine derivatives as aldosterone synthase inhibitors
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7,...
US-1,003,5803 Synthesis of copanlisib and its dihydrochloride salt
The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said...
US-1,003,5802 Solid state forms of ibrutinib
The present invention encompasses solid state forms of Ibrutinib, including forms G, J and K, and pharmaceutical compositions thereof.
US-1,003,5801 Pyrazolo compounds and uses thereof
Provided are compounds useful as inhibitors of one or more histone demethylases, such as KDM5. The invention also provides pharmaceutically acceptable...
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