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Patent # Description
US-1,005,9750 Modified toxins
The present application relates to compositions of modified toxins exhibiting cytotoxicity and/or reduced immunogenicity. Also provided are polypeptide...
US-1,005,9749 Composition for preventing Mycoplasma spp. infection
The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine against Mycoplasma spp. The present invention...
US-1,005,9748 Pharmaceutical compositions for prevention or treatment of neurodegenerative diseases
The present invention relates to methods and compositions for the prevention or treatment of neurodegenerative diseases.
US-1,005,9747 Crimean-congo haemorrhagic fever virus antigenic composition
The present invention provides a viral vector or bacterial vector, said vector comprising a nucleic acid sequence encoding a Crimean-Congo Haemorrhagic Fever...
US-1,005,9746 Methods of improving vaccine immunogenicity
The present invention provides a process called "Immune Banking" that enhances vaccine efficacy by exploiting existing humoral responses. The process involves...
US-1,005,9745 Applications of the protein muNS and the derivates thereof
The invention is based on the identification of the minimum region of the avian Orthoreovirus muNS protein which is capable of forming inclusions as well as on...
US-1,005,9744 .alpha.4.beta.7 thioether peptide dimer antagonists
The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of .alpha.4.beta.7 to the mucosal addressing cell adhesion molecule...
US-1,005,9743 Peptide derivative for regulating thymic stromal lymphoid protein-mediated signaling and pharmaceutical...
The present invention relates to a peptide derivative for regulating the thymic stromal lymphoid protein-mediated signaling and a pharmaceutical composition...
US-1,005,9742 Peptides and methods and uses thereof for preventing retinal disorders
The present disclosure relates to methods and uses of C-terminal peptides for inhibiting neuronal cell death or dysfunction, such as retinal ganglion cell death...
US-1,005,9741 Peptidomimetic macrocycles
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
US-1,005,9740 Integrin interaction inhibitors for the treatment of cancer
Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by...
US-1,005,9739 Non-benzenoid aromatic systems for imaging, monitoring and therapy
This invention is directed to non-benzenoid aromatic compounds. Other aspects include methods of using non-benzenoid aromatic compounds for imaging and...
US-1,005,9738 Process for the production of a dipeptide derivative
The present invention is related to a novel and improved process for the manufacture of compounds of formula (I) or salts thereof herein designated as...
US-1,005,9737 Molecular recognition systems with pyrimidine analog pairing
This invention is for a new molecular recognition system, where DNA-like molecules comprising segments built from nucleotides that carry only a small which...
US-1,005,9736 Ionic liquid supported synthesis
The present invention relates to ionic liquids for use in chemical applications and capable of serving the dual function of solvent and liquid support. The...
US-1,005,9735 Nucleoside heterocycle that binds to both thymidine and cytidine
This application discloses nucleoside analogs that when incorporated into a oligonucleotide, forms a nucleobase pair with either thymidine or cytidine that are...
US-1,005,9734 Thionucleoside derivative or salt thereof, and pharmaceutical composition
Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired...
US-1,005,9733 Gemcitabine analogs
Gemcitabine analogs, including monophosphorylated analogs, are described herein and are suitable for use in pharmaceutical compositions, kits and treatment...
US-1,005,9732 Non-caloric sweeteners and methods for synthesizing
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
US-1,005,9731 Process for depolymerization of lignin by laccases
A method for depolymerization of lignin includes oxidizing non-phenolic lignin by putting into presence, in at least one solvent, non-phenolic lignin, laccase,...
US-1,005,9730 High purity lignin, lignin compositions, and higher structured lignin
Disclosed are lignins and lignin compositions having high purity. Also disclosed are lignins having unique structural characteristics, including less structural...
US-1,005,9729 Ruthenium complex, method for producing same, and use of same
The present invention provides a novel ruthenium complex that is easy to produce and handle and that can be supplied relatively inexpensively, a method for...
US-1,005,9728 Method for the preparation of functionalized cyclosiloxanes
The present invention relates to a method for preparing functionalized cyclosiloxanes of Formula I, ##STR00001## wherein R, R.sup.1, R.sup.2, m, n1 and n2 are...
US-1,005,9727 Flame retardant filler
A flame retardant filler having brominated silica particles, for example, imparts flame retardancy to manufactured articles such as printed circuit boards...
US-1,005,9726 Base-catalyzed silylation of terminal olefinic C--H bonds
The present invention is directed to a mild, efficient, and general direct C(sp.sup.2)-H bond silylation of terminal olefins. Various embodiments includes...
