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Patent # Description
US-1,007,1172 Endogenous neogenesis of beta cells
Methods are disclosed for producing pancreatic beta cells in a subject. The methods include administering to the subject a vector encoding heterologous Pancreas...
US-1,007,1171 Polypeptide complex comprising non-peptidyl polymer having three functional ends
Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends...
US-1,007,1170 Antibody-drug conjugate having improved stability and use thereof
The present invention relates to an antibody-drug conjugate comprising a drug conjugated to an antibody, a preparation method thereof and the use thereof.
US-1,007,1169 Enzymatic conjugation of polypeptides
One embodiment relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents,...
US-1,007,1168 Polyoxazoline antibody drug conjugates
In the present disclosure, polymer conjugates, including polymer-antibody-drug conjugates (polymer ADCs) are described, as well as the use of such conjugates to...
US-1,007,1167 Method of preventing and treating type 1 diabetes, allograft rejection and lung fibrosis (by targeting the...
The present invention relates to the role of purinergic receptors and ATP in T cell activation and autocrine system signaling. In one embodiment, the present...
US-1,007,1166 Protein complex using an immunoglobulin fragment and method for the preparation thereof
Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active...
US-1,007,1165 Protein-cell conjugate, preparation method and use thereof
The present invention pertains to immunology, biomedicine field, specifically relates to a protein-cell conjugate, which is characterized in that the protein...
US-1,007,1164 Estrogen-related receptor alpha based protac compounds and associated methods of use
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of...
US-1,007,1163 Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or...
US-1,007,1162 Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
The present invention is directed to a preserved liquid aqueous pharmaceutical composition comprising one or more etherified cyclodextrin derivatives; one or...
US-1,007,1161 Methods and materials for therapeutic delivery
Method for preparing a supramolecular therapeutic agent delivery assembly are provided. A carbonate-containing precursor, a functionalized aliphatic precursor,...
US-1,007,1160 Derivatized hyperbranched polyglycerols
Herein are provided derivatized hyperbranched polyglycerols ("dHPGs"). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with...
US-1,007,1159 Oral care compositions
Described herein are compositions comprising an active compound from an extract of magnolia, or a derivative thereof; and a non-surfactant electrolyte in an...
US-1,007,1158 Combination of the application of antibodies for immunostimulation together with glucocorticoids
The present invention relates to methods for reducing or eliminating the non-specific release of a cytokine associated with a disease comprising administering...
US-1,007,1157 Method of inducing tolerance to an allergen
The present invention relates generally to the field of allergies. More particularly, the present invention provides a method for treating an allergy in a...
US-1,007,1156 Aqueous gel formulations containing immune response modifiers
Aqueous gel formulations, including an immune response modifier (IRM), such as those chosen from imidazoquinoline amines, tetrahydroimidazoquinoline amines,...
US-1,007,1155 Nasal mucosal vaccine composition
The present invention provides a nasal mucosal vaccine composition which is safe, useful as a preventive or therapeutic agent for infectious diseases or...
US-1,007,1154 Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same
Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination...
US-1,007,1153 Therapeutic peptides and vaccines
Compositions are disclosed that induce broadly HIV therapeutic and vaccine inducing antibodies against diverse HIV clades and relate to the ability to identify...
US-1,007,1152 Tilapia lake virus vaccines
The present invention relates to vaccine compositions comprising attenuated strain of Tilapia Lake Virus (TiLV) for protecting tilapia fish against infection by...
US-1,007,1151 Therapeutic HPV16 vaccines
Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
US-1,007,1150 Immunity enhancing therapeutic vaccine for HPV and related diseases
An immunity enhancing therapeutic vaccine includes a gene vector based on recombinant adenovirus and three elements: 1) an HPV antigen including the E6 and E7...
US-1,007,1149 Temperature sensitive multivalent Bordetella avium vaccines
The present invention is related to various vaccine compositions against Bordetella avium and methods for preparing and administering the various vaccine...
US-1,007,1148 Immunotherapy against several tumors, such as lung cancer, including NSCLC
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
US-1,007,1147 Method for enhancing immune response in the treatment of infectious and malignant diseases
The present invention pertains to a new approach for the treatment of infectious and malignant diseases. The present invention provides new DNA and protein...
US-1,007,1146 Peptide compositions having 4 linked CTL epitopes and uses thereof
This invention provides a cancer antigen peptide that can be administered to a wide range of cancer patients in the form of a peptide vaccine for cancer without...
