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Patent # Description
US-1,004,0817 Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or...
This invention relates to methods of stimulating the activity of the human and animal enteric nervous system. The method comprises orally administering an...
US-1,004,0816 Antagonists of CB1 receptor
The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of...
US-1,004,0815 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of...
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as described herein, and their prodrugs or...
US-1,004,0814 Uracyl spirooxetane nucleosides
The present invention relates to compounds of the formula I: ##STR00001## including any possible stereoisomers thereof, wherein R.sup.9 has the meaning as...
US-1,004,0813 Compounds as positive allosteric modulators for erythropoietin and erythropoietin receptor to treat...
Disclosed are compounds which can act as a positive allosteric modulator for erythropoietin and erythropoietin receptor and have the activity in promoting...
US-1,004,0812 Hypervalent iodine CF2CF2X reagents and their use
A hypervalent iodine of formula (I) or formula (II) wherein R is a nucleophile and a method for their production is described. Such compounds can be used for...
US-1,004,0811 Multi-element standard for nuclear magnetic resonance spectroscopy
Organic compounds which contain nitrogen, fluorine, and phosphorus atoms together with carbon atoms and hydrogen atoms and which can be used as a multi-element...
US-1,004,0810 Derivatives of bisacylphosphinic acid, their preparation and use as photoinitiators
Bisacylphosphine oxide or bisacylphosphine sulfide compounds of formula (I) or (II) ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.1a, R.sub.2a and...
US-1,004,0809 Method for preparing tris(trialkylsilyl)phosphine
The present invention relates to a method for preparing a tris(trialkylsilyl)phosphine in high yield and high purity with safety and no risk of fire or explosion.
US-1,004,0808 Silane-modified formamides
The invention relates to novel silane-modified formamide-polymers and/or pre-polymers for bonding and/or sealing diverse substrate materials, such as, for...
US-1,004,0807 Flame retardant filler
A flame retardant filler having brominated silica particles, for example, imparts flame retardancy to manufactured articles such as printed circuit boards...
US-1,004,0806 Microbiocidally active benzoxaboroles
Compounds of formula (I) are as defined in the claims, and their use in compositions and methods for the control and/or prevention of microbial infection,...
US-1,004,0805 Substituted imidazo[1,5-a]pyrazines as Btk inhibitors
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof,...
US-1,004,0804 Compounds targeting proteins, compositions, methods, and uses thereof
The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1.alpha., GSPT1, aiolos, and/or...
US-1,004,0803 4-((2-acrylamidophenyl)amino)thieno[3,2-D]pyrimidine-7-carboxamide derivatives as protein kinase inhibitors
The present invention relates to a novel 4-((2-acrylamidophenyl)amino)thieno[3,2-d]pyrimidine-7-carboxamide compound, an anticancer agent containing the...
US-1,004,0802 Thienopyrazine inhibitors of IRAK4 activity
The present invention relates to thienopyrazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods...
US-1,004,0801 Method for preparing thienopyrimidine compound and intermediates used therein
The present invention provides a novel method for preparing a thienopyrimidine compound of Formula 1, which is a selective inhibitor of tyrosine kinase...
US-1,004,0800 Synthesis of substituted salicylaldehyde derivatives
Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde...
US-1,004,0799 Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating...
Disclosed are new small molecules having a 4-methylpyrrrolo[1,2-a]pyrimidine-8-carboxamide core structure and the uses thereof for modulating glucocerebrosidase...
US-1,004,0798 Pyrrolopyridazine inhibitors of IRAK4 activity
The present invention relates to pyrrolopyridazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods...
US-1,004,0797 Therapeutic compounds and synthesis
The invention provides compounds of Formula 1: ##STR00001## or a stereoisomer, pharmaceutically acceptable salt, or mixture thereof; and methods of making and...
US-1,004,0796 Therapeutic compounds for pain and synthesis thereof
The invention provides compounds of Formula 1: ##STR00001## and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of...
US-1,004,0795 Therapeutic compounds for pain and synthesis thereof
The invention provides compounds of Formula 1: ##STR00001## and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of...
US-1,004,0794 Condensed cyclic compound and organic light-emitting device including the same
A condensed cyclic compound represented by Formulae 1A or 1B: ##STR00001## wherein in Formulae 1A and 1 B, groups, rings, substituents, and variables are...
