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United States Patent Application	20040213744
Kind Code	A1
Lulla, Amar ;   et al.	October 28, 2004

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Foreign Application Data

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Date	Code	Application Number
May 20, 1999	IN	382/BOM/99
Aug 17, 1999	IN	582/BOM/2000
Jan 13, 2000	IN	43/BOM/2000
Jan 13, 2000	IN	44/BOM/2000

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Claims

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1. A sprayable composition for topical application, comprising: from about 0.0001% to about 30% of at least one medicament for systemic or topical availability, at least one film former, at least one vehicle; and at least one component selected from the group at least one permeation enhancer: at least one solubilizer: at least one plasticizer; and at least one water soluble additive the composition forming a stable, breathable film upon application to a surface.

2. The composition according to claim 1, comprising from about 0.0001% to about 10% of the at least one medicament.

3. The composition according to claim 1, comprising from about 0.0001% to about 5% of the at least one medicament.

4. The composition according to claim 1, wherein the film former comprises from about 0.0001% to about 10% of the composition.

5. (Canceled)

6. The composition according to claim 1, comprising at least one permeation enhancer in an amount of from about 0.0001% to about 8% of the composition.

7. (Canceled)

8. The composition according to claim 1, comprising at least one solubilizer in an amount of from about 0.0001% to about 10% of the composition.

9. (Canceled)

10. The composition according to claim 1, comprising at least one plasticizer in an amount of from about 0.0001% to about 10% of the composition.

11. The composition according to claim 1, the composition comprising at least one water soluble additive in an amount of from about 0.0001% to about 7%.

12. The composition according to claim 1, wherein the at least one medicament is locally or transdermally available.

13. (Canceled)

14. The composition according to claim 1, wherein the composition comprises at least one medicament which is released from the composition immediately upon application to a biological surface.

15. The composition according to claim 1, wherein the composition comprises at least one medicament which is released from the composition over an extended period of time after application to a biological surface.

16. (Canceled)

17. The composition according to claim 1, wherein the at least one medicament is selected from the group consisting of anti-emetics, anti-anginals, anti-inflammatory agents, steroids, steroid hormones, bronchodilators, drugs used to treat osteoporosis, drugs used to treat incontinence, antidepressants/anxiolytics, antimigraine agents, agents used in smoking cessation therapy, antidiarrheals, antiulcerants, anticholinerginics, anticonvulsants, drugs for mood disorders/obsessive compulsive disorder, ACE inhibitors, calcium channel blockers, antihypertensives/diuretics, antiobesity drugs, hormonal peptides and analogues, drugs for benign prostatic hyperplasia/urinary retention and erectile dysfunctions, antiparkinson agents such as dopamine agonists and MAO inhibitors, drugs for sleep disorders and antidiabetic agents.

18. The composition according to claim 1, wherein the at least one medicament is selected from the group consisting of scopolamine, nitroglycerine, clonidine isosorbide dinitrate, propanolol hydrochloride, timolol maleate, clonazepam, verapamil, diclofenac sodium, naproxen sodium, ibuprofen, ketoprofen, indomethacin, piroxicam, ketorolac, tromethamine, nimesulide, hydrocortisone and esters thereof, dexamethasone, fluocinolone acetonide and betamethasone and salts thereof, estradiol and norethisterone or their pharmaceutically acceptable salts and combinations thereof, testosterone, progesterone, salbutamol and salts thereof, bambuterol, salmeterol xinafoate, fluticasone propionate, mometasone furoate, budesonide, beclomethasone dipropionate, sodium cromoglycate or isoprenaline sulphate, alendronic acid, pamidronic acid, etidronic acid or salts thereof, vasopressin, oxybutynin, imipramine, mitrazapine, desipramine, naratriptan, zolmitriptan, sumatriptan, nicotine, loperamide, misoprostol, hyoscyamine, atropine, trihexyphenidyl, lorazepam, diazepam, tiagabine, fluoxetine, paroxetine, lisinopril, trandolapril, captopril, amlodipine, felodipine, prazosin, amiloride, methamphetamine, sibutramine hydrochloride, nafarelin, leuprolide acetate, insulin, growth hormone and analogues thereof, doxazosin, tamsulosin, terazosin, finasteride, alprostadil, sildenafil citrate, bromocriptine, cabergoline, selegiline, melatonin, glimepiride, rosiglitazone, glyburide, glipizide and combinations thereof.

19. The composition according to claim 1, wherein the at least one medicament is present as a single enantiomer.

20. The composition according to claim 6, wherein the at least one permeation enhancer is selected from the group consisting of lipophilic solvents, surfactants, oleic acid, octyl dimethyl benzoic acid, menthol, mixed esters of capric and caprylic acid, polyhydric alcohols, dimethyl sulfoxide, dimethyl formamide, isopropyl myristate, Tween, sodium lauryl sulfate, propylene glycol, transcutol and combinations thereof.

