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Patent # Description
US-1,003,4897 Methods and compositions for muscular and neuromuscular diseases
The present invention generally relates to compositions and methods for treatment of subjects in need of muscle growth or repair. In some cases, the composition...
US-1,003,4896 Compositions and methods for treatment of osteoporosis and other indications
The present invention generally relates to compositions and methods for treatment of subjects having or at risk of osteoporosis or other conditions. In some...
US-1,003,4895 Local application of D-lactic acid dimer is selectively cytotoxic when applied to cancer cells
At equimolar concentrations, D-lactic acid dimer is more cytotoxic than L-lactic acid when directly applied to human HeLa cells in culture. The cytotoxicity of...
US-1,003,4894 Method of treating inflammation
The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising...
US-1,003,4893 5, 6-D.sub.2 uridine nucleoside/tide derivatives
In one aspect, the invention provides compounds represented by Formula I, ##STR00001## and pharmaceutically acceptable salts, esters, stereoisomers,...
US-1,003,4892 Composition and methods of use of small molecules as binding ligands for the modulation of proprotein...
This invention is related to the field of PCSK9 biology and the composition and methods of use of small molecule ligands for modulation of PCSK9 biological...
US-1,003,4891 Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof
The invention pertains to the use of compounds represented by the formula, Q-G.sup.1-G.sup.2-G.sup.3-G.sup.4-Z, where Q is ##STR00001## The compounds can be...
US-1,003,4890 Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain...
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions,...
US-1,003,4889 Pharmaceutical composition including migratory factor for guiding pluripotent stem cells to damage
The purpose of the present invention is to identify a migratory factor that guides pluripotent stem cells (Muse cells) useful in new medical applications to...
US-1,003,4888 Method for making bismuth containing liquid pharmaceutical suspensions
A method of producing a liquid pharmaceutical suspension by mixing magnesium aluminum silicate, gellan gum, bismuth subsalicylate, and methyl cellulose.
US-1,003,4887 Compositions and methods for the treatment of meibomian gland dysfunction
Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said compositions and methods comprise keratolytic agents, such...
US-1,003,4886 GLP-1 receptor modulators
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic...
US-1,003,4885 Corneal thickness modulating agent
The present invention provides a novel corneal thickness modulating agent. The present invention pertains to a corneal thickness modulating agent containing ...
US-1,003,4884 Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors
There is provided a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture...
US-1,003,4883 Mesoporous dosage forms for poorly soluble drugs
The present invention is directed to a new pharmaceutical dosage form comprising mesoporous particles loaded with a poorly soluble active pharmaceutical...
US-1,003,4882 Tofacitinib orally disintegrating tablets
The present invention relates to Orally Disintegrating Tablets (ODT) of Tofacitinib and its pharmaceutically acceptable salts and the process to produce the...
US-1,003,4881 2,3-disubstituted 1 -acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors
The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
US-1,003,4880 Ophthalmic suspension formulation
The present invention relates to a stable ophthalmic suspension formulation comprising ...
US-1,003,4879 Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation,...
US-1,003,4877 Treatment for diabetes in patients inappropriate for metformin therapy
The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases,...
US-1,003,4876 Liquid formulations of salts of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]-piperazine
Liquid formulations of lactic acid addition salts of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine are provided.
US-1,003,4875 Product and method for treating diarrhea
A method of treating diarrhea in a patient includes administering an H1 receptor antagonist and an H2 receptor antagonist to the patient.
US-1,003,4874 Nalmefene for reduction of alcohol consumption in specific target populations
The present invention relates to nalmefene for use in the reduction of alcohol consumption in a patient with alcohol dependence who has a high drinking risk...
US-1,003,4873 C-met modulator pharmaceutical compositions
Pharmaceutical compositions and unit dosage forms comprising Compound I are disclosed. ##STR00001##
US-1,003,4872 Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
Methods of treating, preventing and/or managing multiple myeloma are disclosed. Specific methods encompass the administration of an immunomodulatory compound,...
US-1,003,4871 Salts and compositions useful for treating disease
The invention provides a combination or salt of lipoic acid and a compound of formula (I): The combinations and salts are useful for treating diabetes.