US-1,004,0793 Key intermediates and impurities of the synthesis of Apixaban: Apixaban glycol esters
Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction....
US-1,004,0792 Synthesis of a compound that modulates kinases
The present disclosure provides processes for the preparation of a compound of formula I: ##STR00001## or a salt thereof, active on the receptor protein...
US-1,004,0791 Isoxazole derivative as mutant isocitrate dehydrogenase 1 inhibitor
It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and...
US-1,004,0790 Bicyclic heterocycles as FGFR inhibitors
The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are...
US-1,004,0789 1,3,4-thiadiazole compounds and their use in treating cancer
A compound of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6-fluoropyridazin-3-yl;...
US-1,004,0788 1,3,4-thiadiazole compounds and their use in treating cancer
The specification relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where Q, R, R.sup.1 and R.sup.2 have any of the meanings...
US-1,004,0787 Prodrugs of NH-acidic compounds
The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a...
US-1,004,0786 Process for preparing a polymorph of rivaroxaban
This invention describes a process for the preparation of rivaroxaban modification I comprising: (i) dissolving rivaroxaban in a mixture of a solvent (e.g. THF)...
US-1,004,0785 Diaryl isoxazoline compound
The present invention concerns compounds of formula (I) or an N-oxide or salt thereof and their use for controlling parasites in and on warm-blooded animals or...
US-1,004,0784 Compositions and methods for acylating lactams
This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni...
US-1,004,0783 Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure...
US-1,004,0782 Hydrochloride salt form for EZH2 inhibition
Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydr- ...
US-1,004,0781 Tank-binding kinase inhibitor compounds
Compounds having the following formula (I) and methods of their use and preparation are disclosed: ##STR00001##
US-1,004,0780 Mcl-1 antagonists
Provided herein are Mcl-1 antagonist compositions and methods of treating g the compositions described herein.
US-1,004,0779 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted 3-aminopyridine...
US-1,004,0778 Anhydrous lenalidomide form-I
Anhydrous polymorphic form-I of anti cancer drug, Lenalidomide whose chemical name is 3-(4-amino-1-oxo-1,3-dihydro-isoindole-2-yl)-piperidine-2,6-dione, is ...
US-1,004,0777 Polymers, co-polymers, and monomers using CO.sub.2 as a reagent
Polymers, co-polymers, and monomers using CO.sub.2 as a reagent and methods of production thereof are described. Polymerization methods include converting...
US-1,004,0776 Pyran derivatives and their preparation
A compound of formula (I) ##STR00001## is provided wherein R represents a linear or branched C5 alkyl group, as well as the use of such compounds in a...
US-1,004,0775 Synthesis of chirally enriched 2,4-disubstituted tetrahydropyran-4-ol and its derivatives
The present invention discloses a process for synthesis of chiral 2,4-disubstituted-tetrahydropyran-4-ol and its derivatives having a general formula (I)...
US-1,004,0774 Preparation of Furfural using mixed solvents
Processes for the preparation of furfural from a xylose containing feedstock and more particularly to an elevated temperature conversion of a xylose containing...
US-1,004,0773 Silver catalysts with improved size and distribution density of silver particles
A silver-based ethylene epoxidation catalyst is provided that exhibits improved performance, i.e., selectivity and activity decline. The catalyst that exhibits...
US-1,004,0772 Quinoxaline-fused dibenzosuberane based helicenes and organic electroluminescent device using the same
A quinoxaline-fused dibenzosuberane based helicene is shown in formula (1), ##STR00001## wherein A is with a structure of formula (2), formula (3a) or formula...
US-1,004,0771 Method for preparing prostacyclin receptor agonist 4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]-1-butanol
The present invention relates to preparation methods of a prostacyclin receptor agonist of ...
US-1,004,0770 Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of...
Provided herein are Diaminopyrimidine Compounds having the following structures: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined...
US-1,004,0769 HDAC inhibitors for the treatment of diabetic peripheral neuropathy
The invention relates to HDAC inhibitors for use in the treatment of diabetic peripheral neuropathy in a subject in need thereof. Also provided herein are...
US-1,004,0768 Carbamate compound and use thereof
A carbamate compound represented by formula (I), wherein, R.sup.1 represents a hydrogen atom or a C1-C3 alkyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5...
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