21. (Canceled)

22. The composition according to claim 1, wherein the at least one vehicle comprises water, at least one non-aqueous solvent, or at least one propellant.

23. The composition according to claim 22, wherein the at least one non-aqueous solvent is selected from the group consisting of acetone, isopropyl alcohol, methylene chloride, methyl ethyl ketone, absolute alcohol, ethyl acetate trichloromonofluoroethane (P11) and methylene dimethyl ether.

24. (Canceled)

25. The composition according to claim 22, wherein the at least one propellant comprises from about 10% to about 90% of the composition.

26. The composition according to claim 22, wherein the at least one propellant is selected from the group consisting of a hydrocarbon, a hydrofluorocarbon, hydrochlorofluorocarbon, a compressed gas propane, butane, isobutane, dimethylether, dichlorodifluoromethane (P12), trichloromonofluoromethane (P11) dichlorofluoroethane, monochlorodifluoromethane (P22), dichlorotetrafluoroethane (P114), difluoroethane (P152A). tetrafluoroethane (P134A), heptafluoropropane (P227B), nitrogen and carbon dioxide.

27. (Canceled)

28. The composition according to claim 1, wherein the at least one vehicle comprises from about 1% to about 20% (w/w) of at least one humectant.

29. The composition according to claim 28, wherein the at least one humectant is selected from the group consisting of polyhydric alcohols polyvinyl pyrrolidone, propylene glycol, butylene glycol, a polyethylene glycol, glycerol and sorbitol.

30. (Canceled)

31. The composition according to claim 1, wherein the at least one film-former is selected from the group consisting of acrylic polymers or copolymers, polyvinyl acetate, cellulose acetate, polyvinyl alcohol, povidone, copolypovidone povidone vinyl acetate, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, methyl cellulose and ethyl cellulose.

32. The composition according to claim 31, wherein the acrylic polymer or copolymer is selected from the group consisting of non-ionic copolymers of methyl methacrylate and butyl methacrylate, copolymers of dimethylamine ethyl methacrylate and a neutral methacrylic acid ester, ammonio methacrylate copolymer type B, ammonio methacrylate copolymer type A, methacrylic acid copolymer type A and methacrylic acid copolymer type B.

33. The composition according claim 8, wherein the at least one solubilizer is selected from the group consisting of copolymers of dimethylamine ethyl methacrylate and a neutral methacrylic acid ester, a surfactant, a polyhydric alcohol, vitamin E, vitamin E TPGS (tocopheryl polyethylene 1000 succinate), labrasol, propylene carbonate, sodium laurel sulphate, Tweens, spans, propylene glycol polyethylene glycol and combinations thereof.

34. (Canceled)

35. The composition according to claim 10, wherein the at least one plasticizer is selected from the group consisting of triethyl citrate, dimethyl isosorbide, acetyltributyl citrate, castor oil, propylene glycol, polyethylene glycol, and combinations thereof.

36. The composition according to claim 11, wherein the at least one water soluble additive is selected from the group consisting of propylene glycol, sodium lauryl sulfate, one or more polaxomers, polyoxyl 35 castor oil, polyoxyl 40 hydrogenated castor oil, cetomacrogol, polyethylene glycol, diethylene glycol, monoethyl ether EP (transcutol), and combinations thereof.

37. The composition according to claim 1, comprising: from about 0.0001% to about 30% of at least one medicament for topical or systemic availability, at least one film-former, at least one solubilizer, at least one permeation enhancer, at least one plasticizer, and at least one vehicle said composition forming a stable, breathable film upon application to a surface.

38. The composition according to claim 37, wherein the at least one medicament comprises from about 0.0001% to about 10% of the composition.

39. The composition according to claim 37, wherein the at least one medicament comprises from about 0.0001% to about 5% of the composition.

40. The composition according to claim 37, wherein the at least one film former comprises from about 0.0001% to about 10% of the composition, the at least one solubilizer comprises from about 0.0001% to about 10% of the composition, the at least one permeation enhancer comprises from about 0.0001% to about 8% of the composition, and the at least one plasticizer comprises from about 0.0001% to about 10% of the compositi.

41-43. (Canceled)

44. The composition according to claim 37, further comprising from about 0.0001% to about 7% of at least one water soluble additive.

45. The composition according to claim 37, wherein the film-former is a non-ionic copolymer of methyl methacrylate and butyl methacrylate and the solubilizer is a copolymer of dimethylamine ethyl methacrylate and a neutral methacrylic acid ester.

46. A stable, breathable film formed on the skin by topically applying a composition to an intended application site, said composition comprising from about 0.001% to about 30% of at least one medicament for topical or systemic availability, at least one film-former; at least one vehicle; and at least one component selected from the group at least one permeation enhancer; at least one solubilizer; at least one plasticizer, and at least one water soluble additive.

