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Patent # Description
US-1,004,7181 Tetrafluoroethylene copolymers
The invention pertains to a tetrafluoroethylene (TFE) copolymer comprising recurring units derived from at least one perfluoroalkyl(oxy)vinylether of formula...
US-1,004,7180 Vinyl-based thermoplastic resin composition, method for manufacturing thereof and vinyl-based thermoplastic...
The present invention relates to vinyl-based thermoplastic resin composition having excellent thermal stability, which comprises a metal complex agent, and a...
US-1,004,7179 Heat-resistant styrene copolymer and styrene resin composition comprising the same
Provided is a styrene resin composition including .alpha.-methyl styrene, acrylonitrile and t-butyl methacrylate, and having an improved conversion rate while...
US-1,004,7178 Mitigation of catalyst inhibition in olefin polymerization
This disclosure relates to a process for polymerization, and in particular to minimizing undesired polymerization reactions downstream of a polymerization...
US-1,004,7177 Process for preparing halogenated polymer having reduced residual acidity and yellowness index of 3.5 and below
The present disclosure provides a process for the reduction of residual acidity of halogenated polymer. The process involves treating the halogenated polymer to...
US-1,004,7176 Multi-reactor slurry polymerization processes with high ethylene purity
A slurry polymerization process for the preparation of polyethylene in a reactor cascade of two or more polymerization reactors including the steps of feeding...
US-1,004,7175 Aqueous dispersion of low molecular weight polytetrafluoroethylene, low molecular weight...
The present invention provides an aqueous dispersion of a low-molecular-weight polytetrafluoroethylene (PTFE), which contains an easily removable surfactant,...
US-1,004,7174 Polymerization initiating system and method to produce highly reactive olefin functional polymers
A method for producing highly reactive olefin polymers wherein at least 50 mol. % of the polymer chains have terminal double bonds, from an isobutylene or a...
US-1,004,7173 Low vinyl bond modified elastomeric copolymers
The present invention relates to a modified elastomeric polymer obtained by reacting a living anionic elastomeric polymer and specific chain end modifying...
US-1,004,7172 Single step functionalization and cross-linking of hyaluronic acid
A process for manufacturing a cross-linked hyaluronic acid (HA) containing a functionalizing group including the step of reacting HA with a mixture of: (i) a...
US-1,004,7171 Amphiphilic bioconjugates obtained from xylan derivatives
The present invention concerns a compound of formula (I): wherein: --n is an integer comprised between 1 and 7; --X.sub.1 is in particular a radical of formula...
US-1,004,7170 Process for the preparation of purified .beta.-(1,3)-D-glucans
There is provided a process for the preparation of purified .beta.-(1,3)-D-glucans, comprising the steps of providing an aqueous .beta.-(1,3)-D-glucan initial...
US-1,004,7169 Process for the preparation of purified .beta.-(1,3)-D-glucans
There is provided a process for the preparation of purified .beta.-(1,3)-D-glucans, comprising the steps of providing an aqueous .beta.-(1,3)-D-glucan initial...
US-1,004,7168 Process for the preparation of purified .beta.-(1,3)-D-glucans
There is provided a process for the preparation of purified .beta.-(1,3)-D-glucans, comprising the steps of providing an aqueous .beta.-(1,3)-D-glucan initial...
US-1,004,7167 Methods for producing fabs and bi-specific antibodies
The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light...
US-1,004,7166 Humanized anti-IgE antibodies that crosslink CD23 on B lymphocytes but do not sensitize mast cells
A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but...
US-1,004,7165 Compositions for inhibiting MASP-2 dependent complement activation
The present invention relates to anti-MASP-2 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of...
US-1,004,7164 Methods and compositions for the treatment of pancreatic cancer
A composition comprising a TLR2 antagonistic antibody or antigen binding fragment thereof for use in the treatment or prophylaxis of pancreatic cancer is...
US-1,004,7163 Multispecific constructs
Provided are novel multispecific antibody constructs and multispecific antibody drug conjugates (ADCs), and methods of using such antibodies and ADCs to treat...
US-1,004,7162 Sequence dependent aggregation
Herein is reported a method for reducing the aggregation of an immunoglobulin in solution comprising the steps of i) comparing the amino acid sequence of the...
US-1,004,7161 Humanized anti-interleukin 3 receptor alpha chain antibodies
The present disclosure provides antibodies that bind to interleukin-3 receptor alpha chain and uses thereof.
US-1,004,7160 Anti-EGFRvIII antibodies and uses thereof
The present invention provides antibodies that bind to the class III variant of EGFR (EGFRvIII) and methods of using the same. According to certain embodiments,...
