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| Patent # | Description |
|---|---|
| US-1,004,0851 |
Antagonists to IL-6 to raise albumin and/or lower CRP The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to... |
| US-1,004,0850 |
Protecting group comprising a purification tag The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from... |
| US-1,004,0849 |
Caninized anti-nerve growth factor antibodies A method of preparing an antibody suitable for use in a canine is provided. Also provided are caninized antibodies which specifically bind to canine neuronal... |
| US-1,004,0848 |
Chimeric and humanized anti-histone antibodies The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific CDR sequences, disclosed herein.... |
| US-1,004,0847 |
Methods of treating a tauopathy The present disclosure provides methods of treating a tauopathy, involving administering an anti-Tau antibody. The present disclosure also provides anti-Tau... |
| US-1,004,0846 |
Compositions and methods for generating a persisting population of T cells
useful for the treatment of cancer The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an... |
| US-1,004,0845 |
Human cytomegalovirus neutralizing antibodies and use thereof The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody... |
| US-1,004,0844 |
Proteolytic release of cell surface antigens for phage biopanning The invention described herein features methods of isolating monoclonal antibodies or polypeptides that bind to a cell surface expressed antigen. The method of... |
| US-1,004,0843 |
Interleukin-10 fusion proteins and uses thereof The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to ... |
| US-1,004,0842 |
Fibronectin type III domain based scaffold compositions, methods and uses A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin),... |
| US-1,004,0841 |
Stable form of signal converting protein fusion proteins, and methods of
use and preparation thereof A stable fusion protein, wherein in solution, a majority of the fusion proteins are in the homo-hexamer form, which may be prepared for example as a CTLA4-FasL... |
| US-1,004,0840 |
Bi-specific annexin A5/IGF-1 proteins and methods of use thereof to
promote regeneration and survival of tissue Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using... |
| US-1,004,0839 |
Insulin derivatives and the medical uses hereof The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel... |
| US-1,004,0838 |
CRHR2 peptide agonists and uses thereof The present invention relates to novel peptides that are selective corticotrophin releasing hormone receptor type 2 (CRHR2) agonists and compositions thereof... |
| US-1,004,0837 |
Nucleotide sequence and pharmaceutical composition based thereon with
prolonged VEGF transgene expression A nucleic acid or transgene comprising a modified VEGF 3'-untranslated region (3'-UTR) polynucleotide sequence and a polynucleotide sequence encoding a Vascular... |
| US-1,004,0836 |
Peptides for the treatment of neurodegenerative diseases An isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the... |
| US-1,004,0835 |
Vectors encoding rod-derived cone viability factor The present invention relates to nucleic acids coding for and capable of expressing a rod-derived cone viability factor (RdCVF) and viral vectors containing... |
| US-1,004,0834 |
Biopolymer optofluidic device and method of manufacturing the same A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution,... |
| US-1,004,0833 |
Nisin production process The present invention relates to fermentation processes. The objective of the invention was to provide methods for producing nisin containing ferments and... |
| US-1,004,0832 |
UspA2 protein constructs and uses thereof The present invention relates to compositions comprising Moraxella catarrhalis (M. catarrhalis) Ubiquitous surface protein A2 (UspA2). More particularly, the... |
| US-1,004,0831 |
Compositions and methods for treating diseases by inhibiting exosome
release A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion... |
| US-1,004,0830 |
Methods and compositions for protein delivery The present invention provides methods and compositions for protein delivery. The invention features virus like particles, methods of making virus like... |
| US-1,004,0829 |
Methods for producing peptides including HERV-W envelope motifs and for
producing antibodies specific for the... A peptide domain necessary for an interaction between an envelope of a virus belonging to an HERV-W interference group and an hASCT receptor comprises (i) an... |
| US-1,004,0828 |
Human respiratory syncytial virus consensus antigens, nucleic acid
constructs and vaccines made therefrom, and... Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode an RSV immunogen are disclosed. Nucleic acid are disclosed... |
| US-1,004,0827 |
B-cell receptor complex binding proteins containing T-cell epitopes The present invention relates to a polypeptide comprising a) a binding peptide binding to at least one protein selected from the group consisting of CD22, CD19,... |
| US-1,004,0826 |
Human immunodeficiency virus type 1 (HIV-1) N-terminal deleted GP120
