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Patent # Description
US-1,004,7110 RNA agents for GST-Pi gene modulation
This invention provides compounds, compositions and methods for modulating the expression of human GST-.pi. using RNA interference. The RNA interference...
US-1,004,7109 Ash-free cyclic organic polyol-based reactive porogens and nanoporous ultra low dielectric film by using the same
The present disclosure relates to a reactive porogen using cyclic organic polyol and an ultra low dielectric film prepared using the same, and more ...
US-1,004,7108 Platinum (II) diene complexes with chelating dianionic ligands and their use in hydrosilylation reactions
A process for the hydrosilylation of an unsaturated compound comprising reacting (a) a silyl hydride with (b) an unsaturated compound in the presence of (c) a...
US-1,004,7107 Small molecule analogs of E4orf1
The invention relates to amino nitrile compounds. Such compounds can increase glucose uptake by cells and preferably do not substantially increase adipogenesis.
US-1,004,7106 Lanthanide complexes comprising at least two betaine groups, which can be used as luminescent markers
The present invention relates to luminescent lanthanide complexes including a chelating agent, formed with a macrocycle or a set of ligands, complexing a...
US-1,004,7105 Gyrase inhibitors
Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth. Compounds of Formula (I), are disclosed: Formula (I),...
US-1,004,7104 Bicyclic heterocyclyl derivatives as IRAK4 inhibitors
The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors,...
US-1,004,7103 Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for...
The present invention provides thiazole compounds of Formula I wherein W, Y, R.sup.0, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X.sup.1, X.sup.2, X.sup.3 and...
US-1,004,7102 Pyridyl-triazabicycles
The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
US-1,004,7101 Flap modulators
The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R.sub.1, L and R.sub.2 are as defined herein, useful as FLAP...
US-1,004,7100 Compounds from renewable resources
Compounds of formula III: ##STR00001## and salts thereof are disclosed. Also disclosed are methods for preparing compounds of formula III, intermediates...
US-1,004,7099 Method of producing anhydrosugar alcohol using steam
The present invention provides a method for producing anhydrosugar alcohol, including: feeding sugar alcohol into a reactor and performing a dehydration...
US-1,004,7098 C5-C6-oxacyclic fused iminopyrimidinone compounds as bace inhibitors, compositions, and their use
In its many embodiments, the present invention provides certain C5-C6-oxacyclic fused iminopyrimidinone compounds, including compounds Formula (I): or a...
US-1,004,7097 Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
US-1,004,7096 Substituted pyridobenzodiazepinone-derivatives and use thereof
The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation...
US-1,004,7095 sGC stimulators
The present patent application discloses at least the compounds according to Formula I' shown below, or pharmaceutically acceptable salts thereof, ##STR00001## ...
US-1,004,7094 Process for the preparation of triazole and salt thereof
An improved process for the preparation of Triazole and salts thereof, a key intermediate for the synthesis of Sitagliptine is disclosed.
US-1,004,7093 Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
The present invention provides protein kinase having one of the following structures (I), (II) or (III): ##STR00001## or a stereoisomer, prodrug, tautomer or...
US-1,004,7092 Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
The present invention is directed to a compound of Formula (I) ##STR00001## and to pharmaceutical compositions comprising compounds of Formula (I). Methods of...
US-1,004,7091 Ionic liquid, lubricating agent, and magnetic recording medium
A lubricating agent including an ionic liquid formed from a Bronsted acid (HX) and a Bronsted base (B), wherein the Bronsted base has a linear hydrocarbon group...
US-1,004,7090 Solid forms of (1S,4S)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-- ...
Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4- ...
US-1,004,7089 Dihydro-6-azaphenalene derivatives for the treatment of CNS, oncological diseases and related disorders
In one embodiment, the present application discloses 2-aza-, 2-oxa- and 2-thia-2,3-dihydro-6-azaphenalene compounds and compositions, and methods for treating a...
US-1,004,7088 1H-1,8-naphthyridin-2-ones as anti proliferative compounds
The present invention relates to novel antiproliferative 1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: ...
US-1,004,7087 Substituted pyrazolo[1,5-A] pyridine as tropomyosin receptor kinase (TrK) inhibitors
The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein...