US-1,003,4870 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
The invention relates to compounds of formula I: ##STR00001## where a, R.sup.1, and R.sup.3-6 are as defined in the specification, or a pharmaceutically...
US-1,003,4869 S1P modulating agents
The present invention provides compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and their use in modulating the activity of S1P...
US-1,003,4868 Methods for the prevention and the treatment of rapidly progressive glomerulonephritis
The present invention relates to the prevention and the treatment of rapidly progressive glomerulonephritis.
US-1,003,4867 Quinuclidine derivatives and medicinal compositions containing the same
Provided is a powder inhaler comprising a powder inhalant comprising 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicy- clo[2.2.2]octane...
US-1,003,4866 Inhalable medicament comprising tiotropium
This invention relates to a solution formulation comprising a tiotropium salt, 12-20% ethanol, 0.1-1.5% of water, 0.05-0.10% citric acid (or other organic acid)...
US-1,003,4865 Surfactant-free HIV protease inhibitor composition and method of manufacturing thereof
Disclosed are pharmaceutical compositions, e.g., in the form of tablets, containing a therapeutically effective amount of an HIV protease inhibitor, e.g.,...
US-1,003,4864 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are...
US-1,003,4863 Compositions for an orally active 1,2,4-oxadiazole for the treatment of disease
The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases...
US-1,003,4862 Solid pharmaceutical composition comprising amlodipine and losartan
The present invention provides a pharmaceutical composition for the prevention or treatment of cardiovascular disorders containing losartan or a...
US-1,003,4861 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the...
US-1,003,4860 Estrogen receptor modulator for the treatment of locally advanced or metastatic estrogen receptor positive...
Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.
US-1,003,4859 Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the...
The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the...
US-1,003,4858 Pharmaceutical composition for topical administration
The present invention relates to a pharmaceutical composition for topical administration comprising a compound of formula I, ...
US-1,003,4857 Triptan powders for pulmonary delivery
The invention provides stable, spray-dried, particle formulations containing a triptan, preferably sumatriptan, or a pharmaceutically acceptable salt thereof,...
US-1,003,4856 Use of N-acetyl-5-methoxytryptamine or analogues thereof, for promoting the mechanism of implantation of the...
The present invention refers to the use of N-acetyl-5-methoxytryptamine (melatonin) and/or an analog thereof, for use in the medical or veterinary field in the...
US-1,003,4855 Solid composition of pyrrole carboxamide
An object is to provide a solid composition of stabilized pyrrole carboxamide. A means for achieving the object is a solid composition for medical use...
US-1,003,4854 Pharmaceutical composition with improved bioavailability
The invention relates to solid dispersions of poorly water soluble compounds, in particular Compound A as disclosed herein, formed by solvent co-precipitation...
US-1,003,4853 PPAR .alpha./.gamma. dual agonist and its application
The present invention discloses a PPAR .alpha./.gamma. dual agonist and its application. The PPAR .alpha./.gamma. dual agonist comprises an effective amount of...
US-1,003,4852 Methods and compositions addressing depressed mood
A method of treating or preventing depressed mood is described, such as for treating or preventing postpartum blues or depression or other conditions associated...
US-1,003,4851 Metal-salen complex compound, local anesthetic and antineoplastic drug
A metal-salen complex compound, which exhibits excellent noninvasiveness and can be efficiently transferred to an affected site, a local anesthetic containing...
US-1,003,4850 Sprayable aqueous composition comprising glyceryl trinitrate
The present application relates to a pharmaceutical preparation comprising (a) from 0.15 to 3 weight percent of glyceryl trinitrate, (b) from 40 to 95 weight...
US-1,003,4849 Omega-3 compositions, dosage forms, and methods of use
Omega-3 compositions, dosage forms, and methods of use are disclosed herein. The omega-3 compositions and dosage forms disclosed herein may comprise DHA and EPA...
US-1,003,4848 Increase of protein synthesis ameliorates synaptopathy-related neurological disorders
Disclosed herein is a method for increasing the dendritic spine formation or dendritic spine density in a subject, who is affected by a dendritic spine defect...
US-1,003,4847 Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
.beta.-Substituted .beta.-amino acids, .beta.-substituted .beta.-amino acid derivatives, and .beta.-substituted .beta.-amino acid analogs and (bio)isosteres and...
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