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Patent # Description
US-1,010,6571 HCV polymerase inhibitors
The invention provides compounds of the formula: ##STR00001## wherein B is a nucleobase selected from the groups (a) to (d): ##STR00002## and the other...
US-1,010,6570 Edible plasticizers for food and food packaging films
Disclosed are plasticizers, salts thereof, chelates thereof and cleavage derivatives thereof, that exhibit a superior combination of properties. The...
US-1,010,6569 Inhibitors of sodium glucose transporter 1 for constipation
Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes...
US-1,010,6568 Hafnium-containing film forming compositions for vapor deposition of hafnium-containing films
Disclosed are Hafnium-containing film forming compositions comprising Silicon- and Hafnium-containing precursors having one of the following formula: ...
US-1,010,6567 Biofilm inhibiting compositions enhancing weight gain in livestock
A method of enhancing the growth of an animal, as well as treating or preventing antimicrobial infections is provided. The method includes causing the animal to...
US-1,010,6566 Compounds and the use thereof in metathesis reactions
The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds...
US-1,010,6565 Phosphorylated dendrimers as antiinflammatory drugs
Dendrimers with monophosphonic or bisphosphonic terminations for the treatment of inflammatory diseases.
US-1,010,6564 Furan-containing flame retardant molecules
A furan-containing flame retardant molecule includes a furan moiety bonded to a phosphorus moiety via a phosphoryl linkage or via a phosphinyl linkage.
US-1,010,6563 Ether compounds for treatment of complement mediated disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-1,010,6562 Process for manufacture of gadofosveset trisodium monohydrate
This application relates to a process for making a pharmaceutically acceptable formulation of gadofosveset trisodium monohydrate, wherein the process uses no...
US-1,010,6560 Process and intermediates for making tubulysin analogs
An improved process for making a compound B of the structure ##STR00001## wherein n, R.sup.1, R.sup.2, and R.sup.3 are as defined in the specification....
US-1,010,6559 Substituted tetrahydrocarbazole and carbazole carboxamide compounds
Disclosed are compounds of Formula (I) ##STR00001## wherein: the two dotted lines represent either two single or two double bonds; Q is: ##STR00002## R.sub.1...
US-1,010,6558 Azolobenzazine compounds, compositions comprising these compounds and their use for controlling invertebrate pests
Azolobenzazine compounds of the formula I and N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof are disclosed, as...
US-1,010,6557 Preparation method for benzoxazoleoxazine ketone compound and intermediate and crystal form thereof
A preparation method for a high-purity benzoxazoleoxazine ketone compound, a crystal form thereof, and an intermediate compound for preparing a compound of...
US-1,010,6556 Heterocyclic compound
The present invention provides a compound having an MAGL inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of...
US-1,010,6555 Max binders as MYC modulators and uses thereof
The present disclosure provides compounds of Formula (I'), Formula (I), Formula (II), Formula (II-A), Formula (III), and Formula (IV). The compounds described...
US-1,010,6554 7-(morpholinyl)-2-(N-piperazinyl) methyl thieno [2, 3-C] pyridine derivatives as anticancer drugs
The present invention relates to novel series of substituted 7-(morpholinyl)-2-(N-piperazinyl)-methyl thieno [2, 3-c] pyridines of the following structure of...
US-1,010,6553 Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are...
US-1,010,6552 Compounds inhibiting eukaryotic elongation factor 2 kinase activity
Eukaryotic elongation factor 2 kinase inhibitors of the formula ##STR00001## where R.sub.1, R.sub.2, R.sub.3a, R.sub.3b, R.sub.4a, R.sub.4b, R.sub.5a,...
US-1,010,6551 Monothiol mucolytic agents
Provided are mucolytic agents represented by formula (Ia)-(Id): ##STR00001## where the structural variables R.sub.1, R.sub.2, R.sub.5 and R.sub.6 are as...
US-1,010,6550 Aza-phenalene-3-ketone derivative, preparation method thereof, and its application as PARP inhibitor
Disclosed are an aza-phenalene-3-ketone derivative, a preparation method thereof and its application as a PARP inhibitor. The aza-phenalene-3-ketone derivative...