immunogens The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same. |
| US-1,004,0825 |
Soluble forms of Hendra and Nipah virus F glycoprotein and uses thereof This invention relates to soluble forms of F glycoprotein from Hendra and Nipah virus and to compositions comprising soluble forms of F glycoprotein from Hendra... |
| US-1,004,0824 |
Flavivirus vaccine Replicon virus-like particles can be used as flavivirus vaccines. |
| US-1,004,0823 |
In vivo methods of monitoring biodistribution Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L... |
| US-1,004,0822 |
Neuroprotective composition and method of use A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines (SEQ ID NO: 1), and further comprising 1 or more... |
| US-1,004,0821 |
Compositions containing HC-HA/PTX3 complexes and methods of use thereof Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of... |
| US-1,004,0820 |
Method for the purification of protein complexes The present invention provides an improved method for the purification of a mixture of complexes comprising a stress protein complexed to a peptide or peptide... |
| US-1,004,0819 |
Chemically modifying peptides A method for chemically modifying a peptide, derivative or analogue thereof is described. The method comprises contacting a peptide, derivative or analogue... |
| US-1,004,0818 |
Selective photoactivation of amino acids for single step peptide coupling Disclosed herein are formulations, substrates, and arrays for amino acid and peptide synthesis on microarrays. In certain embodiments, methods for manufacturing... |
| US-1,004,0817 |
Methods and compositions for stimulation of the intestinal enteroendocrine
system for treating diseases or... This invention relates to methods of stimulating the activity of the human and animal enteric nervous system. The method comprises orally administering an... |
| US-1,004,0816 |
Antagonists of CB1 receptor The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of... |
| US-1,004,0815 |
3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for
the treatment and prophylaxis of... The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as described herein, and their prodrugs or... |
| US-1,004,0814 |
Uracyl spirooxetane nucleosides The present invention relates to compounds of the formula I: ##STR00001## including any possible stereoisomers thereof, wherein R.sup.9 has the meaning as... |
| US-1,004,0813 |
Compounds as positive allosteric modulators for erythropoietin and
erythropoietin receptor to treat... Disclosed are compounds which can act as a positive allosteric modulator for erythropoietin and erythropoietin receptor and have the activity in promoting... |
| US-1,004,0812 |
Hypervalent iodine CF2CF2X reagents and their use A hypervalent iodine of formula (I) or formula (II) wherein R is a nucleophile and a method for their production is described. Such compounds can be used for... |
| US-1,004,0811 |
Multi-element standard for nuclear magnetic resonance spectroscopy Organic compounds which contain nitrogen, fluorine, and phosphorus atoms together with carbon atoms and hydrogen atoms and which can be used as a multi-element... |
| US-1,004,0810 |
Derivatives of bisacylphosphinic acid, their preparation and use as
photoinitiators Bisacylphosphine oxide or bisacylphosphine sulfide compounds of formula (I) or (II) ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.1a, R.sub.2a and... |
| US-1,004,0809 |
Method for preparing tris(trialkylsilyl)phosphine The present invention relates to a method for preparing a tris(trialkylsilyl)phosphine in high yield and high purity with safety and no risk of fire or explosion. |
| US-1,004,0808 |
Silane-modified formamides The invention relates to novel silane-modified formamide-polymers and/or pre-polymers for bonding and/or sealing diverse substrate materials, such as, for... |
| US-1,004,0807 |
Flame retardant filler A flame retardant filler having brominated silica particles, for example, imparts flame retardancy to manufactured articles such as printed circuit boards... |
| US-1,004,0806 |
Microbiocidally active benzoxaboroles Compounds of formula (I) are as defined in the claims, and their use in compositions and methods for the control and/or prevention of microbial infection,... |
| US-1,004,0805 |
Substituted imidazo[1,5-a]pyrazines as Btk inhibitors The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof,... |
| US-1,004,0804 |
Compounds targeting proteins, compositions, methods, and uses thereof The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1.alpha., GSPT1, aiolos, and/or... |
| US-1,004,0803 |
4-((2-acrylamidophenyl)amino)thieno[3,2-D]pyrimidine-7-carboxamide
derivatives as protein kinase inhibitors The present invention relates to a novel 4-((2-acrylamidophenyl)amino)thieno[3,2-d]pyrimidine-7-carboxamide compound, an anticancer agent containing the... |
| US-1,004,0802 |
Thienopyrazine inhibitors of IRAK4 activity The present invention relates to thienopyrazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods... |
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