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Patent # Description
US-1,006,4889 Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the...
The present invention discloses a mercapto-modified biocompatible macromolecule derivative with a low degree of modification. The mercapto-modified...
US-1,006,4888 Pectin based nanoparticles
This invention provides (a) nanoparticle made of: sugar-beet pectin; and a bioactive compound (such as a nutraceutical or a drug) bound to sugar-beet pectin....
US-1,006,4887 Pharmaceutical compositions containing hyaluronic acid for use in the treatment of black disc disease
The present invention describes and claims pharmaceutical compositions in gel form for use in the treatment of intervertebral disc degeneration, in particular...
US-1,006,4886 Composition based on xyloglucan and proteins for the treatment of intestinal disorders
Disclosed are compositions comprising synergic combinations of xyloglucans and plant or animal proteins, which are useful in the treatment of intestinal disorders.
US-1,006,4885 Metabolic gene, enzyme, and flux targets for cancer therapy
A novel pathway in cancer cell metabolism is identified. Targeting of any gene, protein, or enzyme that modulates activity or flux through this pathway,...
US-1,006,4884 Composition and methods of treating acne and photoaging
Pharmaceutical compositions comprising a first anti-acne compound, a second anti-acne compound, and an anti-photoaging compound are described. Methods for the...
US-1,006,4883 Lipiodol-based anti-tumour emulsion for treating cancer
The present invention relates to a pharmaceutical composition including Lipiodol and a molecule with anti-tumor activity and secondarily a hydroxyethyl starch....
US-1,006,4882 Methods of treating pulmonary disorders with liposomal amikacin formulations
Disclosed herein are methods of treating pulmonary disorders comprising administering to the patient an effective dose of a nebulized liposomal amikacin...
US-1,006,4881 Natural formulations
Provided is an all natural composition including naturally-obtained plant extracts.
US-1,006,4880 Silanol based therapeutic payloads
Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting...
US-1,006,4879 Method for treating depression and/or depression status with substituted quinoxaline compounds
A heterocyclic compound represented by the general formula (1) or a salt thereof: ##STR00001## wherein m, l, and n respectively represent an integer of 1 or...
US-1,006,4878 Controlled release and taste masking oral pharmaceutical compositions
The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least one...
US-1,006,4877 Materials and methods for treatment and diagnosis of disorders associated with oxidative stress
The subject invention pertains to materials and methods for the prevention and treatment of disease conditions associated with oxidative stress or a compromised...
US-1,006,4876 Bile acid receptor agonism for treating addiction
Compositions and methods for treating addiction in a subject are disclosed. In particular, compositions and methods for treating addiction to a dopaminergic...
US-1,006,4875 Topical formulations comprising a steroid
The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are...
US-1,006,4874 Methods of reducing mammographic breast density and/or breast cancer risk
The present disclosure is directed to generally methods and/or compositions for treating mammographic breast density and/or breast stiffness in a patient in...
US-1,006,4873 Compounds and compositions for treating HIV with derivatives of Betulin
The present invention relates to compounds characterized by having a structure according to the following Formula I: ##STR00001## or a pharmaceutically...
US-1,006,4872 Oil-in-water method for making polymeric implants containing a hypotensive lipid
Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the...
US-1,006,4871 Methods of treating skin disorders
A method of treating a skin disorder (e.g., an inflammatory or neoplastic skin disorder) in a subject in need thereof is carried out by administering (e.g.,...
US-1,006,4870 Sol-gel polymer composites and uses thereof
The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a gelation agent, and optional additional...
US-1,006,4869 MTH1 inhibitors for treatment of inflammatory and autoimmune conditions
A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions. ...
US-1,006,4868 (Alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles,...
Provided herein are (alpha-substituted aralkylamino or heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula I, and...
US-1,006,4867 Hsp90 inhibitors
The disclosure relates to Compounds of Formula (1): ##STR00001## and pharmaceutically acceptable salts thereof wherein Z.sub.1, Z.sub.2, Z.sub.3, Xa, Xb, Xc,...
US-1,006,4866 Treatment of B-cell malignancies by a combination JAK and PI3K inhibitors
This invention relates to methods of treating B-cell malignancies using a combination of inhibitors of JAK1 and/or JAK2 and inhibitors of PI3K.delta..
US-1,006,4864 Anti-angiogenesis compound, intermediate and use thereof
Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect...
US-1,006,4863 Formulations of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione
Pharmaceutical compositions and single unit dosage forms of Compound A (3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione), or an enantiomer or...
US-1,006,4862 Antiviral axin stabilizer
Methods and compositions for preventing and/or treating viral infections are provided. The methods involve administering an agent that stabilizes or enhances...