US-1,004,7159 Bispecific single chain antibodies with specificity for high molecular weight target antigens
The present invention provides a method for the selection of bispecific single chain antibodies comprising a first binding domain capable of binding to an...
US-1,004,7158 Anti-TIGIT antibodies and methods of use
The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
US-1,004,7157 Humanized anti-ACTH antibodies and use thereof
The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Embodiments of this invention relate to the binding...
US-1,004,7156 Anti-CXCL1, CXCL7 and CXCL8 antibodies and their applications
The invention provides an isolated antibody or a fragment thereof, which is directed to the human chemokines CXCL1, CXCL7 and CXCL8, said antibody or fragment...
US-1,004,7155 Antibodies targeting bone morphogenetic protein 9 (BMP9) and methods therefor
The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.
US-1,004,7154 Angiopoietin-2 specific antibodies and uses thereof
An Ang2 specific antibody, a method of inhibiting angiogenesis or a method of treating a disease related to the activation and/or overproduction of Ang2 using...
US-1,004,7153 Human antibodies to Fel d1 and methods of use thereof
The present invention provides antibodies that bind to the cat allergen, Fel d1, compositions comprising the antibodies, nucleic acids encoding the antibodies...
US-1,004,7152 Human antibodies to fel D1 and methods of use thereof
The present invention provides antibodies that bind to the cat allergen, Fel d1, compositions comprising the antibodies, nucleic acids encoding the antibodies...
US-1,004,7151 Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
Uses of the protein cereblon as a predictor of clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment.
US-1,004,7150 Anti-neublastin antibodies and uses thereof
Antibodies and antigen binding fragments that bind to neublastin polypeptides are disclosed. Also disclosed are methods of using the antibodies and antigen...
US-1,004,7149 Compositions and methods related to antibodies to Staphylococcal protein A
Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects...
US-1,004,7148 Neutralizing GP41 antibodies and their use
Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are...
US-1,004,7147 Neutralizing GP41 antibodies and their use
Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are...
US-1,004,7146 Broadly-neutralizing anti-HIV antibodies
The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS),...
US-1,004,7145 Antibodies that potently neutralize RSV and uses thereof
The invention relates to antibodies, and antigen binding fragments thereof, that neutralize infection of both group A and group B RSV. The invention also...
US-1,004,7144 Methods of purifying antibodies
The invention provides methods of purifying antibodies using various antibody-specific purification media to rapidly and efficiently separate mixtures of...
US-1,004,7142 Factor VIII variants having a decreased cellular uptake
The present invention relates to modified coagulation factors. In particular, the present invention relates to modied Factor VIII molecules having decreased...
US-1,004,7141 Method of manufacturing a protein by perfusion in media with a low amino acid concentration
Perfusion media are disclosed providing excellent cell density, titer and product quality for production of a therapeutic protein in a perfusion process.
US-1,004,7140 Methods and compositions for the inhibition of TRPV4
TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number...
US-1,004,7139 Fc fusion high affinity IgE receptor .alpha.-chain
Provided is an Fc fusion high affinity IgE receptor .alpha.-chain having excellent stability at low pH. An Fc fusion protein comprising: (i) a high affinity...
US-1,004,7138 Fusion protein, cells expressing the fusion protein, and uses thereof
Described herein are novel fusion proteins and nucleic acids encoding these fusion proteins. T cells into which such nucleic acids have been introduced are also...
US-1,004,7137 Antibodies against novel PD1 isoforms and uses thereof
The present invention pertains to antibodies against a novel isoform of human PD1 protein (.DELTA.42PD1) that contains a 42-nucleotide in-frame deletion in exon...
US-1,004,7136 Consumable cryopreserved cells transiently overexpressing gene(s) encoding drug transporter protein(s)
The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter proteins...
US-1,004,7135 Compounds with reduced ring size for use in diagnosing and treating melanoma, including metastatic melanoma and...
The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in...
US-1,004,7134 Process for expression of recombinant proteins in Pichia pastoris using a fed batch model
The present disclosure relates to a comprehensive model for expression of recombinant peptides by Pichia pastoris. The model uses an easily controllable...
US-1,004,7133 Glycosaminoglycan-antagonising fusion proteins and methods of using same
The present invention relates to novel monomeric fusion proteins derived from human GAG binding proteins such as chemokines with increased glycosaminoglycan...
US-1,004,7132 Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators
The present disclosure provides isolated stabilized EPO-derived peptides and their mimics that protect against tissue damage in subjects having diverse forms of...
US-1,004,7131 Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
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