47. The film according to claim 46, wherein the composition comprises up to about 10% of the at least one medicament.

48. The film according to claim 46, wherein the composition comprises up to about 5% of the at least one medicament.

49-51. (Canceled)

52. The film according to claim 46, wherein the film is formed over a fixed surface area.

53. The film according to claim 52, wherein the fixed surface area is less than about 50cm.sup.2.

54. The film according to claim 52, wherein the fixed surface area is from about 10 cm.sup.2 to about 25 cm.sup.2.

55. The film according to claim 46, wherein the at least one medicament is locally or transdermally available.

56. A stable, breathable film formed on the skin by topically applying a composition according to claim 37.

57. A method of using at least one medicament, comprising the steps of: providing a composition for topical application, and dispensing a metered dose of said composition onto an intended application site on the skin; wherein the composition comprises from about 0.0001% to about 30% of at least one medicament for systemic or topical availability, at least one film former, at least one vehicle; and at least one component selected from the group at least one permeation enhancer; at least one solubilizer; at least one plasticizer; and at least one water soluble additive.

58. The method according to claim 57, wherein the composition comprises up to about 10% of the at least one medicament.

59. The method according to claim 57, wherein the composition comprises up to about 5% of the at least one medicament.

60. The method according to claim 57, wherein the at least one film former comprises from about 0.0001% to about 10% of the composition.

61-66. (Canceled)

67. The method according to claim 57, wherein the metered dose is dispensed over a fixed surface area.

68. The method according to claim 67, wherein the fixed surface area is not more than about 50 cm.sup.2.

69. The method according to claim 68, wherein the fixed surface area is from about 10 cm.sup.2 to about 25 cm.sup.2.

70. The method according to claim 57, wherein said dispensing comprises spraying.

71. The method according to claim 57, wherein the composition forms a stable, breathable film after dispensing on the application site.

72. The method of claim 70, wherein said dispensing is conducted by an apparatus selected from the group consisting of a pump dispenser and an aerosol dispenser.

73. (Canceled)

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Description

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[0001] This application is a continuation of U.S. application Ser. No. 09/503,843, filed Feb. 15, 2000, which claims priority to Indian Patent Application Nos. 382/BOM/99, filed May 20, 1999; 582/BOM/99, filed Aug. 17, 1999; 43/BOM/2000, filed Jan. 13, 2000; and 44/BOM/2000, Jan. 13, 2000, eacjh of which is incorporated herein by reference in its entirety.

BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] This invention relates to compositions for topical application of pharmaceutical compounds. Specifically, the invention relates to topical medicinal spray compositions, their use and films formed upon use. The compositions may be used to treat a variety of disorders.

[0004] 2. Background of the Invention

[0005] Many delivery systems for the topical application of pharmaceutical compounds are currently available and include lotions, creams, gels, ointments, transdermal patches and sprays. The choice of delivery system usually depends upon the desired pharmacokinetic profile of the drug, for example, whether immediate or sustained release is required. Many of these systems suffer from occlusion problems and may cause skin irritation. For example, many compounds, including hormonal drugs, are conventionally delivered using a transdermal patch. These patches comprise an occlusive backing membrane which often results in local skin irritation. A further disadvantage of transdermal patches is that percutaneous penetration of the drug is often poor.

[0006] The problem of skin irritation associated with transdermal patches is not as pronounced when topical spray formulations are used. For example, British Patent Specification No. 1,372,721 discloses a container of antiseptic for the topical treatment of bums and scalds, containing a topically acceptable antiseptic active agent against Pseudomonas aeruginosa, a pressuring agent and at least one surfactant admixed with water. The container comprises an outlet, and valve means operable to allow discharge of the contents of the container through the outlet in the form of a foam which is effective in the control of Pseudomonas aeruginosa at the site of a burn or scald. U.S. Pat. No. 4,534,958 describes and claims "a sprayable aerosol foam treatment composition which is a liquid in the aerosol container and forms a gel upon application to the skin". The composition in U.S. Pat. No. 4,534,958 comprises water, propellant, volatile solvent, a polyoxyethylene copolymer whose function is not described, and optionally a burn treatment agent and one or more adjuvants. The composition is used "for treating living skin".

[0007] However, conventional topical spray formulations tend to remain at the application site for only a short time. For example, they are easily rubbed off. As a result, the medicament to be absorbed through the skin is only available transiently. By contrast, medicament in a transdermal patch is potentially available for as long as the patch remains in place.

[0008] This invention provides advantages not previously realized. Specifically, the invention provides a composition for the topical application of pharmaceutical compounds without causing occlusion problems or skin irritation. Moreover, the inventive compositions remove the need for an adhesive patch. The invention further provides a topically applied composition that may remain as a breathable film on the skin for an extended period of time.

SUMMARY OF THE INVENTION

[0009] Through this invention, the advantages offered by transdermal patches and topical sprays have been combined, while the disadvantages associated with each have been minimized. This invention relates to a topical spray composition which can be sprayed onto the skin to form a breathable film or patch, which remains stable and in place over a period of days. In this way, a medicament can be delivered transdermally over a period of time. Since the film is non-occlusive, the problem of local skin irritation associated with transdermal patches is substantially reduced.

