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Patent # Description
US-1,005,9953 Plant terminator sequences
This invention relates to gene expression regulatory sequences, specifically transcription terminator sequences. Plant transcription terminator sequences are...
US-1,005,9952 Yeast strains for protein production
Method and system for expression systems, based on ade1 and ade2 auxotrophic strains of yeast and fungi, including P. pastoris are disclosed. The expression...
US-1,005,9951 Functional ligands to nerve agent metabolites
This invention relates to functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, more particularly to...
US-1,005,9950 Compositions comprising an internalizing nucleic acid molecule, and their methods of use
Provided are internalizing nucleic acid molecules ("iNA") that can bind and internalize into target cells containing a cell surface molecule to which the iNA...
US-1,005,9949 Treatment of age-related macular degeneration using RNA complexes that target MYD88 or TLR3
In certain aspects, provided herein are RNA complexes that inhibit Myeloid differentiation primary response gene 88 (MyD88) and/or Toll-like receptor 3 (TLR3)...
US-1,005,9948 Antisense treatment of radiation induced diseases in the gastrointestinal tract
This invention relates to a composition comprising an antisense oligonucleotide for use in treating radiation induced disease of the gastrointestinal tract.
US-1,005,9947 Nucleic acids and methods for the treatment of Pompe disease
The invention relates to nucleic acids and methods for restoring acid alpha-glucosidase (GAA) activity in patients with Pompe disease using splice-switching...
US-1,005,9946 Method for treatment of heart failure
The present invention relates to an inhibitor of NGAL gene expression or a NGAL antagonist for use in the prevention or the treatment of heart failure.
US-1,005,9945 Methods of controlling cell fate and consequences for disease
Provided herein are methods for performing cellular reprogramming that include treatment of somatic cells with an inhibitor of CAF-1, Sumo2, Nutd21, or...
US-1,005,9944 SiRNA targeting HSR1
The invention provides siRNA molecules, combinations of such siRNA molecules, and locked nucleic acid (LNA) antisense oligonucleotides, which target Heat Shock...
US-1,005,9943 RIG-I ligands and methods for producing them
The present invention relates to new triphosphate-modified oligonucleotides which may act as RIG-I ligands as well as a new method allowing the synthesis and...
US-1,005,9942 Therapeutic oligonucleotides comprising pyrazolotriazine nucleotide analogues
Disclosed herein are double-stranded RNA nucleic acid molecules, which include at least one pyrazolotriazine nucleotide analog and have been modified to exhibit...
US-1,005,9941 Compositions and methods for modulating SMN gene family expression
Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of SMN1 or SMN2. Further aspects provide compositions...
US-1,005,9940 Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents
Provided herein are chemically ligated guide RNA oligonucleotides (lgRNA) which comprise two functional RNA modules (crgRNA and tracrgRNA) joined by...
US-1,005,9939 Screening methods for human embryonic stem cells
This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder...
US-1,005,9938 Gene expression analysis
The present invention is directed to methods and kits for gene analysis. The methods of the invention comprise the steps of providing nucleic acid; synthesis of...
US-1,005,9937 Method and kit for generating high affinity binding agents
A combined ribosome-display and phage-display method and kit for carrying out the method are provided. The method includes screening a ribosome-display library...
US-1,005,9936 Multi-chain eukaryotic display vectors and uses thereof
A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of...
US-1,005,9935 Composite of Paracoccus denitrificans immobilized on modified graphene oxide and its preparation method and...
This invention provided a preparation method of the composite which was immobilized Paracoccus denitrificans on modified graphene oxide and its application. The...
US-1,005,9934 Leucine beta roll domains and uses thereof
In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of...
US-1,005,9933 Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also...
US-1,005,9932 Mutant of cellulase-producing microorganism, production method of cellulase and production method of...
An object is to provide a mutant of a cellulase-producing microorganism which produces a cellulase capable of preferentially producing a cello-oligosaccharide...
US-1,005,9931 Genetically engineered Pichia strain and methods of using the same
The present invention provides a novel dual-function lipase variant and its application in processing of flour products. The amino acid sequence of the lipase...
US-1,005,9929 Modified template-independent enzymes for polydeoxynucleotide synthesis
The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides...
US-1,005,9928 Polymerases
Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate...
US-1,005,9927 Compositions and methods for controlling microbial growth
Provided are modified microorganisms which are modified such that their growth can be controlled using exogenously provided compounds. The microorganisms can be...