US-1,004,7086 Imidazopyridines and imidazopyrazines as LSD1 inhibitors
The present invention is directed to imidazo[1,5-a]pyridine and imidazo[1,5-a]pyrazine derivatives of Formula I, or a pharmaceutically acceptable salt thereof,...
US-1,004,7085 Dihydropyrrolopyridine inhibitors of ROR-gamma
Provided are novel compounds of Formula (I): ##STR00001## pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful...
US-1,004,7084 Imidazolone derivatives, pharmaceutical compositions and uses thereof
This application relates to imidazolone compounds, pharmaceutically acceptable salts, solvents, polymorphs or prodrugs thereof, and further relates to...
US-1,004,7083 Dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory...
A compound according to Formula Ia: ##STR00001## wherein L.sub.1, G, and R.sup.1 are as described herein. The present invention relates to novel compounds...
US-1,004,7082 Octahydro fused azadecalin glucocorticoid receptor modulators
The present invention provides octahydro fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
US-1,004,7081 BACE1 inhibitors
The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
US-1,004,7080 (R)-2-methyl-piperazine derivatives as CXCR3 receptor modulators
The invention relates to compounds of Formula (I) ##STR00001## wherein R.sup.1 and R.sup.2 are as described in the description; to pharmaceutically acceptable...
US-1,004,7079 N-pyridinyl acetamide derivatives as inhibitors of the Wnt signaling pathway
Disclosed are compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In...
US-1,004,7078 Aminothiazole compounds
Aminothiazole compounds of Formula (I) shown herein and pharmaceutical compositions containing one of such compounds.
US-1,004,7077 Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
Provided herein are deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams, pharmaceutical compositions thereof and methods...
US-1,004,7076 Halogen-substituted compounds
The invention relates inter alia to halogen-substituted compounds of the general formula (I) ##STR00001## in which the A.sub.1-A.sub.4, T, W, Q, R.sup.1 and...
US-1,004,7075 Pyridines and pyrimidines and use thereof
The present disclosure provides pyridines and pyrimidines of Formula I and pharmaceutically acceptable salts and solvates thereof: wherein A, G, W.sup.1,...
US-1,004,7074 Pharmaceutical compound
Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the...
US-1,004,7073 Histone deacetylase inhibitors and compositions and methods of use thereof
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##
US-1,004,7072 Therapeutic polymeric nanoparticles and methods of making and using same
Described herein are polymeric nanoparticles that include a therapeutic agent which is ...
US-1,004,7071 Dihydropyrimidinone derivatives
A dihydropyrimidinone derivative includes a compound having a chemical structure according to Formula 1: ##STR00001## Z is selected from O, S and N; Y is N...
US-1,004,7070 Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers,...
US-1,004,7069 Compositions comprising an inhibitor of lysine specific demethylase-1
Described herein are amorphous and crystalline forms of pharmaceutically acceptable salts of the lysine specific demethylase-1 inhibitor ...
US-1,004,7068 Optical resolution method of lenalidomide
The problem addressed by the present invention is to provide a novel method for separating and purifying pure enantiomer of lenalidomide. Pure enantiomer of...
US-1,004,7067 Composition for treating kidney disease comprising pyrazole derivative
The present invention provides a composition for preventing or treating kidney disease, the composition comprising a pyrazole derivative compound or a...
US-1,004,7066 IDO inhibitors
Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a...
US-1,004,7065 Formation of chromanes based on intermolecular reaction of alkynes with dimethylfuran in the presence of...
The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group...
US-1,004,7064 Flavagline derivatives
The invention relates to compounds of the following general formula (I) in the form of one of the enantiomers thereof or a mixture of the enantiomers thereof,...
US-1,004,7063 Method for improving the oxygen-releasing ability of hemoglobin to organs or peripheral tissues in human bodies...
A method for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin or hemoglobin-based blood substitutes to organs...
US-1,004,7062 Methods of chemical synthesis of Diaminophenothiazinium compounds including methylthioninium chloride (MTC)
Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including...
US-1,004,7061 Water-soluble triazabutadienes
Water-soluble triazabutadiene molecules and methods for producing and using such compounds. The triazabutadiene molecules may be more labile at pH levels below...
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