[0010] The invention provides a composition for topical application of one or more medicaments, comprising at least one medicament for systemic or topical availability, at least one film former, and one or more vehicles. The composition contains preferably up to about 30% of the at least one medicament, more preferably up to about 10% of the at least one medicament and most preferably up to about 5% of the at least one medicament. The composition may further comprise one or more additional components selected from the group consisting of permeation enhancers, solubilizers, plasticizers, and water soluble additives, including humectants. Medicaments in the composition may be present in a form that is solubilized or suspended. After application, the medicaments may be locally or transdermlly available and may be released from the composition. A wide range of medicaments for human or veterinary use may be used in the composition and the medicament may be present in chiral form. The compositions are preferably in a form suitable for application by spraying from an aerosol or pump spray container.

[0011] The invention further provides a stable, breathable film formed by applying the inventive compositions. The film is preferably formed over a fixed surface area. The fixed surface area is preferably less than about 50 cm.sup.2 and more preferably from about 10 cm.sup.2 to about 25 cm.sup.2. Medicaments of the composition may be locally or transdermlly available for release from the film.

[0012] Moreover, the invention comprises a method of using the inventive compositions pursuant to which a metered dose of the composition is dispensed onto an intended application site. The intended application site is preferably skin, and the metered dose is preferably applied over a fixed surface area. The fixed surface area is preferably less than about 50 cm.sup.2 and more preferably from about 10 cm.sup.2 to about 25 cm.sup.2. The metered dose of the composition is preferably dispensed by spraying the composition from a pump or aerosol spray dispenser. In one embodiment, the composition forms a stable, breathable film on the intended application site after dispensing.

[0013] The above objectives and advantages of the invention are illustrative, and not exhaustive, of those which can be achieved by the invention. The examples presented herein are non-limiting.

DETAILED DESCRIPTION OF THE INVENTION

[0014] In describing the invention, the following definitions are applicable throughout.

[0015] "Breathable film" refers to a film formed on the surface of the skin that does not interfere with perspiration, respiration and other metabolic activities of the skin.

[0016] "Film-formers" refers to compounds, preferably polymers, that form stable films on a surface when applied. Within the meaning of the present invention, a film is stable if it is resistant to removal by rubbing for an extended period of time. The extended period of time is preferably at least about 24 hours and most preferably from about 1 day to about 5 days.

[0017] "Topical application" refers to being applied to a surface such as skin.

[0018] "Topically active" refers to the composition or medicament for topical application which treats predominately the surface on which it is applied.

[0019] "Percutaneous penetration" or "transdermally available" means that the medicament of the composition is absorbed through skin when applied topically. Typically, although not necessarily, the medicament will then be distributed throughout the body resulting in systemic action as opposed to being only locally active.

[0020] "Permeation Enhancer" refers to a component used to enhance the penetration rate of drugs through the skin, preferably by temporarily diminishing the impermeability of the skin. Permeation enhancers have also been called "accelerants" and "sorption promoters." Examples of permeation enhancers include lipophilic solvents, surfactants, menthol, fatty acid esters and polyhydric alcohols.

[0021] "Plasticizer" refers to a component that aids a composition in forming a flexible, adherent film on the skin. Examples of plasticizers include citrate esters, dimethyl isosorbide, castor oil, propylene glycol and polyethylene glycol.

[0022] "Solubilizer" refers to components that aid in the dissolution or dispersement of the drug in the formulation. Examples of solubilizers include acrylate and methacrylate ester polymers and copolymers, surfactants, polyhydric alcohols, Vitamin E, Vitamin E TPGS and labrasol.

[0023] The present invention includes a topical, medicinal spray composition comprising a drug or combination of drugs as a solution or suspension in a vehicle optionally containing a polymer or combination of polymers which, when sprayed on the surface of the skin, forms a film on the skin. The compositions of the invention preferably comprise up to about 30% of at least one medicament (e.g., 0.0001% to about 30%), more preferably up to about 10% of at least one medicament (e.g., 0.0001% to about 10%) and most preferably up to about 5% of at least one medicament (e.g., 0.0001% to about 5%) dissolved or suspended in one or more vehicles which comprise up to 90% of the composition (e.g., 0.0001% to about 90%). The composition may further contain one or more film former, solubilizer, permeation enhancer and plasticizer. The composition may contain one or more of these additives in amounts of up to about 10% film-former (e.g., 0.0001% to about 10%), up to about 10% solubilizer (e.g., 0.0001% to about 10%), up to about 8% permeation enhancer (e.g., 0.0001% to about 8%), and up to about 10% plasticizer (e.g., 0.0001% to about 10%). The inventive composition may be sprayed on a topical site to form a stable, breathable film on the site, from which film the medicaments act locally on the surface or are transdermally available. Preferably, the composition further comprises up to about 7% (w/w) of one or more water-soluble additives (e.g., 0.0001% to about 7%). The drug or combination of drugs so deposited in the matrix of the film-former may remain solubilized or suspended. The exact formulation of the composition may vary depending on the nature of the particular medicament used (for example, the solubility profile) and the release profile desired. The compositions can be dispensed from any dispenser, preferably a dispenser which provides the composition as a spray, and may be used for systemic action or topical action. The drug from the composition may be released over a period of time or immediately.

