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Patent # Description
US-1,004,7080 (R)-2-methyl-piperazine derivatives as CXCR3 receptor modulators
The invention relates to compounds of Formula (I) ##STR00001## wherein R.sup.1 and R.sup.2 are as described in the description; to pharmaceutically acceptable...
US-1,004,7079 N-pyridinyl acetamide derivatives as inhibitors of the Wnt signaling pathway
Disclosed are compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In...
US-1,004,7078 Aminothiazole compounds
Aminothiazole compounds of Formula (I) shown herein and pharmaceutical compositions containing one of such compounds.
US-1,004,7077 Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
Provided herein are deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams, pharmaceutical compositions thereof and methods...
US-1,004,7076 Halogen-substituted compounds
The invention relates inter alia to halogen-substituted compounds of the general formula (I) ##STR00001## in which the A.sub.1-A.sub.4, T, W, Q, R.sup.1 and...
US-1,004,7075 Pyridines and pyrimidines and use thereof
The present disclosure provides pyridines and pyrimidines of Formula I and pharmaceutically acceptable salts and solvates thereof: wherein A, G, W.sup.1,...
US-1,004,7074 Pharmaceutical compound
Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the...
US-1,004,7073 Histone deacetylase inhibitors and compositions and methods of use thereof
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##
US-1,004,7072 Therapeutic polymeric nanoparticles and methods of making and using same
Described herein are polymeric nanoparticles that include a therapeutic agent which is ...
US-1,004,7071 Dihydropyrimidinone derivatives
A dihydropyrimidinone derivative includes a compound having a chemical structure according to Formula 1: ##STR00001## Z is selected from O, S and N; Y is N...
US-1,004,7070 Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers,...
US-1,004,7069 Compositions comprising an inhibitor of lysine specific demethylase-1
Described herein are amorphous and crystalline forms of pharmaceutically acceptable salts of the lysine specific demethylase-1 inhibitor ...
US-1,004,7068 Optical resolution method of lenalidomide
The problem addressed by the present invention is to provide a novel method for separating and purifying pure enantiomer of lenalidomide. Pure enantiomer of...
US-1,004,7067 Composition for treating kidney disease comprising pyrazole derivative
The present invention provides a composition for preventing or treating kidney disease, the composition comprising a pyrazole derivative compound or a...
US-1,004,7066 IDO inhibitors
Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a...
US-1,004,7065 Formation of chromanes based on intermolecular reaction of alkynes with dimethylfuran in the presence of...
The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group...
US-1,004,7064 Flavagline derivatives
The invention relates to compounds of the following general formula (I) in the form of one of the enantiomers thereof or a mixture of the enantiomers thereof,...
US-1,004,7063 Method for improving the oxygen-releasing ability of hemoglobin to organs or peripheral tissues in human bodies...
A method for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin or hemoglobin-based blood substitutes to organs...
US-1,004,7062 Methods of chemical synthesis of Diaminophenothiazinium compounds including methylthioninium chloride (MTC)
Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including...
US-1,004,7061 Water-soluble triazabutadienes
Water-soluble triazabutadiene molecules and methods for producing and using such compounds. The triazabutadiene molecules may be more labile at pH levels below...
US-1,004,7060 Process methods for phosphatidylinositol 3-kinase inhibitors
A process for the synthesis of quinazolinone containing compounds which may be useful for the treatment of cancer, is hereby disclosed. In addition, compound...
US-1,004,7059 Substituted quinoxalines for inhibiting kinase activity
Described herein are kinase inhibitors represented by Formula I: ##STR00001## pharmaceutical compositions thereof, and uses thereof including but not limited...
US-1,004,7058 Compounds and methods for inhibiting vacuolar ATPase
A compound of Formula II, ##STR00001## is provided. R.sub.1, R.sub.2 and R.sub.3 are independently either hydrogen, alkyl, aryl, halogen, alkoxy, nitro, amino...
US-1,004,7057 Functionalized tyrosine kinase inhibitors modified with precious metal electrophiles and methods associated...
Newly synthesized thiourea-modified 3-chloro-4-fluoroanilino-quinazoline derivatives have been studied as terminal carrier ligands in linear gold(I) complexes....
US-1,004,7056 Hepatitis C virus inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical...
US-1,004,7055 Liver X receptor (LXR) modulators
Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of LXR-associated diseases, disorders or...
