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Patent # Description
US-1,007,2077 Antibody useful in neurological or neurodegenerative disorders
The present invention relates to an anti-NMDA antibody or fragment or derivative thereof which is effective in inhibiting the deleterious effects of tissue-type...
US-1,007,2076 Human antibodies to NA.sub.v1.7
The present invention provides antibodies that bind to the human voltage gated sodium channel designated Na.sub.v1.7 and methods of using same. According to...
US-1,007,2075 Optimized variants of anti-VEGF antibodies and methods of treatment thereof by reducing or inhibiting angiogenesis
The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and...
US-1,007,2074 Human islet amyloid polypeptide (HIAPP) specific antibodies and uses thereof
Provided are novel human islet amyloid polypeptide, also known as amylin and IAPP and proIAPP respectively, specific antibodies as well as fragments,...
US-1,007,2073 Glycans as functional cancer targets and antibodies thereto
A glycan having the structure gal.beta.1-3GLcNac.beta.1-3Gal.beta.1-4(Fuc.alpha.1-3)GlcNAc (LecLe.sup.x) which is attached to a lipid or protein backbone, and ...
US-1,007,2072 Antibody neutralizing human respiratory syncytial virus
The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids...
US-1,007,2071 Antibodies that neutralize RSV, MPV and PVM and uses thereof
The invention relates to antibodies, and antigen binding fragments thereof, that neutralize infection of both RSV, MPV and PVM. The invention also relates to...
US-1,007,2070 Potent anti-influenza A neuraminidase subtype N1 antibody
Isolated monoclonal antibodies and antigen binding fragments thereof that specifically bind neuraminidase (NA) of an N1 subtype influenza virus are disclosed...
US-1,007,2069 Humanized monoclonal antibodies from a transgenic rat
The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The...
US-1,007,2068 Method for altering the binding specificity of plasma proteins by oxidation
The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an...
US-1,007,2067 Fetal hemoglobin for genetic correction of sickle cell disease
Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for...
US-1,007,2066 Methods and compositions for treatment of a beta thalessemia
Methods and compositions for treatment of a beta thalessemia are provided.
US-1,007,2065 Peptide-mediated delivery of immunoglobulins across the blood-brain barrier
Provided herein are materials and methods for delivering immunoglobulins (e.g. therapeutic immunoglobulins) across the blood-brain barrier.
US-1,007,2064 Composition comprised of antigen linked to a TNF superfamily ligand
The invention provides fusion proteins comprising antigens of infectious disease agents and cancer cells linked to multiple-trimer forms of TNF SuperFamily...
US-1,007,2063 Peptides and combination of peptides for use in immunotherapy against various tumors
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,007,2062 Methods and compositions for modification of a HLA locus
Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA...
US-1,007,2061 Tumor targeted TNF-related apoptosis inducing ligand fusion polypeptide, methods and uses therefor
Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds...
US-1,007,2060 Islet amyloid polypeptides with improved solubility
Isolated non-naturally occurring, mutant-human islet amyloid polypeptides (hIAPP) are disclosed. These polypeptides can be formulated or co-formulated at...
US-1,007,2059 Targeting of human interferon antagonists
The present invention relates to a fusion protein, comprising a cytokine antagonist and a targeting moiety, preferably an antibody or anti-body like molecule....
US-1,007,2058 Chimeric virus-like particles incorporating fusion GPI anchored GM-CSF and IL-4 conjugates
This disclosure relates to a GM-CSF and IL-4 conjugate fused to a glycolipid (GPI)-anchoring sequence that is incorporated into chimeric virus-like particles...
US-1,007,2057 Alternative nucleic acid molecules containing reduced uracil content and uses thereof
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides...
US-1,007,2056 Proteins specific for pyoverdine and pyochelin
The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical...
US-1,007,2055 Anti-inflammatory pharmaceutical products
Polypeptides having homology to regions of the N-terminal 50 residues of human Annexin 1 are provided for medical use as anti-inflammatory agents. Some of the...
US-1,007,2054 Vaccine and methods for detecting and preventing filariasis
The present invention is a multivalent vaccine for immunizing an animal against filariasis. In some embodiments, the antigens of the multivalent vaccine are...
US-1,007,2053 Nucleic acids for treatment of allergies
The present invention provides DNA vaccines for the treatment of allergies. The vaccines comprise the coding sequence for one or more allergenic epitopes, and...