[0024] The compositions of the present invention are preferably applied in a metered dose over a predetermined surface area. Accordingly, the present invention may also provide for the administration of the composition by spraying the composition from a dispenser. The invention further provides a method for applying the composition and the resultant film.

[0025] Preferably, the composition is dispensed from a pump dispenser or from an aerosol dispenser. In the latter case, the composition additionally comprises from about 10% to 90% of propellant in order to provide a suitable pressure within the aerosol dispenser. Generally, propellant is not required for compositions dispensed from a pump dispenser. However, if desired, such compositions may also comprise from about 10% to 90% of a propellant which is liquid at room temperature, for example, trichloromonofluoromethane (P11).

[0026] The invention also provides a method of preparing a pump dispenser containing the spray composition of the invention comprising mixing the ingredients of the composition with or without liquid propellant and placing the mixed ingredients in a pump dispenser.

[0027] In addition, the invention provides a method of preparing an aerosol dispenser containing the spray composition of the invention comprising mixing the ingredients of the composition without propellant and charging the mixture together with propellant into an aerosol dispenser. The composition is preferably dispensed from the chosen dispenser in a metered dose.

[0028] The medicament can be any medicinal compound in the salt or base form or a combination of compounds which is stable on mixing with the other ingredients of the composition and effective on topical administration. The medicament is preferably a drug which is an anti-emetic, an anti-anginal, an anti-inflammatory, a steroid, a steroid hormone, a bronchodilator or a drug used to treat osteoporosis. Additional preferred medicaments include drugs used to treat incontinence, antidepressants/anxiolytics, antimigraine agents, agents used in smoking cessation therapy, antidiarrheals, anticholinergics, anticonvulsants, drugs for mood disorders/obsessive compulsive disorder, ACE inhibitors, calcium channel blockers, antihypertensives/diuretics, antiobesity drugs, hormonal peptides and analogues, drugs for benign prostatic hyperplasia/urinary retention and erectile dysfunctions, antiparkinson agents such as dopamine agonists and MAO inhibitors, drugs for sleep disorders and antidiabetic agents.

[0029] One preferred anti-emetic is scopolamine. Preferred anti-anginals include nitroglycerine, clonidine, isosorbide dinitrate, propanolol HCl, timolol maleate, clonazepam and verapamil. Preferred anti-inflammatory drugs include diclofenac sodium, naproxen sodium, ibuprofen, ketoprofen, indomethacin, piroxicam, ketorolac, tromethamine and nimesulide. Preferred steroids include hydrocortisone and esters thereof, dexamethasone, fluocinolone acetonide and betamethasone and salts thereof. Preferred hormonal steroids include estradiol or noethisterone and their pharmaceutically acceptable salts or a combination thereof, testosterone or progesterone. Preferred bronchodilators include salbutamol and salts thereof, bambuterol, salmeterol xinafoate, fluticasone propionate, mometasone furoate, budesonide, beclomethasone dipropionate, sodium cromoglycate and isoprenaline sulphate. Preferred drugs used in case of osteoporosis include alendronic acid, pamidronic acid, etidronic acid and their pharmaceutically acceptable salts. Preferred drugs used to treat incontinence include vasopressin and oxybutynin. Preferred antidepressants/anxiolytics include imipramine, mirtazapine and desipramine. Preferred antimigraine agents include naratriptan, zolmitriptan and sumatriptan. One preferred antidiarrheal is loperamide. One preferred antiulcerant is misoprostol. Preferred anticholinergics include hyoscyamine, atropine and trihexyphenidyl. Preferred anticonvulsants include lorazepam, diazepam and tiagabine. Preferred drugs for antimood disorders/obsessive compulsive disorder include fluoxetine and paroxetine. Preferred ACE inhibitors include lisinopril, trandolapril and captopril. Preferred calcium channel blockers include amlodipine and felodipine. Preferred antihypertensives/diuretics include prazosin and amiloride. Preferred antiobesity drugs include methamphetamine and sibutramine hydrochloride. Preferred hormonal peptides and analogues include GnRH analogues such as nafarelin, leuprolide acetate, insulin and growth hormone and analogues thereof. Preferred drugs for benign prostatic hyperplasia/urinary retention include doxazosin, tamsulosin, terazosin and finasteride. Preferred drugs for erectile dysfunction include alprostadil and sildenafil citrate. Preferred antiparkinson agents include dopamine agonists such as bromocriptine and cabergoline and MAO inhibitors such as selegiline HCl. One preferred agent for sleep disorders is melatonin. Preferred antidiabetic agents include first and second generation sulphonyl ureas such as glimepiride, rosiglitazone, glyburide and glipizide. The chiral forms of all the drugs mentioned above, as well as achiral forms, can be used to make the topical spray composition of the present invention.