US-1,007,1145 Local engineering of the lymph node environment to promote immune tolerance
A method of inducing specific immune tolerance to myelin in an individual is provided. The method includes introducing directly into a lymph node of the...
US-1,007,1144 Cell therapy for the treatment of neurodegeneration
Methods are described for the isolation and selection of a heterogeneous bone marrow cell population, called NCS-01, that is effective at treating ...
US-1,007,1143 Methods for non-surgical treatment of carpal tunnel syndrome
Provided is a non-surgical method of treatment of carpal tunnel syndrome by administering an effective amount of purified collagenase I and II by injection onto...
US-1,007,1142 Enzymes and methods for cleaving N-glycans from glycoproteins
Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly...
US-1,007,1141 Albumin-based non-covalent complexes and methods of use thereof
A non-covalent complex of an albumin molecule and a hydrophobic ligand, compositions containing the same, and methods of use thereof are provided. The present...
US-1,007,1140 Amylin analogues
The present invention relates to amylin analogues and to their use in the treatment or prevention of a variety of diseases, conditions or disorders, including...
US-1,007,1139 Methods for treatment of conditions associated with elevated triglycerides with an ANGPTL8 polypeptide fragment
Methods and compositions for reducing one or more of triglyceride levels, total cholesterol levels and LDL cholesterol levels in a subject are provided. The...
US-1,007,1138 Compositions and methods for modulating stem cells and uses thereof
There are provided compositions and methods for modulating stem cell division decisions, in particular, division symmetry. It has been demonstrated that wnt7a...
US-1,007,1137 Method for decreasing mortality associated with chronic liver disease by use of long-acting human recombinant...
The proposed invention involves the use of new drugs with the recombinant soluble tumor necrosis .alpha. receptor (HusTNFR) and belongs to the gene engineering...
US-1,007,1136 Stable liquid formulations of recombinant fusion proteins
Provided is a liquid formulation that enables the stable storage of recombinant fusion proteins, comprising a recombinant fusion protein, a buffer salt, a...
US-1,007,1135 Method of identifying an agent that promotes bone growth or increases bone density
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
US-1,007,1134 Therapeutic uses of CD137pos regulatory T cells
A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a...
US-1,007,1133 Method for destroying exosomes, kit for destroying exosomes, and method for isolating exosomes derived from...
A method for destroying exosomes of the present invention includes a step of preparing an antimicrobial peptide; and a step of allowing the antimicrobial...
US-1,007,1132 Optically-based stimulation of target cells and modifications thereto
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for...
US-1,007,1131 Compositions and methods for modulating the immune system
A novel class of embryo derived peptides are described (Preimplantation factor) that were generated synthetically and were tested on peripheral blood immune...
US-1,007,1130 Methods and compositions related to Hsp90 inhibitors and breast cancer
Embodiments of the invention are directed to methods of treating cancer cells, particularly breast cancer cells, such as chemo-resistant cells, with an Hsp90...
US-1,007,1129 Method for identifying bromodomain inhibitors
Disclosed herein are methods and compositions useful for inhibiting interaction between a bromodomain protein and an immunoglobulin (Ig) regulatory element. The...
US-1,007,1128 Method for preparing granules or pills containing extracts in high concentration
The present invention relates to a method for preparing a granule or a pill containing a plant, medicinal herb or traditional oriental medicine decoction...
US-1,007,1127 Hydrogenation of cannabis oil
The present invention relates to the extraction and hydrogenation of essential oil of a cannabis plant. The invention includes hydrogenated cannabis compounds...
US-1,007,1126 Conditionally replicating adenovirus to express REIC gene
An object of the present invention is to provide a conditionally replicating adenovirus having a strong anticancer effect. A conditionally replicating...
US-1,007,1125 Nutritional composition with probiotics
A composition comprising Bifidobacterium breve, a non-digestible saccharide A and a non-digestible saccharide B, optionally combined with Lactobacillus...
US-1,007,1124 Treatment of post-traumatic stress disorder with isolated Mycobacterium
The present invention relates to treatment or prevention of post-traumatic stress disorder (PTSD). In particular, the present invention relates to an isolated...
US-1,007,1123 Treatment of pulmonary arterial hypertension with mesenchymal stem cells
The application is directed to a method for treating or preventing vasculopathy comprising administrating to a subject in need thereof a pharmaceutical...
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