US-1,007,2052 Method for the synthesis of phycocyanin
The invention discloses microorganism cell culture conditions that result in increased cellular and media concentrations of a biological pigment. The invention...
US-1,007,2051 Anti-inflammatory lipopeptide and preparing method and application thereof
Disclosed is an anti-inflammatory lipopeptide, which comprises peptide chains and aliphatic chains, the peptide chain being linked to the aliphatic chain...
US-1,007,2050 Caustic stable chromatography ligands
The present invention relates to chromatography ligands having improved caustic stability, e.g., ligands based on immunoglobulin-binding proteins such as,...
US-1,007,2049 Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery...
US-1,007,2048 Astexin peptides
Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and...
US-1,007,2047 Tagged hepadnavirus e antigen and its use in screening antiviral substances
The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit...
US-1,007,2046 Non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) and methods of using
A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally...
US-1,007,2045 Antibacterial lipopeptides and methods for their preparation and use
Novel antibacterial lipopeptides, pharmaceutical compositions, and methods for their preparation and use are described.
US-1,007,2044 Modified kisspeptin peptides and uses thereof
The present application provides synthetic modified peptides of five to seven natural or non-natural amino acids as well as pharmaceutical compositions...
US-1,007,2043 Inhibitors of protein tyrosine phosphatases
Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP....
US-1,007,2042 Atom transfer radical polymerization under biologically compatible conditions
Methods for conducting controlled grafting-from radical polymerizations from biomolecules under conditions that are biologically compatible are described. The...
US-1,007,2041 Method for preparing peptides by assembling multiple peptide fragments
Method for preparing a peptide assembly of n fragments and n-1 amino acids bearing a thiol function, represented by the formula: ...
US-1,007,2040 Tylosin A analogs and derivatives
The present invention pertains to derivatives of tylosin A. In particular, the present invention pertains to compounds having a structure of Formula (I). The...
US-1,007,2039 Process for the production of Fondaparinux sodium
The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at...
US-1,007,2038 Crystal of ammonium N-acetylneuraminate anhydrate, and process for producing same
According to the present invention, a crystal of ammonium N-acetylneuraminate anhydrate, and a process for producing a crystal of ammonium N-acetylneuraminate...
US-1,007,2037 Method for producing high purity lignin
The method is for separation of lignin from original black liquor (BL.sub.IN) that has a first precipitation stage (PR) for precipitation of lignin by a first...
US-1,007,2036 N-heterocyclic carbene complexes of metal imido alkylidenes and metal OXO alkylidenes, and the use of same
The invention relates to an N-heterocyclic carbene complex of general formulas I to IV (I) (II) (III) (IV), according to which A1 stands for NR2 or PR2, A2...
US-1,007,2035 Phenanthroline phosphonic acid derivative and preparation method therefor and application thereof
The present invention relates to a novel phenanthroline phosphonic acid compound and a pharmaceutical salt thereof, as well as an application of the compound...
US-1,007,2034 Kinase inhibitors
There are provided compounds of formula I, ##STR00001## wherein T, A, Q, Z, G, R.sup.4, R.sup.5a, R.sup.5b and n have meanings given in the description, which...
US-1,007,2033 N-(phosphinoalkyl)-N-(thioalkyl)amine derivative, method for producing same, and metal complex thereof
The purpose of the present invention is to provide: a ligand that is useful in a catalytic organic synthetic reaction; a method for producing said ligand; and a...
US-1,007,2031 Systems and methods for mechanosynthesis
Systems and methods for mechanosynthesis including those that avoid the need for a bootstrap process, avoid the need to build tips via mechanosynthesis, avoid...
US-1,007,2030 Base-catalyzed silylation of terminal alkyne C--H bonds
The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising...
US-1,007,2029 Crystalline form of a proteasome inhibitor
The present disclosure relates to a novel crystalline form of a proteasome inhibitor, and to the processes for the preparation thereof. The novel crystalline...
US-1,007,2028 Cross-coupling of unactivated secondary boronic acids
Provided are methods for site- and stereo-retentive cross-couplings with unactivated secondary boronic acids, which methods are particularly useful in building...
US-1,007,2027 Preparation of high-purity gadobutrol
What is described is a process for producing high-purity gadobutrol in a purity (according to HPLC) of more than 99.7 or 99.8 or 99.9% and the use for preparing...
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