[0030] The film-formers preferably include acrylic polymers or copolymers, including methacrylic polymers and copolymers. Preferred film-formers include a non-ionic copolymer of methyl methacrylate and butyl methacrylate (Plastoid B.RTM.), a copolymer of dimethylamine ethyl methacrylate and a neutral methacrylic acid ester (Eudragit E100.RTM.), ammonio methacrylate copolymer type B (Eudragit RS.RTM., USP/NF), ammonio methacrylate copolymer type A (Eudragit RL.RTM., USP/NF), methacrylic acid copolymer type A (Eudragit L100.RTM., USP/NF), methacrylic acid copolymer type B (Eudragit S100.RTM. USP/NF), polyvinyl acetate, cellulose acetate, polyvinyl alcohol, povidone, povidone vinyl acetate, hydroxypropyl methyl cellulose, hydroxy ethyl cellulose, methyl cellulose and ethyl cellulose.

[0031] The breathability of the film is achieved by the absence of any occlusive backing membrane together with the generally hydrophilic properties of the film-forming polymer(s). These polymers can partially dissolve on exposure to moisture (from the skin or air), the dissolution resulting in the formation of a porous film. This porosity can be enhanced by including additional water-soluble additives, such as those detailed below.

[0032] Preferred solubilizers include a copolymer of dimethylamine ethyl methacrylate and a neutral methacrylic acid ester (Eudragit E100.RTM., USP/NF); surfactants, for example, sodium lauryl sulphate; polyhydric alcohols, for example, propylene glycol or polyethylene glycol; vitamin E, vitamin E TPGS (tocopheryl polyethylene glycol 1000 succinate) and labrasol; or any two or more of the above in combination. Preferably, the solubilizer is a copolymer of dimethylamine ethyl methacrylate and a neutral methacrylic acid ester (Eudragit E100.RTM.) in combination with, a non-ionic copolymer of methyl methacrylate and butyl methacrylate (Plastoid B.RTM.). The solubilizers serve to dissolve the drug in the chosen vehicle. Many of the solubilizers also enhance percutaneous penetration of drug and/or act as humectants.

[0033] Preferred plasticizers include triethyl citrate, dimethyl isosorbide, acetyltributyl citrate, castor oil, propylene glycol, and polyethylene glycol, or any two or more of the above in combination.

[0034] The permeation enhancer is preferably a lipophilic solvent, for example, dimethyl sulfoxide, dimethyl formamide or isopropyl myristate; a surfactant, for example, Tweens or sodium lauryl sulfate; menthol; oleic acid, octyl dimethyl para-amino benzoic acid (Padimate 0); mixed esters of capric and caprylic acid; or a polyhydric alcohol, for example, propylene glycol or diethylene glycol monoethyl ether EP (transcutol); or any two or more of the above in combination.

[0035] The vehicle can be water or a non-aqueous solvent. Preferred nonaqueous vehicles include acetone, isopropyl alcohol, methylene chloride, methyl-ethyl-ketone, absolute alcohol, ethyl acetate and trichloromonofluoromethane (P11), methylene dimethyl ether or any two or more of the above in combination.

[0036] The aqueous or non-aqueous vehicle may additionally comprise (weight/weight of vehicle) up to 20% of one or more humectants. Preferred humectants include polyhydric alcohols and polyvinyl pyrrolidone. Preferred polyhydric alcohols are propylene glycol, butylene glycol, polyethylene glycol, glycerol and sorbitol.

[0037] The water-soluble additive is preferably propylene glycol, sodium lauryl sulphate, one or more polaxomers, polyoxyl 35 castor oil, polyoxyl 40 hydrogenated castor oil, cetomacrogol, polyethylene glycol or transcutol, or any two or more of the above in combination.

[0038] When the composition is dispensed as an aerosol, the vehicle partly comprises a propellant in an amount to provide from about 10% to about 90% (w/w) of the composition. The propellant can be any pharmaceutically acceptable propellant which provides a suitable pressure within an aerosol dispenser, preferably a pressure of from about 20 p.s.i.g. to about 130 p.s.i.g. Preferred propellants include hydrocarbons, for example, propane, butane, isobutane, or dimethylether; hydrofluorocarbons and hydrochlorofluorocarbons, for example, dichlorodifluoromethane (P12), trichloromonofluoromethane (P11), dichlorofluoroethane, monochlorodifluoromethane (P22), dichlorotetrafluoroethane (P114), difluoroethane (P152a), tetrafluoroethane (134a), heptafluoropropane (P227b); or compressed gases, for example, nitrogen or carbon dioxide.

