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Patent # Description
US-1,004,0801 Method for preparing thienopyrimidine compound and intermediates used therein
The present invention provides a novel method for preparing a thienopyrimidine compound of Formula 1, which is a selective inhibitor of tyrosine kinase...
US-1,004,0800 Synthesis of substituted salicylaldehyde derivatives
Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde...
US-1,004,0799 Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating...
Disclosed are new small molecules having a 4-methylpyrrrolo[1,2-a]pyrimidine-8-carboxamide core structure and the uses thereof for modulating glucocerebrosidase...
US-1,004,0798 Pyrrolopyridazine inhibitors of IRAK4 activity
The present invention relates to pyrrolopyridazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods...
US-1,004,0797 Therapeutic compounds and synthesis
The invention provides compounds of Formula 1: ##STR00001## or a stereoisomer, pharmaceutically acceptable salt, or mixture thereof; and methods of making and...
US-1,004,0796 Therapeutic compounds for pain and synthesis thereof
The invention provides compounds of Formula 1: ##STR00001## and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of...
US-1,004,0795 Therapeutic compounds for pain and synthesis thereof
The invention provides compounds of Formula 1: ##STR00001## and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of...
US-1,004,0794 Condensed cyclic compound and organic light-emitting device including the same
A condensed cyclic compound represented by Formulae 1A or 1B: ##STR00001## wherein in Formulae 1A and 1 B, groups, rings, substituents, and variables are...
US-1,004,0793 Key intermediates and impurities of the synthesis of Apixaban: Apixaban glycol esters
Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction....
US-1,004,0792 Synthesis of a compound that modulates kinases
The present disclosure provides processes for the preparation of a compound of formula I: ##STR00001## or a salt thereof, active on the receptor protein...
US-1,004,0791 Isoxazole derivative as mutant isocitrate dehydrogenase 1 inhibitor
It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and...
US-1,004,0790 Bicyclic heterocycles as FGFR inhibitors
The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are...
US-1,004,0789 1,3,4-thiadiazole compounds and their use in treating cancer
A compound of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6-fluoropyridazin-3-yl;...
US-1,004,0788 1,3,4-thiadiazole compounds and their use in treating cancer
The specification relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where Q, R, R.sup.1 and R.sup.2 have any of the meanings...
US-1,004,0787 Prodrugs of NH-acidic compounds
The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a...
US-1,004,0786 Process for preparing a polymorph of rivaroxaban
This invention describes a process for the preparation of rivaroxaban modification I comprising: (i) dissolving rivaroxaban in a mixture of a solvent (e.g. THF)...
US-1,004,0785 Diaryl isoxazoline compound
The present invention concerns compounds of formula (I) or an N-oxide or salt thereof and their use for controlling parasites in and on warm-blooded animals or...
US-1,004,0784 Compositions and methods for acylating lactams
This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni...
US-1,004,0783 Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure...
US-1,004,0782 Hydrochloride salt form for EZH2 inhibition
Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydr- ...
US-1,004,0781 Tank-binding kinase inhibitor compounds
Compounds having the following formula (I) and methods of their use and preparation are disclosed: ##STR00001##
US-1,004,0780 Mcl-1 antagonists
Provided herein are Mcl-1 antagonist compositions and methods of treating g the compositions described herein.
US-1,004,0779 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted 3-aminopyridine...
US-1,004,0778 Anhydrous lenalidomide form-I
Anhydrous polymorphic form-I of anti cancer drug, Lenalidomide whose chemical name is 3-(4-amino-1-oxo-1,3-dihydro-isoindole-2-yl)-piperidine-2,6-dione, is ...
US-1,004,0777 Polymers, co-polymers, and monomers using CO.sub.2 as a reagent
Polymers, co-polymers, and monomers using CO.sub.2 as a reagent and methods of production thereof are described. Polymerization methods include converting...
US-1,004,0776 Pyran derivatives and their preparation
A compound of formula (I) ##STR00001## is provided wherein R represents a linear or branched C5 alkyl group, as well as the use of such compounds in a...
US-1,004,0775 Synthesis of chirally enriched 2,4-disubstituted tetrahydropyran-4-ol and its derivatives
The present invention discloses a process for synthesis of chiral 2,4-disubstituted-tetrahydropyran-4-ol and its derivatives having a general formula (I)...