US-1,005,9725 Compound having triphenylsilyl group and triarylamine structure, and organic electroluminescent device
The invention provides a light emitting layer host compound and an electron-blocking compound that have high excited triplet levels, and can completely confine...
US-1,005,9724 Pyridine complex of zirconium, catalytic system comprising said pyridine complex of zirconium and process of...
Pyridine complex of zirconium having general formula (I): Said pyridine complex of zirconium having general formula (I) may advantageously be used in a...
US-1,005,9723 Histone deacetylase inhibitors
This invention relates to generally inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).
US-1,005,9722 Cephalosporin derivatives and methods of use
This invention provides cephalosporin derivatives for killing or inhibiting the spread of microorganisms such as non-replicating Mycobacterium tuberculosis and...
US-1,005,9721 Substituted thieno[3,2-b]pyrazines for inhibiting cancer cell proliferation and inducing cancer cell apoptosis
The present invention relates to a novel 4-(aryl)-N-(2-alkoxythieno[3,2-b]pyrazin-3-yl)-piperazin-1-carboxamide derivative compound useful in the prevention or...
US-1,005,9720 Pyridine derivative
The problem to be solved by the present invention is to provide a compound suitable for a pharmaceutical composition, specifically a pharmaceutically...
US-1,005,9719 Process for making isoidide
A process is provided for making isoidide, wherein a dextrose feed is first converted by a combination of epimerization and hydrogenation to an iditol-enriched...
US-1,005,9718 Fused quadracyclic compounds, compositions and uses thereof
Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the...
US-1,005,9717 Urea compounds containing 3,4-dihydropyrimido[4,5-D]pyrimidin-2(1H)-one skeleton as protein kinase inhibitors
The present invention provides a pharmaceutical composition, as an effective ingredient, a urea compound having a protein kinase inhibitory activity and...
US-1,005,9716 Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections
Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating...
US-1,005,9715 Acid addition salt of ibrutinib
The present invention relates to acid addition salts of ibrutinib, a pharmaceutical composition comprising the same as well as a method of preparing the same.
US-1,005,9714 Protein kinase B inhibitors
The invention relates to a novel group of compounds of Formula (I) or salts thereof: ##STR00001## wherein Y, Z.sup.1, Z.sup.2, R.sup.1, R.sup.4, R.sup.5 and n...
US-1,005,9713 3-substituted 2-amino-indole derivatives
The present invention provides compounds of formula (I) (Formula (I)) and pharmaceutically acceptable salts thereof, wherein Q, X % X.sup.4, X.sup.5 X.sup.6,...
US-1,005,9712 N-benzyl tryptanthrin derivative, and preparation method and application thereof
The present invention relates to an N-benzyl tryptanthrin derivative, and preparation method and use thereof. The N-benzyl tryptanthrin derivative of the...
US-1,005,9711 Compounds and methods for the treatment of malaria
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the...
US-1,005,9710 Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical...
US-1,005,9709 Compounds
The invention relates to a compound of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and...
US-1,005,9708 Therapeutic targeting of the interleukin 1 receptor-associated kinase 4 (IRAK4) in leukemias characterized by...
Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods...
US-1,005,9707 Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro- ...
The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihy- ...
US-1,005,9706 Pyrazolopyridine sulfonamides as nematicides
Disclosed are compounds of formula (I) which possess nematicidal properties ##STR00001## wherein the structural elements have the meaning as indicated in the...
US-1,005,9705 Acyclic cyanoethylpyrazolo pyridones as janus kinase inhibitors
The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as...
US-1,005,9704 1,4-disubstituted 1,2,3-triazoles, methods for preparing same, and diagnostic and therapeutic uses thereof
A compound having the following general formula (I): ##STR00001## wherein: X is a nitrogen atom and Y is a carbon atom; or X is a carbon atom and Y is a...
US-1,005,9703 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1H)-one derivatives as fungicides
This present disclosure is related to the field of 3-alkyl-5-fluoro-4-substituted-imino-3,4-5 dihydropyrimidin-2(1H)-ones and their derivatives and to the use...
US-1,005,9702 Inhibitors of LC3/ATG3 interaction and their use in the treatment of cancer
The present inventors discovered that the molecule pyridinylthiazolamine (PTA) specifically prevents the protein-protein interaction of hLC3 with hAtg3 in vitro...
US-1,005,9701 Heteroaryl compounds as IRAK inhibitors and uses thereof
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
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