[0039] The topical compositions of the present invention are quick drying, non-occlusive formulations which cause marked enhancement of the skin permeation of the drug both in vitro and in vivo when compared with existing transdermal patches. They offer the advantages of lower skin irritation, greater ease of use, increased dosage flexibility and a simpler method of manufacture when compared to existing transdermal patches.

[0040] The present compositions are a significant advance over conventional medicinal aerosol compositions, since they permit the application of a medicament by a method whereby no physical contact on the area of application is required, except by the film-forming spray itself. The topical films formed by the present compositions show excellent stability and peelability and can be easily removed from the site of application by washing with water.

[0041] The compositions are generally prepared by mixing the ingredients, without liquefied propellant, at a temperature of from 0.degree. C. to 100.degree. C. and at ambient pressure. If propellant is to be added, the resulting mixture is then charged with the liquefied propellant into an aerosol dispenser to achieve the final composition. Mixing is preferably carried out at a temperature of from 10.degree. C. to 25.degree. C. Alternatively, the mixed composition is placed in a pump dispenser, for example, a metered dose pump, which dispenses the composition typically without liquefied propellant since a pressurized atmosphere is not required. Propellant which is liquid at room temperature may, however, be included in a pump dispenser composition as part of the aqueous vehicle. The composition so prepared is sprayed from the dispenser onto a topical site, at which site it forms a stable, plastic film or patch.

[0042] The aerosol dispenser is preferably a conventional aerosol can having a conventional metered spray aerosol valve. The pump dispenser is preferably a conventional can or bottle having a conventional metered spray pump. Preferably, the aerosol dispenser has an all position valve having a shroud that permits spraying when the dispenser is held at any angle. In this way, horizontal bottom surfaces, as well as horizontal top surfaces and vertical surfaces, can be sprayed. The valve actuator can be any actuator which produces a spray and not a foam at the nozzle. A preferred valve actuator is a mechanical breakup actuator, which employs mechanical forces rather than expansion and evaporation of the propellant to produce a spray. A typical mechanical breakup actuator has a conical or cylindrical swirl chamber with an inlet channel oriented perpendicular to the axis thereof. This structure imparts a swirling motion to the aerosol mixture upon discharge. The swirling motion occurs around the axis of the swirl chamber forming a thin conical film of discharged mixture, which breaks into droplets as it leaves the swirl chamber and travels in the direction of the axis thereof. The result is a fine, soft, dispersed spray which can be easily controlled to produce a stable thin film of even thickness completely contacting the application site. In dispensing a composition of the invention, the dispenser is typically held about 1 to 2 inches (2.5 to 5 cm) from the application site and produces a film of even thickness. The dispensers used in the present invention are preferably compact units. They can be conveniently used for quick and easy application of a medicament over a large surface area.

[0043] The composition is preferably applied over a fixed surface area. Typically, the fixed surface area is not more than 50 cm.sup.2, and is more preferably from 10 cm.sup.2 to 25 cm.sup.2.

[0044] In general, a composition according to the present invention suitable for use in an aerosol dispenser can be prepared as follows:

[0045] 1. Dissolve the film former in the chosen vehicle with stirring to form a clear solution;

[0046] 2. Dissolve or suspend the active ingredient and solubilizer(s) along with the permeation enhancer, together with any water-soluble additives required, in the solution formed in step 1;

[0047] 3. Add the plasticizer to the solution and fill a conventional aerosol can with the mixture; and

[0048] 4. Charge the filled can with liquefied propellant.

[0049] The following examples illustrate the preparation of compositions according to the present invention.

[0050] Examples 1 and 2 below represent partly generalized formulas which can be used with any suitable medicament to prepare compositions according to the present invention for use in an aerosol dispenser.

EXAMPLE 1

[0051]

1 Ingredients Percent w/w Active ingredient 0.5-10.0 Plastoid B 2.25 Eudragit E 100 0.25 Propylene glycol 3.0 Sodium lauryl sulfate 3.5 Acetone 20 Propellant q.s. Vitamin E 0.1 Transcutol 1.0

EXAMPLE 2

[0052]

2 Ingredients Percent w/w Active ingredient 15 Povidone 3 Povidone VA-64 2 Vitamin E 0.5 PEG 400 1.0 Propylene glycol 1.5 Ethanol 15 Acetone 15 Propellant q.s.

[0053] More specific examples of compositions for use in an aerosol dispenser are set forth in Examples 3 through 5.