US-1,005,9926 Mutant lactate dehydrogenase
A method of screening a microorganism having a mutant lactate dehydrogenase with increased activity, a mutant lactate dehydrogenase polypeptide, a...
US-1,005,9925 High titer recombinant influenza viruses with enhanced replication in vero cells
The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an...
US-1,005,9924 Clerodendrum viscosum and methods of use
The present invention provides for a composition and formulations comprising an extract from Clerodendrum viscosum, and a method of obtaining the extract. The...
US-1,005,9923 Methods for off-the-shelf tumor immunotherapy using allogeneic T-cell precursors
The inventive subject matter relates to methods for treating a T-cell deficiency in a subject in need thereof, comprising administering to said subject a T-cell...
US-1,005,9922 Methods and systems for separating components of a biological sample with gravity sedimentation
Aspects of the present disclosure include methods for separating components having different densities from a biological sample droplet. Methods according to...
US-1,005,9921 Methods of making spheroids including biologically-relevant materials
Methods of making a spheroid are provided whereby a suspension is first produced including one or more biologically-relevant materials dispersed within a...
US-1,005,9920 Synthetic methylotrophy to liquid fuels and chemicals
A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at...
US-1,005,9919 Bioprotection using Lactobacillus paracasei strains
The present invention is related to the field of bioprotection, in particular to the strain of Lactobacillus paracasei CHCC14676 with accession no. DSM25612....
US-1,005,9918 Method of vitally supporting microalgae in a flexible bioreactor
Some embodiments include a method. The method can include: inoculating a bioreactor with one or more first microorganisms and a first fluidic support medium,...
US-1,005,9917 Apparatus and method of stimulating cells using 3D clinostat and ultrasonic wave
Provided is an apparatus for stimulating cells using a 3D clinostat and ultrasonic waves in experiment equipment for studying adverse influences on a human body...
US-1,005,9916 Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
A method for filtering a gas includes delivering a gas into a compartment of a gas filter, the compartment being at least partially bounded by a casing...
US-1,005,9915 Cell culture method in a bioreactor system using micro-carriers
A system and method for compartmentalizing micro-carriers in a bioreactor includes a container configured to store micro-carriers and a vessel configured to...
US-1,005,9914 Disposable bioreactors and methods for construction and use thereof
In one embodiment, a disposable bioreactor including a headplate and a stirrer. The headplate has at least one inlet port aperture and one outlet port aperture...
US-1,005,9913 Bioartifical lung
Presented is an airway organ bioreactor apparatus, and methods of use thereof, as well as bioartificial airway organs produced using the methods, and methods of...
US-1,005,9912 Multi-compartment water-soluble capsules
A multi-compartment water-soluble capsule thermoformed from two sheets of water-soluble film, the capsule comprising a least two compartments with a different...
US-1,005,9911 Washing hydrogen water producing method and producing apparatus
A method of producing washing hydrogen water in an embodiment, includes: a step of storing ammonia water in a first tank; a step of transferring the ammonia...
US-1,005,9910 Wash water maintenance for sustainable practices
Methods for use of enzymes for sustainable wash water maintenance are disclosed. The invention relates to use of enzymes for removing soils from wash water...
US-1,005,9909 Surfactant and detergent compositions containing ethoxylated glycerine
The present invention relates generally to surfactant and detergent compositions and, more specifically, to surfactant and detergent compositions containing an...
US-1,005,9908 Use of lactones as odor masking agents
Suggested is a method for masking odoriferous incorrect notes in oleochemical preparations, by adding to said compositions specific lactones.
US-1,005,9907 Microcapsules
A novel microcapsule which is endowed for example with reduced leakage of encapsulated materials. The microcapsule contains one or more fragrances and is...
US-1,005,9906 Solventless winterization of microbial oil
Provided herein are methods for winterizing oil. The methods include heating the oil to a first temperature and maintaining the oil at the first temperature for...
US-1,005,9905 Method to recover free fatty acids from fats and oils
Methods for producing oil from fats and oils having high free fatty acid content are provided. In the method, fats and oils are treated with a mixture including...
US-1,005,9904 Solvent-free process for obtaining phospholipids and neutral enriched krill oils using melting and evaporation
The invention relates to a new solvent-free process for simultaneously obtaining phospholipids-enriched krill oil and neutral lipid enriched-krill oil...
US-1,005,9903 Branched diesters for use as a base stock and in lubricant applications
This application relates to branched diester compositions that can be used as a base stock for lubricant applications, or as a base stock blend component for...
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