US-1,006,4861 Macrocyclic pyridazinone derivatives
A compound of formula (I) is provided: ##STR00001## wherein R1, R2, R3, R4, L and Z have the meaning given in the claims. Further provided is the prophylaxis...
US-1,006,4860 Pharmaceutical compositions containing clofazimine for inhibiting Clostridium difficile activity
Methods for inhibiting the activity of Clostridium difficile in a subject comprises administering to the subject a pharmaceutical composition consisting of...
US-1,006,4859 Crystallization process of aripiprazole derivatives in extended release formulations for treatment of schizophrenia
Processes for providing depot injections of recrystallized aripiprazole lauroxil in which particles of the aripiprazole lauroxil have a surface area of about...
US-1,006,4858 Methods and compositions for treating bacterial infections with iron chelators
The present invention provides methods and compositions for treating or preventing bacterial infections, where a pharmaceutically acceptable iron chelator that...
US-1,006,4857 Bupropion as a modulator of drug activity
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
US-1,006,4856 Pharmaceutical compositions
Methods and compositions are provided which comprise effective amounts of an analgesic to treat a subject, including reducing or eliminating an adverse effect...
US-1,006,4855 Composite nanoparticles and uses thereof
Provided herein are composite nanoparticles, methods of making composite nanoparticles and methods of using composite nanoparticles to treat or ameliorate...
US-1,006,4854 Cyclopropylamines as LSD1 inhibitors
This invention relates to the use of cyclopropylamine derivatives for the modulation, notably the inhibition of the activity of Lysine-specific demethylase 1...
US-1,006,4853 Compounds for use in methods for treating diseases or conditions mediated by protein disulfide isomerase
The invention provides compounds of formula (I) that inhibit PDI, for use in methods to treat or prevent a disease or condition in a subject that would benefit...
US-1,006,4852 Decreasing expression level of apoptosis-related genes by treating a human subject with a nitroxide
Disclosed herein are methods for treating a human subject having a disease associated with an increased level of apoptosis using a nitroxide. Further disclosed...
US-1,006,4851 Method for the treatment of neurological disorders by enhancing the activity of .beta.-glucocerebrosidase
Provided is a method of increasing the stability of wild-type .beta.-glucocerebrosidase. Also provided are methods of treating and/or preventing an individual...
US-1,006,4850 Compositions and methods for prophylaxis and treatment of addictions
The present invention relates to methods of treating or preventing addiction and relapse use of addictive agents, and treating or preventing addictive or...
US-1,006,4849 Pharmaceutical compositions for direct systemic introduction
The invention relates to pharmaceutical compositions for direct systemic introduction, are also known as DSI pharmaceutical compositions, for used as human...
US-1,006,4848 Pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof
Compounds for the preparation of pyridone derivatives are provided. In particular, compounds of formula (IA) are provided, wherein the variable groups are as...
US-1,006,4846 Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a...
The present invention provides uses of a glucokinase activator in combination with metformin. Uses include treating type 2 diabetes, lowering blood glucose,...
US-1,006,4845 Compositions and methods of treating muscular dystrophy with thromboxane-A.sub.2 receptor antagonists
The present invention is directed to methods of treating and/or ameliorating muscular dystrophy and/or treating cardiomyopathy in muscular dystrophy patients by...
US-1,006,4844 Pharmaceutical compositions comprising an aromatse inhibitors
The present invention relates to low-dose pharmaceutical compositions comprising the aromatase inhibitor ...
US-1,006,4843 Bis-amide derivative and use thereof
The present invention relates to a novel bis-amide derivative compound or a pharmaceutically acceptable salt thereof; a method of preparation thereof; and a...
US-1,006,4842 KCNQ channels as therapeutic targets
The present disclosure relates to methods and compositions for modulating the activity of KCNQ channels as a means for reducing the effects of aberrant KCNQ...
US-1,006,4841 Isoandrographolide-19-propionate for treatment of non-alcoholic fatty liver disease (NAFLD)
Isoandrographolide-19-propionate for treatment of non-alcoholic fatty liver disease (NALFD) relates to the compound isoandrographolide-19-propionate (IAN-19P),...
US-1,006,4840 Pharmaceutical composition for the treatment of multi-drug resistant infections
A pharmaceutical composition for the treatment of multi-drug resistant infections includes an antimicrobial agent in combination the ...
US-1,006,4839 Methods of treating liver diseases
The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g.,...
US-1,006,4838 Method for treating tau-associated diseases using tetrahydropyranol derivatives
A method for treating tau-associated disease by administering a pharmaceutical composition comprising a tetrahydropyranol derivative to a subject in need is...
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