EXAMPLE 3

[0054]

3 Ingredients Percent w/w Estradiol 1 PVP-K-30 6 PVP VA 4 Vitamin E 1 PEG 6000 2 Propylene glycol 3 P 12 58.1 P 11 24.9

EXAMPLE 4

[0055]

4 Ingredients Percent w/w Estradiol 2 PVP K-30 6 PVP VA 4 Vitamin E 1 PEG 6000 2 Propylene glycol 3 P 12 24.9 P 11 57.1

EXAMPLE 5

[0056]

5 Ingredients Percent w/w Alendronate sodium 1 PVP K-30 6 PVP VA 4 Vitamin E 0.5 Menthol 0.05 Dimethyl isosorbide 3.0 Acetone 10 Ethanol 10 Tetrafluoroethane (P134) 25.45 Dichlorodifluoromethane 40 (P12)

[0057] To prepare a composition according to the present invention suitable for use in a pump dispenser, the general method set forth above for an aerosol dispenser can be used, except that it is not necessary to charge the pump dispenser with liquefied propellant to provide a pressurized atmosphere. The mixture itself may contain propellant which is liquid at room temperature as part of the vehicle.

[0058] Examples 6 through 9 represent partly generalized formulas which can be used with any suitable medicament to prepare compositions according to the present invention for use in a pump dispenser.

EXAMPLE 6

[0059]

6 Ingredients Percent w/w Active ingredient 0.5-10.0 Plastoid B 5.6 Eudragit E 100 0.6 Propylene glycol 4.0 Sodium lauryl sulfate 3.0 Acetone 20 Isopropyl alcohol q.s. Vitamin E 0.2 Transcutol 2.0

EXAMPLE 7

[0060]

7 Ingredients Percent w/w Active ingredient 25 Povidone 6 Povidone VA-64 4 Vitamin-E 1.0 Propylene glycol 3 Ethanol 27 Acetone q.s. Methylene chloride 27

EXAMPLE 8

[0061]

8 Ingredients Percent w/w Active ingredient 15 PVP K 30 6 PVP VA 4 Vitamin-E TPGS 0.5 Dimethyl isosorbide 5 Ethanol 20 Trichloromonofluoromethane q.s. (P11)

EXAMPLE 9

[0062]

9 Ingredients Percent w/w Active ingredient 0.5-10 PVP VA 10 Vitamin E 0.5 Propylene glycol 3 Ethanol 25 Trichloromonofluoromethane q.s. (P11)

[0063] More specific examples of compositions which can be used in a pump dispenser are set forth in Examples 10 through 12.

EXAMPLE 10

[0064]

10 Ingredients Percent w/w Estradiol 2 PVP K-30 6 PVP VA 4 Vitamin E 1 PEG 6000 2 Propylene glycol 3 Acetone 27 Methylene chloride 27 Ethanol 28 Dichlorodifluoromethane 40 (P12)

EXAMPLE 11

[0065]

11 Ingredients Percent w/w Estradiol 1 PVP K-30 6 PVP VA 4 Vitamin E 1 PEG 6000 2 Polyethylene glycol 3 Acetone 27 Methylene chloride 28 Ethanol 28

EXAMPLE 12

[0066]

12 Ingredients Percent w/w Estradiol 1 PVP K-30 6 PVP VA 4 Vitamin E 1 Menthol 0.05 Dimethyl Isosorbide 5 Acetone 27.48 Ethanol 27.48 P11 27.48

[0067] The following further explanation is given of the above examples. Eudragit E 100 is a self-adhesive, hydrophilic matrix system. It also acts as a solubilizer for the drug Estradiol. Plastoid B is a film-former. When used together, Eudragit E 100 and Plastoid B give better peelability and water washability than when either is used alone. Acetone is a volatile, quick-drying, non-occlusive vehicle which helps to dispense the contents of the spray over a large surface area. Propylene glycol acts as a humectant to prevent the excessive drying of the application site after application of the medicament. It also acts as a plasticizer for the film formed after application. Propylene glycol additionally acts as a solubilizer for the drug and a permeation enhancer. Sodium lauryl sulfate acts as a solubilizer for the drug

[0068] Propellant is necessary for developing proper pressure within an aerosol container and for expulsion of the composition when the valve is open. It is also responsible, together with the valve, for dispensing the product as a fine spray. The preferred propellants are very stable compounds and relatively non-toxic, inert and non-flammable.

[0069] The compositions in the above examples were discharged from the dispenser as a fine, soft dispersed spray which could be easily controlled to produce a stable thin film of even thickness on a target surface, for example, a laboratory cover glass. The films have been observed to last for at least 24 hours. The concentrations of the film-formers in the composition can be varied as required to obtain a patch which can deliver the drug in a sustained manner for a period of up to 1 to 5 days. The film is easily removable from the application site by water in preparation for reapplication of the film or other treatment.

[0070] The embodiments illustrated and discussed in this specification are intended only to teach those skilled in the art the best way known to the inventors to make and use the invention. Nothing in this specification should be considered as limiting the scope of the present invention. The above-described embodiments of the invention may be modified or varied, and elements added or omitted, without departing from the invention, as appreciated by those skilled in the art in light of the above teachings. It is therefore to be understood that, within the scope of the claims and their equivalents, the invention may be practiced otherwise than as specifically described.

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