US-1,004,7054 Method for the production of MDI dimer
The invention relates to a method for the production of 4,4'-methylenebis(phenylisocyanate) dimer (MDI dimer) which is distinguished by an MDI dimer being...
US-1,004,7053 Deuterated CFTR potentiators
This invention relates to compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof. This invention also provides compositions...
US-1,004,7052 Bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use
The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting...
US-1,004,7051 Substituted pyridines and method of use
The invention discloses compounds of Formula I ##STR00001## wherein X, R.sup.1, R.sup.2, and R.sup.3 are as defined herein. The present invention relates to...
US-1,004,7050 3,4-di-substituted pyridine compound, methods of using and compositions comprising the same
2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is useful in the modulation of blood or serum uric acid levels. In some embodiments, ...
US-1,004,7049 Process for preparing pridopidine
This invention provides a pridopidine base in a solid form, a method of preparing the solid pridopidine base, and a composition comprising the pridopidine base...
US-1,004,7048 Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
The present invention relates to a compound of formula (3Z,5S)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrro- lidin-3-one O-meth19243yloxime,...
US-1,004,7047 Nitric oxide donating derivatives of latanoprost free acid
The present invention relates to 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid, their use for the treatment of...
US-1,004,7046 Salt and photoresist composition containing the same
A salt having a group represented by the formula (aa): ##STR00001## wherein X.sup.a and X.sup.b independently each represent an oxygen atom or a sulfur atom,...
US-1,004,7045 Fluorinated compounds containing a -OSF.sub.5 group and process for their preparation
A process for the preparation of fluorinated compounds having at least one --OSF.sub.5 group, said method comprising the step of reacting SOF.sub.4 with a...
US-1,004,7044 Amine Mining Collectors
A family of amine mining collectors that uses alkoxylates allows for the easy adjustment of solubility and molecular weight useful because anionic and cationic...
US-1,004,7043 Thiol compound composition for optical material
According to the present invention, it is possible to provide a polythiol composition, which comprises a polythiol (A) represented by formula (1) and a thiol...
US-1,004,7042 Method for producing D-form or L-form amino acid derivative having thiol group
The object of the present invention is to provide a method of efficiently manufacturing an optically active D- and/or L-form amino acid possessing a thiol group...
US-1,004,7041 Amino-phenyl-sulfonyl-acetate derivatives and use thereof
The present invention relates to a novel amino-phenyl-sulfonyl-acetate derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical...
US-1,004,7040 Sulfonylaminobenzamide compounds as anthelmintics
The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt...
US-1,004,7039 Compounds, compositions and methods for treating tumors
Disclosed herein are compounds, compositions and methods for treating tumors, particularly tumors that metastasize, via inhibiting tumor cells-induced platelet...
US-1,004,7038 Waste treatment process
A waste treatment process and system is described, which finds application in dechlorinating carbohydrates and/or hydrolyzing dimethyl formamide and/or dimethyl...
US-1,004,7037 Method for producing 2-amino-substituted benzaldehyde compound
The present invention provides a method for producing a benzaldehyde in which an amino group is bonded in the 2 position, a halogeno group or an alkoxy group is...
US-1,004,7036 Method for the synthesis of hydroxy-triglycerides and uses thereof for the prevention and treatment of diseases
The present invention relates to hydroxy-triglycerides, their synthesis, a pharmaceutical and/or nutraceutical composition which comprises at least one of said...
US-1,004,7035 Process for continuously preparing di-C.sub.1-3-alkyl succinates
The invention relates to a process for continuously preparing di-C.sub.1-3-alkyl succinates by reacting succinic acid with an C.sub.1-3-alkanol in the presence...
US-1,004,7034 Polyhydroxylated pentacyclic triterpene acids as HMG-COA reductase inhibitors
The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-CoA reductase inhibitors in the...
US-1,004,7033 Compositions comprising oxo-derivatives of fatty acids and methods of making and using same
The present disclosure provides 15-oxo-EPA and 15-oxo-DGLA, compositions comprising 15-oxo-EPA and/or 15-oxo-DGLA, and methods of treating and/or preventing...
US-1,004,7032 Preparation method of organic zinc catalyst and poly(alkylene carbonate) resin
The present invention relates to a preparation method of an organic zinc catalyst capable of preparing an organic zinc catalyst having a finer and more uniform...
US-1,004,7031 Organic compounds
A fragrance precursor of 3-(4-isobutyl-2-methyl phenyl)propanal, comprising at least an enamine and/or an aminal as reaction product of ...
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