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Patent # Description
US-1,004,7130 Methods and compositions for red-shifted chromophore substitution for optogenetic applications
The present disclosure provides compositions and methods used for optogenetics, wherein the composition comprises an optogenetic device and a retinoid...
US-1,004,7129 Modified alpha hemolysin polypeptides and methods of use
Provided herein are alpha hemolysin polypeptides comprising modified amino acid sequences that can reduce the rate of translocation of a polymer. Also provided...
US-1,004,7128 Encryption of adeno-associated viruses with enzymatically decoded peptide locks
The present invention is a peptide lock that comprises at least one peptide that is genetically encoded into the Adeno-associated virus (AAV) capsid that block...
US-1,004,7127 De novo structural protein design for manufacturing high strength materials
Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming...
US-1,004,7126 Polymyxin derivatives as antimicrobial compounds
The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of...
US-1,004,7125 Peptide having activity to improve skin condition and use thereof
A peptide having activity to improve skin condition is described. The peptide exhibits a very excellent effect in improving skin condition by inhibiting MMP2...
US-1,004,7124 Immunotherapy against several tumors including neuronal and brain tumors
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
US-1,004,7123 Immunotherapy against several tumors including neuronal and brain tumors
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
US-1,004,7122 Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box...
US-1,004,7121 Amyloid-beta binding proteins
The present invention relates to amyloid-beta (A.beta.) binding proteins. Antibodies of the invention have high affinity to .LAMBDA..beta.(20-42) globulomer or...
US-1,004,7120 Method for producing a composition for treating a tooth lesion
The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing...
US-1,004,7119 Inhibitor of apoptosis protein (IAP) antagonists
Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPB), compositions comprising the compounds, and methods of using...
US-1,004,7118 C17-aryl substituted betulinic acid analogs
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid...
US-1,004,7117 Preparation and uses of obeticholic acid
The present invention relates to obeticholic acid: ##STR00001## or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic...
US-1,004,7116 Nanoparticles, process for preparation and use thereof as carrier for amphipatic and hydrophobic molecules in...
The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja...
US-1,004,7115 Cyclic dinucleotides useful for the treatment of inter alia cancer
A compound of formula (I) ##STR00001## or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said...
US-1,004,7114 Nucleotide and oligonucleotide prodrugs
The present invention discloses compounds of formula (I): ##STR00001## which exhibit antiviral properties. The present invention further relates to...
US-1,004,7113 Feruloyl-CoA:monolignol transferase
The invention relates to nucleic acids encoding a feruloyl-CoA:monolignol transferase and the feruloyl-CoA:monolignol transferase enzyme that enables...
US-1,004,7112 Fluorescent labeled inhibitors
Provided herein are a series of fluorescently labeled phosphonate and phosphate compounds such as can be used for affinity probes to detect certain enzymes...
US-1,004,7111 RNA interference agents for GST-PI gene modulation
This invention provides compounds, compositions and methods for modulating the expression of human GST-.pi. using RNA interference. The RNA interference...
US-1,004,7110 RNA agents for GST-Pi gene modulation
This invention provides compounds, compositions and methods for modulating the expression of human GST-.pi. using RNA interference. The RNA interference...
US-1,004,7109 Ash-free cyclic organic polyol-based reactive porogens and nanoporous ultra low dielectric film by using the same
The present disclosure relates to a reactive porogen using cyclic organic polyol and an ultra low dielectric film prepared using the same, and more ...
US-1,004,7108 Platinum (II) diene complexes with chelating dianionic ligands and their use in hydrosilylation reactions
A process for the hydrosilylation of an unsaturated compound comprising reacting (a) a silyl hydride with (b) an unsaturated compound in the presence of (c) a...
US-1,004,7107 Small molecule analogs of E4orf1
The invention relates to amino nitrile compounds. Such compounds can increase glucose uptake by cells and preferably do not substantially increase adipogenesis.
US-1,004,7106 Lanthanide complexes comprising at least two betaine groups, which can be used as luminescent markers
The present invention relates to luminescent lanthanide complexes including a chelating agent, formed with a macrocycle or a set of ligands, complexing a...