US-1,010,6549 10',11'-modified saxitoxins useful for the treatment of pain
Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating conditions...
US-1,010,6548 Crystalline forms of a Bruton's tyrosine kinase inhibitor
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
US-1,010,6547 Triazolo[4,5-D] pyramidine derivatives and their use as purine receptor antagonists
Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making...
US-1,010,6546 Immunoregulatory agents
Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such...
US-1,010,6545 Pyrazolopyrimidine compounds
The present teachings provide a compound represented by structural formula (I-0), or a pharmaceutically acceptable salt thereof. Also described are...
US-1,010,6544 1,2-dihydro-3H-pyrrolo[1,2-C]imidazol-3-one derivatives and their use as antibacterial agents
The invention relates to antibacterial compounds of formula I ##STR00001## wherein R.sup.1 is one of the groups represented below ##STR00002## wherein A is a...
US-1,010,6543 Antimicrobial compounds and methods of making and using the same
The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for...
US-1,010,6542 Substituted 6,7-dihydropyrazolo[1,5-a]pyrazines as negative allosteric modulators of mGluR2 receptors
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives of formula (I) ##STR00001## as negative allosteric modulators...
US-1,010,6541 Intermediates for preparing CGRP receptor antagonists
The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for...
US-1,010,6540 HDAC6 inhibitors and their uses
The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present...
US-1,010,6539 Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV)
Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L is a single bond, C.sub.1-3 alkylene,...
US-1,010,6538 Inhibitors of protein kinases
Protein kinases are regulators of cellular signaling and their functional dysregulation is common in carcinogenesis and many other disease states or disorders....
US-1,010,6537 Fluorinated integrin antagonists
The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to...
US-1,010,6536 Imidazo(4,5-B) pyridin-2-yl amides as KV7 channel activators
Compounds represented by formula 1 can be potent and/or partially selective for the Kv7.2/7.3 heteromultimer. They may be useful in treating disorders related...
US-1,010,6535 Histone deacetylase inhibitors and compositions and methods of use thereof
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##
US-1,010,6534 Histone demethylase inhibitors
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine...
US-1,010,6532 Inhibitors of beta-hydroxylase for treatment of cancer
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel ...
US-1,010,6531 Compound useful to treat mycoses
This invention relates to compounds, as defined in the specification and as represented by the compound of formula (I): ##STR00001## that are useful in the...
US-1,010,6530 Pyrazolyl substituted tetrahydropyranylsulfones
The invention relates to pyrazolyl substituted tetrahydropyranylsulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing...
US-1,010,6529 Compounds that modulate intracellular calcium
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels....
US-1,010,6528 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as APJ agonists
The present invention provides compounds of Formula (I): ##STR00001## wherein all variables are as defined in the specification, and compositions comprising...
US-1,010,6527 Isoquinolin-3-yl carboxamides and preparation and use thereof
Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline...
US-1,010,6526 Inhibitors of cyclin-dependent kinase 7 (CDK7)
The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers,...
US-1,010,6525 Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
The disclosure provides rho kinase inhibitor BA-1049(R), an hydroxy metabolite of BA-1049(R), and adipate salts and deuterated forms thereof, useful for...
US-1,010,6524 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2H-pyrrol-5-amine compound inhibitors of beta-secretase
The present invention relates to 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2H-pyrrol-5-amine compound inhibitors of beta-secretase having the structure...
US-1,010,6523 Amide compound
A compound which is useful as an active ingredient of a pharmaceutical composition, for example, a pharmaceutical composition for treating chronic renal failure...
US-1,010,6522 Benzimidazole derivatives as antihistamine agents
The invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, a method of synthesis of said compounds,...
US-1,010,6521 Eckol derivatives, methods of synthesis and uses thereof
Provided herein are eckol derivatives, methods of synthesis thereof and pharmaceutical compositions thereof. In other embodiments, provided herein are methods...
US-1,010,6520 Apparatus and method for producing cyclic carbonate
An apparatus and method for continuously producing a cyclic carbonate which are easily scaled up without requiring a large-sized reactor or excessive ancillary...
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