US-1,004,0774 Preparation of Furfural using mixed solvents
Processes for the preparation of furfural from a xylose containing feedstock and more particularly to an elevated temperature conversion of a xylose containing...
US-1,004,0773 Silver catalysts with improved size and distribution density of silver particles
A silver-based ethylene epoxidation catalyst is provided that exhibits improved performance, i.e., selectivity and activity decline. The catalyst that exhibits...
US-1,004,0772 Quinoxaline-fused dibenzosuberane based helicenes and organic electroluminescent device using the same
A quinoxaline-fused dibenzosuberane based helicene is shown in formula (1), ##STR00001## wherein A is with a structure of formula (2), formula (3a) or formula...
US-1,004,0771 Method for preparing prostacyclin receptor agonist 4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]-1-butanol
The present invention relates to preparation methods of a prostacyclin receptor agonist of ...
US-1,004,0770 Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of...
Provided herein are Diaminopyrimidine Compounds having the following structures: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined...
US-1,004,0769 HDAC inhibitors for the treatment of diabetic peripheral neuropathy
The invention relates to HDAC inhibitors for use in the treatment of diabetic peripheral neuropathy in a subject in need thereof. Also provided herein are...
US-1,004,0768 Carbamate compound and use thereof
A carbamate compound represented by formula (I), wherein, R.sup.1 represents a hydrogen atom or a C1-C3 alkyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5...
US-1,004,0767 Benzimidazole derivatives and uses thereof
Benzimidazole derivatives of Formula I, that modulate the activity of ACSS2 are disclosed for therapeutic use. The fused imidazole ring of the compounds...
US-1,004,0766 Ubiquitination inhibitors
Disclosed are sulfonamidoquinoline compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure ...
US-1,004,0764 Processes for the preparation of 4-alkoxy-3-(acyl or alkyl)oxypicolinamdes
A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic...
US-1,004,0763 Electrochromic compounds with improved color stability in their radical states
The invention relates to an electrochromic device and uses thereof, wherein the electrochromic device includes an electrochromic compound with reduced...
US-1,004,0762 Sterically hindered amines
An intermediate of the formula (I) wherein the radicals R.sub.1 are independently of one another methyl, ethyl or n-propyl, is suitable for preparing a compound...
US-1,004,0761 Branched hetero polyethylene glycol and intermediate
A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: ##STR00001## wherein X and Y represent each an...
US-1,004,0760 Pyrrolidine compound
Compound (1) is useful as a catalyst since compound (III) can be obtained by reacting compound (I) with compound (II) in the presence of compound (I). ...
US-1,004,0759 Substituted azetidinyl compounds as GlyT1 inhibitors
The invention provides a chemical entity of Formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, and Y have any of the values described herein, and...
US-1,004,0758 Mixed decyl mercaptans compositions and methods of making same
Compositions comprising branched C.sub.10 mercaptans selected from the group consisting of 5-methyl-1-mercapto-nonane, 3-propyl-1-mercapto-heptane,...
US-1,004,0757 Substituted biaryl sulfonamides and the use thereof
Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of...
US-1,004,0756 Specific sulfonate compounds that can be used as electrolyte solvent for lithium batteries
The invention relates to sulfonate compounds with the following formula (I): ##STR00001## in which: R.sup.2 represents an ethyl group, an n-propyl group or...
US-1,004,0755 Process for producing alkali taurinate
There is disclosed a process for producing alkali taurinate from alkali isethionate by the ammonolysis of a solution of alkali isethionate, alkali ditaurinate,...
US-1,004,0754 Cellulose acylate film, novel compound, polarizing plate and liquid crystal display device
A cellulose acylate film, which includes a compound denoted by general formula (I) below, the equivalent U of which, calculated as a value obtained by dividing...
US-1,004,0753 Method for preparing diisocyanates in the gas phase
Methods for the preparation of diisocyanates by the reaction of the corresponding primary diamines with phosgene in the gas phase are described, wherein the...
US-1,004,0752 Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine,...
US-1,004,0751 Intermediates for macrocyclic compounds
The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: ##STR00001##...
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