US-1,004,7105 Gyrase inhibitors
Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth. Compounds of Formula (I), are disclosed: Formula (I),...
US-1,004,7104 Bicyclic heterocyclyl derivatives as IRAK4 inhibitors
The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors,...
US-1,004,7103 Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for...
The present invention provides thiazole compounds of Formula I wherein W, Y, R.sup.0, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X.sup.1, X.sup.2, X.sup.3 and...
US-1,004,7102 Pyridyl-triazabicycles
The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
US-1,004,7101 Flap modulators
The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R.sub.1, L and R.sub.2 are as defined herein, useful as FLAP...
US-1,004,7100 Compounds from renewable resources
Compounds of formula III: ##STR00001## and salts thereof are disclosed. Also disclosed are methods for preparing compounds of formula III, intermediates...
US-1,004,7099 Method of producing anhydrosugar alcohol using steam
The present invention provides a method for producing anhydrosugar alcohol, including: feeding sugar alcohol into a reactor and performing a dehydration...
US-1,004,7098 C5-C6-oxacyclic fused iminopyrimidinone compounds as bace inhibitors, compositions, and their use
In its many embodiments, the present invention provides certain C5-C6-oxacyclic fused iminopyrimidinone compounds, including compounds Formula (I): or a...
US-1,004,7097 Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
US-1,004,7096 Substituted pyridobenzodiazepinone-derivatives and use thereof
The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation...
US-1,004,7095 sGC stimulators
The present patent application discloses at least the compounds according to Formula I' shown below, or pharmaceutically acceptable salts thereof, ##STR00001## ...
US-1,004,7094 Process for the preparation of triazole and salt thereof
An improved process for the preparation of Triazole and salts thereof, a key intermediate for the synthesis of Sitagliptine is disclosed.
US-1,004,7093 Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
The present invention provides protein kinase having one of the following structures (I), (II) or (III): ##STR00001## or a stereoisomer, prodrug, tautomer or...
US-1,004,7092 Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
The present invention is directed to a compound of Formula (I) ##STR00001## and to pharmaceutical compositions comprising compounds of Formula (I). Methods of...
US-1,004,7091 Ionic liquid, lubricating agent, and magnetic recording medium
A lubricating agent including an ionic liquid formed from a Bronsted acid (HX) and a Bronsted base (B), wherein the Bronsted base has a linear hydrocarbon group...
US-1,004,7090 Solid forms of (1S,4S)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-- ...
Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4- ...
US-1,004,7089 Dihydro-6-azaphenalene derivatives for the treatment of CNS, oncological diseases and related disorders
In one embodiment, the present application discloses 2-aza-, 2-oxa- and 2-thia-2,3-dihydro-6-azaphenalene compounds and compositions, and methods for treating a...
US-1,004,7088 1H-1,8-naphthyridin-2-ones as anti proliferative compounds
The present invention relates to novel antiproliferative 1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: ...
US-1,004,7087 Substituted pyrazolo[1,5-A] pyridine as tropomyosin receptor kinase (TrK) inhibitors
The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein...
US-1,004,7086 Imidazopyridines and imidazopyrazines as LSD1 inhibitors
The present invention is directed to imidazo[1,5-a]pyridine and imidazo[1,5-a]pyrazine derivatives of Formula I, or a pharmaceutically acceptable salt thereof,...
US-1,004,7085 Dihydropyrrolopyridine inhibitors of ROR-gamma
Provided are novel compounds of Formula (I): ##STR00001## pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful...
US-1,004,7084 Imidazolone derivatives, pharmaceutical compositions and uses thereof
This application relates to imidazolone compounds, pharmaceutically acceptable salts, solvents, polymorphs or prodrugs thereof, and further relates to...
US-1,004,7083 Dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory...
A compound according to Formula Ia: ##STR00001## wherein L.sub.1, G, and R.sup.1 are as described herein. The present invention relates to novel compounds...
US-1,004,7082 Octahydro fused azadecalin glucocorticoid receptor modulators
The present invention provides octahydro fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
US-1,004,7081 BACE1 inhibitors
The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
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